Reduced physiologically-based pharmacokinetic model of repaglinide: Impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk

Pharmaceutical Research

Volumn 31, Issue 9, 2014, Pages 2367-2382

  Gertz, Michael ^a,b   Tsamandouras, Nikolaos ^a   Säll, Carolina ^a   Houston, J Brian ^a   Galetin, Aleksandra ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

drug drug interactions; OATP1B1; physiologically based pharmacokinetic models; repaglinide

Indexed keywords

ANTIDIABETIC AGENT; CARBAMIC ACID DERIVATIVE; CYTOCHROME P450 2C8; ORGANIC ANION TRANSPORTER; PIPERIDINE DERIVATIVE; REPAGLINIDE; SLCO1B1 PROTEIN, HUMAN;

BIOLOGICAL MODEL; BLOOD; COMPUTER SIMULATION; DRUG INTERACTION; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; MONTE CARLO METHOD; PROSPECTIVE STUDY;

CARBAMATES; COMPUTER SIMULATION; CYTOCHROME P-450 CYP2C8; DRUG INTERACTIONS; GENOTYPE; HUMANS; HYPOGLYCEMIC AGENTS; MODELS, BIOLOGICAL; MONTE CARLO METHOD; ORGANIC ANION TRANSPORTERS; PIPERIDINES; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES;

EID: 84895776723     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1333-3     Document Type: Article

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