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Volumn 7, Issue 1, 1997, Pages 91-101

Modeling tracer kinetics in dynamic Gd-DTPA MR imaging

Author keywords

Dynamic MRI; Extravascular extracellular space; Gd DTPA; Permeability; Rate constant; Tracer kinetics

Indexed keywords

GADOLINIUM PENTETATE;

EID: 0031404162     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmri.1880070113     Document Type: Review
Times cited : (1315)

References (59)
  • 1
    • 0025883259 scopus 로고
    • NMR imaging study of the pharmacodynamics of polylysine-gadolinium-DTPA in the rabbit and the rat
    • van Hecke P, Marchal G, Bosmans H, et al. NMR imaging study of the pharmacodynamics of polylysine-gadolinium-DTPA in the rabbit and the rat. Magn Reson Imaging 1991; 9:313-321.
    • (1991) Magn Reson Imaging , vol.9 , pp. 313-321
    • Van Hecke, P.1    Marchal, G.2    Bosmans, H.3
  • 2
    • 0027231199 scopus 로고
    • Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging: A quantitative noninvasive technique
    • Shames DM, Kuwatsuru R, Vexler V, Muhler A, Brasch R Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging: a quantitative noninvasive technique. Magn Reson Med 1993; 29:616-622.
    • (1993) Magn Reson Med , vol.29 , pp. 616-622
    • Shames, D.M.1    Kuwatsuru, R.2    Vexler, V.3    Muhler, A.4    Brasch, R.5
  • 3
    • 0025332783 scopus 로고
    • Cerebral blood flow: Assessment with dynamic contrast-enhanced T2*-weighted MR imaging at 1.5T
    • Edelman RR, Mattle HP, Atkinson DJ, et al. Cerebral blood flow: assessment with dynamic contrast-enhanced T2*-weighted MR imaging at 1.5T. Radiology 1990; 176:211-220.
    • (1990) Radiology , vol.176 , pp. 211-220
    • Edelman, R.R.1    Mattle, H.P.2    Atkinson, D.J.3
  • 4
    • 0030000382 scopus 로고    scopus 로고
    • Measurement of cerebral blood volume via the relaxing effect of low-dose gadopentetate dimeglumine during bolus transit
    • Hacklander T, Reichenbach JR, Hofer M, Modder U. Measurement of cerebral blood volume via the relaxing effect of low-dose gadopentetate dimeglumine during bolus transit. AJNR Am J Neuroradiol 1996; 17:821-830.
    • (1996) AJNR Am J Neuroradiol , vol.17 , pp. 821-830
    • Hacklander, T.1    Reichenbach, J.R.2    Hofer, M.3    Modder, U.4
  • 5
    • 0019783061 scopus 로고
    • Methods for quantifying the transport of drugs across brain barrier systems
    • Fenstermacher JD, Blasberg RG, Patlak CS. Methods for quantifying the transport of drugs across brain barrier systems. Pharmacol Ther 1981; 14:217-248.
    • (1981) Pharmacol Ther , vol.14 , pp. 217-248
    • Fenstermacher, J.D.1    Blasberg, R.G.2    Patlak, C.S.3
  • 6
    • 77049129026 scopus 로고
    • Passage of molecules through capillary walls
    • Pappenheimer JR. Passage of molecules through capillary walls. Physiol Rev 1953; 33:387-423.
    • (1953) Physiol Rev , vol.33 , pp. 387-423
    • Pappenheimer, J.R.1
  • 7
    • 13344292421 scopus 로고
    • Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles
    • Renkin EM. Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles. Am J Physiol 1959; 197: 1205-1210.
    • (1959) Am J Physiol , vol.197 , pp. 1205-1210
    • Renkin, E.M.1
  • 8
    • 78651133453 scopus 로고
    • The permeability of capillaries in various organs as determined by use of the 'indicator diffusion' method
    • Crone C. The permeability of capillaries in various organs as determined by use of the 'indicator diffusion' method. Acta Physiol Scand 1963; 58:292-305.
