Selection of radioresistant tumor cells and presence of ALDH1 activity in vitro

Radiotherapy and Oncology

Volumn 99, Issue 3, 2011, Pages 300-306

  Mihatsch, Julia ^a   Toulany, Mahmoud ^a   Bareiss, Petra M ^b   Grimm, Sabrina ^b   Lengerke, Claudia ^b   Kehlbach, Rainer ^a   Rodemann, H Peter ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Department of Hematology and Oncology   (Germany)

Author keywords

Aldehyde dehydrogenase 1; Cancer stem cell markers; Radioresistance

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; CD133 ANTIGEN; DOUBLE STRANDED DNA; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; BREAST CANCER; CANCER STEM CELL; CELL SELECTION; CELL SURVIVAL; CLONOGENIC ASSAY; COLONY FORMATION; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION EXPOSURE; RADIOSELECTION; RADIOSENSITIVITY;

ANTIGENS, CD; BLOTTING, WESTERN; BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL SURVIVAL; DNA BREAKS; FEMALE; GLYCOPROTEINS; HUMANS; ISOENZYMES; LUNG NEOPLASMS; NEOPLASTIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; PEPTIDES; PHENOTYPE; RADIATION TOLERANCE; RETINAL DEHYDROGENASE; SOXB1 TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; TUMOR MICROENVIRONMENT;

EID: 79960348627     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.06.003     Document Type: Article

References (47)

