메뉴 건너뛰기




Volumn 33, Issue 2-3, 2014, Pages 823-832

Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: Perspectives in diagnosis and therapy

Author keywords

"Warburg effect"; Extracellular acidity; Invasiveness; Metastatic dissemination; Molecular imaging; Novel therapeutic strategies; Stemness; Tumor metabolism

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 84905096091     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/s10555-014-9506-4     Document Type: Review
Times cited : (161)

References (132)
  • 1
    • 0021268289 scopus 로고
    • Tumor progression, oncogenes and the evolution of metastatic phenotypic diversity
    • Nicolson, G. L. (1984). Tumor progression, oncogenes and the evolution of metastatic phenotypic diversity. Clinical and Experimental Metastasis, 2, 85-105.
    • (1984) Clinical and Experimental Metastasis , vol.2 , pp. 85-105
    • Nicolson, G.L.1
  • 2
    • 0025324197 scopus 로고
    • Cellular interactions in metastasis
    • DOI 10.1007/BF00047586
    • Miller, F. R., & Heppner, G. H. (1990). Cellular interactions in metastasis. Cancer and Metastasis Reviews, 9, 21-34. (Pubitemid 20237641)
    • (1990) Cancer and Metastasis Reviews , vol.9 , Issue.1 , pp. 21-34
    • Miller, F.R.1    Heppner, G.H.2
  • 3
    • 46449130084 scopus 로고    scopus 로고
    • Tumor-microenvironment interactions: Dangerous liaisons
    • Witz, I. P. (2008). Tumor-microenvironment interactions: dangerous liaisons. Advances in Cancer Research, 100, 203-229.
    • (2008) Advances in Cancer Research , vol.100 , pp. 203-229
    • Witz, I.P.1
  • 4
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen, D. X., Bos, P. D., & Massague, J. (2009). Metastasis: from dissemination to organ-specific colonization. Nature Reviews Cancer, 9, 274-284.
    • (2009) Nature Reviews Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 5
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce, J. A., & Pollard, J. W. (2009). Microenvironmental regulation of metastasis. Nature Reviews Cancer, 9, 239-252.
    • (2009) Nature Reviews Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 6
    • 35548936833 scopus 로고    scopus 로고
    • Models, mechanisms and clinical evidence for cancer dormancy
    • Aguirre-Ghiso, J. A. (2007). Models, mechanisms and clinical evidence for cancer dormancy. Nature Reviews Cancer, 7, 834-846.
    • (2007) Nature Reviews Cancer , vol.7 , pp. 834-846
    • Aguirre-Ghiso, J.A.1
  • 7
    • 46449115631 scopus 로고    scopus 로고
    • Contact interactions between cells that suppress neoplastic development: Can they also explain metastatic dormancy?
    • Rubin, H. (2008). Contact interactions between cells that suppress neoplastic development: can they also explain metastatic dormancy? Advances in Cancer Research, 100, 159-202.
    • (2008) Advances in Cancer Research , vol.100 , pp. 159-202
    • Rubin, H.1
  • 8
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 9
    • 76749083490 scopus 로고    scopus 로고
    • Lymphangiogenesis: Molecular mechanisms and future promise
    • Tammela, T., & Alitalo, K. (2010). Lymphangiogenesis: molecular mechanisms and future promise. Cell, 140, 460-476.
    • (2010) Cell , vol.140 , pp. 460-476
    • Tammela, T.1    Alitalo, K.2
  • 11
    • 34447258681 scopus 로고    scopus 로고
    • Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize
    • DOI 10.1002/jcb.21187
    • Fukumura, D., & Jain, R. K. (2007). Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. Journal of Cellular Biochemistry, 101, 937-949. (Pubitemid 47040874)
    • (2007) Journal of Cellular Biochemistry , vol.101 , Issue.4 , pp. 937-949
    • Fukumura, D.1    Jain, R.K.2
  • 12
    • 0016300146 scopus 로고
    • History of the Pasteur effect and its pathobiology
    • Racker, E. (1974). History of the Pasteur effect and its pathobiology. Molecular and Cellular Biochemistry, 5, 17-23.
    • (1974) Molecular and Cellular Biochemistry , vol.5 , pp. 17-23
    • Racker, E.1
  • 13
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • DOI 10.1038/nrc1478
    • Gatenby, R. A., & Gillies, R. J. (2004). Why do cancers have high aerobic glycolysis? Nature Reviews Cancer, 4, 891-899. (Pubitemid 39472955)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 14
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 324, 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 15
    • 84856364753 scopus 로고    scopus 로고
    • Is there a role for carbohydrate restriction in the treatment and prevention of cancer?
    • Klement, R. J., & Kämmerer, U. (2011). Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Nutrition & Metabolism (London), 8, 75.
    • (2011) Nutrition & Metabolism (London) , vol.8 , pp. 75
    • Klement, R.J.1    Kämmerer, U.2
  • 16
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia, HIF1 and glucose metabolism in the solid tumour
    • Denko, N. C. (2008). Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nature Reviews Cancer, 8, 705-713.
    • (2008) Nature Reviews Cancer , vol.8 , pp. 705-713
    • Denko, N.C.1
  • 17
    • 57449087215 scopus 로고    scopus 로고
    • Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
    • DeBerardinis, R. J. (2008). Is cancer a disease of abnormal cellular metabolism? New angles on an old idea. Genetics in Medicine, 10, 767-777.
    • (2008) Genetics in Medicine , vol.10 , pp. 767-777
    • DeBerardinis, R.J.1
  • 19
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • DOI 10.1074/jbc.M202487200
    • Lu, H., Forbes, R. A., & Verma, A. (2002). Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. Journal of Biological Chemistry, 277, 23111-23115. (Pubitemid 34952134)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.26 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 20
    • 0028805375 scopus 로고
    • Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences
    • Ebert, B. L., Firth, J. D., & Ratcliffe, P. J. (1995). Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. Journal of Biological Chemistry, 270(49), 29083-29089.
