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Volumn 2, Issue 7, 2003, Pages 581-587

The bicyclam AMD3100 story

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); ALPHA N ACETYLNONA DEXTRO ARGININE AMIDE; AMD 070; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIMONIOTUNGSTATE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CYCLAM; JM 1493; JM 1590; JM 1657; JM 2763; JM 2820; JM 2987; METAL OXIDE; RECEPTOR BLOCKING AGENT; T 140; TC 14012; UNCLASSIFIED DRUG; GLYCOPROTEIN GP 120; HETEROCYCLIC COMPOUND;

EID: 0038681342     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd1134     Document Type: Article
Times cited : (437)

References (50)
  • 1
    • 84889482949 scopus 로고
    • Antimoniotungstate (HPA 23) treatment of three patients with AIDS and one with prodrome
    • Rozenbaum, W. et al. Antimoniotungstate (HPA 23) treatment of three patients with AIDS and one with prodrome. Lancet 1, 450-451 (1985).
    • (1985) Lancet , vol.1 , pp. 450-451
    • Rozenbaum, W.1
  • 2
    • 0028941196 scopus 로고
    • Antiviral therapy for human immunodeficiency virus infections
    • De Clercq, E. Antiviral therapy for human immunodeficiency virus infections. Clin. Microbiol. Rev. 8, 200-239 (1995).
    • (1995) Clin. Microbiol. Rev. , vol.8 , pp. 200-239
    • De Clercq, E.1
  • 3
    • 0030835628 scopus 로고    scopus 로고
    • Antiviral metal complexes
    • De Clercq, E. Antiviral metal complexes. Metal-Based Drugs 4, 173-192 (1997).
    • (1997) Metal-Based Drugs , vol.4 , pp. 173-192
    • De Clercq, E.1
  • 4
    • 0027055782 scopus 로고
    • Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents
    • Yamamoto, N. et al. Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents Mol. Pharmacol. 42, 1109-1117 (1992).
    • (1992) Mol. Pharmacol. , vol.42 , pp. 1109-1117
    • Yamamoto, N.1
  • 5
    • 0031059381 scopus 로고    scopus 로고
    • Anti-HIV activities of anionic metalloporphyrins and related compounds
    • Song, R. et al. Anti-HIV activities of anionic metalloporphyrins and related compounds. Antivir. Chem. Chemother. 8, 85-97 (1997).
    • (1997) Antivir. Chem. Chemother. , vol.8 , pp. 85-97
    • Song, R.1
  • 6
    • 0026683326 scopus 로고
    • Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event
    • De Clercq, E. et al. Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event. Proc. Natl Acad. Sci. USA 89, 5286 5290 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5286-5290
    • De Clercq, E.1
  • 7
    • 0028209166 scopus 로고
    • Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100
    • De Clercq, E. et al. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrob. Agents Chemother. 38, 668-674 (1994).
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 668-674
    • De Clercq, E.1
  • 8
    • 0029939009 scopus 로고    scopus 로고
    • The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding
    • De Vreese, K. et al. The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding. Antiviral Res. 29, 209-219 (1996).
    • (1996) Antiviral Res. , vol.29 , pp. 209-219
    • De Vreese, K.1
  • 9
    • 0029916728 scopus 로고    scopus 로고
    • Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1
    • Esté, J. et al. Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1. Antiviral Res. 29, 297-307 (1996).
    • (1996) Antiviral Res. , vol.29 , pp. 297-307
    • Esté, J.1
  • 10
    • 0003973947 scopus 로고    scopus 로고
    • The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication
    • De Vreese, K. et al. The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication. J. Virol. 70, 689-696 (1996).
    • (1996) J. Virol. , vol.70 , pp. 689-696
    • De Vreese, K.1
  • 11
    • 0030781371 scopus 로고    scopus 로고
    • Sensitivity of human immunodeficiency virus to bicyclam derivatives is influenced by the three-dimensional structure of gp120
    • De Vreese, K., Van Nerum, I., Vermeire, K., Anné, J. & De Clercq, E. Sensitivity of human immunodeficiency virus to bicyclam derivatives is influenced by the three-dimensional structure of gp120. Antimicrob. Agents Chemother. 41, 2616-2620 (1997).
