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Volumn 23, Issue 5, 1998, Pages 635-644

Blood-brain barrier carrier-mediated transport and brain metabolism of amino acids

Author keywords

Albumin; Aspartame; Cerebral microvasculature; Phenylalanine; Protein synthesis; Tryptophan

Indexed keywords

ALBUMIN; AMINO ACID; AMINOACYL TRANSFER RNA; ASPARTAME; PHENYLALANINE; TRYPTOPHAN;

EID: 0031898769     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022482604276     Document Type: Article
Times cited : (239)

References (42)
  • 1
    • 0015186836 scopus 로고
    • Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
    • Oldendorf, W. H. 1971. Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am. J. Physiol. 221: 1629-1639.
    • (1971) Am. J. Physiol. , vol.221 , pp. 1629-1639
    • Oldendorf, W.H.1
  • 2
    • 0017689969 scopus 로고
    • Morphology of blood-brain interfaces
    • Brightman, M. W. 1977. Morphology of blood-brain interfaces. Exp. Eye Res. 25(Suppl.):1-25.
    • (1977) Exp. Eye Res. , vol.25 , Issue.SUPPL. , pp. 1-25
    • Brightman, M.W.1
  • 3
    • 0000212114 scopus 로고
    • Regulation of amino acid availability to the brain
    • Wurtman, R. J., and Wurtman, J. J., (eds.), Raven Press, New York
    • Pardridge, W. M. 1977. Regulation of amino acid availability to the brain. Pages 141-204, in Wurtman, R. J., and Wurtman, J. J., (eds.), Nutrition and the Brain, Raven Press, New York.
    • (1977) Nutrition and the Brain , pp. 141-204
    • Pardridge, W.M.1
  • 4
    • 0017600519 scopus 로고
    • Transport of metabolic substrates through the blood-brain barrier
    • Pardridge, W. M., and Oldendorf, W. H. 1977. Transport of metabolic substrates through the blood-brain barrier. J. Neurochem. 28:5-12.
    • (1977) J. Neurochem. , vol.28 , pp. 5-12
    • Pardridge, W.M.1    Oldendorf, W.H.2
  • 5
    • 0021020420 scopus 로고
    • Brain metabolism: A perspective from the blood-brain barrier
    • Pardridge, W. M. 1983. Brain metabolism: A perspective from the blood-brain barrier. Physiol. Rev. 63:1481-1535.
    • (1983) Physiol. Rev. , vol.63 , pp. 1481-1535
    • Pardridge, W.M.1
  • 7
    • 0015074912 scopus 로고
    • Brain uptake of selenomethionine Se75. II. Reduced brain uptake of selenomethionine Se75 in phenylketonuria
    • Oldendorf, W. H., Sisson, W. B., and Silverstein, A. 1971. Brain uptake of selenomethionine Se75. II. Reduced brain uptake of selenomethionine Se75 in phenylketonuria. Arch Neurol. 24:524.
    • (1971) Arch Neurol. , vol.24 , pp. 524
    • Oldendorf, W.H.1    Sisson, W.B.2    Silverstein, A.3
  • 8
    • 0016715315 scopus 로고
    • Kinetic analysis of blood-brain barrier transport of amino acids
    • Pardridge, W. M., and Oldendorf, W. H. 1975. Kinetic analysis of blood-brain barrier transport of amino acids. Biochim. Biophys. Acta. 401:128-136.
    • (1975) Biochim. Biophys. Acta , vol.401 , pp. 128-136
    • Pardridge, W.M.1    Oldendorf, W.H.2
  • 9
    • 0002734767 scopus 로고    scopus 로고
    • Biology of the blood-brain glucose transporter
    • Pardridge, W. M. (ed.), Cambridge University Press, in press
    • Drewes, L. R. 1998. Biology of the blood-brain glucose transporter, in Pardridge, W. M. (ed.), An Introduction to the Blood-Brain Barrier: Methodology and Biology, Cambridge University Press, in press.
    • (1998) An Introduction to the Blood-Brain Barrier: Methodology and Biology
    • Drewes, L.R.1
  • 10
    • 0029892792 scopus 로고    scopus 로고
    • Molecular biology of mammalian amino acid transporters
    • Malandro, M. S., and Kilberg, M. S. 1996. Molecular biology of mammalian amino acid transporters. Annu. Rev. Biochem. 65: 305-36.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 305-336
    • Malandro, M.S.1    Kilberg, M.S.2
  • 11
    • 0014888279 scopus 로고
    • Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard
    • Oldendorf, W. H. 1970. Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard. Brain Res. 24:372.