    • (1963) Acta Physiol Scand , vol.58 , pp. 292-305
    • Crone, C.1
  • 9
    • 0018237164 scopus 로고
    • Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat
    • Ohno K, Pettigrew KD, Rapoport SI. Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat. Am J Physiol 1978; 235:H299-307.
    • (1978) Am J Physiol , vol.235
    • Ohno, K.1    Pettigrew, K.D.2    Rapoport, S.I.3
  • 10
    • 0020956774 scopus 로고
    • Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data
    • Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983; 3:1-7.
    • (1983) J Cereb Blood Flow Metab , vol.3 , pp. 1-7
    • Patlak, C.S.1    Blasberg, R.G.2    Fenstermacher, J.D.3
  • 11
    • 0026744894 scopus 로고
    • Measurement of blood-brain barrier permeability in a tumor model using magnetic resonance imaging with gadolinium-DTPA
    • Kenny J, Schmiedl U, Maravilla K, Starr F, Graham M, Spence A, Nelson J. Measurement of blood-brain barrier permeability in a tumor model using magnetic resonance imaging with gadolinium-DTPA. Magn Reson Med 1992; 27:68-75.
    • (1992) Magn Reson Med , vol.27 , pp. 68-75
    • Kenny, J.1    Schmiedl, U.2    Maravilla, K.3    Starr, F.4    Graham, M.5    Spence, A.6    Nelson, J.7
  • 12
    • 0026462459 scopus 로고
    • Kinetics of pathologic blood-brain barrier permeability in a astrocytic glioma using contrast-enhanced MR
    • Schmiedl U, Kenny J, Maravilla K. Kinetics of pathologic blood-brain barrier permeability in a astrocytic glioma using contrast-enhanced MR. AJNR Am J Neuroradiol 1992; 13:5-14.
    • (1992) AJNR Am J Neuroradiol , vol.13 , pp. 5-14
    • Schmiedl, U.1    Kenny, J.2    Maravilla, K.3
  • 14
    • 0023189211 scopus 로고
    • Simplified, noninvasive PET measurement of blood-brain barrier permeability
    • Iannotti F, Fieschi C, Alfano B, et al. Simplified, noninvasive PET measurement of blood-brain barrier permeability. J Comput Assist Tomogr 1987; 11:390-397.
    • (1987) J Comput Assist Tomogr , vol.11 , pp. 390-397
    • Iannotti, F.1    Fieschi, C.2    Alfano, B.3
  • 15
    • 0026000386 scopus 로고
    • Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma
    • Ott RJ, Brada M, Flower MA, Babich JW, Cherry SR, Deehan BJ. Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma. Eur J Cancer 1991; 27:1356-1361.
    • (1991) Eur J Cancer , vol.27 , pp. 1356-1361
    • Ott, R.J.1    Brada, M.2    Flower, M.A.3    Babich, J.W.4    Cherry, S.R.5    Deehan, B.J.6
  • 17
    • 0026673377 scopus 로고
    • In vivo CT measurement of blood-brain transfer constant of iopamidol in human brain tumors
    • Yeung WTI, Lee TY, Del Maestro RF, Kozak R Brown T. In vivo CT measurement of blood-brain transfer constant of iopamidol in human brain tumors. J Neurooncol 1992; 14:177-187.
    • (1992) J Neurooncol , vol.14 , pp. 177-187
    • Yeung, W.T.I.1    Lee, T.Y.2    Del Maestro, R.F.3    Kozak, R.4    Brown, T.5
  • 19
    • 0028858194 scopus 로고
    • Quantification of liver blood volume: Comparison of ultra short TI inversion recovery echo planar imaging (ULSTIR-EPI), with dynamic 3D-gradient recalled echo imaging
    • Schwickert HC, Roberts TPL, Shames DM, et al. Quantification of liver blood volume: comparison of ultra short TI inversion recovery echo planar imaging (ULSTIR-EPI), with dynamic 3D-gradient recalled echo imaging. Magn Reson Med 1995; 34:845-852.
