Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved

Clinical Pharmacokinetics

Volumn 53, Issue 8, 2014, Pages 659-678

  Li, Rui ^a   Barton, Hugh A ^a   Varma, Manthena V ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANGIOTENSIN RECEPTOR ANTAGONIST; ATORVASTATIN; BILE SALT EXPORT PUMP; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEINS AND BINDING PROTEINS; CLARITHROMYCIN; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; GEMFIBROZIL; GLIBENCLAMIDE; ITRACONAZOLE; KETOCONAZOLE; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 6; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER B; ORGANIC CATION TRANSPORTER 1; REPAGLINIDE; RIFAMPICIN; SODIUM BILE ACID COTRANSPORTER; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B2; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; CARRIER PROTEIN; DRUG;

ACTIVE TRANSPORT; AREA UNDER THE CURVE; ASIAN; BILIARY EXCRETION; CAUCASIAN; COMPETITIVE INHIBITION; DRUG CLEARANCE; DRUG DISPOSITION; DRUG INTERACTION; DRUG TRANSPORT; ENTEROHEPATIC CIRCULATION; ETHNICITY; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEPATOBILIARY SYSTEM; HEPATOBILIARY TRANSPORT; HUMAN; INTESTINE ABSORPTION; KIDNEY CLEARANCE; LIQUID CHROMATOGRAPHY; LIVER BLOOD FLOW; LIVER CELL; LIVER CLEARANCE; LIVER MICROSOME; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM MASS SPECTROMETRY; BIOLOGICAL MODEL; BLOOD; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; LIVER; METABOLIC CLEARANCE RATE; METABOLISM; PREDICTIVE VALUE; PROCEDURES; TIME; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG INTERACTIONS; HUMANS; LIVER; MEMBRANE TRANSPORT PROTEINS; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PREDICTIVE VALUE OF TESTS; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 84905013159     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-014-0156-z     Document Type: Review

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