    • (1995) Journal of Biological Chemistry , vol.270 , Issue.49 , pp. 29083-29089
    • Ebert, B.L.1    Firth, J.D.2    Ratcliffe, P.J.3
  • 21
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switchrequired for cellular adaptation to hypoxia
    • Kim, J. W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006). HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switchrequired for cellular adaptation to hypoxia. Cell Metabolism, 3, 177-185.
    • (2006) Cell Metabolism , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 22
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza, G. L., Jiang, B. H., Leung, S. W., Passantino, R., Concordet, J. P., Maire, P., et al. (1996). Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. Journal of Biological Chemistry, 271(51), 32529-32537.
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.51 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6
  • 25
    • 69949124867 scopus 로고    scopus 로고
    • Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells
    • Feron, O. (2009). Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiotherapy and Oncology, 92, 329-333.
    • (2009) Radiotherapy and Oncology , vol.92 , pp. 329-333
    • Feron, O.1
  • 26
    • 79957922046 scopus 로고    scopus 로고
    • Evidence for a stromal-epithelial 'lactate shuttle' in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
    • Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Lin, Z., Ertel, A., Flomenberg, N., Witkiewicz, A. K., et al. (2011). Evidence for a stromal-epithelial 'lactate shuttle' in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Cell Cycle, 10, 1772-1783.
    • (2011) Cell Cycle , vol.10 , pp. 1772-1783
    • Whitaker-Menezes, D.1    Martinez-Outschoorn, U.E.2    Lin, Z.3    Ertel, A.4    Flomenberg, N.5    Witkiewicz, A.K.6
  • 27
    • 71249103087 scopus 로고    scopus 로고
    • Cell-cell and intracellular lactate shuttles
    • Brooks, G. A. (2009). Cell-cell and intracellular lactate shuttles. Journal of Physiology, 587, 5591-5600.
    • (2009) Journal of Physiology , vol.587 , pp. 5591-5600
    • Brooks, G.A.1
  • 28
    • 4043110513 scopus 로고    scopus 로고
    • Lactate metabolism: A new paradigm for the third millennium
    • Gladden, L. B. (2004). Lactate metabolism: a new paradigm for the third millennium. Journal of Physiology, 558, 5-30.
    • (2004) Journal of Physiology , vol.558 , pp. 5-30
    • Gladden, L.B.1
  • 29
    • 84865335195 scopus 로고    scopus 로고
    • Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with "Warburg- like" cancer metabolism and L-lactate production
    • Guido, C., Whitaker-Menezes, D., Capparelli, C., Balliet, R., Lin, Z., Pestell, R. G., et al. (2012). Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production. Cell Cycle, 11(16), 3019-3035.
    • (2012) Cell Cycle , vol.11 , Issue.16 , pp. 3019-3035
    • Guido, C.1    Whitaker-Menezes, D.2    Capparelli, C.3    Balliet, R.4    Lin, Z.5    Pestell, R.G.6
  • 30
    • 84867112200 scopus 로고    scopus 로고
    • Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay
    • Fiaschi, T., Marini, A., Giannoni, E., Taddei, M. L., Gandellini, P., De Donatis, A., et al. (2012). Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. Cancer Research, 72, 5130-5140.
    • (2012) Cancer Research , vol.72 , pp. 5130-5140
    • Fiaschi, T.1    Marini, A.2    Giannoni, E.3    Taddei, M.L.4    Gandellini, P.5    De Donatis, A.6
  • 32
    • 84883182637 scopus 로고    scopus 로고
    • Disrupting proton dynamics and energy metabolism for cancer therapy
    • Parks, S. K., Chiche, J., & Pouysségur, J. (2013). Disrupting proton dynamics and energy metabolism for cancer therapy. Nature Reviews Cancer, 13(9), 611-623.
    • (2013) Nature Reviews Cancer , vol.13 , Issue.9 , pp. 611-623
    • Parks, S.K.1    Chiche, J.2    Pouysségur, J.3
  • 33
    • 84865963556 scopus 로고    scopus 로고
    • Extracellular acidity as favouring factor of tumor progression and metastatic dissemination
    • Calorini, L., Peppicelli, S., & Bianchini, F. (2012). Extracellular acidity as favouring factor of tumor progression and metastatic dissemination. Experimental Oncology, 34(2), 79-84.
    • (2012) Experimental Oncology , vol.34 , Issue.2 , pp. 79-84
    • Calorini, L.1    Peppicelli, S.2    Bianchini, F.3
  • 34
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • Walenta, S., Wetterling, M., Lehrke, M., Schwickert, G., Sundfør, K., Rofstad, E. K., et al. (2000). High lactate levels predict likelihood ofmetastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Research, 60, 916-921. (Pubitemid 30129526)
    • (2000) Cancer Research , vol.60 , Issue.4 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfor, K.5    Rofstad, E.K.6    Mueller-Klieser, W.7
  • 35
    • 0026623304 scopus 로고
    • Clastogenicity of low pH to various cultured mammalian cells
    • Morita, T., Nagaki, T., Fukuda, I., & Okumura, K. (1992). Clastogenicity of low pH to various cultured mammalian cells. Mutation Research, 268, 297-305.