1. C. Li, M. Iida, E.F. Dunn, and D.L. Wheeler Dasatinib blocks cetuximab- and radiation-induced nuclear translocation of the epidermal growth factor receptor in head and neck squamous cell carcinoma Radiother Oncol 97 2010 330 337
2. Z. Khan, N. Khan, R.P. Tiwari, I.K. Patro, G.B. Prasad, and P.S. Bisen Down-regulation of surviving by oxaliplatin diminishes radioresistance of head and neck squamous carcinoma cells Radiother Oncol 96 2010 267 273
3. N.K. Taunk, S. Goyal, M.S. Moran, Q. Yang, R. Parikh, and B.G. Haffty Prognostic significance of IGF-1R expression in patients treated with breast-conserving surgery and radiation therapy Radiother Oncol 96 2010 204 208
4. Z. Jing, L. Gong, and C.Y. Xie Reverse resistance to radiation in KYSE-150R esophageal carcinoma cell after epidermal growth factor receptor signal pathway inhibition by cetuximab Radiother Oncol 93 2009 468 473
5. S. Hehlgans, I. Eke, K. Storch, M. Haase, G.B. Baretton, and N. Cordes Caveolin-1 mediated radioresistance of 3D grown pancreatic cancer cells Radiother Oncol 92 2009 362 370
6. J.A. Bonner, H.Q. Trummell, C.D. Willey, B.A. Plants, and K.P. Raisch Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma Radiother Oncol 92 2009 339 344
7. J. Theys, B. Jutten, and L. Dubois The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment Radiother Oncol 92 2009 399 404
8. R.E. Meyn, A. Munshi, J.V. Haymach, L. Milas, and K.K. Ang Receptor signaling as a regulatory mechanism of DNA repair Radiother Oncol 92 2009 316 322
9. M.F. Clarke, J.E. Dick, and P.B. Dirks Cancer stem cells - Perspectives on current status and future directions: AACR Workshop on cancer stem cells Cancer Res 66 2006 9339 9344 (Pubitemid 44623625)
10. M. Baumann, M. Krause, and R. Hill Exploring the role of cancer stem cells in radioresistance Nat Rev Cancer 8 2008 545 554 (Pubitemid 351881850)
11. S. Bao, Q. Wu, and R.E. McLendon Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature 444 2006 756 760 (Pubitemid 44949604)
12. T.M. Phillips, W.H. Mc Bride, and F. Pajonk The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation J Natl Cancer Inst 98 2006 1777 1785 (Pubitemid 46017929)
13. S.H. Chiou, C.L. Kao, and Y.W. Chen Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor PLoS One 3 2008 e2090
14. F. Pajonk, E. Vlashi, and W.H. Mc Bride Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited Stem cells 28 2010 639 648
15. A. Yaromina, M. Krause, and H. Thames Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation Radiother Oncol 83 2007 304 310 (Pubitemid 46915546)
16. S. Facchino, M. Abdouh, W. Chatoo, and G. Bernier BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery J Neurosci 30 2010 10096 10111
17. M. Diehn, R.W. Cho, and N.A. Lobo Association of reactive oxygen species levels and radioresistance in cancer stem cells Nature 458 2009 780 783
18. D. Ponti, A. Costa, and N. Zaffaroni Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties Cancer Res 65 2005 5506 5511 (Pubitemid 40911148)
19. R. Xiang, D. Liao, and T. Cheng Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer Br J Cancer 104 2011 1931
20. S. Saigusa, K. Tanaka, and Y. Toiyama Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy Ann Surg Oncol 16 2009 3488 3498
21. Y.C. Chen, Y.W. Chen, and H.S. Hsu Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer Biochem Biophys Res Commun 385 2009 307 313
22. C. Ginestier, M.H. Hur, and E. Charafe-Jauffret ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome Cell Stem Cell 1 2007 555 567 (Pubitemid 350056407)
23. D. Balicki Moving forward in human mammary stem cell biology and breast cancer prognostication using ALDH1 Cell Stem Cell 1 2007 485 487 (Pubitemid 350079967)
24. M. Rasper, A. Schafer, and G. Piontek Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity Neuro Oncol 12 2010 1024 1033
25. A. Yoshida, L.C. Hsu, and V. Dave Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase Enzyme 46 1992 239 244 (Pubitemid 23047772)
26. J.P. Chute, G.G. Muramoto, and J. Whitesides Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells Proc Natl Acad Sci USA 103 2006 11707 11712 (Pubitemid 44182515)
27. M. Toulany, M. Minjgee, R. Kehlbach, J. Chen, M. Baumann, and H.P. Rodemann ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway Radiother Oncol 97 2010 338 345
28. M. Toulany, U. Kasten-Pisula, and I. Brammer Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair Clin Cancer Res 12 2006 4119 4126 (Pubitemid 44078101)
29. K. Dittmann, C. Mayer, R. Kehlbach, Rothmund.M.C. Peter, and H. Rodemann Radiation-induced lipid peroxidation activates src kinase and triggers nuclear EGFR transport Radiother Oncol 92 2009 379 382
30. M. Toulany, T.A. Schickfluss, W. Eicheler, R. Kehlbach, B. Schittek, and H.P. Rodemann Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation Breast Cancer Res 13 2011 R28
31. U. Kasten-Pisula, A. Menegakis, and I. Brammer The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair Radiother Oncol 90 2009 257 264
32. M. Toulany, K. Dittmann, M. Baumann, and H.P. Rodemann Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS Radiother Oncol 74 2005 117 129 (Pubitemid 40331868)
33. J.E. Russo, D. Hauguitz, and J. Hilton Inhibition of mouse cytosolic aldehyde dehydrogenase by 4-(diethylamino)benzaldehyde Biochem Pharmacol 37 1988 1639 1642 (Pubitemid 18093362)
34. M. Toulany, R. Kehlbach, and U. Florczak Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair Mol Cancer Ther 7 2008 1772 1781
35. S.P. Jackson Sensing and repairing DNA double-strand breaks Carcinogenesis 23 2002 687 696 (Pubitemid 34567505)
36. G.C. Smith, and S.P. Jackson The DNA-dependent protein kinase Genes Dev 13 1999 916 934 (Pubitemid 29200976)
37. L.F. Povirk, R.Z. Zhou, D.A. Ramsden, S.P. Lees-Miller, and K. Valerie Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts Nucleic Acids Res 35 2007 3869 3878 (Pubitemid 47244611)
38. M. Toulany, R. Kehlbach, H.P. Rodemann, and H. Mozdarani Radiocontrast media affect radiation-induced DNA damage repair in vitro and in vivo by affecting Akt signalling Radiother Oncol 94 2010 110 116
39. X. Meng, M. Li, X. Wang, Y. Wang, and D. Ma Both CD133+ and CD133- subpopulations of A549 and H446 cells contain cancer-initiating cells Cancer Sci 100 2009 1040 1046
40. C. Dittfeld, A. Dietrich, and S. Peickert CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell line HCT-116 Radiother Oncol 94 2010 375 383
41. S. Masui, Y. Nakatake, and Y. Toyooka Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells Nat Cell Biol 9 2007 625 635 (Pubitemid 47214724)
42. H. Niwa, J. Miyazaki, and A.G. Smith Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells Nat Genet 24 2000 372 376 (Pubitemid 30187435)
43. C. Lengerke, T. Fehm, and R. Kurth Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma BMC Cancer 11 2011 42
44. B.G. Debeb, W. Xu, and H. Mok Differential radiosensitizing effect of valproic acid in differentiation versus self-renewal promoting culture conditions Int J Radiat Oncol Biol Phys 76 2010 889 895
45. W. Matsui, C.A. Huff, and Q. Wang Characterization of clonogenic multiple myeloma cells Blood 103 2004 2332 2336 (Pubitemid 38326254)
46. J.S. Moreb, H.V. Baker, and L.J. Chang ALDH isozymes downregulation affects cell growth, cell motility, gene expression in lung cancer cells Mol Cancer 7 2008 87
47. M. Baumann, M. Krause, H. Thames, K. Trott, and D. Zips Cancer stem cells and radiotherapy Int J Radiat Biol 85 2009 391 402