메뉴 건너뛰기




Volumn 10, Issue 9, 2014, Pages 1713-1731

Applications of nanoparticles for brain cancer imaging and therapy

Author keywords

Blood brain barrier (BBB); Brain metastasis; Drug delivery; Glioma; Molecular imaging; Nanoparticles

Indexed keywords

BLOOD; DRUG DELIVERY; MOLECULAR IMAGING; NANOPARTICLES; PATHOLOGY; TUMORS;

EID: 84904891918     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2014.1896     Document Type: Review
Times cited : (27)

References (208)
  • 1
    • 27644546807 scopus 로고    scopus 로고
    • Brain metastases: Epidemiology and pathophysiology
    • I. T. Gavrilovic and J. B. Posner, Brain metastases: Epidemiology and pathophysiology. J. Neurooncol. 75, 5 (2005).
    • (2005) J. Neurooncol. , vol.75 , pp. 5
    • Gavrilovic, I.T.1    Posner, J.B.2
  • 2
    • 4344694453 scopus 로고    scopus 로고
    • Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the metropolitan detroit cancer surveillance system
    • J. S. Barnholtz-Sloan, A. E. Sloan, F. G. Davis, F. D. Vigneau, P. Lai, and R. E. Sawaya, Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the metropolitan detroit cancer surveillance system. J. Clin. Oncol. 22, 2865 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2865
    • Barnholtz-Sloan, J.S.1    Sloan, A.E.2    Davis, F.G.3    Vigneau, F.D.4    Lai, P.5    Sawaya, R.E.6
  • 3
    • 0037093972 scopus 로고    scopus 로고
    • Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma
    • L. J. Schouten, J. Rutten, H. A. Huveneers, and A. Twijnstra, Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer 94, 2698 (2002).
    • (2002) Cancer , vol.94 , pp. 2698
    • Schouten, L.J.1    Rutten, J.2    Huveneers, H.A.3    Twijnstra, A.4
  • 4
    • 0036337301 scopus 로고    scopus 로고
    • Metastasis to and from the central nervous system - The 'relatively protected site.'
    • A. Subramanian, A. Harris, K. Piggott, C. Shieff, and R. Bradford, Metastasis to and from the central nervous system - the 'relatively protected site.' Lancet. Oncol. 3, 498 (2002).
    • (2002) Lancet. Oncol. , vol.3 , pp. 498
    • Subramanian, A.1    Harris, A.2    Piggott, K.3    Shieff, C.4    Bradford, R.5
  • 5
    • 6944255523 scopus 로고    scopus 로고
    • Delivery of therapeutic agents to the central nervous system: The problems and the possibilities
    • D. J. Begley, Delivery of therapeutic agents to the central nervous system: The problems and the possibilities. Pharmacol. Ther. 104, 29 (2004).
    • (2004) Pharmacol. Ther. , vol.104 , pp. 29
    • Begley, D.J.1
  • 10
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • P. Y. Wen and S. Kesari, Malignant gliomas in adults. N. Engl. J. Med. 359, 492 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 492
    • Wen, P.Y.1    Kesari, S.2
  • 13
    • 0031965788 scopus 로고    scopus 로고
    • Outwitting the blood-brain barrier for therapeutic purposes: Osmotic opening and other means
    • R. A. Kroll and E. A. Neuwelt, Outwitting the blood-brain barrier for therapeutic purposes: Osmotic opening and other means. Neurosurgery 42, 1083 (1998).
    • (1998) Neurosurgery , vol.42 , pp. 1083
    • Kroll, R.A.1    Neuwelt, E.A.2
  • 14
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: Glioblastoma stem cells and the vascular niche
    • R. J. Gilbertson and J. N. Rich, Making a tumour's bed: Glioblastoma stem cells and the vascular niche. Nat. Rev. Cancer 7, 733 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 733
    • Gilbertson, R.J.1    Rich, J.N.2
  • 16
    • 80053435892 scopus 로고    scopus 로고
    • Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain
    • S. Agarwal, R. Sane, R. Oberoi, J. R. Ohlfest, and W. F. Elmquist, Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain. Expert. Rev. Mol. Med. 13, e17 (2011).
    • (2011) Expert. Rev. Mol. Med. , vol.13
    • Agarwal, S.1    Sane, R.2    Oberoi, R.3    Ohlfest, J.R.4    Elmquist, W.F.5
  • 17
    • 0031039632 scopus 로고    scopus 로고
    • Interstitial fluid pressure in intracranial tumours in patients and in rodents
    • Y. Boucher, H. Salehi, B. Witwer, G. R. t. Harsh, and R. K. Jain, Interstitial fluid pressure in intracranial tumours in patients and in rodents. Br. J. Cancer 75, 829 (1997).
    • (1997) Br. J. Cancer , vol.75 , pp. 829
    • Boucher, Y.1    Salehi, H.2    Witwer, B.3    Harsh, G.R.T.4    Jain, R.K.5
  • 18
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carriers
    • V. P. Torchilin, Recent advances with liposomes as pharmaceutical carriers. Nat. Rev. Drug Discov. 4, 145 (2005).
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 145
    • Torchilin, V.P.1
  • 19
    • 0037224431 scopus 로고    scopus 로고
    • Doxorubicin-loaded Fab' fragments of anti-disialoganglioside immunoliposomes selectively inhibit the growth and dissemination of human neuroblastoma in nude mice
    • F. Pastorino, C. Brignole, D. Marimpietri, P. Sapra, E. H. Moase, T. M. Allen, and M. Ponzoni, Doxorubicin-loaded Fab' fragments of anti- disialoganglioside immunoliposomes selectively inhibit the growth and dissemination of human neuroblastoma in nude mice. Cancer Res. 63, 86 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 86
    • Pastorino, F.1    Brignole, C.2    Marimpietri, D.3    Sapra, P.4    Moase, E.H.5    Allen, T.M.6    Ponzoni, M.7
  • 20
    • 0025341615 scopus 로고
    • Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
    • A. L. Klibanov, K. Maruyama, V. P. Torchilin, and L. Huang, Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 268, 235 (1990).
    • (1990) FEBS Lett , vol.268 , pp. 235
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3    Huang, L.4
  • 21
    • 0035005359 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin: Metamorphosis of an old drug into a new form of chemotherapy
    • A. A. Gabizon, Pegylated liposomal doxorubicin: Metamorphosis of an old drug into a new form of chemotherapy. Cancer Invest. 19, 424 (2001).
    • (2001) Cancer Invest. , vol.19 , pp. 424
    • Gabizon, A.A.1
  • 24
    • 84862668236 scopus 로고    scopus 로고
    • Transport of drugs across the blood-brain barrier by nanoparticles
    • S. Wohlfart, S. Gelperina, and J. Kreuter, Transport of drugs across the blood-brain barrier by nanoparticles. J. Control Release 161, 264 (2012).
    • (2012) J. Control Release , vol.161 , pp. 264
    • Wohlfart, S.1    Gelperina, S.2    Kreuter, J.3
  • 25
    • 84897731702 scopus 로고    scopus 로고
    • Nanotherapeutic approaches for brain cancer management
    • Epub ahead of print
    • L. S. Del Burgo, R. M. Hernandez, G. Orive, and J. L. Pedraz, Nanotherapeutic approaches for brain cancer management. Nanomedicine, Epub ahead of print (2013).
    • (2013) Nanomedicine
    • Del Burgo, L.S.1    Hernandez, R.M.2    Orive, G.3    Pedraz, J.L.4
  • 26
    • 70449529637 scopus 로고    scopus 로고
    • Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
    • R. Gabathuler, Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol. Dis. 37, 48 (2010).
    • (2010) Neurobiol. Dis. , vol.37 , pp. 48
    • Gabathuler, R.1
  • 28
    • 84859996647 scopus 로고    scopus 로고
    • Modern methods for delivery of drugs across the blood-brain barrier
    • Y. Chen and L. Liu, Modern methods for delivery of drugs across the blood-brain barrier. Adv. Drug Deliv. Rev. 64, 640 (2012).
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 640
    • Chen, Y.1    Liu, L.2
  • 29
    • 34547632714 scopus 로고    scopus 로고
    • Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development
    • S. Ohtsuki and T. Terasaki, Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm. Res. 24, 1745 (2007).