    • (1992) Mutation Research , vol.268 , pp. 297-305
    • Morita, T.1    Nagaki, T.2    Fukuda, I.3    Okumura, K.4
  • 36
    • 0034884690 scopus 로고    scopus 로고
    • Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone
    • DOI 10.1038/sj.neo.7900151
    • Raghunand, N., Mahoney, B., van Sluis, R., Baggett, B., & Gillies, R. J. (2001). Acute metabolic alkalosis enhances response of C3H mousemammary tumors to the weak basemitoxantrone. Neoplasia, 3, 227-235. (Pubitemid 32747571)
    • (2001) Neoplasia , vol.3 , Issue.3 , pp. 227-235
    • Raghunand, N.1    Mahoney, B.2    Van Sluis, R.3    Baggett, B.4    Gillies, R.J.5
  • 37
    • 0019964896 scopus 로고
    • Radioresistance secondary to low pH in human glial cells and Chinese hamster ovary cells
    • Rottinger, E. M., & Mendonca, M. (1982). Radioresistance secondary to low pH in human glial cells and Chinese hamster ovary cells. International Journal of Radiation Oncology, Biology, and Physics, 8, 1309-1314. (Pubitemid 12031979)
    • (1982) International Journal of Radiation Oncology Biology Physics , vol.8 , Issue.8 , pp. 1309-1314
    • Rottinger, E.M.1    Mendonca, M.2
  • 39
    • 34548038993 scopus 로고    scopus 로고
    • Serial in vivo spectroscopic nuclear magnetic resonance imaging of lactate and extracellular pH in rat gliomas shows redistribution of protons away from sites of glycolysis
    • DOI 10.1158/0008-5472.CAN-06-3459
    • Provent, P., Benito, M., Hiba, B., Farion, R., López-Larrubia, P., Ballesteros, P., et al. (2007). Serial in vivo spectroscopic nuclear magnetic resonance imaging of lactate and extracellular pH in rat gliomas shows redistribution of protons away from sites of glycolysis. Cancer Research, 67, 7638-7645. (Pubitemid 47281356)
    • (2007) Cancer Research , vol.67 , Issue.16 , pp. 7638-7645
    • Provent, P.1    Benito, M.2    Hiba, B.3    Farion, R.4    Lopez-Larrubia, P.5    Ballesteros, P.6    Remy, C.7    Segebarth, C.8    Cerdan, S.9    Coles, J.A.10    Garcia-Martin, M.L.11
  • 40
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • DOI 10.1038/nature04871, PII NATURE04871
    • Pouyssegur, J., Dayan, F., & Mazure, N. M. (2006). Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature, 441, 437-443. (Pubitemid 44050138)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 41
    • 0030614893 scopus 로고    scopus 로고
    • 2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • DOI 10.1038/nm0297-177
    • Helmlinger, G., Yuan, F., Dellian, M., & Jain, R. K. (1997). Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nature Medicine, 3, 177-182. (Pubitemid 27064702)
    • (1997) Nature Medicine , vol.3 , Issue.2 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 43
    • 1042289739 scopus 로고    scopus 로고
    • Solution structure of human cofilin. Actin binding, pH sensitivity, and relationship to actin-depolymerizing factor
    • DOI 10.1074/jbc.M310148200
    • Pope, B. J., Zierler-Gould, K. M., Kühne, R., Weeds, A. G., & Ball, L. J. (2004). Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor. Journal of Biological Chemistry, 279(6), 4840-4848. (Pubitemid 38199079)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.6 , pp. 4840-4848
    • Pope, B.J.1    Zierler-Gould, K.M.2    Kuhne, R.3    Weeds, A.G.4    Ball, L.J.5
  • 44
    • 34250199732 scopus 로고    scopus 로고
    • Acid-induced equilibrium folding intermediate of human platelet profilin
    • DOI 10.1021/bi0602359
    • McLachlan, G. D., Cahill, S. M., Girvin, M. E., & Almo, S. C. (2007). Acid-induced equilibrium folding intermediate of human platelet profiling. Biochemistry, 46, 6931-6943. (Pubitemid 46906422)
    • (2007) Biochemistry , vol.46 , Issue.23 , pp. 6931-6943
    • McLachlan, G.D.1    Cahill, S.M.2    Girvin, M.E.3    Almo, S.C.4
  • 45
    • 33646704772 scopus 로고    scopus 로고
    • Twinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo
    • DOI 10.1242/jcs.02860
    • Moseley, J. B., Okada, K., Balcer, H. I., Kovar, D. R., Pollard, T. D., & Goode, B. L. (2006). Twinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo. Journal of Cell Science, 119, 1547-1557. (Pubitemid 43732981)
    • (2006) Journal of Cell Science , vol.119 , Issue.8 , pp. 1547-1557
    • Moseley, J.B.1    Okada, K.2    Balcer, H.I.3    Kovar, D.R.4    Pollard, T.D.5    Goode, B.L.6
  • 46
    • 29444454319 scopus 로고    scopus 로고
    • Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: Contribution of His41 to the pH-dependent stability of the N-terminal subdomain
    • DOI 10.1016/j.jmb.2005.11.001, PII S0022283605013641
    • Grey, M. J., Tang, Y., Alexov, E., McKnight, C. J., Raleigh, D. P., & Palmer, A. G., III. (2006). Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH dependent stability of the N-terminal subdomain. Journal of Molecular Biology, 355, 1078-1094. (Pubitemid 43012149)
    • (2006) Journal of Molecular Biology , vol.355 , Issue.5 , pp. 1078-1094
    • Grey, M.J.1    Tang, Y.2    Alexov, E.3    McKnight, C.J.4    Raleigh, D.P.5    Palmer III, A.G.6
  • 48
    • 35949000834 scopus 로고    scopus 로고
    • + efflux by the Na-H exchanger NHE1 for polarity of migrating cells
    • DOI 10.1083/jcb.200704169
    • Frantz, C., Karydis, A., Nalbant, P., Hahn, K. M., & Barber, D. L. (2007). Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells. The Journal of Cell Biology, 179, 403-410. (Pubitemid 350074786)
    • (2007) Journal of Cell Biology , vol.179 , Issue.3 , pp. 403-410
    • Frantz, C.1    Karydis, A.2    Nalbant, P.3    Hahn, K.M.4    Barber, D.L.5
  • 50
    • 79251633163 scopus 로고    scopus 로고
    • Acidic extracellular pH promotes activation of integrin αvβ3
    • Paradise, R. K., Lauffenburger, D. A., & Van Vliet, K. J. (2011). Acidic extracellular pH promotes activation of integrin αvβ3. PLoS ONE, 6, e15746.
