Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinemic rats

Biopharmaceutics and Drug Disposition

Volumn 17, Issue 7, 1996, Pages 607-621

  Yamazaki, Masayo ^a,c   Kobayashi, Kazuo ^b   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c TOHO UNIVERSITY   (Japan)

Author keywords

Canalicular membrane; Eisai hyperbiIirubinemic rats; Mutant rats; Pravastatin

Indexed keywords

PRAVASTATIN;

ANIMAL EXPERIMENT; ARTICLE; BILE FLOW; DRUG BINDING; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG LABELING; DRUG TISSUE LEVEL; DRUG TRANSPORT; DRUG UPTAKE; HYDROPHILICITY; HYPERBILIRUBINEMIA; ISOTOPE LABELING; LIVER FUNCTION; MALE; MEMBRANE POTENTIAL; NONHUMAN; RAT;

ANIMALS; BILIARY TRACT; BIOLOGICAL TRANSPORT, ACTIVE; ENZYME INHIBITORS; HYPERBILIRUBINEMIA; LIVER; MALE; PRAVASTATIN; RATS; RATS, MUTANT STRAINS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 0029782268     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-081X(199610)17:7<607::AID-BDD977>3.0.CO;2-L     Document Type: Article

References (39)

1. Y. Tsujita, M. Kuroda, Y. Shimada, K. Tanzawa, M. Arai, I. Kaneko, M. Tanaka, H. Masuda, C. Tarumi, Y. Watanabe and S. Fujii, CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipodemic effect on various animal species. Biochim. Biophys. Acta, 877, 50-60 (1986).
2. T. Koga, Y. Shimada, M. Kuroda, Y. Tsujita, K. Hasegawa and M. Yamazaki, Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxymethylglutaryl coenzyme A reductase inhibitor. Biochim, Biophys. Acta, 1045, 115-120 (1990).
3. +-independent multispecific anion transporter mediates active transport of pravastatin into rat liver. Am. J. Physiol., 246, G36-G44 (1993).
4. T. Komai, E. Shigehara, T. Tokui, T. Koga, M. Ishigami, C. Kuroiwa and S. Horiuchi, Carrier-mediated uptake of pravastatin by rat hepatocytes in primary culture. Biochem. Pharmacol., 43, 667-670 (1992).
5. K. Ziegler and W. Stunkel, Tissue-selective action of pravastatin due to hepatocellular uptake via a sodium-independent bile acid transporter. Biochim. Biophys. Acta, 1139, 203-209 (1992).
6. M. Arai, N. Serizawa, A. Terahara, Y. Tsujita, M. Tanaka, H. Masuda and S. Ishikawa, Pravastatin sodium (CS-514), a novel cholesterol-lowering agent which inhibits HMG-CoA reductase. Sankyo Kenkyusyo Nempo, 20, 1-38 (1988).
7. T. Komai, K. Kawai, T. Tokui, Y. Tokui, E. Kuroiwa, E. Shigehara and M. Tanaka, Disposition and metabolism of pravastatin sodium in rats, dogs and monkeys. Eur. J. Metab. Pharmacokinet., 17, 103-113 (1992).
8. P. L. M. Jansen, W. H. Peters and W. H. Lamers, Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology, 5, 573-579 (1985).
9. P. L. M. Jansen, W. H. M. Peters and D. K. F. Meijer, Hepatobiliary excretion of organic anions in double-mutant rats with a combination of defective canalicular transport and uridine 5′-diphosphate-glucuronyltransferase deficiency. Gastroenterology, 93, 1094-1103 (1987).
10. P. L. M. Jansen, G. M. M. Groothuis, W. H. M. Peters and D. F. K. Meijer, Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia. Hepatology, 7, 71-76 (1987).
11. R. P. J. Oude Elferink, J. D. Haan, K. Lambert, A. F. Hofmann and P. L. M. Jansen, Metabolism and biliary secretion of nordeoxycholate in normal and mutant rats. Evidence for separate excretory pathways for unconjugated and conjugated bile acids. Hepatology, 7, 1109 (Abstract) (1987).
12. R. P. J. Oude Elferink, R. Ottenhoff, W. G. M. Liefting, B. Shoemaker, A. K. Groen and P. L. M. Jansen, ATP-dependent efflux of GSSG and GS-conjugate from isolated rat hepatocytes. Am. J. Physiol., 258, G699-706 (1990).
13. R. P. J. Oude Elferink, R. Ottenhoff, W. Liefting, J. D. Haan and P. L. M. Jansen, Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia. J. Clin. Invest., 84, 476-483 (1989).
14. M. Huber, A. Guhlmann, P. L. M. Jansen and D. Keppler, Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion. Hepatology, 7, 224-228 (1987).
15. T. Mikami, T. Nozaki, O. Tagaya, S. Hosokawa, T. Nakura, H. Mori and S. Kondou, The characters of a new mutant rats with hyperbilirubinuria syndrome. Cong. Anom., 26, 250-251 (1986).
16. S. Hosokawa, O. Tagaya, T. Mikami, Y. Nozaki, A. Kawaguchi, K. Yamatsu and M. Shamoto, A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions. Lab. Anim. Sci., 42, 27-34 (1992).