    • (2007) Pharm. Res. , vol.24 , pp. 1745
    • Ohtsuki, S.1    Terasaki, T.2
  • 30
    • 0031959341 scopus 로고    scopus 로고
    • CNS drug design based on principles of blood-brain barrier transport
    • W. M. Pardridge, CNS drug design based on principles of blood-brain barrier transport. J. Neurochem. 70, 1781 (1998).
    • (1998) J. Neurochem. , vol.70 , pp. 1781
    • Pardridge, W.M.1
  • 31
    • 0031898769 scopus 로고    scopus 로고
    • Blood-brain barrier carrier-mediated transport and brain metabolism of amino acids
    • W. M. Pardridge, Blood-brain barrier carrier-mediated transport and brain metabolism of amino acids. Neurochem. Res. 23, 635 (1998).
    • (1998) Neurochem. Res. , vol.23 , pp. 635
    • Pardridge, W.M.1
  • 32
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • B. T. Hawkins and T. P. Davis, The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57, 173 (2005).
    • (2005) Pharmacol. Rev. , vol.57 , pp. 173
    • Hawkins, B.T.1    Davis, T.P.2
  • 34
    • 25844495011 scopus 로고    scopus 로고
    • Medicinal chemical properties of successful central nervous system drugs
    • H. Pajouhesh and G. R. Lenz, Medicinal chemical properties of successful central nervous system drugs. NeuroRx. 2, 541 (2005).
    • (2005) NeuroRx , vol.2 , pp. 541
    • Pajouhesh, H.1    Lenz, G.R.2
  • 35
    • 33644555861 scopus 로고    scopus 로고
    • Fluorescence imaging of blood-brain barrier disruption
    • B. T. Hawkins and R. D. Egleton, Fluorescence imaging of blood-brain barrier disruption. J. Neurosci. Methods 151, 262 (2006).
    • (2006) J. Neurosci. Methods , vol.151 , pp. 262
    • Hawkins, B.T.1    Egleton, R.D.2
  • 38
    • 80052622812 scopus 로고    scopus 로고
    • Tissue concentration of systemically administered antineoplastic agents in human brain tumors
    • M. W. Pitz, A. Desai, S. A. Grossman, and J. O. Blakeley, Tissue concentration of systemically administered antineoplastic agents in human brain tumors. J. Neurooncol. 104, 629 (2011).
    • (2011) J. Neurooncol. , vol.104 , pp. 629
    • Pitz, M.W.1    Desai, A.2    Grossman, S.A.3    Blakeley, J.O.4
  • 39
    • 35748933247 scopus 로고    scopus 로고
    • Human brain tumors: Multidrug-resistance P-glycoprotein expression in tumor cells and intratumoral capillary endothelial cells
    • S. Fattori, F. Becherini, M. Cianfriglia, G. Parenti, A. Romanini and M. Castagna, Human brain tumors: Multidrug-resistance P-glycoprotein expression in tumor cells and intratumoral capillary endothelial cells. Virchows. Arch. 451, 81 (2007).
    • (2007) Virchows. Arch. , vol.451 , pp. 81
    • Fattori, S.1    Becherini, F.2    Cianfriglia, M.3    Parenti, G.4    Romanini, A.5    Castagna, M.6
  • 40
    • 0345688604 scopus 로고    scopus 로고
    • Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
    • L. Doyle and D. D. Ross, Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 22, 7340 (2003).
    • (2003) Oncogene , vol.22 , pp. 7340
    • Doyle, L.1    Ross, D.D.2
  • 43
    • 0026440587 scopus 로고
    • Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice
    • R. D. Zhang, J. E. Price, T. Fujimaki, C. D. Bucana, and I. J. Fidler, Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice. Am. J. Pathol. 141, 1115 (1992).
    • (1992) Am. J. Pathol. , vol.141 , pp. 1115
    • Zhang, R.D.1    Price, J.E.2    Fujimaki, T.3    Bucana, C.D.4    Fidler, I.J.5
  • 45
    • 84876923405 scopus 로고    scopus 로고
    • Longitudinal MRI evaluation of intracranial development and vascular characteristics of breast cancer brain metastases in a mouse model
    • H. Zhou, M. Chen, and D. Zhao, Longitudinal MRI evaluation of intracranial development and vascular characteristics of breast cancer brain metastases in a mouse model. PLoS One 8 e62238 (2013).
    • (2013) PLoS One , vol.8
    • Zhou, H.1    Chen, M.2    Zhao, D.3
  • 46
    • 80053577831 scopus 로고    scopus 로고
    • In vivo characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: A complementary magnetic resonance imaging approach
    • D. B. Percy, E. J. Ribot, Y. Chen, C. McFadden, C. Simedrea, P. S. Steeg, A. F. Chambers, and P. J. Foster, In vivo characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: A complementary magnetic resonance imaging approach. Invest. Radiol. 46, 718 (2011).
    • (2011) Invest. Radiol. , vol.46 , pp. 718
    • Percy, D.B.1    Ribot, E.J.2    Chen, Y.3    McFadden, C.4    Simedrea, C.5    Steeg, P.S.6    Chambers, A.F.7    Foster, P.J.8
  • 47
    • 0031404162 scopus 로고    scopus 로고
    • Modeling tracer kinetics in dynamic Gd-DTPA MR imaging
    • P. S. Tofts, Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J. Magn. Reson. Imaging 7, 91 (1997).
    • (1997) J. Magn. Reson. Imaging , vol.7 , pp. 91
    • Tofts, P.S.1
  • 53
    • 14644399827 scopus 로고    scopus 로고
    • Advanced strategies in liposomal cancer therapy: Problems and prospects of active and tumor specific drug release
    • T. L. Andresen, S. S. Jensen, and K. Jorgensen, Advanced strategies in liposomal cancer therapy: Problems and prospects of active and tumor specific drug release. Prog. Lipid Res. 44, 68 (2005).
    • (2005) Prog. Lipid Res. , vol.44 , pp. 68
    • Andresen, T.L.1    Jensen, S.S.2    Jorgensen, K.3
  • 54
    • 84884327479 scopus 로고    scopus 로고
    • Complete regression of local cancer using temperature-sensitive liposomes combined with ultrasound-mediated hyperthermia
    • A. Kheirolomoom, C. Y. Lai, S. M. Tam, L. M. Mahakian, E. S. Ingham, K. D. Watson, and K. W. Ferrara, Complete regression of local cancer using temperature-sensitive liposomes combined with ultrasound-mediated hyperthermia. J. Control. Release 172, 266 (2013).
    • (2013) J. Control. Release , vol.172 , pp. 266
    • Kheirolomoom, A.1    Lai, C.Y.2    Tam, S.M.3    Mahakian, L.M.4    Ingham, E.S.5    Watson, K.D.6    Ferrara, K.W.7
  • 55
    • 84864284975 scopus 로고    scopus 로고
    • Neurotoxicity of intra-CSF liposomal cytarabine (DepoCyt) administered for the treatment of leptomeningeal metastases: A retrospective case series
    • M. C. Chamberlain, Neurotoxicity of intra-CSF liposomal cytarabine (DepoCyt) administered for the treatment of leptomeningeal metastases: A retrospective case series. J. Neurooncol. 109, 143 (2012).
    • (2012) J. Neurooncol. , vol.109 , pp. 143
    • Chamberlain, M.C.1
  • 56
    • 84862617442 scopus 로고    scopus 로고
    • Treatment of experimental brain metastasis with MTO-liposomes: Impact of fluidity and LRP-targeting on the therapeutic result
    • A. Orthmann, R. Zeisig, R. Suss, D. Lorenz, M. Lemm, and I. Fichtner, Treatment of experimental brain metastasis with MTO-liposomes: Impact of fluidity and LRP-targeting on the therapeutic result. Pharm. Res. 29, 1949 (2012).
    • (2012) Pharm. Res. , vol.29 , pp. 1949
    • Orthmann, A.1    Zeisig, R.2    Suss, R.3    Lorenz, D.4    Lemm, M.5    Fichtner, I.6
  • 57
    • 84877623397 scopus 로고    scopus 로고
    • Glioma targeting and blood-brain barrier penetration by dual-targeting doxorubincin liposomes
    • J.-Q. Gao, Q. Lv, L.-M. Li, X.-J. Tang, F.-Z. Li, Y.-L. Hu, and M. Han, Glioma targeting and blood-brain barrier penetration by dual-targeting doxorubincin liposomes. Biomaterials 34, 5628 (2013).
