Approaches for predicting human pharmacokinetics using interspecies pharmacokinetic scaling

Archives of Pharmacal Research

Volumn 34, Issue 11, 2011, Pages 1779-1788

  Kang, Hee Eun ^a   Lee, Myung Gull ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Allometric scaling; Human pharmacokinetic predictions; Interspecies scaling; Preclinical pharmacokinetics

Indexed keywords

3' (2 AMINO 1 HYDROXYETHYL) 4' FLUOROMETHANESULFONANILIDE; ANTINEOPLASTIC AGENT;

ALLOMETRY; DOSE CALCULATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE ESCALATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RESEARCH; DRUG SAFETY; DRUG STRUCTURE; HUMAN; MAXIMUM PLASMA CONCENTRATION; MAXIMUM TOLERATED DOSE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RELIABILITY; REVIEW; STEADY STATE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BODY SIZE; CLINICAL TRIALS AS TOPIC; DRUG EVALUATION, PRECLINICAL; DRUG INDUSTRY; DRUGS, INVESTIGATIONAL; HUMANS; MODELS, BIOLOGICAL; SPECIES SPECIFICITY;

EID: 83655197435     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-1101-4     Document Type: Review

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