    • (1970) Brain Res. , vol.24 , pp. 372
    • Oldendorf, W.H.1
  • 12
    • 0016671063 scopus 로고
    • Kinetics of blood-brain barrier transport of hexoses
    • Pardridge, W. M., and Oldendorf, W. H. 1975. Kinetics of blood-brain barrier transport of hexoses. Biochim. Biophys. Acta. 382: 377-392.
    • (1975) Biochim. Biophys. Acta , vol.382 , pp. 377-392
    • Pardridge, W.M.1    Oldendorf, W.H.2
  • 13
    • 0017335853 scopus 로고
    • Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier
    • Pardridge, W. M. 1977. Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier. J. Neurochem. 28:103-108.
    • (1977) J. Neurochem. , vol.28 , pp. 103-108
    • Pardridge, W.M.1
  • 14
    • 0020044879 scopus 로고
    • Kinetics of neutral amino acid transport through the blood-brain barrier of the new-born rabbit
    • Pardridge, W. M., and Mietus, L. J. 1982. Kinetics of neutral amino acid transport through the blood-brain barrier of the new-born rabbit. J. Neurochem. 38:955-962.
    • (1982) J. Neurochem. , vol.38 , pp. 955-962
    • Pardridge, W.M.1    Mietus, L.J.2
  • 15
    • 0022196660 scopus 로고
    • Kinetic constants for blood-brain barrier amino acid transport in conscious rats
    • Miller, L. P., Pardridge, W. M., Braun, L. D., and Oldendorf, W. H. 1985. Kinetic constants for blood-brain barrier amino acid transport in conscious rats. J. Neurochem. 45:1427-1432.
    • (1985) J. Neurochem. , vol.45 , pp. 1427-1432
    • Miller, L.P.1    Pardridge, W.M.2    Braun, L.D.3    Oldendorf, W.H.4
  • 18
    • 0022966985 scopus 로고
    • Phenylalanine transport at the human blood-brain barrier. Studies in isolated human brain capillaries
    • Choi, T., and Pardridge, W. M. 1986. Phenylalanine transport at the human blood-brain barrier. Studies in isolated human brain capillaries. J. Biol. Chem. 261:6536-6541.
    • (1986) J. Biol. Chem. , vol.261 , pp. 6536-6541
    • Choi, T.1    Pardridge, W.M.2
  • 19
    • 0024230927 scopus 로고
    • Neutral amino acid transport at the human blood-brain barrier
    • Hargreaves, K. M., and Pardridge, W. M. 1988. Neutral amino acid transport at the human blood-brain barrier. J. Biol. Chem. 263:19392-19397.
    • (1988) J. Biol. Chem. , vol.263 , pp. 19392-19397
    • Hargreaves, K.M.1    Pardridge, W.M.2
  • 20
    • 0023634699 scopus 로고
    • Kinetics of neutral amino acid transport across the blood-brain barrier
    • Smith, Q. R., Aoyagi, M., Robinson, P. J., and Rapoport, S. I. 1987. Kinetics of neutral amino acid transport across the blood-brain barrier. J. Neurochem. 49:1651-1658.
    • (1987) J. Neurochem. , vol.49 , pp. 1651-1658
    • Smith, Q.R.1    Aoyagi, M.2    Robinson, P.J.3    Rapoport, S.I.4
  • 21
    • 0014458686 scopus 로고
    • Some special kinetic problems of transport
    • Christensen, H. N. 1969. Some special kinetic problems of transport. Adv. Enzymol. 32:1-20.
    • (1969) Adv. Enzymol. , vol.32 , pp. 1-20
    • Christensen, H.N.1
  • 22
    • 0015526241 scopus 로고
    • Brain serotonin content-physiological regulation by plasma neutral amino acids
    • Fernstrom, J. D., and Wurtman, R. J. 1972. Brain serotonin content-physiological regulation by plasma neutral amino acids. Science. 178:414-416.
    • (1972) Science , vol.178 , pp. 414-416
    • Fernstrom, J.D.1    Wurtman, R.J.2
  • 23
    • 0016591488 scopus 로고
    • Insulin, plasma aminoaid imbalance, and hepatic coma
    • Munro, H. N., Fernstrom, J. D., and Wurtman, R. J. 1975. Insulin, plasma aminoaid imbalance, and hepatic coma. Lancet. 1:722-726.
    • (1975) Lancet , vol.1 , pp. 722-726
    • Munro, H.N.1    Fernstrom, J.D.2    Wurtman, R.J.3
  • 24
    • 0016841918 scopus 로고
    • Tryptophan and hepatic encephalopathy
    • Pardridge, W. M. 1975. Tryptophan and hepatic encephalopathy. The Lancet. 1:1035.
    • (1975) The Lancet , vol.1 , pp. 1035
    • Pardridge, W.M.1
  • 25
    • 0018091132 scopus 로고
    • Blood-brain neutral amino acid transport activity is increased after portacaval anastomosis