    • (2013) Biomaterials , vol.34 , pp. 5628
    • Gao, J.-Q.1    Lv, Q.2    Li, L.-M.3    Tang, X.-J.4    Li, F.-Z.5    Hu, Y.-L.6    Han, M.7
  • 61
    • 79960926267 scopus 로고    scopus 로고
    • TRAIL and doxorubicin combination enhances anti-glioblastoma effect based on passive tumor targeting of liposomes
    • L. Guo, L. Fan, Z. Pang, J. Ren, Y. Ren, J. Li, J. Chen, Z. Wen and X. Jiang, TRAIL and doxorubicin combination enhances anti-glioblastoma effect based on passive tumor targeting of liposomes. J. Control Release 154, 93 (2011).
    • (2011) J. Control Release , vol.154 , pp. 93
    • Guo, L.1    Fan, L.2    Pang, Z.3    Ren, J.4    Ren, Y.5    Li, J.6    Chen, J.7    Wen, Z.8    Jiang, X.9
  • 65
    • 69949168025 scopus 로고    scopus 로고
    • A modified protocol for efficient DNA encapsulation into pegylated immunoliposomes (PILs)
    • T. Skjørringe, T. Gjetting, and T. G. Jensen, A modified protocol for efficient DNA encapsulation into pegylated immunoliposomes (PILs). J. Control. Release 139, 140 (2009).
    • (2009) J. Control. Release , vol.139 , pp. 140
    • Skjørringe, T.1    Gjetting, T.2    Jensen, T.G.3
  • 67
    • 58549114669 scopus 로고    scopus 로고
    • Liposome encapsulated polyethylenimine/ODN polyplexes for brain targeting
    • Y. T. Ko, R. Bhattacharya, and U. Bickel, Liposome encapsulated polyethylenimine/ODN polyplexes for brain targeting. J. Control. Release 133, 230 (2009).
    • (2009) J. Control. Release , vol.133 , pp. 230
    • Ko, Y.T.1    Bhattacharya, R.2    Bickel, U.3
  • 68
    • 44849143150 scopus 로고    scopus 로고
    • Intravenous administration of arsenic trioxide encapsulated in liposomes inhibits the growth of C6 gliomas in rat brains
    • S. Zhao, X. Zhang, J. Zhang, J. Zhang, H. Zou, Y. Liu, X. Dong, and X. Sun, Intravenous administration of arsenic trioxide encapsulated in liposomes inhibits the growth of C6 gliomas in rat brains. J. Chemother. 20, 253 (2008).
    • (2008) J. Chemother. , vol.20 , pp. 253
    • Zhao, S.1    Zhang, X.2    Zhang, J.3    Zhang, J.4    Zou, H.5    Liu, Y.6    Dong, X.7    Sun, X.8
  • 69
    • 84875615823 scopus 로고    scopus 로고
    • Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas
    • T. Yin, P. Wang, J. Li, R. Zheng, B. Zheng, D. Cheng, R. Li, J. Lai, and X. Shuai, Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas. Biomaterials 34, 4532 (2013).
    • (2013) Biomaterials , vol.34 , pp. 4532
    • Yin, T.1    Wang, P.2    Li, J.3    Zheng, R.4    Zheng, B.5    Cheng, D.6    Li, R.7    Lai, J.8    Shuai, X.9
  • 71
    • 64249091937 scopus 로고    scopus 로고
    • Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma
    • J.-I. Kuroda, J.-I. Kuratsu, M. Yasunaga, Y. Koga, Y. Saito, and Y. Matsumura, Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma. Int. J. Cancer 124, 2505 (2009).
    • (2009) Int. J. Cancer , vol.124 , pp. 2505
    • Kuroda, J.-I.1    Kuratsu, J.-I.2    Yasunaga, M.3    Koga, Y.4    Saito, Y.5    Matsumura, Y.6
  • 72
    • 65949110136 scopus 로고    scopus 로고
    • Therapeutic efficacy of a polymeric micellar doxorubicin infused by convectionenhanced delivery against intracranial 9L brain tumor models
    • T. Inoue, Y. Yamashita, M. Nishihara, S. Sugiyama, Y. Sonoda, T. Kumabe, M. Yokoyama, and T. Tominaga, Therapeutic efficacy of a polymeric micellar doxorubicin infused by convectionenhanced delivery against intracranial 9L brain tumor models. Neuro. Oncol. 11, 151 (2009).
    • (2009) Neuro. Oncol. , vol.11 , pp. 151
    • Inoue, T.1    Yamashita, Y.2    Nishihara, M.3    Sugiyama, S.4    Sonoda, Y.5    Kumabe, T.6    Yokoyama, M.7    Tominaga, T.8
  • 73
    • 84893167889 scopus 로고    scopus 로고
    • Magnetic resonance imaging-visible and pH-sensitive polymeric micelles for tumor targeted drug delivery
    • Z. Zhang, Q. Sun, J. Zhong, Q. Yang, H. Li, D. Cheng, B. Liang, and X. Shuai, Magnetic resonance imaging-visible and pH-sensitive polymeric micelles for tumor targeted drug delivery. J. Biomed. Nanotechnol. 10, 216 (2014).
    • (2014) J. Biomed. Nanotechnol. , vol.10 , pp. 216
    • Zhang, Z.1    Sun, Q.2    Zhong, J.3    Yang, Q.4    Li, H.5    Cheng, D.6    Liang, B.7    Shuai, X.8
  • 74
    • 84862790727 scopus 로고    scopus 로고
    • A dualtargeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas
    • Y. Li, H. He, X. Jia, W.-L. Lu, J. Lou, and Y. Wei, A dualtargeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas. Biomaterials 33, 3899 (2012).
    • (2012) Biomaterials , vol.33 , pp. 3899
    • Li, Y.1    He, H.2    Jia, X.3    Lu, W.-L.4    Lou, J.5    Wei, Y.6
  • 75
    • 84872799173 scopus 로고    scopus 로고
    • Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier
    • H. M. Teow, Z. Zhou, M. Najlah, S. R. Yusof, N. J. Abbott, and A. D'Emanuele, Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier. Int. J. Pharm. 441, 701 (2013).
    • (2013) Int. J. Pharm. , vol.441 , pp. 701
    • Teow, H.M.1    Zhou, Z.2    Najlah, M.3    Yusof, S.R.4    Abbott, N.J.5    D'Emanuele, A.6
  • 76
    • 79959903861 scopus 로고    scopus 로고
    • Imaging brain tumor by dendrimerbased optical/paramagnetic nanoprobe across the blood-brain barrier
    • H. Yan, J. Wang, P. Yi, H. Lei, C. Zhan, C. Xie, L. Feng, J. Qian, J. Zhu, W. Lu, and C. Li, Imaging brain tumor by dendrimerbased optical/paramagnetic nanoprobe across the blood-brain barrier. Chem. Commun. 47, 8130 (2011).
    • (2011) Chem. Commun. , vol.47 , pp. 8130
    • Yan, H.1    Wang, J.2    Yi, P.3    Lei, H.4    Zhan, C.5    Xie, C.6    Feng, L.7    Qian, J.8    Zhu, J.9    Lu, W.10    Li, C.11
  • 81
    • 84874728069 scopus 로고    scopus 로고
    • Poly (amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells
    • X. Liu, G. Li, Z. Su, Z. Jiang, L. Chen, J. Wang, S. Yu, and Z. Liu, Poly (amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells. Oncol. Rep. 29, 1387 (2013).
    • (2013) Oncol. Rep. , vol.29 , pp. 1387
    • Liu, X.1    Li, G.2    Su, Z.3    Jiang, Z.4    Chen, L.5    Wang, J.6    Yu, S.7    Liu, Z.8
  • 82
    • 84873441992 scopus 로고    scopus 로고
    • Integrin-facilitated transcytosis for enhanced penetration of advanced gliomas by poly(trimethylene carbonate)-based nanoparticles encapsulating paclitaxel
    • X. Jiang, X. Sha, H. Xin, X. Xu, J. Gu, W. Xia, S. Chen, Y. Xie, L. Chen, Y. Chen, and X. Fang, Integrin-facilitated transcytosis for enhanced penetration of advanced gliomas by poly(trimethylene carbonate)-based nanoparticles encapsulating paclitaxel. Biomaterials 34, 2969 (2013).
