Nuclear localization of CXCR4 determines prognosis for colorectal cancer patients

Cancer Microenvironment

Volumn 2, Issue 1, 2009, Pages 1-7

  Speetjens, Frank M ^a   Liefers, Gerrit Jan ^a   Korbee, Cornelis J ^a   Mesker, Wilma E ^a   Van De Velde, Cornelis J H ^a   Van Vlierberghe, Ronald L ^a   Morreau, Hans ^a   Tollenaar, Rob A ^a   Kuppen, Peter J K ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Biomarker; Chemokines; Colorectal cancer; CXCR4; Prognosis

Indexed keywords

CHEMOKINE RECEPTOR CXCR4;

ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER INVASION; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CELL MIGRATION; CELL PROLIFERATION; CLINICAL TRIAL; COHORT ANALYSIS; COLORECTAL CARCINOMA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOPLASM; DIAGNOSTIC ACCURACY; DISEASE FREE SURVIVAL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METASTASIS; OVERALL SURVIVAL; PRIMARY TUMOR; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL;

EID: 73449099315     PISSN: 18752292     EISSN: 18752284     Source Type: Journal    
DOI: 10.1007/s12307-008-0016-1     Document Type: Article

References (32)

1. S Paget 1889 The distribution of secondary growths in cancer of the breast Lancet 1 571 573 10.1016/S0140-6736(00)49915-0
2. E Fuchs 1882 Das Sarkom des Uvealtractus Graefe's Archiv für Ophthalmologie XII 233
3. PA Ruffini P Morandi N Cabioglu, et al. 2007 Manipulating the chemokine-chemokine receptor network to treat cancer Cancer 109 2392 2404 10.1002/cncr.22706 1:CAS:528:DC%2BD2sXns1aksrc%3D 17503430 (Pubitemid 46906457)
4. A Zlotnik O Yoshie H Nomiyama 2006 The chemokine and chemokine receptor superfamilies and their molecular evolution Genome Biol 7 243 10.1186/gb-2006-7-12-243 17201934 (Pubitemid 46995589)
5. K Bacon M Baggiolini H Broxmeyer, et al. 2002 Chemokine/chemokine receptor nomenclature J Interferon Cytokine Res 22 1067 1068 10.1089/107999002760624305 12433287 (Pubitemid 35379019)
6. A Muller B Homey H Soto, et al. 2001 Involvement of chemokine receptors in breast cancer metastasis Nature 410 50 56 10.1038/35065016 1:CAS:528:DC%2BD3MXhvVSgu74%3D 11242036 (Pubitemid 32225831)
7. IS Zeelenberg L Ruuls-Van Stalle E Roos 2003 The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases Cancer Res 63 3833 3839 1:CAS:528:DC%2BD3sXltVGqs7k%3D 12839981
8. T Koshiba R Hosotani Y Miyamoto, et al. 2000 Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression Clin Cancer Res 6 3530 3535 1:CAS:528:DC%2BD3cXntFCis7c%3D 10999740
9. RS Taichman C Cooper ET Keller, et al. 2002 Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone Cancer Res 62 1832 1837 1:CAS:528:DC%2BD38XisVSit70%3D 11912162
10. J Kim T Mori SL Chen, et al. 2006 Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome Ann Surg 244 113 120 10.1097/01.sla.0000217690. 65909.9c 16794396 (Pubitemid 44297455)
11. N Lapteva AG Yang DE Sanders, et al. 2005 CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo Cancer Gene Ther 12 84 89 10.1038/sj.cgt.7700770 1:CAS:528:DC%2BD2cXhtVOht77M 15472715 (Pubitemid 39665246)
12. Z Liang Y Yoon J Votaw, et al. 2005 Silencing of CXCR4 blocks breast cancer metastasis Cancer Res 65 967 971 1:CAS:528:DC%2BD2MXhtVWntbw%3D 15705897
13. A Ottaiano R Franco TA Aiello, et al. 2006 Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients Clin Cancer Res 12 2795 2803 10.1158/1078-0432.CCR-05-2142 1:CAS:528:DC%2BD28Xltlamtrw%3D 16675573 (Pubitemid 43752119)
14. J Kim H Takeuchi ST Lam, et al. 2005 Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival J Clin Oncol 23 2744 2753 10.1200/JCO.2005.07.078 1:CAS:528: DC%2BD2MXktleqtrg%3D 15837989 (Pubitemid 46179464)
