Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma

Ultrasound in Medicine and Biology

Volumn 38, Issue 10, 2012, Pages 1716-1725

  Treat, Lisa H ^a,b   McDannold, Nathan ^b   Zhang, Yongzhi ^b   Vykhodtseva, Natalia ^b   Hynynen, Kullervo ^c  

^a HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

9L gliosarcoma; Blood brain barrier; Doxorubicin; Focused ultrasound; Survival

Indexed keywords

9L GLIOSARCOMA; BLOOD-BRAIN BARRIER; DOXORUBICIN; FOCUSED ULTRASOUND; SURVIVAL;

BLOOD; DRUG DELIVERY; ENZYME INHIBITION; MAGNETIC RESONANCE IMAGING; RATS; TUMORS;

ULTRASONICS;

DOXORUBICIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; GLIOMA; GLIOMA CELL; GLIOSARCOMAL CELL; HIGH INTENSITY FOCUSED ULTRASOUND; HISTOPATHOLOGY; INOCULATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SURVIVAL TIME;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CELL LINE, TUMOR; DOXORUBICIN; GLIOSARCOMA; LIPOSOMES; MAGNETIC RESONANCE IMAGING, INTERVENTIONAL; MALE; MICROBUBBLES; RATS; RATS, SPRAGUE-DAWLEY; SONICATION; TREATMENT OUTCOME;

EID: 84865766754     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2012.04.015     Document Type: Article

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