    • (2013) Biomaterials , vol.34 , pp. 2969
    • Jiang, X.1    Sha, X.2    Xin, H.3    Xu, X.4    Gu, J.5    Xia, W.6    Chen, S.7    Xie, Y.8    Chen, L.9    Chen, Y.10    Fang, X.11
  • 83
    • 84875279479 scopus 로고    scopus 로고
    • SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery
    • C.-H. Fan, C.-Y. Ting, H.-J. Lin, C.-H. Wang, H.-L. Liu, T.-C. Yen and C.-K. Yeh, SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery. Biomaterials 34, 3706 (2013).
    • (2013) Biomaterials , vol.34 , pp. 3706
    • Fan, C.-H.1    Ting, C.-Y.2    Lin, H.-J.3    Wang, C.-H.4    Liu, H.-L.5    Yen, T.-C.6    Yeh, C.-K.7
  • 84
    • 84860765571 scopus 로고    scopus 로고
    • Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma
    • Y. Ling, K. Wei, F. Zou, and S. Zhong, Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma. Int. J. Pharm. 430, 266 (2012).
    • (2012) Int. J. Pharm. , vol.430 , pp. 266
    • Ling, Y.1    Wei, K.2    Zou, F.3    Zhong, S.4
  • 85
    • 84871034471 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide and drug complex-embedded acoustic droplets for ultrasound targeted theranosis
    • C. H. Wang, S. T. Kang, and C. K. Yeh, Superparamagnetic iron oxide and drug complex-embedded acoustic droplets for ultrasound targeted theranosis. Biomaterials 34, 1852 (2013).
    • (2013) Biomaterials , vol.34 , pp. 1852
    • Wang, C.H.1    Kang, S.T.2    Yeh, C.K.3
  • 88
    • 77955388676 scopus 로고    scopus 로고
    • EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma
    • C. G. Hadjipanayis, R. Machaidze, M. Kaluzova, L. Wang, A. J. Schuette, H. Chen, X. Wu, and H. Mao, EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma. Cancer Res. 70, 6303 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 6303
    • Hadjipanayis, C.G.1    Machaidze, R.2    Kaluzova, M.3    Wang, L.4    Schuette, A.J.5    Chen, H.6    Wu, X.7    Mao, H.8
  • 90
    • 77953303635 scopus 로고    scopus 로고
    • Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures
    • R. Chopra, N. Vykhodtseva, and K. Hynynen, Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures. ACS Chem. Neurosci. 1, 391 (2010).
    • (2010) ACS Chem. Neurosci. , vol.1 , pp. 391
    • Chopra, R.1    Vykhodtseva, N.2    Hynynen, K.3
  • 91
    • 34547121440 scopus 로고    scopus 로고
    • Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound
    • L. H. Treat, N. McDannold, N. Vykhodtseva, Y. Zhang, K. Tam, and K. Hynynen, Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int. J. Cancer 121, 901 (2007).
    • (2007) Int. J. Cancer , vol.121 , pp. 901
    • Treat, L.H.1    McDannold, N.2    Vykhodtseva, N.3    Zhang, Y.4    Tam, K.5    Hynynen, K.6
  • 92
    • 84865766754 scopus 로고    scopus 로고
    • Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma
    • L. H. Treat, N. McDannold, Y. Zhang, N. Vykhodtseva, and K. Hynynen, Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound Med. Biol. 38, 1716 (2012).
    • (2012) Ultrasound Med. Biol. , vol.38 , pp. 1716
    • Treat, L.H.1    McDannold, N.2    Zhang, Y.3    Vykhodtseva, N.4    Hynynen, K.5
  • 93
    • 84867359055 scopus 로고    scopus 로고
    • Ultrasound-mediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model
    • E. J. Park, Y. Z. Zhang, N. Vykhodtseva, and N. McDannold, Ultrasound-mediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model. J. Control. Release 163, 277 (2012).
    • (2012) J. Control. Release , vol.163 , pp. 277
    • Park, E.J.1    Zhang, Y.Z.2    Vykhodtseva, N.3    McDannold, N.4
  • 94
    • 84861985598 scopus 로고    scopus 로고
    • Focused ultrasound and interleukin-4 receptortargeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme
    • F.-Y. Yang, T.-T. Wong, M.-C. Teng, R.-S. Liu, M. Lu, H.-F. Liang and M.-C. Wei, Focused ultrasound and interleukin-4 receptortargeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme. J. Control. Release 160, 652 (2012).
    • (2012) J. Control. Release , vol.160 , pp. 652
    • Yang, F.-Y.1    Wong, T.-T.2    Teng, M.-C.3    Liu, R.-S.4    Lu, M.5    Liang, H.-F.6    Wei, M.-C.7
  • 95
    • 0042899083 scopus 로고    scopus 로고
    • Blood-brain barrier drug targeting: The future of brain drug development
    • W. M. Pardridge, Blood-brain barrier drug targeting: The future of brain drug development. Mol. Interv. 3, 90 (2003).
    • (2003) Mol. Interv. , vol.3 , pp. 90
    • Pardridge, W.M.1
  • 97
    • 84862638523 scopus 로고    scopus 로고
    • Transferrin adsorption onto PLGA nanoparticles governs their interaction with biological systems from blood circulation to brain cancer cells
    • J. Chang, A. Paillard, C. Passirani, M. Morille, J. P. Benoit, D. Betbeder, and E. Garcion, Transferrin adsorption onto PLGA nanoparticles governs their interaction with biological systems from blood circulation to brain cancer cells. Pharm. Res. 29, 1495 (2011).
    • (2011) Pharm. Res. , vol.29 , pp. 1495
    • Chang, J.1    Paillard, A.2    Passirani, C.3    Morille, M.4    Benoit, J.P.5    Betbeder, D.6    Garcion, E.7
  • 98
    • 79955037020 scopus 로고    scopus 로고
    • Computed tomography imaging of transferrin targeting liposomes encapsulating both boron and iodine contrast agents by convection-enhanced delivery to F98 rat glioma for boron neutron capture therapy
    • S. Miyata, S. Kawabata, R. Hiramatsu, A. Doi, N. Ikeda, T. Yamashita, T. Kuroiwa, S. Kasaoka, K. Maruyama, and S. Miyatake, Computed tomography imaging of transferrin targeting liposomes encapsulating both boron and iodine contrast agents by convection-enhanced delivery to F98 rat glioma for boron neutron capture therapy. Neurosurgery 68, 1380 (2011).
    • (2011) Neurosurgery , vol.68 , pp. 1380
    • Miyata, S.1    Kawabata, S.2    Hiramatsu, R.3    Doi, A.4    Ikeda, N.5    Yamashita, T.6    Kuroiwa, T.7    Kasaoka, S.8    Maruyama, K.9    Miyatake, S.10
  • 99
    • 84862015950 scopus 로고    scopus 로고
    • Transferrin-modified c[RGDfK]-paclitaxel loaded hybrid micelle for sequential blood-brain barrier penetration and glioma targeting therapy
    • P. Zhang, L. Hu, Q. Yin, L. Feng, and Y. Li, Transferrin-modified c[RGDfK]-paclitaxel loaded hybrid micelle for sequential blood-brain barrier penetration and glioma targeting therapy. Mol. Pharm. 9, 1590 (2012).
    • (2012) Mol. Pharm. , vol.9 , pp. 1590
    • Zhang, P.1    Hu, L.2    Yin, Q.3    Feng, L.4    Li, Y.5
  • 102
    • 84862777853 scopus 로고    scopus 로고
    • The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2
    • J. Ren, S. Shen, D. Wang, Z. Xi, L. Guo, Z. Pang, Y. Qian, X. Sun and X. Jiang, The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2. Biomaterials 33, 3324 (2012).
    • (2012) Biomaterials , vol.33 , pp. 3324
    • Ren, J.1    Shen, S.2    Wang, D.3    Xi, Z.4    Guo, L.5    Pang, Z.6    Qian, Y.7    Sun, X.8    Jiang, X.9
  • 103
    • 68549110328 scopus 로고    scopus 로고
    • Twenty years of cell-penetrating peptides: From molecular mechanisms to therapeutics
    • F. Heitz, M. C. Morris, and G. Divita, Twenty years of cell-penetrating peptides: From molecular mechanisms to therapeutics. Br. J. Pharmacol. 157, 195 (2009).
