Conformational changes of the glucocorticoid receptor ligand binding domain induced by ligand and cofactor binding, and the location of cofactor binding sites determined by hydrogen/deuterium exchange mass spectrometry

Protein Science

Volumn 15, Issue 4, 2006, Pages 722-730

  Frego, Lee ^a   Davidson, Walter ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Glucocorticoid receptor; H D exchange; Mass spectrometry

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; MIFEPRISTONE; NUCLEAR RECEPTOR COACTIVATOR 2; NUCLEAR RECEPTOR COREPRESSOR;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; DRUG BINDING; DRUG STRUCTURE; ESCHERICHIA COLI; LIGAND BINDING; MASS SPECTROMETRY; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; DEXAMETHASONE; HUMANS; LIGANDS; MASS SPECTROMETRY; MIFEPRISTONE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; NUCLEAR RECEPTOR COACTIVATOR 2; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCOCORTICOID; REPRESSOR PROTEINS;

ESCHERICHIA COLI;

EID: 33645512016     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.051781406     Document Type: Article

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