Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes

Journal of Pharmaceutical Sciences

Volumn 102, Issue 9, 2013, Pages 3252-3263

  Qiu, Xi ^a   Bi, Yi An ^a   Balogh, Larissa M ^a   Lai, Yurong ^a,b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Hepatic transport; Hepatocytes; LC MS MS; NTCP; Target proteomics; Transporters

Indexed keywords

MEMBRANE PROTEIN; POLYPEPTIDE; SODIUM TAUROCHOLATE COTRANSPORTING POLYPEPTIDE; STABLE ISOTOPE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ACCURACY; ADULT; AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; FEMALE; HAPLORHINI; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOTOPE LABELING; LIMIT OF QUANTITATION; LIVER; LIVER CELL; MALE; MASS SPECTROMETRY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN EXPRESSION; RAT; SPECIES DIFFERENCE;

HEPATIC TRANSPORT; HEPATOCYTES; LC-MS/MS; NTCP; TARGET PROTEOMICS; TRANSPORTERS;

AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; FEMALE; HAPLORHINI; HEPATOCYTES; HUMANS; MALE; MICE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RATS; SEQUENCE ALIGNMENT; SPECIES SPECIFICITY; SYMPORTERS; TANDEM MASS SPECTROMETRY;

EID: 84881612960     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23582     Document Type: Article

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