Contact Interactions Between Cells That Suppress Neoplastic Development: Can They Also Explain Metastatic Dormancy?

Advances in Cancer Research

Volumn 100, Issue , 2008, Pages 159-202

  Rubin, Harry ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CD146 ANTIGEN; CELL ADHESION MOLECULE; LOW DENSITY LIPOPROTEIN; PLATELET DERIVED GROWTH FACTOR;

ANTIBODY SPECIFICITY; APOPTOSIS; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL ADHESION; CELL COMMUNICATION; CELL GROWTH; CELL INTERACTION; CELL ISOLATION; CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; DISEASE COURSE; DISEASE SEVERITY; DOWN REGULATION; DYSPLASIA; EPITHELIUM CELL; FIBROBLAST; GENE LOCUS; GENE OVEREXPRESSION; GROWTH CURVE; GROWTH REGULATION; HUMAN; HUMAN CELL CULTURE; KERATINOCYTE; MELANOCYTE; MELANOMA; MESENCHYME; METABOLIC REGULATION; METASTASIS; NONHUMAN; PARENCHYMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REVIEW; ROUS SARCOMA ONCOVIRUS; SKIN TUMOR; TUMOR CELL; TUMOR VASCULARIZATION; ULTRAVIOLET RADIATION;

CELL ADHESION; CELL COMMUNICATION; CELL MEMBRANE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; EPITHELIAL CELLS; FIBROBLASTS; HUMANS; IMMUNITY, NATURAL; MELANOMA; MESODERM; MODELS, BIOLOGICAL; NEOPLASM METASTASIS; REACTION TIME;

EID: 46449115631     PISSN: 0065230X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-230X(08)00006-7     Document Type: Review

References (143)

1. Abercrombie M., and Ambrose E.J. Interference microscope studies of cell contacts in tissue culture. Exp. Cell Res. 15 (1958) 332-345
2. Abercrombie M., and Heaysman J.E.M. Observations on the social behavior of cells in tissue culture. II. "Monolayering" of fibroblasts. Exp. Cell Res. 6 (1954) 293-306
3. SAPK1. Cancer Res. 63 (2003) 1684-1695
4. Al-Mehdi A.B., Tozawa K., Fisher A.B., Shientag L., Lee A., and Muschel R.J. Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: A new model for metastasis. Nature Med. 6 (2000) 100-102
5. Alexander D.B., Ichikawa H., Bechberger J.F., Valiunas V., Ohki M., Naus C.C.G., Kunimoto T., Tsuda H., Miller W.T., and Goldberg G.S. Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and Src activity. Cancer Res. 64 (2004) 1347-1358
6. Alt-Holland A., Zhang W., Margulis A., and Garlick J. Microenvironmental control of premalignant disease: The role of intercellular adhesion in the progression of squamous cell carcinoma. Sem. Cancer Biol. 15 (2005) 84-96
7. Auerbach R., Lu W.C., Pardon E., Gumkowski F., Kaminska G., and Kaminski M. Specificity of adhesion between murine tumor cells and capillary endothelium: An in vitro correlate of preferential metastasis in vivo. Cancer Res. 47 (1987) 1492-1496
8. Auersperg N., Pan J., Grove B.D., Peterson T., Fisher J., Maines-Bandiera S., Somasiri A., and Rosekelley C.D. E-cadherin induces mesenchymal-to-epithelial transition in human ovarian epithelium. Proc. Natl. Acad. Sci. USA 96 (1999) 6249-6254
9. Bahar R., Hartmann C., Rodriguez K.A., Denny A.D., Busuttil R.A., Dollé M.E.T., Calder R.B., Chisholm G.B., Pollock B.H., Klein C.A., and Vijg J. Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 441 (2006) 1011-1014
10. Balaban G.B., Herlyn M., Guerry D., Bartolo R., Koprowski H., Clark Jr. W.H., and Nowell P.C. Cytogenetics of human malignant melanoma and premalignant lesions. Cancer Genet. Cytogenet. 11 (1984) 429-439
11. Belloni P.N., and Nicolson G.L. Differential expression of cell surface glycoproteins on various organ-derived microvascular endothelia and endothelial cell cultures. J. Cell Physiol. 136 (1988) 398-410
12. Belloni P.N., Tressler R.J., and Nicolson G.L. Identification of endothelial cell surface glycoproteins associated with preferential adhesion of metastatic murine RAW117 large cell lymphoma to organ-derived endothelial cells. J. Cell Biol. 103 (1986) 461a