    • (2011) PLoS ONE , vol.6
    • Paradise, R.K.1    Lauffenburger, D.A.2    Van Vliet, K.J.3
  • 51
    • 84867405330 scopus 로고    scopus 로고
    • pH regulators in invadosomal functioning: Proton delivery for matrix tasting
    • Brisson, L., Reshkin, S. J., Goré, J., & Roger, S. (2012). pH regulators in invadosomal functioning: proton delivery for matrix tasting. European Journal of Cell Biology, 91, 847-860.
    • (2012) European Journal of Cell Biology , vol.91 , pp. 847-860
    • Brisson, L.1    Reshkin, S.J.2    Goré, J.3    Roger, S.4
  • 52
    • 84455170179 scopus 로고    scopus 로고
    • Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK)
    • Lucien, F., Brochu-Gaudreau, K., Arsenault, D., Harper, K., & Dubois, C. M. (2011). Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK). PLoS One, 6, e28851.
    • (2011) PLoS One , vol.6
    • Lucien, F.1    Brochu-Gaudreau, K.2    Arsenault, D.3    Harper, K.4    Dubois, C.M.5
  • 54
    • 0028618307 scopus 로고
    • Pericellular pH affects distribution and secretion of cathepsin B in malignant cells
    • Rozhin, J., Sameni, M., Ziegler, G., & Sloane, F. B. (1994). Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Research, 54, 6517-6525.
    • (1994) Cancer Research , vol.54 , pp. 6517-6525
    • Rozhin, J.1    Sameni, M.2    Ziegler, G.3    Sloane, F.B.4
  • 55
    • 0033380522 scopus 로고    scopus 로고
    • Alterations in proteolytic activity at low pH and its association with invasion: A theoretical model
    • DOI 10.1023/A:1006667303583
    • Webb, S. D., Sherratt, J. A., & Fish, R. G. (1999). Alterations in proteolytic activity at low pH and its association with invasion: a theoretical model. Clinical and Experimental Metastasis, 17, 397-407. (Pubitemid 30019997)
    • (1999) Clinical and Experimental Metastasis , vol.17 , Issue.5 , pp. 397-407
    • Webb, S.D.1    Sherratt, J.A.2    Fish, R.G.3
  • 56
    • 0026516022 scopus 로고
    • Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L
    • Goretzki, L., Schmitt, M., Mann, K., Calvete, J., Chucholowski, N., Kramer, M., et al. (1992). Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L. FEBS Letters, 297, 112-118.
    • (1992) FEBS Letters , vol.297 , pp. 112-118
    • Goretzki, L.1    Schmitt, M.2    Mann, K.3    Calvete, J.4    Chucholowski, N.5    Kramer, M.6
  • 57
    • 0029943568 scopus 로고    scopus 로고
    • Plasminogen activators and matrix metalloproteinases in angiogenesis
    • Mignatti, P., & Rifkin, D. B. (1996). Plasminogen activators and matrix metalloproteinases in angiogenesis. Enzyme and Protein, 49, 117-137. (Pubitemid 26181742)
    • (1996) Enzyme and Protein , vol.49 , Issue.1-3 , pp. 117-137
    • Mignatti, P.1    Rifkin, D.B.2
  • 58
    • 0023916551 scopus 로고
    • Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium
    • Lyons, R. M., Keski-Oja, J., & Moses, H. L. (1988). Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium. Journal of Cell Biology, 106, 1659-1665.
    • (1988) Journal of Cell Biology , vol.106 , pp. 1659-1665
    • Lyons, R.M.1    Keski-Oja, J.2    Moses, H.L.3
  • 59
    • 0027076170 scopus 로고
    • The urokinase receptor: Involvement in cell surface proteolysis and cancer invasion
    • DOI 10.1111/j.1749-6632.1992.tb51591.x
    • Ellis, V., Pyke, C., Eriksen, J., Solberg, H., & Danø, K. (1992). The urokinase receptor: involvement in cell surface proteolysis and cancer invasion. Annals of the New York Academy of Sciences, 667, 13-31. (Pubitemid 23061557)
    • (1992) Annals of the New York Academy of Sciences , vol.667 , pp. 13-31
    • Ellis, V.1    Pyke, C.2    Eriksen, J.3    Solberg, H.4    Dano, K.5
  • 61
    • 0037052641 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer: Prognostic markers and therapeutic targets
    • DOI 10.1002/ijc.10329
    • Vihinen, P., & Kähäri, V. M. (2002). Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. International Journal of Cancer, 99(2), 157-166. (Pubitemid 34309470)
    • (2002) International Journal of Cancer , vol.99 , Issue.2 , pp. 157-166
    • Vihinen, P.1    Kahari, V.-M.2
  • 63
    • 0032031861 scopus 로고    scopus 로고
    • Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
    • Itoh, T., Tanioka, M., Yoshida, H., Yoshioka, T., Nishimoto, H., & Itohara, S. (1998). Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Research, 58(5), 1048-1051. (Pubitemid 28182477)
    • (1998) Cancer Research , vol.58 , Issue.5 , pp. 1048-1051
    • Itoh, T.1    Tanioka, M.2    Yoshida, H.3    Yoshioka, T.4    Nishimoto, H.5    Itohara, S.6
  • 64
    • 0026667311 scopus 로고
    • Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines
    • Kato, Y., Nakayama, Y., Umeda, M., & Miyazaki, K. (1992). Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines. Journal of Biological Chemistry, 267(16), 11424-11430.