    • (1995) Magn Reson Med , vol.34 , pp. 845-852
    • Schwickert, H.C.1    Roberts, T.P.L.2    Shames, D.M.3
  • 20
    • 0024476841 scopus 로고
    • Assessment of T1 time course changes and tissue-blood ratios after Gd-DTPA administration in brain tumors
    • Yoshida K, Furuse M, Kaneoke Y, et al. Assessment of T1 time course changes and tissue-blood ratios after Gd-DTPA administration in brain tumors. Magn Reson Imaging 1989; 7:9-15.
    • (1989) Magn Reson Imaging , vol.7 , pp. 9-15
    • Yoshida, K.1    Furuse, M.2    Kaneoke, Y.3
  • 21
    • 0344741267 scopus 로고
    • Measurement of blood brain permeability using Gd-DTPA scanning
    • Tofts PS, Kermode AG. Measurement of blood brain permeability using Gd-DTPA scanning. Magn Reson Imaging 1989; 7: 150.
    • (1989) Magn Reson Imaging , vol.7 , pp. 150
    • Tofts, P.S.1    Kermode, A.G.2
  • 22
    • 0024708886 scopus 로고
    • Blood brain permeability measured in multiple sclerosis using labelled DTPA with PET, CT and MRI
    • Tofts PS, Kermode AG. Blood brain permeability measured in multiple sclerosis using labelled DTPA with PET, CT and MRI. J Neurol Neurosurg Psychiatry 1989; 52:1019-1020.
    • (1989) J Neurol Neurosurg Psychiatry , vol.52 , pp. 1019-1020
    • Tofts, P.S.1    Kermode, A.G.2
  • 25
    • 0026549870 scopus 로고
    • Measurement of blood brain barrier permeability using dynamic Gd-DTPA scanning: A comparison of methods
    • Larsson HBW, Tofts PS. Measurement of blood brain barrier permeability using dynamic Gd-DTPA scanning: a comparison of methods. Magn Reson Med 1992; 24:174-176.
    • (1992) Magn Reson Med , vol.24 , pp. 174-176
    • Larsson, H.B.W.1    Tofts, P.S.2
  • 26
    • 0025047826 scopus 로고
    • Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors
    • Larsson HBW, Stubgaard M, Frederiksen JL, Jensen M, Henriksen O, Paulson OB. Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors. Magn Reson Med 1990; 16:117-131.
    • (1990) Magn Reson Med , vol.16 , pp. 117-131
    • Larsson, H.B.W.1    Stubgaard, M.2    Frederiksen, J.L.3    Jensen, M.4    Henriksen, O.5    Paulson, O.B.6
  • 27
    • 0026011540 scopus 로고
    • Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging: 1. Fundamental concepts
    • Tofts PS, Kermode AG. Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging: 1. Fundamental concepts. Magn Reson Med 1991; 17:357-367.
    • (1991) Magn Reson Med , vol.17 , pp. 357-367
    • Tofts, P.S.1    Kermode, A.G.2
  • 30
    • 18244422938 scopus 로고
    • Non-invasive measurement of human blood-brain barrier transfer constant using dynamic magnetic resonance imaging
    • Kermode AG, Tofts PS. Non-invasive measurement of human blood-brain barrier transfer constant using dynamic magnetic resonance imaging. J Physiol 1990; 423:42P.
    • (1990) J Physiol , vol.423
    • Kermode, A.G.1    Tofts, P.S.2
  • 31
    • 0021727964 scopus 로고
    • Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers
    • Weinmann HJ, Laniado M, Mutzel W. Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers. Physiol Chem Phys Med NMR 1984; 16:167-172.
    • (1984) Physiol Chem Phys Med NMR , vol.16 , pp. 167-172
    • Weinmann, H.J.1    Laniado, M.2    Mutzel, W.3
  • 32
    • 0000121417 scopus 로고
    • Rapid measurement of capillary permeability using the early part of the dynamic Gd-DTPA MRI enhancement curve
    • Tofts PS, Berkowitz BA. Rapid measurement of capillary permeability using the early part of the dynamic Gd-DTPA MRI enhancement curve. J Magn Reson (part B) 1993; 102:129-136.