13. Benchimol S., Fuks A., Jothy S., Beauchemin N., Shirota K., and Stanners C.P. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57 (1989) 327-334
14. Bilder D. Epithelial polarity and proliferation control: Links from Drosophila neoplastic tumor suppressors. Genes Dev. 18 (2004) 1909-1925
15. Bindels E.M.J., Vermey M., van den Beemd R., Dinjens W.N.M., and Van Der Kwast T.H. E-cadherin promotes intraepithelial expansion of bladder carcinoma cells in an in vitro model of carcinoma in situ. Cancer Res. 60 (2000) 177-183
16. 2+ and pyrophosphate. J. Cell. Physiol. 117 (1983) 51-61
17. Brulliard M., Lorphelin D., Collignon O., Lorphelin W., Thouvenot B., Gothie E., Jacquenet S., Ogier V., Roitel O., Monnez J.-M., Vallois P., Yen F.T., et al. Nonrandom variations in human cancer ESTs indicate that mRNA heterogeneity increases during carcinogenesis. Proc. Natl. Acad. Sci. USA 104 (2007) 7522-7527
18. Brumby A.M., and Richardson H.S. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 22 (2003) 5769-5779
19. Cairns J. Cancer: Science and Society (1978), W.H. Freeman, San Francisco
20. Cameron M.D., Schmidt E.E., Kerkvliet N., Nadkarni K.V., Morris V.L., Groom A.C., Chambers A.F., and MacDonald I.C. Temporal progression of metastasis in lung: Cell survival, dormancy and location dependence of metastatic inefficiency. Cancer Res. 60 (2000) 2541-2546
21. Carney D.H., and Cunningham D.D. Initiation of chick cell division by trypsin action at the cell surface. Nature 268 (1977) 602-606
22. Caspersson T., and Santesson L. Studies on protein metabolism in the cells of epithelial tumors. Acta Radiol. Suppl. 46 (1942) 5-105
23. Castor L.N. Contact regulation of cell division in an epithelial-like cell line. J. Cell Physiol. 72 (1968) 161-172
24. Cha R.S., Thilly W.G., and Zarbl H. N-Nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras 1 gene mutations. Proc. Natl. Acad. Sci. USA 91 (1994) 3749-3753
25. Chekmareva M.A., Kadkhodaian M.M., Hollowell C.M., Kim H., Yoshida B.A., Stadler W.M., and Rinker-Schaeffer C.W. Chromosome 17-mediated dormancy of AT6.1 prostate cancer micrometastases. Cancer Res. 58 (1998) 4963-4969
26. Clark W.H. From the melanocyte to melanoma to tumor biology. Adv. Cancer Res. 65 (1994) 113-140
27. Clark W.H., Elder D.E., and Van Horn M. The biologic forms of malignant melanoma. Human Pathol. 17 (1986) 443-450
28. Clark Jr. W.H., Elder D.E., Guerry IV D., Epstein M.N., Greene M.H., and Van Horne M. A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma. Human Pathol. 15 (1984) 1147-1165
29. Coleman W.B., Wennerberg A.E., Smith G.J., and Grisham J.W. Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment. Am. J. Pathol. 142 (1993) 1373-1382
30. Coman D.R. Decreased mutual adhesiveness, a property of cells from squamous cell carcinomas. Cancer Res. 4 (1944) 625-629
31. Coman D.R. Mechanisms responsible for the origin and distribution of blood-borne tumor metastases: A review. Cancer Res. 13 (1953) 397-404
32. Cramer W., and Stowell R.E. The early stages of carcinogenesis by 20-methylcholanthrene in the skin of the mouse. I. Experimental technique and macroscopic changes. J. Natl. Cancer Inst. 2 (1942) 369-378
33. Crissman J.D., Hatfield J., Schaldenbrand M., Sloane B.F., and Honn K.V. Arrest and extravasation of B16 amelanotic melanoma in murine lungs. A light and electron study. Lab. Invest. 53 (1985) 470-478
34. Cuatrecasas P. Interaction of insulin with the cell membrane: The primary action of insulin. Proc. Natl. Acad. Sci. USA 63 (1969) 450-457
35. Demicheli R., Abattista A., Miceli R., Valagussa P., and Bonadonna G. Time distribution of the recurrence risk for breast cancer patients undergoing mastectomy: Further support for the concept of tumor dormancy. Breast Cancer Res. Treat. 41 (1996) 177-185