    • (1992) Journal of Biological Chemistry , vol.267 , Issue.16 , pp. 11424-11430
    • Kato, Y.1    Nakayama, Y.2    Umeda, M.3    Miyazaki, K.4
  • 65
    • 0033588093 scopus 로고    scopus 로고
    • Human heparanase. Purification, characterization, cloning, and expression
    • Toyoshima, M., & Nakajima, M. (1999). Human heparanase. Purification, characterization, cloning, and expression. Journal of Biological Chemistry, 274, 24153-24160.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 24153-24160
    • Toyoshima, M.1    Nakajima, M.2
  • 66
    • 0035927544 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
    • DOI 10.1038/sj.onc.1204500
    • Shi, Q., Le, X., Wang, B., Abbruzzese, J. L., Xiong, Q., He, Y., et al. (2001). Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. Oncogene, 20, 3751-3756. (Pubitemid 32624967)
    • (2001) Oncogene , vol.20 , Issue.28 , pp. 3751-3756
    • Shi, Q.1    Le, X.2    Wang, B.3    Abbruzzese, J.L.4    Xiong, Q.5    He, Y.6    Xie, K.7
  • 67
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura, D., Xu, L., Chen, Y., Gohongi, T., Seed, B., & Jain, R. K. (2000). Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Research, 61, 6020-6024.
    • (2000) Cancer Research , vol.61 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 68
    • 0034662635 scopus 로고    scopus 로고
    • Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells
    • Xu, L., & Fidler, I. J. (2000). Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells. Cancer Research, 60(16), 4610-4616. (Pubitemid 32103647)
    • (2000) Cancer Research , vol.60 , Issue.16 , pp. 4610-4616
    • Xu, L.1    Fidler, I.J.2
  • 70
    • 33644822574 scopus 로고    scopus 로고
    • The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells
    • Su, J. L., Yang, P. C., Shih, J. Y., Yang, C. Y., Wei, L. H., Hsieh, C. Y., et al. (2006). The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell, 9, 209-223.
    • (2006) Cancer Cell , vol.9 , pp. 209-223
    • Su, J.L.1    Yang, P.C.2    Shih, J.Y.3    Yang, C.Y.4    Wei, L.H.5    Hsieh, C.Y.6
  • 71
    • 27644473229 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition
    • Radisky, D. C. (2005). Epithelial-mesenchymal transition. Journal of Cell Science, 118(Pt 19), 4325-4326.
    • (2005) Journal of Cell Science , vol.118 , Issue.PART 19 , pp. 4325-4326
    • Radisky, D.C.1
  • 72
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • DOI 10.1172/JCI200320530
    • Kalluri, R., & Neilson, E. G. (2003). Epithelial-mesenchymal transition and its implications for fibrosis. The Journal of Clinical Investigation, 112(12), 1776-1784. (Pubitemid 38063698)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.12 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 73
    • 67651005404 scopus 로고    scopus 로고
    • EMT: When epithelial cells decide to become mesenchymal-like cells
    • Kalluri, R. (2009). EMT: when epithelial cells decide to become mesenchymal-like cells. The Journal of Clinical Investigation, 119(6), 1417-1419.
    • (2009) The Journal of Clinical Investigation , vol.119 , Issue.6 , pp. 1417-1419
    • Kalluri, R.1
  • 74
    • 84898596660 scopus 로고    scopus 로고
    • Contribution of acidic melanoma cells undergoing epithelial-to- mesenchymal transition to aggressiveness of non-acidic melanoma cells
    • Peppicelli, S., Bianchini, F., Torre, E., Calorini, L. (2014). Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells. Clinical and Experimental Metastasis.
    • (2014) Clinical and Experimental Metastasis
    • Peppicelli, S.1    Bianchini, F.2    Torre, E.3    Calorini, L.4
  • 75
    • 0031577714 scopus 로고    scopus 로고
    • Low extracellular pH induces activation of ERK 2, JNK, and p38 in A431 and Swiss 3T3 cells
    • DOI 10.1006/bbrc.1997.7759
    • Xue, L., & Lucocq, J. M. (1997). Low extracellular pH induces activation of ERK 2, JNK, and p38 in A431 and Swiss 3 T3 cells. Biochemical and Biophysical Research Communications, 241(2), 236-242. (Pubitemid 28020086)
    • (1997) Biochemical and Biophysical Research Communications , vol.241 , Issue.2 , pp. 236-242
    • Xue, L.1    Lucocq, J.M.2
  • 77
    • 54049087754 scopus 로고    scopus 로고
    • Acidic preconditioning suppresses apoptosis and increases expression of Bcl-xL in coronary endothelial cells under simulated ischaemia
    • Kumar, S., Reusch, H. P., & Ladilov, Y. (2008). Acidic preconditioning suppresses apoptosis and increases expression of Bcl-xL in coronary endothelial cells under simulated ischaemia. Journal of Cellular and Molecular Medicine, 12(5A), 1584-1592.
    • (2008) Journal of Cellular and Molecular Medicine , vol.12 , Issue.5 A , pp. 1584-1592
    • Kumar, S.1    Reusch, H.P.2    Ladilov, Y.3
  • 78
    • 84864974250 scopus 로고    scopus 로고
    • Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: Involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk
    • Ryder, C., McColl, K., Zhong, F., & Distelhorst, C. W. (2012). Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk. Journal of Biological Chemistry, 287(33), 27863-27875.