    • James, J. H., Escourrou, J., and Fischer, J. E. 1978. Blood-brain neutral amino acid transport activity is increased after portacaval anastomosis. Science. 200:1395-1397.
    • (1978) Science , vol.200 , pp. 1395-1397
    • James, J.H.1    Escourrou, J.2    Fischer, J.E.3
  • 26
    • 0028227096 scopus 로고
    • Structure of serum albumin
    • Carter, D. C., and He, J. X. 1994. Structure of serum albumin. Adv. Protein Chem. 45:153-203.
    • (1994) Adv. Protein Chem. , vol.45 , pp. 153-203
    • Carter, D.C.1    He, J.X.2
  • 27
    • 0002761145 scopus 로고
    • Serum albumin: Amino acid sequence
    • Rosehoer, V. M., Oratz, M., and Rothschild, M. A. (eds.), Pergamon Press, New York
    • Brown, J. R. 1977. Serum albumin: Amino acid sequence. Pages 27-51, in Rosehoer, V. M., Oratz, M., and Rothschild, M. A. (eds.), Albumin Structure, Function, and Uses, Pergamon Press, New York.
    • (1977) Albumin Structure, Function, and Uses , pp. 27-51
    • Brown, J.R.1
  • 28
    • 0020376406 scopus 로고
    • The kinetics of the binding of warfarin to human serum albumin as studied by stopped-flow spectrophotometry
    • Wilting, J., Kremer, J. M. H., Ijzerman, A. P., and Schulman, G. 1982. The kinetics of the binding of warfarin to human serum albumin as studied by stopped-flow spectrophotometry. Biochim. Biophys. Acta. 706:96-104.
    • (1982) Biochim. Biophys. Acta , vol.706 , pp. 96-104
    • Wilting, J.1    Kremer, J.M.H.2    Ijzerman, A.P.3    Schulman, G.4
  • 29
    • 0024334522 scopus 로고
    • The albumin receptor effect may be due to a surface-induced conformational change in albumin
    • Reed, R. G., and Burrington, C. M. 1989. The albumin receptor effect may be due to a surface-induced conformational change in albumin. J. Biol. Chem. 264:9867-9872.
    • (1989) J. Biol. Chem. , vol.264 , pp. 9867-9872
    • Reed, R.G.1    Burrington, C.M.2
  • 30
    • 0038226498 scopus 로고    scopus 로고
    • Targeted delivery of hormones to tissues by plasma proteins
    • in press. Conn, P. M. (ed.), Oxford University Press, New York
    • Pardridge, W. M. 1998, in press. Targeted delivery of hormones to tissues by plasma proteins. In Conn, P. M. (ed.), Handbook of Physiology - Cellular Mechanisms, Oxford University Press, New York.
    • (1998) Handbook of Physiology - Cellular Mechanisms
    • Pardridge, W.M.1
  • 31
    • 0025230840 scopus 로고
    • Transport of tryptophan into brain from the circulating albumin-bound pool in rats and in rabbits
    • Pardridge, W. M., and Fierer, G. 1990. Transport of tryptophan into brain from the circulating albumin-bound pool in rats and in rabbits. J. Neurochem. 54:971-976.
    • (1990) J. Neurochem. , vol.54 , pp. 971-976
    • Pardridge, W.M.1    Fierer, G.2
  • 32
    • 0020354211 scopus 로고
    • The effects of chronic hyperphenylalaninemia on mouse brain protein synthesis can be prevented by other amino acids
    • Binek-Singer, P., and Johnson, T. C. 1982. The effects of chronic hyperphenylalaninemia on mouse brain protein synthesis can be prevented by other amino acids. Biochem. J. 206:407-414.
    • (1982) Biochem. J. , vol.206 , pp. 407-414
    • Binek-Singer, P.1    Johnson, T.C.2
  • 33
    • 0025237420 scopus 로고
    • Measurement of free-intracellular and transfer RNA amino acid specific activity and protein synthesis in rat brain in vivo
    • Hargreaves-Wall, K. M., Buciak, J. B., and Pardridge, W. M. 1990. Measurement of free-intracellular and transfer RNA amino acid specific activity and protein synthesis in rat brain in vivo. J. Cerebral Blood Flow Metabol. 10:162-169.
    • (1990) J. Cerebral Blood Flow Metabol. , vol.10 , pp. 162-169
    • Hargreaves-Wall, K.M.1    Buciak, J.B.2    Pardridge, W.M.3
  • 34
    • 0025280664 scopus 로고
    • Decreases in brain protein synthesis elicited by moderate increases in plasma phenylalanine