36. DeOme K., Miyamoto M., Osborn R., Guzman R., and Lum K. Detection of inapparent nodule-transformed cells in the mammary gland tissue of virgin female BALB/cfC3H mice. Cancer Res. 38 (1978) 2103-2111
37. Eagle H., and Levine E.M. Growth regulatory effects of cellular interaction. Nature 213 (1967) 1102-1106
38. Elsasser W.M. Reflections on a Theory of Organisms (1998), Johns Hopkins University Press, Baltimore, MD
39. Faulkin Jr. L.J., and DeOme K.B. Regulation of growth and spacing of gland elements in the mammary fat pad of the C3H mouse. J. Natl. Cancer Inst. 24 (1960) 953-968
40. Fidler I.J. Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res. 38 (1978) 2651-2660
41. Fischer A. Biology of Tissue Cells (1946), Cambridge University Press, Cambridge, England
42. Fisher B., and Fisher E.R. Experimental evidence in support of the dormant tumor cell. Science 130 (1959) 918-919
43. Foty R.A., Pfleger C.M., Forgacs G., and Steinberg M.S. Surface tensions of embryonic tissues predict their mutual envelopment behavior. Development 122 (1996) 1611-1620
44. Foty R.A., and Steinberg M.S. Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy. Int. J. Dev. Biol. 48 (2004) 397-409
45. Fry R.J.M., Tyler S.A., and Lesher S. In: Lindop P.J., and Sacher G.A. (Eds). Radiation and Ageing (1966), Taylor & Francis, London 43-55
46. Fukunaga-Kalabis M., Martinez G., Liu Z.-J., Kalabis J., Mrass P., Weninger W., Firth S.M., Planque N., Perbal B., and Herlyn M. CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1. J. Cell Biol. 175 (2006) 563-569
47. Gateff E. Malignant neoplasms of genetic origin in Drosophila melanogaster. Science 200 (1978) 1448-1459
48. Gibson T., and Norris W. Skin fragments removed by injection needles. Lancet 4 (1958) 983-985
49. Gillett N.A., Thomassen D.G., Buchholz A., and Kelly G. Cell-line-dependent inhibition of phenotypic expression of preneoplastic and neoplastic tracheal epithelial cells by normal tracheal cells in denuded tracheal transplants. Carcinogenesis 10 (1989) 1147-1154
50. Goodison S., Kawai K., Hibara J., Jiang P., Yang M., Urquidi V., Hoffman R.M., and Tarin D. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein. Clin. Cancer Res. 9 (2003) 3808-3814
51. Gumbiner B.M., and Yamada K.M. Cell-to-cell contact and extracellular matrix. Curr. Opin. Cell Biol. 5 (1993) 769-771
52. Hennings H., Lowry D.T., Robinson V.A., Morgan D.L., Fujiki H., and Yuspa S.H. Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis. Carcinogenesis 13 (1992) 2145-2151
53. Hennings H., Michael D., Cheng C., Steinert P., Holbrook K., and Yuspa S.H. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19 (1980) 245-254
54. Hennings H., Robinson V.A., Michael D.M., Pettit G.R., Jung R., and Yuspa S.H. Development of an in vitro analogue of initiated mouse epidermis to study tumor promoters and antipromoters. Cancer Res. 50 (1990) 4794-4800
55. Heppner G.H. Tumor heterogeneity. Cancer Res. 44 (1984) 2259-2265
56. Herlyn M., Rodeck U., Mancianti M.-L., Cardillo F.M., Lang A., Ross A.H., Jambrosic J., and Koprowski H. Expression of melanoma-associated antigens in rapidly dividing human melanocytes in culture. Cancer Res. 47 (1987) 3057-3061
57. Herlyn M., Balaban G., Bennicelli J., Guerry D., Halaban R., Herlyn D., Elder D.E., Maul G.G., Steplewski Z., Nowell P.C., Clark W.H., and Koprowski H. Primary melanoma cells of the vertical growth phase: Similarities to metastatic cells. JNCI 74 (1985) 283-289
58. Herlyn M., Thurin J., Balaban G., Bennicelli J., Herlyn D., Elder D.E., Bondi E., Guerry D., Nowell P.C., Clark W.H., and Koprowski H. Characteristics of cultured human melanocytes isolated from different stages of tumor progression. Cancer Res. 45 (1985) 5670-5676