    • (1993) J Magn Reson (Part B) , vol.102 , pp. 129-136
    • Tofts, P.S.1    Berkowitz, B.A.2
  • 33
    • 0026620241 scopus 로고
    • Accurate and precise measurement of blood-retinal barrier breakdown using dynamic Gd-DTPA MRI
    • Berkowitz BA, Tofts PS, Sen HA, Ando N, de Juan E. Accurate and precise measurement of blood-retinal barrier breakdown using dynamic Gd-DTPA MRI. Invest Ophthalmol Vis Sci 1992; 33:3500-3506.
    • (1992) Invest Ophthalmol Vis Sci , vol.33 , pp. 3500-3506
    • Berkowitz, B.A.1    Tofts, P.S.2    Sen, H.A.3    Ando, N.4    De Juan, E.5
  • 34
    • 0028134490 scopus 로고
    • Effect of vitreous fluidity on the measurement of blood-retinal barrier permeability using contrast enhanced MRI
    • Berkowitz BA, Wilson CA, Tofts PS, Peshock RM. Effect of vitreous fluidity on the measurement of blood-retinal barrier permeability using contrast enhanced MRI. Magn Reson Med 1994; 31:61-66.
    • (1994) Magn Reson Med , vol.31 , pp. 61-66
    • Berkowitz, B.A.1    Wilson, C.A.2    Tofts, P.S.3    Peshock, R.M.4
  • 35
    • 0028120762 scopus 로고
    • Measurement of capillary permeability from the Gd enhancement curve: A comparison of bolus and constant infusion injection methods
    • Tofts PS, Berkowitz B. Measurement of capillary permeability from the Gd enhancement curve: a comparison of bolus and constant infusion injection methods. Magn Reson Imaging 1994; 12:81-91.
    • (1994) Magn Reson Imaging , vol.12 , pp. 81-91
    • Tofts, P.S.1    Berkowitz, B.2
  • 36
    • 0028963102 scopus 로고
    • Quantitative analysis of dynamic Gd-DTPA enhancement in breast tumours using a permeability model
    • Tofts PS, Berkowitz B, Schnall M. Quantitative analysis of dynamic Gd-DTPA enhancement in breast tumours using a permeability model. Magn Reson Med 1995; 33:564-568.
    • (1995) Magn Reson Med , vol.33 , pp. 564-568
    • Tofts, P.S.1    Berkowitz, B.2    Schnall, M.3
  • 37
    • 0029946531 scopus 로고    scopus 로고
    • Dynamic contrast enhanced magnetic resonance imaging reveals stress induced angiogenesis in MCF7 human breast tumors
    • Furman-Haran E, Margalit R, Grobgeld D, Degani H. Dynamic contrast enhanced magnetic resonance imaging reveals stress induced angiogenesis in MCF7 human breast tumors. PNAS 1996; 93:6247-6251.
    • (1996) PNAS , vol.93 , pp. 6247-6251
    • Furman-Haran, E.1    Margalit, R.2    Grobgeld, D.3    Degani, H.4
  • 38
    • 0029930790 scopus 로고    scopus 로고
    • Optimal detection of blood-brain barrier defects with Gd-DTPA: The influences of delayed imaging and optimised repetition time
    • Tofts PS. Optimal detection of blood-brain barrier defects with Gd-DTPA: the influences of delayed imaging and optimised repetition time. Magn Reson Imaging 1996; 14:373-380.
    • (1996) Magn Reson Imaging , vol.14 , pp. 373-380
    • Tofts, P.S.1
  • 41
    • 0028432267 scopus 로고
    • In vivo quantification of the unidirectional influx constant for Gd-diffusion across myocardial capillaries with MR imaging
    • Larsson HBW, Stubgaard M, Sondergaard L, Henriksen O. In vivo quantification of the unidirectional influx constant for Gd-diffusion across myocardial capillaries with MR imaging. J Magn Reson Imaging 1994; 4:433-440.