    • Wall, K. M., and Pardridge, W. M. 1990. Decreases in brain protein synthesis elicited by moderate increases in plasma phenylalanine. Biochem. Biophys. Res. Comm. 168:1177-1183.
    • (1990) Biochem. Biophys. Res. Comm. , vol.168 , pp. 1177-1183
    • Wall, K.M.1    Pardridge, W.M.2
  • 35
    • 0024209795 scopus 로고
    • Measurement of local cerebral protein synthesis in vivo: Influence of recycling of amino acids derived from protein degradation
    • Smith, C. B., Deibler, G. E., Eng, N., Schmidt, K., and Sokoloff, L. 1988. Measurement of local cerebral protein synthesis in vivo: Influence of recycling of amino acids derived from protein degradation. Proc. Natl. Acad. Sci. USA 85:9341-9345.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9341-9345
    • Smith, C.B.1    Deibler, G.E.2    Eng, N.3    Schmidt, K.4    Sokoloff, L.5
  • 36
    • 0023284380 scopus 로고
    • Changes in brain metabolism in hepatic encephalopathy
    • Hawkins, R. A., Mans, A. M., and Biebuyck, J. F. 1987. Changes in brain metabolism in hepatic encephalopathy. Neurochem. Pathol. 6:35-66.
    • (1987) Neurochem. Pathol. , vol.6 , pp. 35-66
    • Hawkins, R.A.1    Mans, A.M.2    Biebuyck, J.F.3
  • 37
    • 0013542826 scopus 로고
    • Effect of aspartame on plasma phenylalanine concentration in humans
    • Wurtman, R. J. and Ritter-Walker E. (eds.), Center for Brain Sciences and Metabolism Charitable Trust, Mass.
    • Filer, L. J. Jr., and Stegink, L. D. 1987. Effect of aspartame on plasma phenylalanine concentration in humans. Pages 25-56, in Wurtman, R. J. and Ritter-Walker E. (eds.), Dietary Phenylalanine and Brain Function, Center for Brain Sciences and Metabolism Charitable Trust, Mass.
    • (1987) Dietary Phenylalanine and Brain Function , pp. 25-56
    • Filer Jr., L.J.1    Stegink, L.D.2
  • 38
    • 0021040495 scopus 로고
    • Effects of untreated maternal phenylketonuria and hyperphenylalaninemia on the fetus
    • Levy, H. L., and Waisbren, S. E. 1983. Effects of untreated maternal phenylketonuria and hyperphenylalaninemia on the fetus. N. Engl. J. Med., 309:1269-1274.
    • (1983) N. Engl. J. Med. , vol.309 , pp. 1269-1274
    • Levy, H.L.1    Waisbren, S.E.2
  • 39
    • 0006313329 scopus 로고
    • Potential effects of the dipeptide sweetener aspartame on the brain
    • Wurtman, R. J., and Wurtman, J. J. (eds.), Raven Press, New York
    • Pardridge, W. M. 1986. Potential effects of the dipeptide sweetener aspartame on the brain. Pages 199-241, in Wurtman, R. J., and Wurtman, J. J. (eds.), Nutrition and the Brain, Vol. 7, Raven Press, New York.
    • (1986) Nutrition and the Brain , vol.7 , pp. 199-241
    • Pardridge, W.M.1
  • 40
    • 0021770948 scopus 로고
    • More on untreated maternal hyperphenylalaninemia
    • Kirkman, H. N. Jr., and Hicks, R. E. 1984. More on untreated maternal hyperphenylalaninemia. N. Engl. J. Med. 311:1125.
    • (1984) N. Engl. J. Med. , vol.311 , pp. 1125
    • Kirkman Jr., H.N.1    Hicks, R.E.2
  • 41
    • 0021990680 scopus 로고
    • Biochemical and neuropsychological effects of elevated plasma phenylalanine in patients with treated phenylketonuria
    • Krause, W., Halminski, M., McDonald, L., Dembure, P., Salvo, R., Freides, D., and Elsas, L. 1985. Biochemical and neuropsychological effects of elevated plasma phenylalanine in patients with treated phenylketonuria. J. Clin. Invest. 75:40-48.
    • (1985) J. Clin. Invest. , vol.75 , pp. 40-48
    • Krause, W.1    Halminski, M.2    McDonald, L.3    Dembure, P.4    Salvo, R.5    Freides, D.6    Elsas, L.7
  • 42
    • 0040811032 scopus 로고
    • Phenylalanine transport at the human blood-brain barrier
    • Kaufman, S. (ed.), Alan R. Liss, Inc., New York
    • Pardridge, W. M. 1987. Phenylalanine transport at the human blood-brain barrier. Pages 43-64, in Kaufman, S. (ed.), Amino Acids in Health and Disease: New Perspectives, Alan R. Liss, Inc., New York.
    • (1987) Amino Acids in Health and Disease: New Perspectives , pp. 43-64
    • Pardridge, W.M.1


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