15. CC Schimanski S Schwald N Simiantonaki, et al. 2005 Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer Clin Cancer Res 11 1743 1750 10.1158/1078-0432.CCR-04-1195 1:CAS:528: DC%2BD2MXitVKrsrs%3D 15755995 (Pubitemid 40471835)
16. A Ottaiano A di Palma M Napolitano, et al. 2005 Inhibitory effects of anti-CXCR4 antibodies on human colon cancer cells Cancer Immunol Immunother 54 781 791 10.1007/s00262-004-0636-3 1:CAS:528:DC%2BD2MXmtVajsbk%3D 15592929 (Pubitemid 40977146)
17. NJ Jordan G Kolios SE Abbot, et al. 1999 Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells J Clin Invest 104 1061 1069 10.1172/JCI6685 1:CAS:528:DyaK1MXmslCru74%3D 10525044
18. MB Dwinell L Eckmann JD Leopard, et al. 1999 Chemokine receptor expression by human intestinal epithelial cells Gastroenterology 117 359 367 10.1053/gast.1999.0029900359 1:CAS:528:DyaK1MXltFKqtrw%3D 10419917 (Pubitemid 29352944)
19. BJ Rollins 1997 Chemokines Blood 90 909 928 1:CAS:528:DyaK2sXkvVWiu7k%3D 9242519
20. O Salvucci A Bouchard A Baccarelli, et al. 2006 The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study Breast Cancer Res Treat 97 275 283 10.1007/s10549-005-9121-8 1:CAS:528: DC%2BD28XmtFSitrg%3D 16344916 (Pubitemid 43945757)
21. N Wang QL Wu Y Fang, et al. 2005 Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome J Transl Med 3 26 10.1186/1479-5876-3-26 15978137 (Pubitemid 41522081)
22. JP Spano F Andre L Morat, et al. 2004 Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome Ann Oncol 15 613 617 10.1093/annonc/mdh136 15033669 (Pubitemid 38559598)
23. Woo SU, Bae JW, Kim CH, et al (2007) A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancer. Ann Surg Oncol
24. JW Dierssen NF de Miranda S Ferrone, et al. 2007 HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression BMC Cancer 7 33 10.1186/1471-2407-7-33 17316446 (Pubitemid 46390741)
25. FM Speetjens EC de Bruin H Morreau, et al. 2008 Clinical impact of HLA class I expression in rectal cancer Cancer Immunol Immunother 57 601 609 10.1007/s00262-007-0396-y 1:CAS:528:DC%2BD1cXitlKjt7k%3D 17874100 (Pubitemid 351641023)
26. AE de Jong PM van Y Hendriks, et al. 2004 Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer Clin Cancer Res 10 972 980 10.1158/1078-0432.CCR- 0956-3 14871975 (Pubitemid 38198898)
27. F Balkwill 2004 The significance of cancer cell expression of the chemokine receptor CXCR4 Semin Cancer Biol 14 171 179 10.1016/j.semcancer.2003. 10.003 1:CAS:528:DC%2BD2cXjvVemsb0%3D 15246052 (Pubitemid 38586742)
28. RL Contento B Molon C Boularan, et al. 2008 CXCR4-CCR5: a couple modulating T cell functions Proc Natl Acad Sci U S A 105 10101 10106 10.1073/pnas.0804286105 1:CAS:528:DC%2BD1cXptFKlur8%3D 18632580
29. O Wald U Izhar G Amir, et al. 2006 CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinoma J Immunol 177 6983 6990 1:CAS:528:DC%2BD28XhtFGrtrrI 17082613
30. H Shim SK Lau S Devi, et al. 2006 Lower expression of CXCR4 in lymph node metastases than in primary breast cancers: potential regulation by ligand-dependent degradation and HIF-1alpha Biochem Biophys Res Commun 346 252 258 10.1016/j.bbrc.2006.05.110 1:CAS:528:DC%2BD28Xls1Gmtrc%3D 16756955 (Pubitemid 43865990)
31. SY Lin K Makino W Xia, et al. 2001 Nuclear localization of EGF receptor and its potential new role as a transcription factor Nat Cell Biol 3 802 808 10.1038/ncb0901-802 1:CAS:528:DC%2BD3MXmvF2ls74%3D 11533659 (Pubitemid 32842685)
32. Huang YC, Hsiao YC, Chen YJ, et al (2007) Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NF-kappaB-dependent pathway in human lung cancer cells. Biochem Pharmacol