Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

International Journal of Cancer

Volumn 131, Issue 3, 2012, Pages 633-640

  Mendler, Anna N ^a   Hu, Bin ^a   Prinz, Petra U ^a   Kreutz, Marina ^b   Gottfried, Eva ^b   Noessner, Elfriede ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

adoptive T cell therapy; cytotoxic T cells; effector phase inhibition; lactic acid; T cell receptor signaling

Indexed keywords

GAMMA INTERFERON; LACTIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ARTICLE; CD8+ T LYMPHOCYTE; CELL GRANULE; CELL PH; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXOCYTOSIS; FLOW CYTOMETRY; LACTIC ACIDOSIS; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SOLID TUMOR;

ACIDOSIS, LACTIC; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; HYDROGEN-ION CONCENTRATION; INTERFERON-GAMMA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LACTIC ACID; MAP KINASE SIGNALING SYSTEM; NEOPLASMS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84861545489     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26410     Document Type: Article

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