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 2616-2620
    • De Vreese, K.1    Van Nerum, I.2    Vermeire, K.3    Anné, J.4    De Clercq, E.5
  • 12
    • 0030830661 scopus 로고    scopus 로고
    • Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4
    • Schols, D. et al. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J. Exp. Med. 186, 1383-1388 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 1383-1388
    • Schols, D.1
  • 13
    • 0030835663 scopus 로고    scopus 로고
    • Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusion/CXCR-4
    • Schols, D., Esté, J. A., Henson, G. & De Clercq, E. Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusion/CXCR-4. Antiviral Res. 35, 147-156 (1997).
    • (1997) Antiviral Res. , vol.35 , pp. 147-156
    • Schols, D.1    Esté, J.A.2    Henson, G.3    De Clercq, E.4
  • 14
    • 0031891516 scopus 로고    scopus 로고
    • AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor
    • Donzella, G. A. et al. AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. Nature Med. 4, 72-77 (1998).
    • (1998) Nature Med. , vol.4 , pp. 72-77
    • Donzella, G.A.1
  • 15
    • 0034752251 scopus 로고    scopus 로고
    • Hamao Umezawa Memorial Award Lecture 'An Odyssey in the Viral Chemotherapy Field'
    • De Clercq, E. Hamao Umezawa Memorial Award Lecture 'An Odyssey in the Viral Chemotherapy Field'. Int. J. Antimicrob. Agents 18, 309-328 (2001).
    • (2001) Int. J. Antimicrob. Agents , vol.18 , pp. 309-328
    • De Clercq, E.1
  • 16
    • 0034062515 scopus 로고    scopus 로고
    • Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists
    • De Clercq, E. Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists. Mol. Pharmacol. 57, 833-839 (2000).
    • (2000) Mol. Pharmacol. , vol.57 , pp. 833-839
    • De Clercq, E.1
  • 17
    • 0032895276 scopus 로고    scopus 로고
    • Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor
    • Esté, J. et al. Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor Mol. Pharmacol. 55, 67-73 (1999).
    • (1999) Mol. Pharmacol. , vol.55 , pp. 67-73
    • Esté, J.1
  • 18
    • 0033059948 scopus 로고    scopus 로고
    • Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4
    • Esté, J. et al. Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4. J. Virol. 73, 5577-5585 (1999).
    • (1999) J. Virol. , vol.73 , pp. 5577-5585
    • Esté, J.1
  • 19
    • 0031968673 scopus 로고    scopus 로고
    • T-Cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1(contains mutations in the envelope gp120 but does not show a switch in coreceptor use
    • Schols, D., Esté, J. A., Cabrera, C. & De Clercq, E. T-Cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1(contains mutations in the envelope gp120 but does not show a switch in coreceptor use. J. Virol. 72, 4032-4037 (1998).
    • (1998) J. Virol. , vol.72 , pp. 4032-4037
    • Schols, D.1    Esté, J.A.2    Cabrera, C.3    De Clercq, E.4
  • 20
    • 0031710734 scopus 로고    scopus 로고
    • The simian immunodeficiency virus mnd(GB-1) strain uses CXCR4, not CCR5, as coreceptor for entry in human cells
    • Schols, D. & De Clercq, E. The simian immunodeficiency virus mnd(GB-1) strain uses CXCR4, not CCR5, as coreceptor for entry in human cells. J. Gen. Virol. 79, 2203-2205 (1998).
    • (1998) J. Gen. Virol. , vol.79 , pp. 2203-2205
    • Schols, D.1    De Clercq, E.2
  • 21
    • 0030780377 scopus 로고    scopus 로고
    • A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection
    • Murakami, T. et al. A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection. J. Exp. Med. 186, 1389-1393 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 1389-1393
    • Murakami, T.1
  • 22
    • 0037319360 scopus 로고    scopus 로고
    • The therapeutic potential of CXCR4 antagonists in the treatment of HIV
    • Fujii, N., Nakashima, H. & Tamamura, H. The therapeutic potential of CXCR4 antagonists in the treatment of HIV. Expert Opin. Investig. Drugs 12, 185-195 (2003).
