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Volumn 25, Issue 2, 2010, Pages 190-199

Hepatitis c virus-related cirrhosis is a major determinant of the expression levels of hepatic drug transporters

Author keywords

Cirrhosis; HCV; Liver; mRNA expression; MRP4; Multiple regression; Transporter

Indexed keywords

ABC TRANSPORTER; CARRIER PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 6; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1B1; ORGANIC ANION TRANSPORTER 1B3; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 2B1; ORGANIC CATION TRANSPORTER 1; UNCLASSIFIED DRUG;

EID: 77952590222     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.25.190     Document Type: Article
Times cited : (68)

References (47)
  • 2
    • 3542995726 scopus 로고    scopus 로고
    • The complexities of hepatic drug transport: Current knowledge and emerging concepts
    • Chandra, P. and Brouwer, K. L.: The complexities of hepatic drug transport: current knowledge and emerging concepts. Pharm. Res., 21: 719-735 (2004).
    • (2004) Pharm. Res. , vol.21 , pp. 719-735
    • Chandra, P.1    Brouwer, K.L.2
  • 3
    • 0345866860 scopus 로고    scopus 로고
    • Pharmacological and physiological functions of the olyspecific organic cation transporters:OCT1, 2, and 3 (SLC22A1-3)
    • Jonker, J. W. and Schinkel A. H.: Pharmacological and physiological functions of the olyspecific organic cation transporters:OCT1, 2, and 3 (SLC22A1-3). J. Pharmacol. Exp. Ther., 308:2-9 (2004).
    • (2004) J. Pharmacol. Exp. Ther , vol.308 , pp. 2-9
    • Jonker, J.W.1    Schinkel, A.H.2
  • 4
    • 33747616258 scopus 로고    scopus 로고
    • Organic anion transporter family: Current knowledge
    • Anzai, N., Kanai, Y. and Endou, H.: Organic anion transporter family: current knowledge. J. Pharmacol. Sci., 100: 411-426 (2006).
    • (2006) J. Pharmacol. Sci , vol.100 , pp. 411-426
    • Anzai, N.1    Kanai, Y.2    Endou, H.3
  • 5
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
    • Hagenbuch, B. and Meier, P. J.: Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflügers. Arch., 447: 653-665 (2004).
    • (2004) Pflügers. Arch , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 7
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
    • Schinkel, A. H. and Jonker, J. W.: Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv. Drug Deliv. Rev., 55: 3-29 (2003).
    • (2003) Adv. Drug Deliv. Rev , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 8
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie, E. M., Deeley, R. G. and Cole, S. P.: Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol., 204:216-237 (2005).
    • (2005) Toxicol. Appl. Pharmacol , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 9
    • 33846681607 scopus 로고    scopus 로고
    • Multidrug resistance-associated proteins 3, 4, and 5
    • Borst, P., de Wolf, C. and van de Wetering, K.: Multidrug resistance-associated proteins 3, 4, and 5. Pflügers. Arch., 453:661-673 (2007).
    • (2007) Pflügers. Arch , vol.453 , pp. 661-673
    • Borst, P.1    de Wolf, C.2    van de Wetering, K.3
  • 11
    • 33846034416 scopus 로고    scopus 로고
    • Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans
    • Kivisto, K. T. and Niemi, M.: Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans. Pharm. Res., 24: 239-247 (2007).
    • (2007) Pharm. Res , vol.24 , pp. 239-247
    • Kivisto, K.T.1    Niemi, M.2
  • 15
    • 33846706434 scopus 로고    scopus 로고
    • The apical conjugate efflux pump ABCC2 (MRP2)
    • Nies, A. T. and Keppler, D.: The apical conjugate efflux pump ABCC2 (MRP2). Pflügers. Arch., 453: 643-659 (2007).
    • (2007) Pflügers. Arch , vol.453 , pp. 643-659
    • Nies, A.T.1    Keppler, D.2
  • 16
    • 0029782485 scopus 로고    scopus 로고
    • Carrier-mediated intestinal transport of drugs
    • Tsuji, A. and Tamai, I.: Carrier-mediated intestinal transport of drugs. Pharm. Res., 13: 963-977 (1996).
    • (1996) Pharm. Res , vol.13 , pp. 963-977
    • Tsuji, A.1    Tamai, I.2
  • 17
    • 0033849976 scopus 로고    scopus 로고
    • Cellular and molecular aspects of drug transport in the kidney
    • Inui, K., Masuda, S. and Saito, H.: Cellular and molecular aspects of drug transport in the kidney. Kidney Int., 58:944-958 (2000).