    • (1994) J Magn Reson Imaging , vol.4 , pp. 433-440
    • Larsson, H.B.W.1    Stubgaard, M.2    Sondergaard, L.3    Henriksen, O.4
  • 43
    • 0029761382 scopus 로고    scopus 로고
    • Measurement of the arterial concentration of Gd-DTPA using MRI: A step towards quantitative perfusion imaging
    • Fritz-Hansen T, Rostrup E, Larsson HBW, Sondergaard L. Ring P, Henriksen O. Measurement of the arterial concentration of Gd-DTPA using MRI: a step towards quantitative perfusion imaging. Magn Reson Med 1996; 35:225-231.
    • (1996) Magn Reson Med , vol.35 , pp. 225-231
    • Fritz-Hansen, T.1    Rostrup, E.2    Larsson, H.B.W.3    Sondergaard, L.4    Ring, P.5    Henriksen, O.6
  • 44
    • 0026527120 scopus 로고
    • Quantification of myocardial blood flow and extracellular volumes using a bolus injection of Gd-DTPA: Kinetic modeling in canine ischaemic tissue
    • Diesbourg LD, Prato FS, Wisenberg G, Drost DJ, Marshall TP, Carroll SE, O'Neill B. Quantification of myocardial blood flow and extracellular volumes using a bolus injection of Gd-DTPA: kinetic modeling in canine ischaemic tissue. Magn Reson Med 1992; 23:239-253.
    • (1992) Magn Reson Med , vol.23 , pp. 239-253
    • Diesbourg, L.D.1    Prato, F.S.2    Wisenberg, G.3    Drost, D.J.4    Marshall, T.P.5    Carroll, S.E.6    O'Neill, B.7
  • 45
    • 0025870664 scopus 로고
    • Factors in myocardial "perfusion" imaging with ultrafast MRI and Gd-DTPA administration
    • Burstein D, Taratuta E, Manning WJ. Factors in myocardial "perfusion" imaging with ultrafast MRI and Gd-DTPA administration. Magn Reson Med 1991; 20:299-305.
    • (1991) Magn Reson Med , vol.20 , pp. 299-305
    • Burstein, D.1    Taratuta, E.2    Manning, W.J.3
  • 46
    • 84889180817 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof.
  • 47
    • 0028917193 scopus 로고
    • Pharmacokinetic mapping of the breast: A new method for dynamic MR mammography
    • Hoffmann U, Brix G, Knopp MV, Hess T, Lorenz WJ. Pharmacokinetic mapping of the breast: a new method for dynamic MR mammography. Magn Reson Med 1995; 33:506-514.
    • (1995) Magn Reson Med , vol.33 , pp. 506-514
    • Hoffmann, U.1    Brix, G.2    Knopp, M.V.3    Hess, T.4    Lorenz, W.J.5
  • 48
    • 0028099603 scopus 로고
    • Quantitative analysis of multi-slice Gd-DTPA enhanced dynamic MR images using an automated simplex minimisation procedure
    • Buckley DL, Kerslake RW, Blackband SJ, Horsman A. Quantitative analysis of multi-slice Gd-DTPA enhanced dynamic MR images using an automated simplex minimisation procedure. Magn Reson Med 1994; 32:646-651.
    • (1994) Magn Reson Med , vol.32 , pp. 646-651
    • Buckley, D.L.1    Kerslake, R.W.2    Blackband, S.J.3    Horsman, A.4
  • 49
    • 0027198943 scopus 로고
    • Quantification of tissue plasma volume in the rat by contrast-enhanced magnetic resonance imaging
    • Kuwatsuru R, Shames DM, Muhler A, et al. Quantification of tissue plasma volume in the rat by contrast-enhanced magnetic resonance imaging. Magn Reson Med 1993; 30:76-81.