59. Horak E., Darling D.L., and Tarin D. Analysis of organ-specific effects on metastatic tumor formation by studies in vitro. J. Natl. Cancer Inst. 76 (1986) 913-922
60. Hsu M., Andl T., Li G., Meinkoth J.L., and Herlyn M. Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression. J. Cell Sci. 113 (2000) 1535-1542
61. Hsu M.-Y., Meier F.E., Nesbit M., Hsu J.-Y., Van Belle P., Elder D.E., and Herlyn M. E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors. Am. J. Pathol. 156 (2000) 1515-1525
62. Javaherian A., Vaccariello M., Fusenig N.E., and Garlick J.A. Normal keratinocytes suppress early stages of neoplastic progression in stratified epithelium. Cancer Res. 58 (1998) 2200-2208
63. Jonason A.S., Kunala S., Price G.J., Restifo R.J., Spinell H.M., Persing J.A., Leffell D.J., Tarone R.E., and Brash D.E. Frequent clones of p53-mutated keratinocytes in normal human skin. Proc. Natl. Acad. USA 93 (1996) 14025-14029
64. Kanno Y., Sasaki Y., Shiba Y., Yoshida-Noro C., and Takeichi M. Monoclonal antibody ECCD-1 inhibits intercellular communication in teratocarcinoma PCC3 cells. Exp. Cell Res. 152 (1984) 270-274
65. Kasami M., Vnencak-Jones C.L., Manning S., Dupont W.D., and Page D.L. Loss of heterozygosity and microsatellite instability in breast neoplasia. No obligate correlation of these genetic alterations with subsequent malignancy. Am. J. Pathol. 150 (1997) 1925-1932
66. Kieran M.W., and Longenecker B.M. Organ specific metastasis with special reference to avian systems. Cancer Metastasis Rev. 2 (1983) 165-182
67. Klein G. Comparative studies of mouse tumors with respect to their capacity for growth as "ascites tumors" and their average nucleic aid content per cell. Exp. Cell Res. 2 (1951) 518-573
68. Koop S., MacDonald I.C., Luzzi K., Schmidt E.E., Morris V.I., Grattan M., Khokha R., Chambers A.F., and Groom A.C. Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate. Cancer Res. 55 (1995) 2520-2523
69. Koop S., Schmidt E.E., MacDonald I.C., Morris V.I., Khokha R., Grattan M., Leone J., Chambers A.F., and Groom A.C. Independence of metastatic ability and extravasation: Metastatic ras-transformed and control fibroblasts extravasate equally well. Proc. Natl. Acad. Sci. USA 93 (1996) 11080-11084
70. Kulesz-Martin M.F., Kilkenny A.E., Holbrook K.A., Digernes V., and Yuspa S.H. Properties of carcinogen altered mouse epidermal cells resistant to calcium-induced terminal differentiation. Carcinogenesis 4 (1983) 1367-1377
71. Kulesz-Martin M.F., Koehler B., Hennings H., and Yuspa S.H. Quantitative assay for carcinogen altered differentiation in mouse epidermal cells. Carcinogenesis 1 (1980) 995-1006
72. Lapis K., Paku S., and Liotta L.A. Endothelialization of embolized tumor cells during metastasis formation. Clin. Exp. Metastasis 6 (1988) 73-89
73. Li G., Fukunaga M., and Herlyn M. Reversal of melanocytic malignancy by keratinocytes is an E-cadherin-mediated process overriding β-catenin signaling. Exp. Cell Res. 297 (2004) 142-151
74. Luzzi K.J., MacDonald I.C., Schmidt E.E., Kerkvliet N., Morris V.L., Chambers A.F., and Groom A.C. Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am. J. Path. 153 (1998) 865-873
75. Mareel M. Molecular cell biology and cancer metastasis. An interview with Garth Nicolson. Int. J. Dev. Biol. 48 (2004) 355-363
76. Mareel M., Van Roy F., and De Baetselier P. The invasive phenotypes. Cancer Metastasis Rev. 9 (1990) 45-62
77. Mareel M., Vermeulen S., Bracke M., and Van Roy F. E-cadherin expression: A counterbalance for cancer cell invasion. Bull. Cancer 79 (1992) 347-355
