Structure, energetics, and dynamics of binding coactivator peptide to the human retinoid X receptor α ligand binding domain complex with 9- cis -retinoic acid

Biochemistry

Volumn 50, Issue 1, 2011, Pages 93-105

  Xia, Gang ^a   Boerma, Leeann J ^b   Cox, Bryan D ^a   Qiu, Cheng ^a   Kang, Sebyung ^b   Smith, Craig D ^a   Renfrow, Matthew B ^b   Muccio, Donald D ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOUND STRUCTURE; COACTIVATORS; EXCHANGE RATES; GENE TRANSCRIPTIONS; HOMODIMERS; HYDROGEN-DEUTERIUM EXCHANGE; IONIC INTERACTION; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING DOMAIN; MASS SPECTROSCOPY; NUCLEAR RECEPTORS; PEPTIDE BINDING; RETINOIC ACIDS; RETINOID X RECEPTOR; RING CONFORMATIONS; SALT BRIDGES; STRUCTURAL CHANGE; TEMPERATURE INDEPENDENTS; UV SPECTRUM;

DEUTERIUM; LIGANDS; MASS SPECTROMETRY; PEPTIDES; TRANSCRIPTION; TRANSCRIPTION FACTORS; ULTRAVIOLET SPECTROSCOPY;

CRYSTAL STRUCTURE;

ALITRETINOIN; BINDING PROTEIN; HOMODIMER; RETINOID X RECEPTOR ALPHA;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENERGY TRANSFER; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR RECEPTOR COACTIVATOR 2; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RETINOID X RECEPTOR ALPHA; SPECTROPHOTOMETRY, ULTRAVIOLET; THERMODYNAMICS; TRETINOIN;

EID: 78650890042     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101288y     Document Type: Article

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