    • (2003) Expert Opin. Investig. Drugs , vol.12 , pp. 185-195
    • Fujii, N.1    Nakashima, H.2    Tamamura, H.3
  • 23
    • 0030773515 scopus 로고    scopus 로고
    • A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor
    • Doranz, B. J. et al. A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor. J. Exp. Med. 186, 1395-1400 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 1395-1400
    • Doranz, B.J.1
  • 24
    • 0037388121 scopus 로고    scopus 로고
    • A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity
    • Ichiyama, K. et al. A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proc. Natl Acad. Sci. USA 100, 4185-4190 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4185-4190
    • Ichiyama, K.1
  • 25
    • 0041893844 scopus 로고    scopus 로고
    • Anti-HIV activity profile of AMD070, an orally bioavailable CXCR4 antagonist
    • The Sixteenth International Conference on Antiviral Research Savannah, Georgia, USA, 27 April-1 May 2003
    • Schols, D. et al. Anti-HIV activity profile of AMD070, an orally bioavailable CXCR4 antagonist. The Sixteenth International Conference on Antiviral Research, Savannah, Georgia, USA, 27 April-1 May 2003. Antiviral Res. 57, A39 (2003).
    • (2003) Antiviral Res. , vol.57
    • Schols, D.1
  • 26
    • 0029976181 scopus 로고    scopus 로고
    • Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry
    • Datema, R. et al. Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrob. Agents Chemother 40, 750-754 (1996).
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 750-754
    • Datema, R.1
  • 27
    • 0034120373 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers
    • Hendrix, C. W. et al. Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers. Antimicrob. Agents Chemother. 44, 1667-1673 (2000).
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 1667-1673
    • Hendrix, C.W.1
  • 28
    • 0011309256 scopus 로고    scopus 로고
    • AMD-3100, a CXCR4 antagonist, reduced HIV viral load and X4 virus levels in humans
    • 9th Conf. on Retroviruses and Opportunistic Infections Seattle, Washington, USA, 24-28 February. Abs, no. 2
    • Schols, D. et al. AMD-3100, a CXCR4 antagonist, reduced HIV viral load and X4 virus levels in humans. 9th Conf. on Retroviruses and Opportunistic Infections Seattle, Washington, USA, 24-28 February. Abs, p. 53, no. 2 (2002).
    • (2002) , pp. 53
    • Schols, D.1
  • 29
    • 0034915564 scopus 로고    scopus 로고
    • Safe use of the CXCR4 inhibitor ALX40-4C in humans
    • Doranz, B. J. et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res. Hum. Retroviruses 17, 475-486 (2001).
    • (2001) AIDS Res. Hum. Retroviruses , vol.17 , pp. 475-486
    • Doranz, B.J.1
  • 30
    • 0242356620 scopus 로고    scopus 로고
    • AMD-3100 alone increases human peripheral blood stem cells which engraft in NOD/SCID mice and also enhances the activity of G-CSF
    • Meeting Quebec, Canada, 5-9 July. Abstracts
    • Dale, D.C. et al. AMD-3100 alone increases human peripheral blood stem cells which engraft in NOD/SCID mice and also enhances the activity of G-CSF. Int. Soc. Hematol. Meeting Quebec, Canada, 5-9 July. Abstracts (2002).
    • (2002) Int. Soc. Hematol.
    • Dale, D.C.1
  • 31
    • 0043085838 scopus 로고    scopus 로고
    • + progenitor cells from normal human volunteers with AMD-3100, a CXCR4 antagonist, and G-CSF
    • Am. Soc. Hematol. Annu. Meeting Philadelphia, Pennsylvania, USA, 6-10 December. Abs. no
    • + progenitor cells from normal human volunteers with AMD-3100, a CXCR4 antagonist, and G-CSF Am. Soc. Hematol. Annu. Meeting Philadelphia, Pennsylvania, USA, 6-10 December. Abs. no. 404. Blood 100, 109a (2002).