78. Martin W., Zempel G., Hülser D., and Willecke K. Growth inhibition of oncogene-transformed rat fibroblasts by cultured normal cells: Relevance of metabolic cooperation mediated by gap junctions. Cancer Res. 51 (1991) 5348-5354
79. McCullough K.D., Coleman W.B., Ricketts S.L., Wilson J.W., Smith G.J., and Grisham J.W. Plasticity of the neoplastic phenotype in vivo is regulated by epigenetic factors. Proc. Natl. Acad. Sci. USA 95 (1998) 15333-15338
80. McCutcheon M., Coman D.R., and Moore F.B. Studies on invasiveness of cancer. Adhesiveness of malignant cells in various human adenocarcinomas. Cancer 1 (1948) 460-467
81. McGuire E.J., Mascali J.J., Grady S.R., and Nicolson G.L. Involvement of cell-cell adhesion molecules in liver colonization by metastatic murine lymphoma/lymphosarcoma variants. Clin. Exp. Metastasis 2 (1984) 213-222
82. Medina D., Shepherd F., and Gropp T.R. Enhancement of the tumorigenicity of preneoplastic mammary nodule lines by enzymatic dissociation. J. Natl. Cancer Inst. 60 (1978) 1121-1126
83. Mehta P.P., Bertram J.S., and Loewenstein W.R. Growth inhibition of transformed cells correlates with their junctional communication with normal cells. Cell 44 (1986) 187-196
84. Middleton C.A. In: Porter R., and Fitzsimons D.W. (Eds). Locomotion of Tissue Cells (1973), Elsevier, Amsterdam 251-270
85. Montel V., Mose E.S., and Tarin D. Tumor-stromal interactions reciprocally modulate gene expression patterns during carcinogenesis and metastasis. Int. J. Cancer 119 (2006) 251-263
86. Mudgil A.V., Segal N., Andriani F., Wang Y., Fusenig N.E., and Garlick J.A. Ultraviolet B irradiation induces expansion of intraepithelial tumor cells in a tissue model of early cancer progression. J. Invest. Dermatol. 121 (2003) 191-197
87. Nakamura T., Yoshimoto K., Nakayama Y., Tomita Y., and Ichihara A. Reciprocal modulation of growth and differentiated functions of mature rat hepatocytes in primary culture by cell-cell contact and cell membranes. Proc. Natl. Acad. Sci. USA 80 (1983) 7229-7233
88. Naumov G.N., Bender E., Zurakowski D., Kang S.-Y., Sampson D., Flynn E., Watnick R.S., Straume O., Akslen L.A., Folkman J., and Almog N. A model of human tumor dormancy: An angioswitch from the nonangiogenic phenotype. JNCI 98 (2006) 316-325
89. Naumov G.N., MacDonald I.C., Weinmeister P.M., Kerkvliet N., Nadkarni K.V., Wilson S.M., Morris V.L., Groom A.C., and Chambers A.F. Persistence of solitary mammary carcinoma cells in a secondary site. Cancer Res. 62 (2002) 2162-2168
90. Nelson C.M., VanDuijn M.M., Inman J.L., Fletcher D.A., and Bissell M.J. Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science 314 (2006) 298-300
91. Nicolson G.L. Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites. Biochem. Biophys. Acta 948 (1988) 175-224
92. Nicolson G.L. Autocrine and paracrine growth mechanisms in cancer progression and metastasis. Encyclopedia of Cancer. 2nd edn Vol. 1 (2002), Elsevier, Amsterdam 165-177
93. Nicolson G.L., and Dulski K.M. Organ specificity of metastatic tumor colonization is related to organ-selective growth properties of malignant cells. Int. J. Cancer 38 (1986) 289-294
94. Nicolson G.L., and Winkelhake J.L. Organ specificity of blood-borne tumour metastasis determined by cell adhesion?. Nature 255 (1975) 230-232
95. Pasqualini R., and Ruoslahti E. Organ targeting in vivo using phage display peptide libraries. Nature 380 (1996) 364-365
96. Pawlowski A., Haberman H.F., and Menon I.A. Junctional and compound pigmented nevi induced by 9,10-dimethyl-1,2-benzanthracene in skin of albino guinea pigs. Cancer Res. 36 (1976) 2813-2821
97. Pezzella F., Pastorino U., Tagliabue E., Andreila S., Sozzi G., Gasparini G., Menard S., Gatter K.C., Harris A.L., KFox S., Buyse M., Pilotti S., et al. Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis. Am. J. Path. 151 (1997) 1417-1423