    • (2012) Journal of Biological Chemistry , vol.287 , Issue.33 , pp. 27863-27875
    • Ryder, C.1    McColl, K.2    Zhong, F.3    Distelhorst, C.W.4
  • 79
    • 84865147552 scopus 로고    scopus 로고
    • Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments
    • Wojtkowiak, J. W., Rothberg, J. M., Kumar, V., Schramm, K. J., Haller, E., Proemsey, J. B., et al. (2012). Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Research, 72(16), 3938-3947.
    • (2012) Cancer Research , vol.72 , Issue.16 , pp. 3938-3947
    • Wojtkowiak, J.W.1    Rothberg, J.M.2    Kumar, V.3    Schramm, K.J.4    Haller, E.5    Proemsey, J.B.6
  • 80
    • 34250864795 scopus 로고    scopus 로고
    • Protein turnover via autophagy: Implications for metabolism
    • DOI 10.1146/annurev.nutr.27.061406.093749
    • Mizushima, N., & Klionsky, D. J. (2007). Protein turnover via autophagy: implications for metabolism. Annual Review of Nutrition, 27, 19-40. (Pubitemid 351373346)
    • (2007) Annual Review of Nutrition , vol.27 , pp. 19-40
    • Mizushima, N.1    Klionsky, D.J.2
  • 84
    • 84880120014 scopus 로고    scopus 로고
    • Cancer-generated lactic acid: A regulatory, immunosuppressive metabolite?
    • Choi, S. Y., Collins, C. C., Gout, P. W., & Wang, Y. (2013). Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite? The Journal of Pathology, 230(4), 350-355.
    • (2013) The Journal of Pathology , vol.230 , Issue.4 , pp. 350-355
    • Choi, S.Y.1    Collins, C.C.2    Gout, P.W.3    Wang, Y.4
  • 85
    • 0035071662 scopus 로고    scopus 로고
    • The effects of extracellular pH on immune function
    • Lardner, A. (2001). The effects of extracellular pH on immune function. Journal of Leukocyte Biology, 69, 522-530.
    • (2001) Journal of Leukocyte Biology , vol.69 , pp. 522-530
    • Lardner, A.1
  • 87
    • 84861861104 scopus 로고    scopus 로고
    • Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes
    • Calcinotto, A., Filipazzi, P., Grioni, M., Iero, M., De Milito, A., Ricupito, A., et al. (2012). Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes. Cancer Research, 72, 2746-2756.
    • (2012) Cancer Research , vol.72 , pp. 2746-2756
    • Calcinotto, A.1    Filipazzi, P.2    Grioni, M.3    Iero, M.4    De Milito, A.5    Ricupito, A.6
  • 89
    • 84879203221 scopus 로고    scopus 로고
    • Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity
    • Ohashi, T., Akazawa, T., Aoki, M., Kuze, B., Mizuta, K., Ito, Y., et al. (2013). Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity. International Journal of Cancer, 133, 1107-1118.
    • (2013) International Journal of Cancer , vol.133 , pp. 1107-1118
    • Ohashi, T.1    Akazawa, T.2    Aoki, M.3    Kuze, B.4    Mizuta, K.5    Ito, Y.6
  • 90
    • 84857716739 scopus 로고    scopus 로고
    • Multiple biological activities of lactic acid in cancer: Influences on tumor growth, angiogenesis and metastasis
    • Dhup, S., Dadhich, R. K., Porporato, P. E., & Sonveaux, P. (2012). Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. Current Pharmaceutical Design, 18, 1319 - 1330.
    • (2012) Current Pharmaceutical Design , vol.18 , pp. 1319-1330
    • Dhup, S.1    Dadhich, R.K.2    Porporato, P.E.3    Sonveaux, P.4
  • 93
    • 79953329777 scopus 로고    scopus 로고
    • Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis
    • Végran, F., Boidot, R., Michiels, C., Sonveaux, P., & Feron, O. (2011). Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis. Cancer Research, 71(7), 2550-2560.
    • (2011) Cancer Research , vol.71 , Issue.7 , pp. 2550-2560
    • Végran, F.1    Boidot, R.2    Michiels, C.3    Sonveaux, P.4    Feron, O.5
  • 94
    • 58149157900 scopus 로고    scopus 로고
    • The genomic analysis of lactic acidosis and acidosis response in human cancers
    • Chen, J. L., Lucas, J. E., Schroeder, T., Mori, S., Wu, J., Nevins, J., et al. (2008). The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genetics, 4, e1000293.
    • (2008) PLoS Genetics , vol.4
    • Chen, J.L.1    Lucas, J.E.2    Schroeder, T.3    Mori, S.4    Wu, J.5    Nevins, J.6
  • 95
    • 33646428345 scopus 로고    scopus 로고
    • Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs
    • Thews, O., Gassner, B., Kelleher, D. K., Schwerdt, G., & Gekle, M. (2006). Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs. Neoplasia, 8, 14352.
    • (2006) Neoplasia , vol.8 , pp. 14352
    • Thews, O.1    Gassner, B.2    Kelleher, D.K.3    Schwerdt, G.4    Gekle, M.5
  • 96
    • 0034143570 scopus 로고    scopus 로고
    • pH and drug resistance in tumors
    • DOI 10.1054/drup.2000.0119
    • Raghunand, N., & Gillies, R. J. (2002). pH and drug resistance in tumors. Drug Resistance Updates, 3, 39-47. (Pubitemid 30246567)
    • (2000) Drug Resistance Updates , vol.3 , Issue.1 , pp. 39-47
    • Raghunand, N.1    Gillies, R.J.2
  • 97
    • 0026720341 scopus 로고
    • Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours
    • Newell, K., Wood, P., Stratford, I., & Tannock, I. (1992). Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours. British Journal of Cancer, 66, 311-317.