    • (2002) Blood , vol.100 , Issue.404
    • Liles, W.C.1
  • 32
    • 79960971604 scopus 로고    scopus 로고
    • Leukocytosis and mobilization of pluripotent hematopoietic progenitor cells in healthy volunteers induced by single dose administration of AMD-3100, a CXCR4 antagonist
    • Am. Soc. Hematol. Annu. Meeting Orlando, Florida, USA, 7-11 December. Abs. no. 3071
    • Liles, W. C. et al. Leukocytosis and mobilization of pluripotent hematopoietic progenitor cells in healthy volunteers induced by single dose administration of AMD-3100, a CXCR4 antagonist. Am. Soc. Hematol. Annu. Meeting Orlando, Florida, USA, 7-11 December. Abs. no. 3071. Blood 98, 737a (2001).
    • (2001) Blood , vol.98
    • Liles, W.C.1
  • 33
    • 0036302147 scopus 로고    scopus 로고
    • G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    • Petit, I. et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nature Immunol. 3, 687-694 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 687-694
    • Petit, I.1
  • 34
    • 0034954455 scopus 로고    scopus 로고
    • 262 of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100
    • 262 of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. Mol. Pharmacol. 60, 164-173 (2001).
    • (2001) Mol. Pharmacol. , vol.60 , pp. 164-173
    • Hatse, S.1
  • 35
    • 0035957911 scopus 로고    scopus 로고
    • Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor
    • Gerlach, L. O., Skerlj R. T., Bridger, G. J. & Schwartz, T. W. Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. J. Biol. Chem. 276, 14153-14160 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 14153-14160
    • Gerlach, L.O.1    Skerlj, R.T.2    Bridger, G.J.3    Schwartz, T.W.4
  • 36
    • 0037469138 scopus 로고    scopus 로고
    • Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor
    • Gerlach, L. O. et al. Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor. Biochemistry 42, 710-717 (2003).
    • (2003) Biochemistry , vol.42 , pp. 710-717
    • Gerlach, L.O.1
  • 37
    • 0037063329 scopus 로고    scopus 로고
    • Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4
    • Hatse, S., Princen, K., Bridger, G., De Clercq, E. & Schols, D. Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett. 527, 255-262 (2002).
    • (2002) FEBS Lett. , vol.527 , pp. 255-262
    • Hatse, S.1    Princen, K.2    Bridger, G.3    De Clercq, E.4    Schols, D.5
  • 38
    • 0033012398 scopus 로고    scopus 로고
    • Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
    • Berger, E. A., Murphy, P. M. & Farber, J. M. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17, 657-700 (1999).
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 657-700
    • Berger, E.A.1    Murphy, P.M.2    Farber, J.M.3
  • 39
    • 0029758113 scopus 로고    scopus 로고
    • Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    • Nagasawa, T. et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382, 635-638 (1996).
    • (1996) Nature , vol.382 , pp. 635-638
    • Nagasawa, T.1
  • 40
    • 0032508033 scopus 로고    scopus 로고
    • The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
    • Tachibana, K. et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393, 591-594 (1998).
    • (1998) Nature , vol.393 , pp. 591-594
    • Tachibana, K.1
  • 41
    • 0001609181 scopus 로고    scopus 로고
    • Interference of the SDF-1/CXCR4 axis in mice with AMD3100 induces rapid high level mobilization of hematopoietic progenitor cells, and AMD3100 acts synergistically with G-CSF and MIP-1 to mobilize progenitors
    • Am. Soc. Hematol. Annu. Meeting Orlando, Florida, USA, 7-11 December. Abs. 3371
    • Broxmeyer, H. E., Hangoc, G , Cooper, S. & Bridger, G. Interference of the SDF-1/CXCR4 axis in mice with AMD3100 induces rapid high level mobilization of hematopoietic progenitor cells, and AMD3100 acts synergistically with G-CSF and MIP-1 to mobilize progenitors. Am. Soc. Hematol. Annu. Meeting Orlando, Florida, USA, 7-11 December. Abs. 3371. Blood 98, 811a (2001).
    • (2001) Blood , vol.98
    • Broxmeyer, H.E.1    Hangoc, G.2    Cooper, S.3    Bridger, G.4
  • 42
    • 0242325230 scopus 로고    scopus 로고
    • AMD3100, an antagonist of CXCR4 and mobilizer of myeloid progenitor cells, is a potent mobilizer of competitive repopulating long term marrow self-renewing stem cells in mice
    • American Soc. Hematol. Annual Meeting Philadelphia, Pennsylvania, USA, 6-10 December Abs. 2397
    • Broxmeyer, H. E. et al. AMD3100, an antagonist of CXCR4 and mobilizer of myeloid progenitor cells, is a potent mobilizer of competitive repopulating long term marrow self-renewing stem cells in mice. American Soc. Hematol. Annual Meeting Philadelphia, Pennsylvania, USA, 6-10 December Abs. 2397. Blood 100, 609a (2002).