    • (2009) Br. J. Pharmacol. , vol.157 , pp. 195
    • Heitz, F.1    Morris, M.C.2    Divita, G.3
  • 104
    • 70349456654 scopus 로고    scopus 로고
    • Recent advances in the use of cell-penetrating peptides for medical and biological applications
    • S. B. Fonseca, M. P. Pereira, and S. O. Kelley, Recent advances in the use of cell-penetrating peptides for medical and biological applications. Adv. Drug Deliv. Rev. 61, 953 (2009).
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 953
    • Fonseca, S.B.1    Pereira, M.P.2    Kelley, S.O.3
  • 109
    • 77950948806 scopus 로고    scopus 로고
    • Tat-BMPs-PAMAM conjugates enhance therapeutic effect of small interference RNA on U251 glioma cells in vitro and in vivo
    • L. Han, A. Zhang, H. Wang, P. Pu, X. Jiang, C. Kang, and J. Chang, Tat-BMPs-PAMAM conjugates enhance therapeutic effect of small interference RNA on U251 glioma cells in vitro and in vivo. Hum. Gene Ther. 21, 417 (2009).
    • (2009) Hum. Gene Ther. , vol.21 , pp. 417
    • Han, L.1    Zhang, A.2    Wang, H.3    Pu, P.4    Jiang, X.5    Kang, C.6    Chang, J.7
  • 110
    • 0036488589 scopus 로고    scopus 로고
    • Role of integrins in cell invasion and migration
    • J. D. Hood and D. A. Cheresh, Role of integrins in cell invasion and migration. Nat. Rev. Cancer 2, 91 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 91
    • Hood, J.D.1    Cheresh, D.A.2
  • 111
    • 0037023363 scopus 로고    scopus 로고
    • Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand
    • J. P. Xiong, T. Stehle, R. Zhang, A. Joachimiak, M. Frech, S. L. Goodman, and M. A. Arnaout, Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science 296, 151 (2002).
    • (2002) Science , vol.296 , pp. 151
    • Xiong, J.P.1    Stehle, T.2    Zhang, R.3    Joachimiak, A.4    Frech, M.5    Goodman, S.L.6    Arnaout, M.A.7
  • 112
    • 33748616254 scopus 로고    scopus 로고
    • Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism
    • W. Cai and X. Chen, Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism. Anticancer Agents Med. Chem. 6, 407 (2006).
    • (2006) Anticancer Agents Med. Chem. , vol.6 , pp. 407
    • Cai, W.1    Chen, X.2
  • 113
    • 84255169451 scopus 로고    scopus 로고
    • Cyclic RGDpolyethylene glycol-polyethylenimine for intracranial glioblastoma-targeted gene delivery
    • C. Zhan, Q. Meng, Q. Li, L. Feng, J. Zhu, and W. Lu, Cyclic RGDpolyethylene glycol-polyethylenimine for intracranial glioblastoma-targeted gene delivery. Chem. Asian, J 7, 91 (2012).
    • (2012) Chem. Asian, J , vol.7 , pp. 91
    • Zhan, C.1    Meng, Q.2    Li, Q.3    Feng, L.4    Zhu, J.5    Lu, W.6
  • 114
    • 0036829110 scopus 로고    scopus 로고
    • Increased exposure of anionic phospholipids on the surface of tumor blood vessels
    • S. Ran, A. Downes, and P. E. Thorpe, Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res. 62, 6132 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 6132
    • Ran, S.1    Downes, A.2    Thorpe, P.E.3
  • 115
    • 0036891466 scopus 로고    scopus 로고
    • Phosphatidylserine is a marker of tumor vasculature and a potential target for cancer imaging and therapy
    • S. Ran and P. E. Thorpe, Phosphatidylserine is a marker of tumor vasculature and a potential target for cancer imaging and therapy. Int. J. Radiat. Oncol. Biol. Phys. 54, 1479 (2002).
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 1479
    • Ran, S.1    Thorpe, P.E.2
  • 116
    • 20144374032 scopus 로고    scopus 로고
    • A monoclonal antibody that binds anionic phospholipids on tumor blood vessels enhances the antitumor effect of docetaxel on human breast tumors in mice
    • X. Huang, M. Bennett, and P. E. Thorpe, A monoclonal antibody that binds anionic phospholipids on tumor blood vessels enhances the antitumor effect of docetaxel on human breast tumors in mice. Cancer Res. 65, 4408 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 4408
    • Huang, X.1    Bennett, M.2    Thorpe, P.E.3
  • 117
    • 0033603823 scopus 로고    scopus 로고
    • Annexin V staining due to loss of membrane asymmetry can be reversible and precede commitment to apoptotic death
    • A. K. Hammill, J. W. Uhr, and R. H. Scheuermann, Annexin V staining due to loss of membrane asymmetry can be reversible and precede commitment to apoptotic death. Exp. Cell Res. 251, 16 (1999).
    • (1999) Exp. Cell Res. , vol.251 , pp. 16
    • Hammill, A.K.1    Uhr, J.W.2    Scheuermann, R.H.3
  • 118
    • 65449122791 scopus 로고    scopus 로고
    • Mobilization of lysosomal calcium regulates the externalization of phosphatidylserine during apoptosis
    • B. Mirnikjoo, K. Balasubramanian, and A. J. Schroit, Mobilization of lysosomal calcium regulates the externalization of phosphatidylserine during apoptosis. J. Biol. Chem. 284, 6918 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 6918
    • Mirnikjoo, B.1    Balasubramanian, K.2    Schroit, A.J.3
  • 119
    • 0037938686 scopus 로고    scopus 로고
    • Aminophospholipid asymmetry: A matter of life and death
    • K. Balasubramanian and A. J. Schroit, Aminophospholipid asymmetry: A matter of life and death. Annu. Rev. Physiol. 65, 701 (2003).
    • (2003) Annu. Rev. Physiol. , vol.65 , pp. 701
    • Balasubramanian, K.1    Schroit, A.J.2
  • 120
    • 34548862588 scopus 로고    scopus 로고
    • Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids
    • J. He, T. A. Luster, and P. E. Thorpe, Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids. Clin Cancer Res. 13, 5211 (2007).
    • (2007) Clin Cancer Res. , vol.13 , pp. 5211
    • He, J.1    Luster, T.A.2    Thorpe, P.E.3
  • 121
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • P. E. Thorpe, Vascular targeting agents as cancer therapeutics. Clin. Cancer Res. 10, 415 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 415
    • Thorpe, P.E.1
  • 123
    • 84890964657 scopus 로고    scopus 로고
    • Liposomal encapsulation enhances in vivo near infrared imaging of exposed phosphatidylserine in a mouse glioma model
    • L. Zhang and D. Zhao, Liposomal encapsulation enhances in vivo near infrared imaging of exposed phosphatidylserine in a mouse glioma model. Molecules 18, 14613 (2013).
    • (2013) Molecules , vol.18 , pp. 14613
    • Zhang, L.1    Zhao, D.2
  • 124
    • 82855176765 scopus 로고    scopus 로고
    • Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model
    • D. Zhao, J. H. Stafford, H. Zhou, and P. E. Thorpe, Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model. Transl. Oncol. 4, 355 (2011).
    • (2011) Transl. Oncol. , vol.4 , pp. 355
    • Zhao, D.1    Stafford, J.H.2    Zhou, H.3    Thorpe, P.E.4
  • 126
    • 33746172167 scopus 로고    scopus 로고
    • Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
    • D. B. Kirpotin, D. C. Drummond, Y. Shao, M. R. Shalaby, K. Hong, U. B. Nielsen, J. D. Marks, C. C. Benz, and J. W. Park, Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res. 66, 6732 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 6732
    • Kirpotin, D.B.1    Drummond, D.C.2    Shao, Y.3    Shalaby, M.R.4    Hong, K.5    Nielsen, U.B.6    Marks, J.D.7    Benz, C.C.8    Park, J.W.9
  • 127
    • 22544459893 scopus 로고    scopus 로고
    • Shedding light on the dynamics of endocytosis and viral budding
    • G. Bao and X. R. Bao, Shedding light on the dynamics of endocytosis and viral budding. Proc. Natl. Acad. Sci. U. S. A. 102, 9997 (2005).
