CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion

Blood

Volumn 100, Issue 7, 2002, Pages 2597-2606

  Libura, Jolanta ^a,b,c,d   Drukala, Justyna ^a,b,c,d   Majka, Marcin ^a,b,c,d   Tomescu, Oana ^a,b,c,d   Navenot, Jean Marc ^a,b,c,d   Kucia, Magda ^a,b,c,d   Marquez, Lean ^a,b,c,d   Peiper, Stephen C ^a,b,c,d   Barr, Frederic G ^a,b,c,d   Janowska Wieczorek, Anna ^a,b,c,d   Ratajczak, Mariusz Z ^a,b,c,d  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c JAGIELLONIAN UNIVERSITY   (Poland)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; FIBRONECTIN; GELATINASE A; GENE PRODUCT; HYBRID PROTEIN; LAMININ; MATRIGEL; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P44; STROMAL CELL DERIVED FACTOR 1; T 140; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PAX3; TRANSCRIPTION FACTOR PAX7; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW METASTASIS; CANCER CELL CULTURE; CELL ACTIVITY; CELL ADHESION; CELL MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CHEMOTAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; FLUORESCENCE ACTIVATED CELL SORTING; GENE FUSION; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPH NODE METASTASIS; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RHABDOMYOSARCOMA;

EID: 0036786348     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-01-0031     Document Type: Article

References (56)