    • (1992) British Journal of Cancer , vol.66 , pp. 311-317
    • Newell, K.1    Wood, P.2    Stratford, I.3    Tannock, I.4
  • 99
    • 0001829242 scopus 로고
    • The effect of environmental factors on the radiosensitivity of lymph nodes cultured in vitro
    • Trowell, O. A. (1953). The effect of environmental factors on the radiosensitivity of lymph nodes cultured in vitro. British Journal of Radiology, 306, 302-309.
    • (1953) British Journal of Radiology , vol.306 , pp. 302-309
    • Trowell, O.A.1
  • 100
    • 0018877325 scopus 로고
    • The influence of pH on the survival after X-irradiation of cultured malignant cells. Effects of carbonylcyanide-3-chlorophenylhydrazone
    • Haveman, J. (1980). The influence of pH on the survival after X-irradiation of cultured malignant cells. Effects of carbonylcyanide-3- chlorophenylhydrazone. International Journal of Radiation Biology, 37, 201-205.
    • (1980) International Journal of Radiation Biology , vol.37 , pp. 201-205
    • Haveman, J.1
  • 101
    • 0030869505 scopus 로고    scopus 로고
    • p53-dependent induction of WAF1 by a low-ph culture condition in human glioblastoma cells
    • Ohtsubo, T., Wang, X., Takahashi, A., Ohnishi, K., Saito, H., Song, C. W., et al. (1997). p53-dependent induction of WAF1 by a low-pH culture condition in human glioblastoma cells. Cancer Research, 57(18), 3910-3913. (Pubitemid 27427674)
    • (1997) Cancer Research , vol.57 , Issue.18 , pp. 3910-3913
    • Ohtsubo, T.1    Wang, X.2    Takahashi, A.3    Ohnishi, K.4    Saito, H.5    Song, C.W.6    Ohnishi, T.7
  • 108
    • 34848885103 scopus 로고    scopus 로고
    • A monomeric membrane peptide that lives in three worlds: In solution, attached to, and inserted across lipid bilayers
    • DOI 10.1529/biophysj.107.109967
    • Reshetnyak, Y. K., Segala, M., Andreev, O. A., & Engelman, D. M. (2007). A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophysical Journal, 93, 2363-2372. (Pubitemid 47511136)
    • (2007) Biophysical Journal , vol.93 , Issue.7 , pp. 2363-2372
    • Reshetnyak, Y.K.1    Segala, M.2    Andreev, O.A.3    Engelman, D.M.4
  • 110
    • 66249099231 scopus 로고    scopus 로고
    • A novel technology for the imaging of acidic prostate tumors by positron emission tomography
    • Vāvere, A. L., Biddlecombe, G. B., Spees, W. M., Garbow, J. R., Wijesinghe, D., Andreev, O. A., et al. (2009). A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Research, 69(10), 4510-4516.
    • (2009) Cancer Research , vol.69 , Issue.10 , pp. 4510-4516
    • Vavere, A.L.1    Biddlecombe, G.B.2    Spees, W.M.3    Garbow, J.R.4    Wijesinghe, D.5    Andreev, O.A.6
  • 111
    • 0033592178 scopus 로고    scopus 로고
    • A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications
    • Aime, S., Botta, M., Crich, S. G., Giovenzana, G., Palmisano, G., & Sisti, M. (1999). A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications. Chemical communications (Cambridge), 16, 1577-1578. (Pubitemid 29391229)
    • (1999) Chemical Communications , Issue.16 , pp. 1577-1578
    • Aime, S.1    Botta, M.2    Crich, S.G.3    Giovenzana, G.4    Palmisano, G.5    Sisti, M.6
  • 112
    • 0033517750 scopus 로고    scopus 로고
    • A novel pH-sensitive MRI contrast agent
    • DOI 10.1002/(SICI)1521-3773(19991102)38:21<3192::AI
    • Zhang, S., Wu, K., & Sherry, A. D. (1999). A novel pH-sensitive MRI contrast agent. Angewandte Chemie International Edition in English, 38, 3192-3194. (Pubitemid 29533893)
    • (1999) Angewandte Chemie - International Edition , vol.38 , Issue.21 , pp. 3192-3194
    • Zhang, S.1    Wu, K.2    Dean, S.A.3
  • 115
    • 65549170684 scopus 로고    scopus 로고
    • The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion
    • Silva, A. S., Yunes, J. A., Gillies, R. J., & Gatenby, R. A. (2009). The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Research, 69, 2677-2684.
    • (2009) Cancer Research , vol.69 , pp. 2677-2684
    • Silva, A.S.1    Yunes, J.A.2    Gillies, R.J.3    Gatenby, R.A.4
  • 117
    • 36349001899 scopus 로고    scopus 로고
    • +-ATPases as a new strategy against cancer
    • DOI 10.1158/0008-5472.CAN-07-1805
    • Fais, S., De Milito, A., You, H., & Qin, W. (2007). Targeting vacuolar H+-ATPases as a new strategy against cancer. Cancer Research, 67, 10627-10630. (Pubitemid 350145883)
    • (2007) Cancer Research , vol.67 , Issue.22 , pp. 10627-10630
    • Fais, S.1    De Milito, A.2    You, H.3    Qin, W.4
  • 118
    • 77953463274 scopus 로고    scopus 로고
    • pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity
    • De Milito, A., Canese, R., Marino, M. L., Borghi, M., Iero, M., Villa, A., et al. (2010). pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity. International Journal of Cancer, 127, 207-219.