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 9997
    • Bao, G.1    Bao, X.R.2
  • 128
    • 34547302844 scopus 로고    scopus 로고
    • Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
    • B. D. Chithrani and W. C. Chan, Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett. 7, 1542 (2007).
    • (2007) Nano Lett. , vol.7 , pp. 1542
    • Chithrani, B.D.1    Chan, W.C.2
  • 129
    • 78650379518 scopus 로고    scopus 로고
    • Strategies for the intracellular delivery of nanoparticles
    • L. Y. Chou, K. Ming, and W. C. Chan, Strategies for the intracellular delivery of nanoparticles. Chem. Soc. Rev. 40, 233 (2010).
    • (2010) Chem. Soc. Rev. , vol.40 , pp. 233
    • Chou, L.Y.1    Ming, K.2    Chan, W.C.3
  • 131
    • 0035556313 scopus 로고    scopus 로고
    • Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion
    • E. V. Batrakova, S. Li, W. F. Elmquist, D. W. Miller, V. Y. Alakhov, and A. V. Kabanov, Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion. Br. J. Cancer 85, 1987 (2001).
    • (2001) Br. J. Cancer , vol.85 , pp. 1987
    • Batrakova, E.V.1    Li, S.2    Elmquist, W.F.3    Miller, D.W.4    Alakhov, V.Y.5    Kabanov, A.V.6
  • 134
    • 84884179298 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by magnetic chitosan-Fe(3)O(4) nanoparticle-encapsulated MDR(1) siRNA in glioblastoma cell line
    • P. Zhao, H. Wang, H. Gao, C. Li, and Y. Zhang, Reversal of multidrug resistance by magnetic chitosan-Fe(3)O(4) nanoparticle-encapsulated MDR(1) siRNA in glioblastoma cell line. Neurol. Res. 35, 821 (2013).
    • (2013) Neurol. Res. , vol.35 , pp. 821
    • Zhao, P.1    Wang, H.2    Gao, H.3    Li, C.4    Zhang, Y.5
  • 135
    • 77956868654 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in glioma: Signal transduction, neuropathology, imaging, and radioresistance
    • K. J. Hatanpaa, S. Burma, D. Zhao, and A. A. Habib, Epidermal growth factor receptor in glioma: Signal transduction, neuropathology, imaging, and radioresistance. Neoplasia 12, 675 (2011).
    • (2011) Neoplasia , vol.12 , pp. 675
    • Hatanpaa, K.J.1    Burma, S.2    Zhao, D.3    Habib, A.A.4
  • 136
    • 29244489232 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo
    • C. Mamot, D. C. Drummond, C. O. Noble, V. Kallab, Z. Guo, K. Hong, D. B. Kirpotin, and J. W. Park, Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo. Cancer Res. 65, 11631 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 11631
    • Mamot, C.1    Drummond, D.C.2    Noble, C.O.3    Kallab, V.4    Guo, Z.5    Hong, K.6    Kirpotin, D.B.7    Park, J.W.8
  • 137
    • 79955475531 scopus 로고    scopus 로고
    • Brain metastases as preventive and therapeutic targets
    • P. S. Steeg, K. A. Camphausen, and Q. R. Smith, Brain metastases as preventive and therapeutic targets. Nat. Rev. Cancer 11, 352 (2011).
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 352
    • Steeg, P.S.1    Camphausen, K.A.2    Smith, Q.R.3
  • 138
    • 79960561767 scopus 로고    scopus 로고
    • Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma
    • S. Huang, J. Li, L. Han, S. Liu, H. Ma, R. Huang, and C. Jiang, Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma. Biomaterials 32, 6832 (2011).
    • (2011) Biomaterials , vol.32 , pp. 6832
    • Huang, S.1    Li, J.2    Han, L.3    Liu, S.4    Ma, H.5    Huang, R.6    Jiang, C.7
  • 140
    • 79955104821 scopus 로고    scopus 로고
    • Angiopep-conjugated poly(ethylene glycol)-co-poly(epsilon-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma
    • H. Xin, X. Jiang, J. Gu, X. Sha, L. Chen, K. Law, Y. Chen, X. Wang, Y. Jiang, and X. Fang, Angiopep-conjugated poly(ethylene glycol)-co-poly(epsilon- caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma. Biomaterials 32, 4293 (2011).
    • (2011) Biomaterials , vol.32 , pp. 4293
    • Xin, H.1    Jiang, X.2    Gu, J.3    Sha, X.4    Chen, L.5    Law, K.6    Chen, Y.7    Wang, X.8    Jiang, Y.9    Fang, X.10
  • 141
    • 84891814166 scopus 로고    scopus 로고
    • Co-administration of dual-targeting nanoparticles with penetration enhancement peptide for antiglioblastoma therapy
    • D. Miao, M. Jiang, Z. Liu, G. Gu, Q. Hu, T. Kang, Q. Song, L. Yao, W. Li, X. Gao, M. Sun, and J. Chen, Co-administration of dual-targeting nanoparticles with penetration enhancement peptide for antiglioblastoma therapy. Mol. Pharm. 11, 90 (2013).
    • (2013) Mol. Pharm. , vol.11 , pp. 90
    • Miao, D.1    Jiang, M.2    Liu, Z.3    Gu, G.4    Hu, Q.5    Kang, T.6    Song, Q.7    Yao, L.8    Li, W.9    Gao, X.10    Sun, M.11    Chen, J.12
  • 142
    • 84865330736 scopus 로고    scopus 로고
    • Nanoparticle-based positron emission tomography, and single photon emission computed tomography imaging of cancer
    • M. Jin, G. Hao, X. Sun, and W. Chen, Nanoparticle-based positron emission tomography, and single photon emission computed tomography imaging of cancer. Rev. Nanosci. Nanotechnol. 1, 3 (2012).
    • (2012) Rev. Nanosci. Nanotechnol. , vol.1 , pp. 3
    • Jin, M.1    Hao, G.2    Sun, X.3    Chen, W.4
  • 144
    • 33846845060 scopus 로고    scopus 로고
    • In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
    • Z. Liu, W. Cai, L. He, N. Nakayama, K. Chen, X. Sun, X. Chen, and H. Dai, In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat. Nanotechnol. 2, 47 (2007).
    • (2007) Nat. Nanotechnol. , vol.2 , pp. 47
    • Liu, Z.1    Cai, W.2    He, L.3    Nakayama, N.4    Chen, K.5    Sun, X.6    Chen, X.7    Dai, H.8
  • 145
    • 83455170991 scopus 로고    scopus 로고
    • Imaging, autoradiography, and biodistribution of (188)Re-labeled PEGylated nanoliposome in orthotopic glioma bearing rat model
    • F. Y. Huang, T. W. Lee, C. H. Kao, C. H. Chang, X. Zhang, W. Y. Lee, W. J. Chen, S. C. Wang, and J. M. Lo, Imaging, autoradiography, and biodistribution of (188)Re-labeled PEGylated nanoliposome in orthotopic glioma bearing rat model. Cancer Biother. Radiopharm. 26, 717 (2011).
    • (2011) Cancer Biother. Radiopharm. , vol.26 , pp. 717
    • Huang, F.Y.1    Lee, T.W.2    Kao, C.H.3    Chang, C.H.4    Zhang, X.5    Lee, W.Y.6    Chen, W.J.7    Wang, S.C.8    Lo, J.M.9
  • 147
    • 77952843621 scopus 로고    scopus 로고
    • In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer
    • X. Lu, C. H. Yan, M. Yuan, Y. Wei, G. Hu, and Y. Kang, In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer Res. 70, 3905 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3905
    • Lu, X.1    Yan, C.H.2    Yuan, M.3    Wei, Y.4    Hu, G.5    Kang, Y.6
  • 148
    • 60149098026 scopus 로고    scopus 로고
    • Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy
    • C. M. McCann, P. Waterman, J. L. Figueiredo, E. Aikawa, R. Weissleder, and J. W. Chen, Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage 45, 360 (2009).
