Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors

Analytical Biochemistry

Volumn 440, Issue 2, 2013, Pages 212-219

  Kovar, Joy L ^a   Curtis, Evan ^b   Othman, Shadi F ^b   Simpson, Melanie A ^b   Olive, D Michael ^a,c  

^a LI COR BIOSCIENCES   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c SVS Consulting   (United States)

Author keywords

Blood brain barrier; Chlorotoxin; In vivo imaging; IRDye 800CW; Medulloblastoma; ND2:SmoA1 homozygous transgenic mouse

Indexed keywords

BLOOD; BRAIN; MAGNETIC RESONANCE IMAGING; SURGERY;

BLOOD-BRAIN BARRIER; CHLOROTOXIN; IN-VIVO IMAGING; IRDYE 800CW; MEDULLOBLASTOMA; TRANSGENIC MICE;

TUMORS;

CONTRAST MEDIUM; EVANS BLUE; IRDYE 800CW CHLOROTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN TUMOR; CANCER CELL CULTURE; CANCER TISSUE; CONTROLLED STUDY; DISEASE MODEL; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VITRO STUDY; MEDULLOBLASTOMA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERMEABILITY BARRIER; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ANIMALIA; MUS MUSCULUS;

BLOOD-BRAIN BARRIER; CHLOROTOXIN; IN VIVO IMAGING; IRDYE 800CW; MEDULLOBLASTOMA; ND2:SMOA1 HOMOZYGOUS TRANSGENIC MOUSE;

ANIMALS; BENZENESULFONATES; BLOOD-BRAIN BARRIER; CELL LINE, TUMOR; CEREBELLAR NEOPLASMS; HUMANS; INDOLES; MATRIX METALLOPROTEINASE 2; MEDULLOBLASTOMA; MICE; SCORPION VENOMS;

EID: 84884953494     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2013.05.013     Document Type: Article

References (27)