98. Phondke G.P., Madyastha K.R., Madyastha P.R., and Barth R.F. Relationship between concanavalin A-induced agglutinability of murine leukemia cells and their propensity to form heterotypic aggregates with syngeneic lymphoid cells. JNCI 66 (1981) 643-647
99. Pitot H.C. Fundamentals of Oncology (2002), Marcel Dekker, New York, NY
100. Purdom L., and Ambrose E.J. A correlation between electrical surface charge and some biological characteristics during the stepwise progression of a mouse sarcoma. Nature 181 (1958) 1586-1587
101. Ramaswamy S., Ross K.N., and Golub T.R. A molecular signature of metastasis in primary solid tumors. Nature Genet. 33 (2003) 49-54
102. Ringertz N., Klein E., and Klein G. Histopathologic studies of peritoneal implantation and lung metastasis at different stages of the gradual transformation of the MC1M mouse sarcoma into ascites form. J. Natl. Cancer Inst. 18 (1957) 173-196
103. Rubin H. An analysis of the assay of Rous sarcoma cells in vitro by the infective center technique. Virology 10 (1960) 29-49
104. Rubin H. The suppression of morphological alterations in cells infected with Rous sarcoma virus. Virology 12 (1960) 14-31
105. Rubin H. Overgrowth stimulating factor released from Rous sarcoma cells. Science 167 (1970) 1271-1272
106. Rubin H. Central role for magnesium in coordinate control of metabolism and growth in animal cells. Proc. Natl. Acad. Sci. USA 72 (1975) 3551-3555
107. Rubin H. Effect of magnesium content on density-dependent regulation of the onset of DNA synthesis in transformed 3T3 cells. Cancer Res. 42 (1982) 1761-1768
108. Rubin H. Cellular epigenetics: Control of the size, shape and spatial distribution of transformed foci by interactions between the transformed and non-transformed cells. Proc. Natl. Acad. Sci. USA 91 (1994) 1039-1043
109. Rubin H. Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and tobacco smoke: A biohistorical perspective with updates. Carcinogenesis 22 (2001) 1903-1930
110. Rubin H. Microenvironmental regulation of the initiated cell. Adv. Cancer Res. 90 (2003) 1-62
111. 2- in the regulation of protein synthesis and cell proliferation: Significance for neoplastic transformation. Adv. Cancer Res. 93 (2005) 1-58
112. Rubin H. What keeps cells in tissues behaving normally in the face of myriad mutations?. BioEssays 28 (2006) 515-524
113. Rubin H. Ordered heterogeneity and its decline in cancer and aging. Adv. Cancer Res. 98 (2007) 117-147
114. Rubin H., and Chu B. Self-normalization of highly transformed 3T3 cells through maximized contact interaction. Proc. Natl. Acad. Sci. USA 79 (1982) 1903-1907
115. Rusciano D., and Burger M.M. Why do cancer cells metastasize into particular organs. BioEssays 14 (1992) 185-194
116. Sardari-Nia P., Van Marck E., and Van Schuil P. Re: A model of human tumor dormancy: An angiogenic escape from the nonangiogenic phenotype. J. Natl. Cancer Inst. 99 (2007) 331
117. Schirrmacher V., Cheingsong-Popov R., and Arnheiter H. Hepatocyte-tumor cell interaction in vitro. I. Conditions for rosette formation and inhibition by anti-H-2 antibody. J. Exp. Med. 151 (1980) 984-989
118. Sefton B.M., and Rubin H. Release from density dependent growth inhibition by proteolytic enzymes. Nature 227 (1970) 843-845
119. Shih I.-M., Elder D.E., Hsu M.-., and Herlyn M. Regulation of Mel-CAM/MUC18 expression on melanocytes of different stages of tumor progression by normal keratinocytes. Am. J. Pathol. 145 (1994) 837-845
120. Shuster J., Thomson D.M.P., Fuks A., and Gold P. Immunologic approaches to the diagnosis of malignancy. Prog. Exp. Tumor Res. 25 (1980) 89-139
121. Stoker M. Regulation of growth and orientation in hamster cells transformed by polyomavirus. Virology 24 (1964) 165-174