    • (2009) Neuroimage , vol.45 , pp. 360
    • McCann, C.M.1    Waterman, P.2    Figueiredo, J.L.3    Aikawa, E.4    Weissleder, R.5    Chen, J.W.6
  • 149
    • 77951214012 scopus 로고    scopus 로고
    • Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice
    • H. Zhou, K. Luby-Phelps, B. E. Mickey, A. A. Habib, R. P. Mason and D. Zhao, Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice. PLoS One 4, e8051 (2009).
    • (2009) PLoS One , vol.4
    • Zhou, H.1    Luby-Phelps, K.2    Mickey, B.E.3    Habib, A.A.4    Mason, R.P.5    Zhao, D.6
  • 150
    • 84884953494 scopus 로고    scopus 로고
    • Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors
    • J. L. Kovar, E. Curtis, S. F. Othman, M. A. Simpson, and D. M. Olive, Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors. Anal. Biochem. 440, 212 (2013).
    • (2013) Anal. Biochem. , vol.440 , pp. 212
    • Kovar, J.L.1    Curtis, E.2    Othman, S.F.3    Simpson, M.A.4    Olive, D.M.5
  • 151
    • 78649629201 scopus 로고    scopus 로고
    • Near-infrared fluorescent nanoprobes for cancer molecular imaging: Status and challenges
    • X. He, J. Gao, S. S. Gambhir, and Z. Cheng, Near-infrared fluorescent nanoprobes for cancer molecular imaging: Status and challenges. Trends. Mol. Med. 16, 574 (2010).
    • (2010) Trends. Mol. Med. , vol.16 , pp. 574
    • He, X.1    Gao, J.2    Gambhir, S.S.3    Cheng, Z.4
  • 152
    • 78149464441 scopus 로고    scopus 로고
    • Molecular imaging of glioblastoma multiforme using anti-insulin-like growth factor-binding protein-7 single-domain antibodies
    • U. Iqbal, H. Albaghdadi, Y. Luo, M. Arbabi, C. Desvaux, T. Veres, D. Stanimirovic, and A. Abulrob, Molecular imaging of glioblastoma multiforme using anti-insulin-like growth factor-binding protein-7 single-domain antibodies. Br. J. Cancer 103, 1606 (2010).
    • (2010) Br. J. Cancer , vol.103 , pp. 1606
    • Iqbal, U.1    Albaghdadi, H.2    Luo, Y.3    Arbabi, M.4    Desvaux, C.5    Veres, T.6    Stanimirovic, D.7    Abulrob, A.8
  • 153
    • 33645986455 scopus 로고    scopus 로고
    • Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: A randomised controlled multicentre phase III trial
    • W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella and H. J. Reulen, Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: A randomised controlled multicentre phase III trial. Lancet. Oncol. 7, 392 (2006).
    • (2006) Lancet. Oncol. , vol.7 , pp. 392
    • Stummer, W.1    Pichlmeier, U.2    Meinel, T.3    Wiestler, O.D.4    Zanella, F.5    Reulen, H.J.6
  • 156
    • 84893443832 scopus 로고    scopus 로고
    • Intraoperative targeted optical imaging: A guide towards tumor-free margins in cancer surgery
    • H. Orbay, J. Bean, Y. Zhang, and W. Cai, Intraoperative targeted optical imaging: A guide towards tumor-free margins in cancer surgery. Curr. Pharm. Biotechnol. 14, 733 (2014).
    • (2014) Curr. Pharm. Biotechnol. , vol.14 , pp. 733
    • Orbay, H.1    Bean, J.2    Zhang, Y.3    Cai, W.4
  • 158
    • 84855929967 scopus 로고    scopus 로고
    • Translation of near-infrared fluorescence imaging technologies: Emerging clinical applications
    • E. M. Sevick-Muraca, Translation of near-infrared fluorescence imaging technologies: Emerging clinical applications. Annu. Rev. Med. 63, 217 (2012).
    • (2012) Annu. Rev. Med. , vol.63 , pp. 217
    • Sevick-Muraca, E.M.1
  • 160
    • 33645962802 scopus 로고    scopus 로고
    • Improving resection of malignant glioma
    • F. G. Barker, 2nd and S. M. Chang, Improving resection of malignant glioma. Lancet. Oncol. 7, 359 (2006).
    • (2006) Lancet. Oncol. , vol.7 , pp. 359
    • Barker II, F.G.1    Chang, S.M.2
  • 162
    • 84893802303 scopus 로고    scopus 로고
    • Comparative anti-cancer properties of quantum dots and gold particles conjugated to chemotherapeutic agents
    • L. Carlini, H. Chibli, X. Zhang, and J. L. Nadeau, Comparative anti-cancer properties of quantum dots and gold particles conjugated to chemotherapeutic agents. Rev. Nanosci. Nanotechnol. 2, 42 (2013).
    • (2013) Rev. Nanosci. Nanotechnol. , vol.2 , pp. 42
    • Carlini, L.1    Chibli, H.2    Zhang, X.3    Nadeau, J.L.4
  • 163
    • 46749091612 scopus 로고    scopus 로고
    • Bioconjugated quantum dots for in vivo molecular and cellular imaging
    • A. M. Smith, H. Duan, A. M. Mohs, and S. Nie, Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv. Drug Deliv. Rev. 60, 1226 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 1226
    • Smith, A.M.1    Duan, H.2    Mohs, A.M.3    Nie, S.4
  • 164
    • 80052893655 scopus 로고    scopus 로고
    • Medical applications of nanoparticles in biological imaging, cell labeling, antimicrobial agents, and anticancer nanodrugs
    • R. Singh and H. S. Nalwa, Medical applications of nanoparticles in biological imaging, cell labeling, antimicrobial agents, and anticancer nanodrugs. J. Biomed. Nanotechnol. 7, 489 (2011).
    • (2011) J. Biomed. Nanotechnol. , vol.7 , pp. 489
    • Singh, R.1    Nalwa, H.S.2
  • 165
    • 84920803884 scopus 로고    scopus 로고
    • Paclitaxel loaded fibrinogen coated CdTe/ZnTe core shell nanoparticles for targeted imaging and drug delivery to breast cancer cells
    • N. S. Rejinold, T. Baby, S. V. Nair, and R. Jayakumar, Paclitaxel loaded fibrinogen coated CdTe/ZnTe core shell nanoparticles for targeted imaging and drug delivery to breast cancer cells. J. Biomed. Nanotechnol. 9, 1657 (2013).
    • (2013) J. Biomed. Nanotechnol. , vol.9 , pp. 1657
    • Rejinold, N.S.1    Baby, T.2    Nair, S.V.3    Jayakumar, R.4
  • 166
    • 79957766661 scopus 로고    scopus 로고
    • Multifunctional magnetic quantum dots for cancer theranostics
    • S. P. Singh, Multifunctional magnetic quantum dots for cancer theranostics. J. Biomed. Nanotechnol. 7, 95 (2011).
    • (2011) J. Biomed. Nanotechnol. , vol.7 , pp. 95
    • Singh, S.P.1
  • 168
    • 84888057148 scopus 로고    scopus 로고
    • Recent progress on the liposomes loaded with quantum dots
    • C. Yang, W. Chen, B. G. Bui, and G. Xiang, Recent progress on the liposomes loaded with quantum dots. Rev. Nanosci. Nanotechnol. 1, 257 (2012).
    • (2012) Rev. Nanosci. Nanotechnol. , vol.1 , pp. 257
    • Yang, C.1    Chen, W.2    Bui, B.G.3    Xiang, G.4
  • 169
    • 84866427416 scopus 로고    scopus 로고
    • Effective photothermal chemotherapy using doxorubicin-loaded gold nanospheres that target EphB4 receptors in tumors
    • J. You, R. Zhang, C. Xiong, M. Zhong, M. Melancon, S. Gupta, A. M. Nick, A. K. Sood, and C. Li, Effective photothermal chemotherapy using doxorubicin-loaded gold nanospheres that target EphB4 receptors in tumors. Cancer Res. 72, 4777 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 4777
    • You, J.1    Zhang, R.2    Xiong, C.3    Zhong, M.4    Melancon, M.5    Gupta, S.6    Nick, A.M.7    Sood, A.K.8    Li, C.9
  • 171
    • 84880901791 scopus 로고    scopus 로고
    • Surface functionalized gold nanoparticles for drug delivery
    • J. Cheng, Y. J. Gu, S. H. Cheng, and W. T. Wong, Surface functionalized gold nanoparticles for drug delivery. J. Biomed. Nanotechnol. 9, 1362 (2013).