    • (2002) Blood , vol.100
    • Broxmeyer, H.E.1
  • 43
    • 23844447551 scopus 로고    scopus 로고
    • AMD-3100, a CXCR4 antagonist, augments incorporation of bone marrow-derived endothelial progenitor cells into sites of myocardial neovascularization
    • American Soc. Hematol. Annual Meeting Philadelphia, Pennsylvania, USA, 6-10 December Abs. 1127
    • Iwakura, A. et al. AMD-3100, a CXCR4 antagonist, augments incorporation of bone marrow-derived endothelial progenitor cells into sites of myocardial neovascularization. American Soc. Hematol. Annual Meeting Philadelphia, Pennsylvania, USA, 6-10 December Abs. 1127. Blood 100, 293a (2002).
    • (2002) Blood , vol.100
    • Iwakura, A.1
  • 44
    • 0035887637 scopus 로고    scopus 로고
    • AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-(receptor-deficient mice
    • Matthys, P. et al. AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-(receptor-deficient mice. J. Immunol. 167, 4686-4692 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 4686-4692
    • Matthys, P.1
  • 45
    • 0036116174 scopus 로고    scopus 로고
    • AMD3100, a CXCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity
    • Lukacs, N. W., Berlin, A., Schols, D., Skerlj, R. T & Bridger, G. J. AMD3100, a CXCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. Am. J. Pathol. 160, 1353-1360 (2002).
    • (2002) Am. J. Pathol. , vol.160 , pp. 1353-1360
    • Lukacs, N.W.1    Berlin, A.2    Schols, D.3    Skerlj, R.T.4    Bridger, G.J.5
  • 46
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Müller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56 (2001).
    • (2001) Nature , vol.410 , pp. 50-56
    • Müller, A.1
  • 47
    • 0348170660 scopus 로고    scopus 로고
    • Antagonists of the chemokine receptor CXCR4 block chemotaxis and inhibit stromal dependent proliferation of acute lymphoblastic leukemia cells
    • American Soc. Hematol. Annual Meeting Philadelphia, Pennsylvania, USA, 6-10 December. Abs. 3015
    • Juarez, J., Bradstock, K. F., Gottlieb, D. J. & Bendall, L. J. Antagonists of the chemokine receptor CXCR4 block chemotaxis and inhibit stromal dependent proliferation of acute lymphoblastic leukemia cells. American Soc. Hematol. Annual Meeting Philadelphia, Pennsylvania, USA, 6-10 December. Abs. 3015. Blood 100, 762a (2002).
    • (2002) Blood , vol.100
    • Juarez, J.1    Bradstock, K.F.2    Gottlieb, D.J.3    Bendall, L.J.4
  • 48
    • 0043085011 scopus 로고    scopus 로고
    • In vitro and preclinical activity of the novel AMD3100 CXCR4 antagonist in lymphoma models
    • American Soc. Hematol. Annual Meeting, Philadelphia, Pennsylvania, USA, 6-10 December Abs. 2276
    • Paul, S. et al. In vitro and preclinical activity of the novel AMD3100 CXCR4 antagonist in lymphoma models. American Soc. Hematol. Annual Meeting, Philadelphia, Pennsylvania, USA, 6-10 December Abs. 2276. Blood 100, 579a (2002).
    • (2002) Blood , vol.100
    • Paul, S.1
  • 49
    • 0033818476 scopus 로고    scopus 로고
    • Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: A possible role for tumor progression
    • Koshiba, T. et al. Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. Clin. Cancer Res. 6, 3530-3535 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3530-3535
    • Koshiba, T.1
  • 50
    • 0037108923 scopus 로고    scopus 로고
    • Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer
    • Scotton, C. J. et al. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res. 62, 5930-5938 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 5930-5938
    • Scotton, C.J.1


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