    • (1993) Magn Reson Med , vol.30 , pp. 76-81
    • Kuwatsuru, R.1    Shames, D.M.2    Muhler, A.3
  • 50
    • 0028065477 scopus 로고
    • Measurement of vascular volume fraction and blood-tissue permeability constants with a pharmacokinetic model: Studies in rat muscle tumors with dynamic Gd-DTPA enhanced MRI
    • Su M, Jao J, Nalcioglu O. Measurement of vascular volume fraction and blood-tissue permeability constants with a pharmacokinetic model: studies in rat muscle tumors with dynamic Gd-DTPA enhanced MRI. Magn Reson Med 1994; 32:714-724.
    • (1994) Magn Reson Med , vol.32 , pp. 714-724
    • Su, M.1    Jao, J.2    Nalcioglu, O.3
  • 51
    • 0026738081 scopus 로고
    • Dynamic studies of gadolinium uptake in brain tumors using inversion-recovery echo-planar imaging
    • Gowland P, Mansfield P, Bullock P, Stehling M, Worthington B, Firth J. Dynamic studies of gadolinium uptake in brain tumors using inversion-recovery echo-planar imaging. Magn Reson Med 1992; 26:241-258.
    • (1992) Magn Reson Med , vol.26 , pp. 241-258
    • Gowland, P.1    Mansfield, P.2    Bullock, P.3    Stehling, M.4    Worthington, B.5    Firth, J.6
  • 52
    • 0027197952 scopus 로고
    • Differentiation of benign from malignant breast masses by time-intensity evaluation of contrast enhanced MRI
    • Flickinger FW, Allison JD, Sherry RM, Wright JC. Differentiation of benign from malignant breast masses by time-intensity evaluation of contrast enhanced MRI. Magn Reson Imaging 1993; 11:617-620.
    • (1993) Magn Reson Imaging , vol.11 , pp. 617-620
    • Flickinger, F.W.1    Allison, J.D.2    Sherry, R.M.3    Wright, J.C.4
  • 55
    • 0027445259 scopus 로고
    • A rapid interleaved method for measuring signal intensity curves in both blood and tissue during contrast agent administration
    • Taylor NJ, Rowland IJ, Tanner SF, Leach MO. A rapid interleaved method for measuring signal intensity curves in both blood and tissue during contrast agent administration. Magn Reson Med 1993; 30:744-749.
    • (1993) Magn Reson Med , vol.30 , pp. 744-749
    • Taylor, N.J.1    Rowland, I.J.2    Tanner, S.F.3    Leach, M.O.4
  • 57
    • 0028239980 scopus 로고
    • Studies of Gd-DTPA relaxivity and proton exchange rates in tissue
    • Donahue KM, Burstein D, Manning WJ, Gray ML. Studies of Gd-DTPA relaxivity and proton exchange rates in tissue. Magn Reson Med 1994; 32:66-76.
    • (1994) Magn Reson Med , vol.32 , pp. 66-76
    • Donahue, K.M.1    Burstein, D.2    Manning, W.J.3    Gray, M.L.4
  • 58
    • 0030003119 scopus 로고    scopus 로고
    • The relaxivity of Gd-EOB-DTPA and Gd-DTPA in liver and kidney of the Wistar rat
    • Shuter B, Tofts PS, Wang SC, Pope JM. The relaxivity of Gd-EOB-DTPA and Gd-DTPA In liver and kidney of the Wistar rat. Magn Reson Imaging 1996; 14:243-253.
    • (1996) Magn Reson Imaging , vol.14 , pp. 243-253
    • Shuter, B.1    Tofts, P.S.2    Wang, S.C.3    Pope, J.M.4
  • 59
    • 0027529272 scopus 로고
    • Ni-DTPA doped agarose gel: A phantom material for Gd-DTPA enhancement measurements
    • PS Tofts, B Shuter and JM Pope. Ni-DTPA doped agarose gel: a phantom material for Gd-DTPA enhancement measurements. Magn Reson Imaging 1993; 11:125-133.
    • (1993) Magn Reson Imaging , vol.11 , pp. 125-133
    • Tofts, P.S.1    Shuter, B.2    Pope, J.M.3


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