    • (2010) International Journal of Cancer , vol.127 , pp. 207-219
    • De Milito, A.1    Canese, R.2    Marino, M.L.3    Borghi, M.4    Iero, M.5    Villa, A.6
  • 119
    • 36948999655 scopus 로고    scopus 로고
    • Erratum (Retracted Article): Blockage of intracellular proton extrusion with proton pump inhibitor induces apoptosis in gastric cancer (Cancer Science)
    • DOI 10.1111/j.1349-7006.2007.00642.x
    • Yeo, M., Kim, D. K., Park, H. J., Cho, S. W., Cheong, J. Y., & Lee, K. J. (2008). Retraction: blockage of intracellular proton extrusion with proton pump inhibitor induces apoptosis in gastric cancer. Cancer Science, 99, 185. (Pubitemid 350239049)
    • (2008) Cancer Science , vol.99 , Issue.1 , pp. 185
    • Yeo, M.1    Kim, D.-K.2    Park, H.-J.3    Cho, S.-W.4    Cheong, J.Y.5    Lee, K.J.6
  • 121
    • 84856612269 scopus 로고    scopus 로고
    • The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2
    • Lauritzen, G., Stock, C. M., Lemaire, J., Lund, S. F., Jensen, M. F., Damsgaard, B., et al. (2012). The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. Cancer Letters, 317, 172-183.
    • (2012) Cancer Letters , vol.317 , pp. 172-183
    • Lauritzen, G.1    Stock, C.M.2    Lemaire, J.3    Lund, S.F.4    Jensen, M.F.5    Damsgaard, B.6
  • 122
    • 33846708762 scopus 로고    scopus 로고
    • + exchanger
    • DOI 10.1016/j.leukres.2006.06.015, PII S014521260600230X
    • He, B., Deng, C., Zhang, M., Zou, D., & Xu, M. (2007). Reduction of intracellular pH inhibits the expression of VEGF in K562 cells after targeted inhibition of the Na+/H+ exchanger. Leukemia Research, 2007(31), 507-514. (Pubitemid 46198933)
    • (2007) Leukemia Research , vol.31 , Issue.4 , pp. 507-514
    • He, B.1    Deng, C.2    Zhang, M.3    Zou, D.4    Xu, M.5
  • 123
    • 84870013632 scopus 로고    scopus 로고
    • Urokinase plasminogen activator receptor induced non-small cell lung cancer invasion and metastasis requires NHE1 transporter expression and transport activity
    • Provost, J. J., Rastedt, D., Canine, J., Ngyuen, T., Haak, A., Kutz, C., et al. (2012). Urokinase plasminogen activator receptor induced non-small cell lung cancer invasion and metastasis requires NHE1 transporter expression and transport activity. Cellular Oncology, 2012(35), 95-110.
    • (2012) Cellular Oncology , vol.2012 , Issue.35 , pp. 95-110
    • Provost, J.J.1    Rastedt, D.2    Canine, J.3    Ngyuen, T.4    Haak, A.5    Kutz, C.6
  • 125
    • 0037100861 scopus 로고    scopus 로고
    • Cytostatic potential of novel agents that inhibit the regulation of intracellular pH
    • Wong, P., Kleemann, H. W., & Tannock, I. F. (2002). Cytostatic potential of novel agents that inhibit the regulation of intracellular pH. British Journal of Cancer, 87(2), 238-245.
    • (2002) British Journal of Cancer , vol.87 , Issue.2 , pp. 238-245
    • Wong, P.1    Kleemann, H.W.2    Tannock, I.F.3
  • 126
    • 84887070095 scopus 로고    scopus 로고
    • Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs - An integral molecular/biochemical/metabolic/ clinical approach after one hundred years of cancer research
    • Harguindey, S., Arranz, J. L., Polo Orozco, J. D., Rauch, C., Fais, S., Cardone, R. A., et al. (2013). Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs - an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. Journal of Translational Medicine, 11(1), 282.
    • (2013) Journal of Translational Medicine , vol.11 , Issue.1 , pp. 282
    • Harguindey, S.1    Arranz, J.L.2    Polo Orozco, J.D.3    Rauch, C.4    Fais, S.5    Cardone, R.A.6
  • 127
    • 80053932947 scopus 로고    scopus 로고
    • Inhibition of K562 leukemia angiogenesis and growth by selective Na+/H+ exchanger inhibitor cariporide through down-regulation of pro-angiogenesis factor VEGF
    • Gao, W., Chang, G., Wang, J., Jin, W., Wang, L., Lin, Y., et al. (2011). Inhibition of K562 leukemia angiogenesis and growth by selective Na+/H+ exchanger inhibitor cariporide through down-regulation of pro-angiogenesis factor VEGF. Leukemia Research, 11, 1506-1511.
    • (2011) Leukemia Research , vol.11 , pp. 1506-1511
    • Gao, W.1    Chang, G.2    Wang, J.3    Jin, W.4    Wang, L.5    Lin, Y.6
  • 130
    • 84863822889 scopus 로고    scopus 로고
    • Effects of pantoprazole as a HIF-1α inhibitor on human gastric adenocarcinoma sgc-7901 cells
    • Shen, Y., Wu, Y., Chen, M., Shen, W., Huang, S., Zhang, L., et al. (2012). Effects of pantoprazole as a HIF-1α inhibitor on human gastric adenocarcinoma sgc-7901 cells. Neoplasma, 59, 142-149.
    • (2012) Neoplasma , vol.59 , pp. 142-149
    • Shen, Y.1    Wu, Y.2    Chen, M.3    Shen, W.4    Huang, S.5    Zhang, L.6
  • 132
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
    • Supuran, C. T. (2008). Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nature Reviews Drug Discovery, 7, 168-181.
    • (2008) Nature Reviews Drug Discovery , vol.7 , pp. 168-181
    • Supuran, C.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.