FXR agonist activity of conformationally constrained analogs of GW 4064

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4733-4739

  Akwabi Ameyaw, Adwoa ^a   Bass, Jonathan Y ^a   Caldwell, Richard D ^a   Caravella, Justin A ^a   Chen, Lihong ^a   Creech, Katrina L ^a   Deaton, David N ^a   Madauss, Kevin P ^a   Marr, Harry B ^a   McFadyen, Robert B ^a   Miller, Aaron B ^a   Navas III, Frank ^a   Parks, Derek J ^a   Spearing, Paul K ^a   Todd, Dan ^a   Williams, Shawn P ^a   Bruce Wisely, G ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Farnesoid X receptor; FXR; Nuclear receptor

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; BENZOTHIOPHENE; BENZOTHIOPHENE DERIVATIVE; FARNESOID X RECEPTOR; FARNESOID X RECEPTOR AGONIST; INDOLE DERIVATIVE; NAPHTHALENE; NAPHTHALENE DERIVATIVE; STILBENE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONFORMATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ANALYSIS;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; ISOXAZOLES; NAPHTHALENES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 67651108945     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.062     Document Type: Article

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