    • (2013) J. Biomed. Nanotechnol. , vol.9 , pp. 1362
    • Cheng, J.1    Gu, Y.J.2    Cheng, S.H.3    Wong, W.T.4
  • 172
    • 84877809609 scopus 로고    scopus 로고
    • Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells
    • T. Gong, M. Olivo, U. S. Dinish, D. Goh, K. V. Kong, and K. T. Yong, Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells. J. Biomed. Nanotechnol. 9, 985 (2013).
    • (2013) J. Biomed. Nanotechnol. , vol.9 , pp. 985
    • Gong, T.1    Olivo, M.2    Dinish, U.S.3    Goh, D.4    Kong, K.V.5    Yong, K.T.6
  • 174
    • 9244244699 scopus 로고    scopus 로고
    • Iron oxide MR contrast agents for molecular and cellular imaging
    • J. W. Bulte and D. L. Kraitchman, Iron oxide MR contrast agents for molecular and cellular imaging. NMR. Biomed. 17, 484 (2004).
    • (2004) NMR. Biomed. , vol.17 , pp. 484
    • Bulte, J.W.1    Kraitchman, D.L.2
  • 175
    • 33645214569 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide nanoparticle probes for molecular imaging
    • D. L. Thorek, A. K. Chen, J. Czupryna, and A. Tsourkas, Superparamagnetic iron oxide nanoparticle probes for molecular imaging. Ann. Biomed. Eng. 34, 23 (2006).
    • (2006) Ann. Biomed. Eng. , vol.34 , pp. 23
    • Thorek, D.L.1    Chen, A.K.2    Czupryna, J.3    Tsourkas, A.4
  • 176
    • 41649110649 scopus 로고    scopus 로고
    • Imaging in the era of molecular oncology
    • R. Weissleder and M. J. Pittet, Imaging in the era of molecular oncology. Nature 452, 580 (2008).
    • (2008) Nature , vol.452 , pp. 580
    • Weissleder, R.1    Pittet, M.J.2
  • 179
    • 84904896865 scopus 로고    scopus 로고
    • High r1 relaxivity Sub-5 nm supersmall iron oxide nanoparticles (sSIO) as T1 weighted MRI contrast agents
    • Savannah, GE
    • J. Huang, L. Wang, L. Yang, and H. Mao, High r1 relaxivity Sub-5 nm supersmall iron oxide nanoparticles (sSIO) as T1 weighted MRI contrast agents, World Molecular Imaging Congress, Savannah, GE (2013).
    • (2013) World Molecular Imaging Congress
    • Huang, J.1    Wang, L.2    Yang, L.3    Mao, H.4
  • 181
    • 48749104610 scopus 로고    scopus 로고
    • PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles
    • H. Y. Lee, Z. Li, K. Chen, A. R. Hsu, C. Xu, J. Xie, S. Sun, and X. Chen, PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. J. Nucl. Med. 49, 1371 (2008).
    • (2008) J. Nucl. Med. , vol.49 , pp. 1371
    • Lee, H.Y.1    Li, Z.2    Chen, K.3    Hsu, A.R.4    Xu, C.5    Xie, J.6    Sun, S.7    Chen, X.8
  • 182
    • 84856164075 scopus 로고    scopus 로고
    • Two-order targeted brain tumor imaging by using an optical/paramagnetic nanoprobe across the blood brain barrier
    • H. Yan, L. Wang, J. Wang, X. Weng, H. Lei, X. Wang, L. Jiang, J. Zhu, W. Lu, X. Wei, and C. Li, Two-order targeted brain tumor imaging by using an optical/paramagnetic nanoprobe across the blood brain barrier. ACS Nano 6, 410 (2012).
    • (2012) ACS Nano , vol.6 , pp. 410
    • Yan, H.1    Wang, L.2    Wang, J.3    Weng, X.4    Lei, H.5    Wang, X.6    Jiang, L.7    Zhu, J.8    Lu, W.9    Wei, X.10    Li, C.11
  • 183
    • 44649105611 scopus 로고    scopus 로고
    • Brain metastases in breast cancer: Clinical and pathologic characteristics associated with improvements in survival
    • M. E. Melisko, D. H. Moore, P. K. Sneed, J. De Franco, and H. S. Rugo, Brain metastases in breast cancer: Clinical and pathologic characteristics associated with improvements in survival. J. Neurooncol. 88, 359 (2008).
    • (2008) J. Neurooncol. , vol.88 , pp. 359
    • Melisko, M.E.1    Moore, D.H.2    Sneed, P.K.3    De Franco, J.4    Rugo, H.S.5
  • 185
    • 67649240336 scopus 로고    scopus 로고
    • The vascular basement membrane as "soil" in brain metastasis
    • W. S. Carbonell, O. Ansorge, N. Sibson, and R. Muschel, The vascular basement membrane as "soil" in brain metastasis. PLoS One. 4, e5857 (2009).
    • (2009) PLoS One , vol.4
    • Carbonell, W.S.1    Ansorge, O.2    Sibson, N.3    Muschel, R.4
  • 189
    • 84874442053 scopus 로고    scopus 로고
    • Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: Implications for the treatment of melanoma brain metastases
    • R. K. Mittapalli, S. Vaidhyanathan, A. Z. Dudek, and W. F. Elmquist, Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: Implications for the treatment of melanoma brain metastases. J. Pharmacol. Exp. Ther. 344, 655 (2013).
    • (2013) J. Pharmacol. Exp. Ther. , vol.344 , pp. 655
    • Mittapalli, R.K.1    Vaidhyanathan, S.2    Dudek, A.Z.3    Elmquist, W.F.4
  • 191
    • 41549138328 scopus 로고    scopus 로고
    • The role of efflux and uptake transporters in N-{3-chloro-4-[(3- fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl] -4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions
    • J. W. Polli, J. E. Humphreys, K. A. Harmon, S. Castellino, M. J. O'Mara, K. L. Olson, L. S. John-Williams, K. M. Koch, and C. J. Serabjit-Singh, The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy] phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl] -4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions. Drug Metab. Dispos. 36, 695 (2008).
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 695
    • Polli, J.W.1    Humphreys, J.E.2    Harmon, K.A.3    Castellino, S.4    O'Mara, M.J.5    Olson, K.L.6    John-Williams, L.S.7    Koch, K.M.8    Serabjit-Singh, C.J.9
  • 193
    • 84891692553 scopus 로고    scopus 로고
    • Incorporation of lapatinib into core-shell nanoparticles improves both the solubility and anti-glioma effects of the drug
    • H. Gao, Y. Wang, C. Chen, J. Chen, Y. Wei, S. Cao, and X. Jiang, Incorporation of lapatinib into core-shell nanoparticles improves both the solubility and anti-glioma effects of the drug. Int. J. Pharm. 461, 478 (2014).
    • (2014) Int. J. Pharm. , vol.461 , pp. 478
    • Gao, H.1    Wang, Y.2    Chen, C.3    Chen, J.4    Wei, Y.5    Cao, S.6    Jiang, X.7
  • 197
    • 0032601166 scopus 로고    scopus 로고
    • Primary and secondary glioblastomas: From concept to clinical diagnosis
    • P. Kleihues and H. Ohgaki, Primary and secondary glioblastomas: From concept to clinical diagnosis. Neuro. Oncol. 1, 44 (1999).
    • (1999) Neuro. Oncol. , vol.1 , pp. 44
    • Kleihues, P.1    Ohgaki, H.2
  • 198
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • J. Chen, Y. Li, T. S. Yu, R. M. McKay, D. K. Burns, S. G. Kernie and L. F. Parada, A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488, 522 (2012).
    • (2012) Nature , vol.488 , pp. 522
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5    Kernie, S.G.6    Parada, L.F.7
  • 201
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • J. Mendelsohn and J. Baselga, The EGF receptor family as targets for cancer therapy. Oncogene 19, 6550 (2000).
    • (2000) Oncogene , vol.19 , pp. 6550
    • Mendelsohn, J.1    Baselga, J.2
  • 202
    • 77951599543 scopus 로고    scopus 로고
    • Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma
    • J. T. Huse and E. C. Holland, Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma. Nat. Rev. Cancer 10, 319 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 319
    • Huse, J.T.1    Holland, E.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.