17. H. Takikawa, N. Sano, T. Narita, Y. Uchida, M. Yamanaka, T. Horie, T. Mikami and O. Tagaya, Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat. Hepatology, 14, 352-360 (1991).
18. J. C. Fernandez-Checa, H. Takikawa, T. Horie, M. Ookhtens and N. Kaplowitz, Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J. Biol. Chem., 267, 1667-1673 (1992).
19. K. Sathirakul, H. Suzuki, K. Yasuda, M. Hanano, O. Tagaya, T. Horie and Y. Sugiyama, Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats (EHBR). J. Pharmacol. Exp. Ther., 265, 1301-1312 (1993).
20. K. Sathirakul, H. Suzuki, T. Yamada, M. Hanano and Y. Sugiyama, Multiple transport systems for organic anions across the bile canalicular membrane. J. Pharmacol. Exp. Ther., 168, 65-73 (1994).
21. K. Kobayashi, Y. Sogame, H. Hara and K. Hayashi, Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J. Biol. Chem., 265, 7737-7741 (1990).
22. -) rats with conjugated hyperbilirubinemia. Proc. Nat. Acad. Sci. USA, 87, 3557-3561 (1990).
23. T. Ishikawa, M. Muller, C. Klunemann, T. Schaub and D. Keppler, ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. J. Biol. Chem., 265, 19279-19286 (1990).
24. K. Kobayashi, S. Komatsu, T. Nishi, H. Hara and K. Hayashi, ATP-dependent transport for glucuronides in canalicular plasma membranes. Biochem. Biophys. Res. Commun., 176, 622-626 (1991).
25. S. C. Tsao, Y. Sugiyama, Y. Sawada, S. Nagase, T. Iga and M. Hanano, Effect of albumin on hepatic uptake of warfarin in normal and analbuminemic mutant rats: analysis by multiple indicator dilution method. J. Pharmacokinet. Biopharm., 14, 51-64 (1986).
26. H. Sato, Y. Sugiyama, Y. Sawada, T. Iga, S. Sakamoto, T. Fuwa and M. Hanano, Dynamic determination of kinetic parameters for the interaction between polypeptide hormones and cell-surface receptors in the perfused rat liver by the multiple indicator dilution method. Proc. Nat. Acad. Sci. USA, 85, 8355-8359 (1988).
27. T. Watanabe, S. Miyauchi, Y. Sawada, T. Iga, M. Hanano, M. Inaba and Y. Sugiyama, Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver: possible roles of P-glycoprotein in biliary excretion of vincristine. J. Hepatol., 16, 77-88 (1992).
28. J. H. Lin, Y. Sugiyama, S. Awazu and M. Hanano, In vitro and in vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models. J. Pharmacokinet. Biopharm., 10, 637-647 (1982).
29. D. K. F. Meijer, W. E. M. Mol, M. Muller and G. Kurz, Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations. J. Pharmacokinet. Biopharm., 18, 35-70 (1990).
30. K. S. Pang and M. Rowland, Hepatic clearance of drugs: I. Theoretical considerations of a 'well-stirred' model and a 'parallel tube' model. J. Pharmacokinet. Biopharm., 5, 625-653 (1977).
31. A. T. M. Serajuddin, S. A. Ranadive and E. M. Mahoney, Relative lipophilicities, solubilities, and structure-pharmacological considerations of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors pravastatin, lovastatin, mevastatin, and simvastatin. J. Pharm. Sci., 80, 830-833 (1991).
32. S. Muramatsu, K. Miyaguchi, H. Iwabuchi, Y. Matsushita, T. Nakamura, T. Kinoshita, M. Tanaka and H. Takahagi, Metabolism of pravastatin sodium in isolated rat hepatocytes. I. Glutathione conjugate formation reaction. Xenobiotica, 22, 487-498 (1992).
33. +-stimulated hydrolysis of adenosine triphosphate. Eur. J. Biochem., 1, 334-343 (1967).
34. K. Yachi, Y. Sugiyama, Y. Sawada, T. Iga, Y. Ikeda, G. Toda and M. Hanano, Characterization of rose bengal binding to sinusoidal and canalicular plasma membrane from rat liver. Biochim. Biophys. Acta, 978, 1-7 (1989).
35. O. H. Lowry, N. J. Rosebrough, A. L. Farr and R. J. Randall, Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275 (1951).
36. E. L. Forker, T. Hicklin and H. Sornson, The clearance of mannitol and erythritol in rat bile. Proc. Soc. Exp. Biol. Med., 126, 115-119 (1967).
37. J. C. Glasinovic, M. Dumont, M. Duval and S. Erlinger, Hepatocellular uptake of erythoritol and mannitol in the dog. Am. J. Physiol., 229, 1455-1460 (1975).
38. E. Roda, R. Aldini, G. Mazzella, D. Festi, F. Bazzoli and A. Roda, Hepatic secretion of bile acids. In Hepatic Transport and Bile Secretion: Physiology and Pathophysiology, N. Tavoloni and P. D. Berk (Eds), Raven, New York, 1993, pp. 553-569.
39. Y. Adachi, H. Kobayashi, M. Kitano, Y. Okuyama, H. Miya, S. Miyawaki and T. Yamamoto. J. Gastroenterol. Hepatol., 11, 580-585 (1996).