    • (2000) Kidney Int , vol.58 , pp. 944-958
    • Inui, K.1    Masuda, S.2    Saito, H.3
  • 18
    • 0035336558 scopus 로고    scopus 로고
    • Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantation
    • Hashida, T., Masuda, S., Uemoto, S., Saito, H., Tanaka, K. and Inui, K.: Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantation. Clin. Pharmacol. Ther., 69: 308-316 (2001).
    • (2001) Clin. Pharmacol. Ther , vol.69 , pp. 308-316
    • Hashida, T.1    Masuda, S.2    Uemoto, S.3    Saito, H.4    Tanaka, K.5    Inui, K.6
  • 19
    • 1642539149 scopus 로고    scopus 로고
    • Expression levels of renal organic anion transporters(OATs) and their correlation with anionic drug excretion in patients with renal diseases
    • Sakurai, Y., Motohashi, H., Ueo, H., Masuda, S., Saito, H., Okuda, M., Mori, N., Matsuura, M., Doi, T., Fukatsu, A., Ogawa, O. and Inui, K.: Expression levels of renal organic anion transporters(OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm. Res., 21: 61-67 (2004).
    • (2004) Pharm. Res , vol.21 , pp. 61-67
    • Sakurai, Y.1    Motohashi, H.2    Ueo, H.3    Masuda, S.4    Saito, H.5    Okuda, M.6    Mori, N.7    Matsuura, M.8    Doi, T.9    Fukatsu, A.10    Ogawa, O.11    Inui, K.12
  • 20
    • 29244454212 scopus 로고    scopus 로고
    • Pharmacokinetic significance of renal OAT3 (SLC22A8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis
    • Sakurai, Y., Motohashi, H., Ogasawara, K., Terada, T., Masuda, S., Katsura, T., Mori, N., Matsuura, M., Doi, T., Fukatsu, A. and Inui, K.: Pharmacokinetic significance of renal OAT3 (SLC22A8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis. Pharm. Res., 22: 2016-2022 (2005).
    • (2005) Pharm. Res , vol.22 , pp. 2016-2022
    • Sakurai, Y.1    Motohashi, H.2    Ogasawara, K.3    Terada, T.4    Masuda, S.5    Katsura, T.6    Mori, N.7    Matsuura, M.8    Doi, T.9    Fukatsu, A.10    Inui, K.11
  • 22
    • 33845632906 scopus 로고    scopus 로고
    • Gene expression and regulation of drug transporters in the intestine and kidney
    • Terada, T. and Inui, K.: Gene expression and regulation of drug transporters in the intestine and kidney. Biochem. Pharmacol.,73: 440-449 (2007).
    • (2007) Biochem. Pharmacol , vol.73 , pp. 440-449
    • Terada, T.1    Inui, K.2
  • 25
    • 0035668415 scopus 로고    scopus 로고
    • The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function
    • Shoda, J., Kano, M., Oda, K., Kamiya, J., Nimura, Y., Suzuki, H., Sugiyama, Y., Miyazaki, H., Todoroki, T., Stengelin, S., Kramer, W.,Matsuzaki, Y. and Tanaka, N.: The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function. Am. J. Gastroenterol., 96:3368-3378 (2001).
    • (2001) Am. J. Gastroenterol , vol.96 , pp. 3368-3378
    • Shoda, J.1    Kano, M.2    Oda, K.3    Kamiya, J.4    Nimura, Y.5    Suzuki, H.6    Sugiyama, Y.7    Miyazaki, H.8    Todoroki, T.9    Stengelin, S.10    Kramer, W.11    Matsuzaki, Y.12    Tanaka, N.13
  • 27
    • 33746548445 scopus 로고    scopus 로고
    • Identification and functional characterization of a new human kidney-specific H+/organiccation antiporter, kidney-specific multidrug and toxin extrusion 2
    • Masuda, S., Terada, T., Yonezawa, A., Tanihara, Y., Kishimoto, K., Katsura, T., Ogawa, O. and Inui, K.: Identification and functional characterization of a new human kidney-specific H+/organiccation antiporter, kidney-specific multidrug and toxin extrusion 2. J. Am. Soc. Nephrol., 17: 2127-2135 (2006).
    • (2006) J. Am. Soc. Nephrol , vol.17 , pp. 2127-2135
    • Masuda, S.1    Terada, T.2    Yonezawa, A.3    Tanihara, Y.4    Kishimoto, K.5    Katsura, T.6    Ogawa, O.7    Inui, K.8
  • 28
    • 10744229154 scopus 로고    scopus 로고
    • Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients
    • Uwai, Y., Masuda, S., Goto, M., Motohashi, H., Saito, H., Okuda, M., Nakamura, E., Ito,N., Ogawa, O. andInui, K.: Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients. J. Hum. Genet., 49: 40-45 (2004).
    • (2004) J. Hum. Genet , vol.49 , pp. 40-45
    • Uwai, Y.1    Masuda, S.2    Goto, M.3    Motohashi, H.4    Saito, H.5    Okuda, M.6    Nakamura, E.7    Ito, N.8    Ogawa, O.9    Inui, K.10
  • 29
  • 30
    • 33644854071 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies
    • Nishimura, M. and Naito, S.: Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies. Drug Metab. Pharmacokinet., 20: 452-477 (2005).
    • (2005) Drug Metab. Pharmacokinet , vol.20 , pp. 452-477
    • Nishimura, M.1    Naito, S.2
  • 31
    • 34547169521 scopus 로고    scopus 로고
    • Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines
    • Hilgendorf, C., Ahlin, G., Seithel, A., Artursson, P., Ungell, A.L. and Karlsson, J.: Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab. Dispos., 35: 1333-1340 (2007).
    • (2007) Drug Metab. Dispos , vol.35 , pp. 1333-1340
    • Hilgendorf, C.1    Ahlin, G.2    Seithel, A.3    Artursson, P.4    Ungell, A.L.5    Karlsson, J.6
  • 32
    • 41349107158 scopus 로고    scopus 로고
    • Multidrug resistance protein 4 (MRP4/ABCC4): A versatile efflux transporter for drugs and signalling molecules
    • Russel, F. G., Koenderink, J. B. and Masereeuw, R.: Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules. Trends Pharmacol. Sci.,29: 200-207 (2008).
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 200-207
    • Russel, F.G.1    Koenderink, J.B.2    Masereeuw, R.3
  • 33
    • 0042766881 scopus 로고    scopus 로고
    • Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
    • Rius, M., Nies, A. T., Hummel-Eisenbeiss, J., Jedlitschky, G. and Keppler, D.: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.Hepatology, 38: 374-384 (2003).
    • (2003) Hepatology , vol.38 , pp. 374-384
    • Rius, M.1    Nies, A.T.2    Hummel-Eisenbeiss, J.3    Jedlitschky, G.4    Keppler, D.5
  • 38
    • 17844403220 scopus 로고    scopus 로고
    • Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis
    • Keitel, V., Burdelski, M., Warskulat, U., Kuhlkamp, T., Keppler, D., Haussinger, D. and Kubitz, R.: Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis. Hepatology, 41: 1160-1172 (2005).
    • (2005) Hepatology , vol.41 , pp. 1160-1172
    • Keitel, V.1    Burdelski, M.2    Warskulat, U.3    Kuhlkamp, T.4    Keppler, D.5    Haussinger, D.6    Kubitz, R.7
  • 39
    • 34547870567 scopus 로고    scopus 로고
    • Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
    • Zollner, G., Wagner, M., Fickert, P., Silbert, D., Gumhold, J., Zatloukal, K., Denk, H. and Trauner, M.: Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis. Liver Int., 27: 920-929 (2007).
    • (2007) Liver Int , vol.27 , pp. 920-929
    • Zollner, G.1    Wagner, M.2    Fickert, P.3    Silbert, D.4    Gumhold, J.5    Zatloukal, K.6    Denk, H.7    Trauner, M.8
  • 43
    • 34547674835 scopus 로고    scopus 로고
    • Redox regulation of hepatitis C in nonalcoholic and alcoholic liver
    • Seronello, S., Sheikh, M. Y. and Choi, J.: Redox regulation of hepatitis C in nonalcoholic and alcoholic liver. Free. Radic. Biol. Med., 43: 869-882 (2007).
    • (2007) Free. Radic. Biol. Med , vol.43 , pp. 869-882
    • Seronello, S.1    Sheikh, M.Y.2    Choi, J.3
  • 44
    • 46249111657 scopus 로고    scopus 로고
    • Hepatitis C virus infection: Molecular pathways to metabolic syndrome
    • Sheikh, M. Y., Choi, J., Qadri, I., Friedman, J. E. and Sanyal, A. J.: Hepatitis C virus infection: molecular pathways to metabolic syndrome. Hepatology, 47: 2127-2133 (2008).
    • (2008) Hepatology , vol.47 , pp. 2127-2133
    • Sheikh, M.Y.1    Choi, J.2    Qadri, I.3    Friedman, J.E.4    Sanyal, A.J.5
  • 45
    • 61449142646 scopus 로고    scopus 로고
    • Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-a or interleukin-6
    • Vee, M. L., Lecureur, V., Stieger, B. and Fardel, O.: Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-a or interleukin-6. Drug Metab. Dispos., 37: 685-693 (2009).
    • (2009) Drug Metab. Dispos , vol.37 , pp. 685-693
    • Vee, M.L.1    Lecureur, V.2    Stieger, B.3    Fardel, O.4
  • 46
    • 76849085285 scopus 로고    scopus 로고
    • Activation of transcription factor Nrf2 by hepatitis C virus induces cell survival pathway
    • (doi:10.1099/vir.0.014340-0)
    • Burdette, D., Olivarez, M. and Waris, G.: Activation of transcription factor Nrf2 by hepatitis C virus induces cell survival pathway. J. Gen. Virol., 91: 681-690 (2010) (doi:10.1099/vir.0.014340-0).
    • (2010) J. Gen. Virol , vol.91 , pp. 681-690
    • Burdette, D.1    Olivarez, M.2    Waris, G.3


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