1. R.J. Packer, P. Cogen, G. Vezina, L.B. Rorke, Medulloblastoma: clinical and biologic aspects, Neuro-Oncol. 1 (1999) 232-250.
2. W.M. Pardridge, Blood-brain barrier biology and methodology, J. Neurovirol. 5 (1999) 556-569. (Pubitemid 30032082)
3. W.M. Pardridge, The blood-brain barrier: bottleneck in brain drug development, NeuroRx 2 (2005) 3-14. (Pubitemid 40128022)
4. J. Deshane, C.C. Garner, H. Sontheimer, Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2, J. Biol. Chem. 278 (2003) 4135-4144. (Pubitemid 36801150)
5. D.C. Hockaday, S. Shen, J. Fiveash, A. Raubitschek, D. Colcher, A. Liu, V. Alvarez, A.N. Mamelak, Imaging glioma extent with 131I-TM-601, J. Nuclear Med. 46 (2005) 580-586.
6. S.A. Lyons, J. O'Neal, H. Sontheimer, Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin, Glia 39 (2002) 162-173. (Pubitemid 34817056)
7. L. Soroceanu, Y. Gillespie, M.B. Khazaeli, H. Sontheimer, Use of chlorotoxin for targeting of primary brain tumors, Cancer Res. 58 (1998) 4871-4879. (Pubitemid 28503684)
8. M. Veiseh, P. Gabikian, S.B. Bahrami, O. Veiseh, M. Zhang, R.C. Hackman, A.C. Ravanpay, M.R. Stroud, Y. Kusuma, S.J. Hansen, D. Kwok, N.M. Munoz, R.W. Sze, W.M. Grady, N.M. Greenberg, R.G. Ellenbogen, J.M. Olson, Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci, Cancer Res. 67 (2007) 6882-6888. (Pubitemid 47105535)
9. Z. Wang, R. Juttermann, P.D. Soloway, TIMP-2 is required for efficient activation of proMMP-2 in vivo, J. Biol. Chem. 275 (2000) 26411-26415.
10. J.A. DeBin, G.R. Strichartz, Chloride channel inhibition by the venom of the scorpion Leiurus quinquestriatus, Toxicon 29 (1991) 1403-1408.
11. N. Ullrich, H. Sontheimer, Biophysical and pharmacological characterization of chloride currents in human astrocytoma cells, Am. J. Physiol. 270 (1996) C1511-C1521.
12. K. Kesavan, J. Ratliff, E.W. Johnson, W. Dahlberg, J.M. Asara, P. Misra, J.V. Frangioni, D.B. Jacoby, Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects, J. Biol. Chem. 285 (2010) 4366-4374.
13. E.M. Burns, G.D. Dobben, T.W. Kruckeberg, P.K. Gaetano, Blood-brain barrier: morphology, physiology, and effects of contrast media, Adv. Neurol. 30 (1981) 159-165.
14. A.R. Hallahan, J.I. Pritchard, S. Hansen, M. Benson, J. Stoeck, B.A. Hatton, T.L. Russell, R.G. Ellenbogen, I.D. Bernstein, P.A. Beachy, J.M. Olson, The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas, Cancer Res. 64 (2004) 7794-7800. (Pubitemid 39446912)
15. M. Akcan, M.R. Stroud, S.J. Hansen, R.J. Clark, N.L. Daly, D.J. Craik, J.M. Olson, Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy, J. Med. Chem. 54 (2011) 782-787.
16. M. Wiranowska, L.O. Colina, J.O. Johnson, Clathrin-mediated entry and cellular localization of chlorotoxin in human glioma, Cancer Cell Int. 11 (2011) 27.
17. L.M. Crane, G. Themelis, H.J. Arts, K.T. Buddingh, A.H. Brouwers, V. Ntziachristos, G.M. van Dam, A.G. van der Zee, Intraoperative near-infrared fluorescence imaging for sentinel lymph node detection in vulvar cancer: first clinical results, Gynecol. Oncol. 120 (2011) 291-295.
18. L.M. Crane, M. van Oosten, R.G. Pleijhuis, A. Motekallemi, S.C. Dowdy, W.A. Cliby, A.G. van der Zee, G.M. van Dam, Intraoperative imaging in ovarian cancer: fact or fiction, Mol Imaging 10 (2011) 248-257.
19. D.A. Heuveling, G.W. Visser, M. de Groot, J.F. de Boer, M. Baclayon, W.H. Roos, G.J. Wuite, C.R. Leemans, R. de Bree, G.A. van Dongen, Nanocolloidal albumin- IRDye 800CW: a near-infrared fluorescent tracer with optimal retention in the sentinel lymph node, Eur. J. Nuclear Med. Mol. Imaging 39 (2012) 1161-1168.
20. M.V. Marshall, D. Draney, E.M. Sevick-Muraca, D.M. Olive, Single-dose intravenous toxicity study of IRDye 800CW in Sprague-Dawley rats: molecular imaging and biology, Mol. Imaging Biol. 12 (2010) 583-594.
21. N. Ullrich, G.Y. Gillespie, H. Sontheimer, Human astrocytoma cells express a unique chloride current, NeuroReport 7 (1996) 1020-1024. (Pubitemid 26194473)
22. O. Veiseh, C. Sun, C. Fang, N. Bhattarai, J. Gunn, F. Kievit, K. Du, B. Pullar, D. Lee, R.G. Ellenbogen, J. Olson, M. Zhang, Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier, Cancer Res. 69 (2009) 6200-6207.
23. F.M. Kievit, O. Veiseh, C. Fang, N. Bhattarai, D. Lee, R.G. Ellenbogen, M. Zhang, Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma, ACS Nano 4 (2010) 4587-4594.
24. M.F. Kircher, U. Mahmood, R.S. King, R. Weissleder, L. Josephson, A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation, Cancer Res. 63 (2003) 8122-8125. (Pubitemid 37549457)
25. C. Sun, O. Veiseh, J. Gunn, C. Fang, S. Hansen, D. Lee, R. Sze, R.G. Ellenbogen, J. Olson, M. Zhang, In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes, Small 4 (2008) 372-379. (Pubitemid 351421268)
26. H. Zhou, K. Luby-Phelps, B.E. Mickey, A.A. Habib, R.P. Mason, D. Zhao, Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice, PLoS One 4 (2009) e8051.
27. J.A. Alves da Silva, K.C. Oliveira, M.A. Camillo, Gyroxin increases blood-brain barrier permeability to Evans Blue dye in mice, Toxicon 57 (2011) 162-167.