Integrin-facilitated transcytosis for enhanced penetration of advanced gliomas by poly(trimethylene carbonate)-based nanoparticles encapsulating paclitaxel

Biomaterials

Volumn 34, Issue 12, 2013, Pages 2969-2979

  Jiang, Xinyi ^a,b   Sha, Xianyi ^a   Xin, Hongliang ^a,c   Xu, Ximing ^b   Gu, Jijin ^a   Xia, Weiyi ^a   Chen, Shuo ^a   Xie, Yike ^a   Chen, Liangcen ^a   Chen, Yanzuo ^a   Fang, Xiaoling ^a  

^a FUDAN UNIVERSITY   (China)

^b JIANGSU UNIVERSITY   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Advanced gliomas; Anti glioma efficacy; Endocytic mechanism; Glioma penetration; Glioma spheroids; In vivo toxicity; PEG PTMC

Indexed keywords

ADVANCED GLIOMAS; ANTI-GLIOMA EFFICACY; GLIOMA PENETRATION; GLIOMA SPHEROIDS; IN-VIVO; PEG-PTMC;

BIOCHEMISTRY; CELL MEMBRANES; CHEMOTHERAPY; MAMMALS; NANOPARTICLES; THREE DIMENSIONAL COMPUTER GRAPHICS; TOXICITY;

TUMORS;

ARGINYLGLYCYLASPARTIC ACID; CARBONIC ACID DERIVATIVE; CYCLIC ARGINYLGLYCYLASPARTIC ACID FUNCTIONALIZED POLY(TRIMETHYLENE CARBONATE) BASED MICELLAR NANOPARTICULATE SYSTEM; CYCLOPROPANE; NANOPARTICLE; PACLITAXEL; POLY(TRIMETHYLENE CARBONATE); UNCLASSIFIED DRUG;

ADVANCED CANCER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CELL COUNT; CELL HOMING; CELL SURFACE; CONTROLLED STUDY; DRUG PENETRATION; FEMALE; GLIOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME; TRANSCYTOSIS;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BRAIN NEOPLASMS; CELL LINE, TUMOR; DIOXANES; DRUG CARRIERS; GLIOMA; HUMANS; INTEGRINS; MICE; MICE, INBRED BALB C; NANOPARTICLES; PACLITAXEL; POLYMERS; TRANSCYTOSIS;

MUS;

EID: 84873441992     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.12.049     Document Type: Article

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