Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate

Science

Volumn 307, Issue 5715, 2005, Pages 1630-1634

  Delamarre, Lélia ^a   Pack, Margit ^a   Chang, Henry ^a   Mellman, Ira ^a   Trombetta, E Sergio ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; BACTERIA; DEGRADATION; DISEASES; IMMUNOLOGY; PROTEINS;

ANTIGEN-PRESENTING CELLS (APC); DENDRITIC CELLS; MICROBES; PROTEOLYSIS;

CELLS;

PROTEINASE;

ANTIGEN; CELLS AND CELL COMPONENTS;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL FUNCTION; DENDRITIC CELL; IMMUNOFLUORESCENCE; IN VIVO STUDY; LYMPHOID ORGAN; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; WESTERN BLOTTING;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS; B-LYMPHOCYTES; CELLS, CULTURED; DENDRITIC CELLS; ENDOCYTOSIS; GREEN FLUORESCENT PROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HORSERADISH PEROXIDASE; LYMPHOID TISSUE; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; PEPTIDE HYDROLASES; RIBONUCLEASE, PANCREATIC; RIBONUCLEASES;

EID: 14844340568     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1108003     Document Type: Article

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22. The excellent professional support provided by R. Carbone, R. Manna, and C. Marks is greatly appreciated. This work was supported by the NIH (R37-AI34098 to I.M.), the American Heart Association (E.S.T.), and the Ludwig Institute for Cancer Research (I.M. and E.S.T.).