1. Zou Y, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 1998;393:595-599.
2. + progenitors to peripheral blood. J Exp Med. 1997;185:111-120.
3. + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood. 1998;91:4523-4530.
4. + cells on vascular endothelium under shear flow. J Clin Invest. 1997;104:1199-1211.
5. Wang J-F, Park I-W, Groopman JE. Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C. Blood. 2000;95:2505-2513.
6. Majka M, Ratajczak J, Kowalska MA, Ratajczak MZ. Binding of stromal derived factor-1α (SDF-1α) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT. Eur J Haematol. 2000;64:164-172.
7. Majka M, Janowska-Wieczorek A, Ratajczak J, et al. Stromal-derived factor-1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. Blood. 2000;96:4142-4151.
8. Majka M, Ratajczak J, Lee B, et al. The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro. Stem Cells. 2000;18:128-138.
9. + cells in response to chemokines. Exp Hematol. 2001;28:1274-1285.
10. Mueller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410:50-56.
11. Ruymann FB, Newton WA, RagabAH, Donaldson MH, Foulkes M. Bone marrow metastases at diagnosis in children and adolescents with rhabdomyosarcoma. Cancer, 1984;53:368-373.
12. Dickman PS, Tsokos M, Triche TJ. Biology of rhabdomyosarcoma: cell culture, xenografts and animal models. In: Maurer HM, Ruymann FB, Pochedly C, eds. Rhabdomyosarcoma and Related Tumours in Children and Adolescents. Boca Raton, FL: CRC Press; 1991:49-88.
13. Sandberg AA, Stone JF, Czarnecki L, Cohen JD. Hematologic masquerade of rhabdomyosarcoma. Am J Hematol. 2001;68:51-57.
14. Barr FG, Galili N, Holick J, Biegel JA, Rovera G, Emanuel BS. Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma. Nat Genet. 1993;3:113-117.
15. Anderson MJ, Shelton GD, Cavenee KW, Arden KC. Embryonic expression of the tumour-associated PAX3-FKHR fusion protein interferes with the developmental functions of PAX3. Proc Natl Acad Sci U S A. 2001;98:1589-1594.
16. Davis RJ, Barr FG. Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma. Proc Natl Acad Sci U S A. 1997;94:8047-8051.
17. Davis RJ, D'Cruz CM, Lovell MA, Biegel JA, Barr FG. Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. Cancer Res. 1994;54:2869-2872.
18. Collins MH, Zhao H, Womer RB, Barr FG. Proliferative and apoptotic differences between alveolar rhabdomyosarcoma subtypes: a comparative study of tumors containing PAX3-FKHR gene fusions. Med Pediatr Oncol. 2000;37:83-89.
19. Bennicelli JL, Advani S, Schafer BW, Barr FG. PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma. Oncogene. 1999;18:4348-4356.
20. Kelly KM, Womer RB, Barr F. 3-FKHR and PAX7-FKHR fusions in rhabdomyosarcoma. J Pediatr Hematol Oncol. 1998;20:517-518.
21. Weigel BJ, Breitfeld PP, Hawkins D, Crist WM, Baker KS. Role of high-dose chemotherapy with hematopoietic stem cell rescue in the treatment of metastatic or recurrent rhabdomyosarcoma. J Ped Hematol Oncol. 2001;23:272-276.
22. Majka M, Rozmyslowicz T, Honczarenko M, et al. Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines. Leukemia. 2000;14:1821-1832.
23. Kijowski J, Baj M, Majka M, et al. The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells. Stem Cells. 2001;19:453-466.
24. Christofidou-Solomidou M, Nakada M, Williams J, Albelda SM, DeLisser H. Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation. J Immunol. 1997;158:4872-4878.
25. Vuorte J, Lindsberg PJ, Kaste M, et al. Anti-ICAM-1 monoclonal antibody R6.5 (Enlimomab) promotes activation of neutrophils in whole blood. J Immunol. 1999;162:2353-2357.
26. Carlos TM, Schwartz BR, Kovach NL, et al. Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood. 1990;76:965-970.
27. McEver RP, Martin NM. A monoclonal antibody to a membrane glycoprotein binds only to activated platelets. J Biol Chem. 1984;259:9799-9804.
28. + cells and megakaryoblasts secrete β-chemokines: implications for infectability by M-tropic human immunodeficiency virus (R5 HIV). J Clin Invest. 1999;104:1739-1749.
29. + cells, myeloblasts, erythroblasts and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. Blood. 2001;97:3075-3085.
30. Barr FG, Chatten J, D'Cruz CM, et al. Molecular analysis for chromosomal translocations in the diagnosis of pediatric soft tissue sarcomas. JAMA. 1995;273:553-557.
31. Wójciak-Stothard B, Madeja Z, Korohoda W, Curtis A, Wilkinson C. Activation of macrophage-like cells by multiple grooved substrata: topographical control of cell behaviour. Cell Biol Int. 1995;19:485-490.
32. Madeja Z, Szymkiewicz I, Zaczek A, Sroka J, Miekus K, Korohoda W. Contact-activated migration of melanoma B16 and sarcoma XC cells. Biochem Cell Biol. 2001;79:1-16.
33. Korohoda W, Golda J, Sroka J, Wojnarowicz A, Jochym P, Madeja Z. Chemotaxis of Amoeba proteus in the developing pH gradient within a pocket-like chamber studied with the computer assisted method. Cell Motil Cytoskeleton. 1997;38:38-53.
34. Korohoda W, Madeja Z. Contact of sarcoma cells with aligned fibroblasts accelerates their displacement: computer-assisted analysis of tumour cell locomotion in co-culture. Biochem Cell Biol. 1997;75:263-276.
35. Clerck LS, Bridts CH, Mertens A, Moens MM, Stevens WJ. Use of fluorescent dyes in the determination of adherence of human leucocytes to endothelial cells and the effect of fluorochromes on cellular function. J Immunol Methods. 1994;172:115-124.
36. + cells and their transmigration through reconstituted basement membrane. Blood. 1999;93:3379-3390.
37. Janowska-Wieczorek A, Marquez LA, Matsuzaki A, et al. Expression of matrix metalloproteinases (MMP-2 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in acute myelogenous leukaemia blasts: comparison with normal bone marrow cells. Br J Haematol. 1999;105:402-411.
38. Albini A, Iwamoto Y, Kleinman HK, et al. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res. 1987;47:3239-3245.
39. Janiak M, Hashmi HR, Janowska-Wieczorek A. Use of the Matrigel-based assay to measure the invasiveness of leukemic cells. Exp Hematol. 1994;22:559-565.
40. Dutt P, Wang JF, Groopman JE. Stromal cell-derived factor-1α and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis. J Immunol. 1998;161:3652-3658.
41. Ganju RK, Brubaker SA, Meyer J, et al. The alpha-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem. 1998;273:23169-23175.
42. Stetler-Stevenson WG, Hewitt R, Corcoran M. Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic. Semin Cancer Biol. 1996;7:147-153.
43. Tamamura H, Xu Y, Hattori T, et al. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998;253:877-882.
44. Tamamura H, Omagari A, Hiramatsu K, et al. Development of specific CXCR-4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett. 2001;11:1897-1902.
45. Tamamura H, Sugioka M, Odagaki Y, et al. Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity. Bioorg Med Chem Lett. 2001;11:359-362.
46. Zhang WW, Navenot JM, Haribabu B, et al. A point mutation that confers constitutive activity to CXCR4 reveals T140 is an inverse agonist and AMD3100 and ALX40-4C are weak partial agonists. J Biol Chem. 2002;277:24515-24521.
47. Murphy PM. Chemokines and the molecular basis of cancer metastasis. N Engl J Med. 2001;345:833-835.
48. Moriuchi M, Moriuchi H, Margolis DM, Fauci AS. USF/c-Myc enhances, while Yin-Yang 1 suppresses, the promoter activity of CXCR4, a coreceptor for HIV-1 entry. J Immunol. 1999;162:5986-5992.
49. Kouraklis G, Triche JT, Wesley R, Tsokos M. Myc oncogene expression and nude mouse tumorigenicity and metastasis formation are higher in alveolar than embryonal rhabdomyosarcoma cell lines. Ped Res. 1999;45:552-558.
50. Rojnuckarin P, Drachman JG, Kaushansky K. Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. Blood. 1999;94:1273-1282.
51. Terranova VP, Hujanen ES, Loeb DM, Martin GR, Homburg I, Glushko V. Use of a reconstituted basement membrane to measure cell invasiveness and select for highly invasive tumor cells. Proc Natl Acad Sci U S A. 1986;83:465-470.
52. Ginsberg JP, Davis RJ, Bennicelli JL, Nauta LE, Barr FG. Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR protein in alveolar rhabdomyosarcoma. Cancer Res. 1998;58:3542-3546.
53. Petit I, Szyper-Krawitz M, Nagler A, et al. Involvement of SDF-1/CXCR4 interactions in G-CSF induced mobilization of human and murine stem/progenitor cells [abstract]. Blood. 2001;98:811a.
54. Baggiolini M, Moser B. Blocking chemokine receptors. J Exp Med. 1997;186:1189-1191.
55. Doranz BJ, Govit-Ferbas K, Sharron MP, et al. A small molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor. J Exp Med. 1997;186:1395-1400.
56. Murakami T, Nakajima T, Koyanagi Y, et al. A small molecule CXCR4 inhibitor that blocks T cell line tropic HIV-1 infection. J Exp Med. 1997;186:1389-1393.