122. Stoker M. Transfer of growth inhibition between normal and virus transformed cells: Autoradiographic studies using marked cells. J. Cell Sci. 2 (1967) 293-304
123. Stoker M., Shearer M., and O'Neill C. Growth inhibition of polyoma-transformed cells by contact with static normal fibroblasts. J. Cell. Sci. 1 (1966) 297-310
124. Strickland J.E., Ueda M., Hennings H., and Yuspa S.H. A model for initiated mouse skin: Suppression of cells in grafts on athymic nude mice. Cancer Res. 52 (1992) 1439-1444
125. Suzuki M., Mose E.S., Montel V., and Tarin D. Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency. Am. J. Path. 169 (2006) 673-681
126. Takeichi M. Cadherin: Cell adhesion receptors as a morphogenetic regulator. Science 251 (1991) 1451-1455
127. Taptiklis N. Dormancy by dissociated thyroid cells in the lings of mice. Eur. J. Cancer 4 (1968) 59-66
128. Taptiklis N. Penetration of the vascular endothelial barrier by non-neoplastic thyroid cells in circulation. Eur. J. Cancer 5 (1969) 445-457
129. Tarin D. In: Tarin D. (Ed). Tissue Interactions in Carcinogenesis; (1972), Academic Press, London and New York 227-289
130. Terzaghi-Howe M. Inhibition of carcinogen-altered rat tracheal epithelial cell proliferation by normal epithelial cells in vivo. Carcinogenesis 8 (1987) 145-150
131. Todaro G.J., Lazar G.K., and Green H. The initiation of cell division in a contact-inhibited mammalian cell line. J. Cell. Comp. Physiol. 66 (1965) 325-334
132. Tsai Y.C., Lu Y., Nichols P.W., Zlotnikov G., Jones P.A., and Smith H.S. Contiguous patches of normal human mammary epithelium derived from a single stem cell. Cancer Res. 56 (1996) 402-404
133. Uehara H., Kim S.J., Karashima T., Shepherd D.L., Fan D., Tsan R., Killion J.J., Logothetis C., Mathew P., and Fidler I.J. Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases. JNCI 95 (2003) 458-470
134. Unkeless J.C., Tobia A., Ossowski L., Quigley J.P., Rifkin D.B., and Reich E. An enzymatic function associated with transformation of fibroblasts by oncogenic viruses I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses. J. Exp. Med. 137 (1973) 85-111
135. Valyi-Nagy I.T., Hirka G., Jensen P.J., Shih I.-M., Juhasz I., and Herlyn M. Undifferentiated keratinocytes control growth, morphology, and antigen expression of normal melanocytes through cell-cell contact. Lab. Investigation 69 (1993) 152-159
136. 1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis. J. Cell Biol. 164 (2004) 935-941
137. Weinberg R.A. The Biology of Cancer (2007), Garland Science, New York, NY
138. Wieser R.J., Heck R., and Oesch F. Involvement of plasma membranes glycoproteins in the contact-dependent inhibition of growth of human fibroblasts. Exp. Cell Res. 158 (1985) 493-499
139. Wittenberger B., and Glaser L. Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface membranes. Proc. Natl. Acad. Sci. USA 74 (1977) 2251-2255
140. Yu W., Kim J., and Ossowski L. Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy. J. Cell Biol. 137 (1997) 767-777
141. Zhang W., Hanks A.N., Boucher K., Florell S.R., Allen S.M., Alexander A., Brash D.E., and Grossman D. UVB-induced apoptosis drives clonal expansion during skin tumor development. Carcinogenesis 26 (2005) 249-257
142. Zhang W., Remenyik E., Zelterman D., Brash D.E., and Wikonkai N.M. Escaping the stem cell compartment: Sustained UVB exposure allows mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations. Proc. Natl. Acad. Sci. USA 98 (2001) 13948-13953
143. Ziegler A., Leffell D.J., Kunala S., Sharma H.W., Gailani M., Simon J.A., Halperin A.J., Baden H.P., Shapiro P.E., Bale A.E., and Brash D.E. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc. Natl. Acad. USA 90 (1993) 4216-4220