An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection

Genes and Immunity

Volumn 15, Issue 5, 2014, Pages 320-332

  Lafferty, E I ^a   Flaczyk, A ^a   Angers, I ^b   Homer, R ^c   D'Hennezel, E ^b   Malo, D ^b   Piccirillo, C A ^b   Vidal, S M ^b   Qureshi, S T ^a,b,d  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; ETHYLNITROSOUREA; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON; L SELECTIN; PROTEIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNC93B1 PROTEIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CHAPERONE; TOLL LIKE RECEPTOR; CARRIER PROTEIN; CXCL10 PROTEIN, MOUSE; UNC93B1 PROTEIN, MOUSE;

ALLELE; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; EXON; EXUDATE; FEMALE; GENETIC COMPLEMENTATION; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INFLUENZA A (H1N1); INFLUENZA VIRUS A H1N1; INNATE IMMUNITY; LOSS OF FUNCTION MUTATION; LYMPHOID CELL; MORTALITY; MOUSE; MUTAGENESIS; NONHUMAN; PERITONEUM MACROPHAGE; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPLICING DEFECT; T LYMPHOCYTE ACTIVATION; VIRAL CLEARANCE; VIRUS LOAD; ANIMAL TISSUE; CYTOKINE PRODUCTION; GENE FUNCTION; IMMUNOCOMPETENT CELL; INFLUENZA; KNOCKOUT MOUSE; LUNG INFECTION; MACROPHAGE ACTIVATION; MALE; NUCLEOTIDE SEQUENCE; ANIMAL; C57BL MOUSE; ENDOSOME; GENETICS; IMMUNOLOGY; LUNG; LYMPHOCYTE ACTIVATION; METABOLISM; MUTATION; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PATHOLOGY;

ALTERNATIVE SPLICING; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINE CXCL10; ENDOSOMES; ETHYLNITROSOUREA; IMMUNITY, INNATE; INFLUENZA A VIRUS, H1N1 SUBTYPE; INTERFERON TYPE I; INTERFERON-GAMMA; L-SELECTIN; LUNG; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MUTATION; ORTHOMYXOVIRIDAE INFECTIONS; TOLL-LIKE RECEPTORS;

EID: 84905001028     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2014.22     Document Type: Article

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