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Volumn 20, Issue 24, 2014, Pages 3863-3874

Pharmacogenetics of non-small cell lung cancer (NSCLC): Time to "work it out"?

Author keywords

Chemotherapy; Genotype phenotype; New targeted anti EGFR agents; Novel methodologies and trials; NSCLC; Pharmacogenetics

Indexed keywords

ANTIINFECTIVE AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; GEMCITABINE; PACLITAXEL; PEMETREXED; PLATINUM; TAXANE DERIVATIVE; ANTINEOPLASTIC AGENT; TUMOR MARKER;

EID: 84904015589     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113196660756     Document Type: Article
Times cited : (3)

References (183)
  • 2
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small cell lung cancer
    • Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small cell lung cancer. N Engl J Med 2002; 346: 92-98.
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3
  • 3
    • 67651216410 scopus 로고    scopus 로고
    • Next generation oncology drug development: Opportunities and challenges
    • Gutierrez ME, Kummar S, Giaccone G. Next generation oncology drug development: opportunities and challenges. Nat Rev Clin Oncol 2009; 6: 259-265.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 259-265
    • Gutierrez, M.E.1    Kummar, S.2    Giaccone, G.3
  • 4
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemo-therapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou C, Wu YL, Chen G, Feng J, et al. Erlotinib versus chemo-therapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011; 12(8): 735-742
    • (2011) Lancet Oncol , vol.12 , Issue.8 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3    Feng, J.4
  • 5
    • 67349279836 scopus 로고    scopus 로고
    • Pharmacogenomics in non-small-cell lung cancer chemotherapy
    • Danesi R, Pasqualetti G, Giovannetti E, et al. Pharmacogenomics in non-small-cell lung cancer chemotherapy. Adv Drug Deliv Rev 2009; 61(5): 408-417.
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.5 , pp. 408-417
    • Danesi, R.1    Pasqualetti, G.2    Giovannetti, E.3
  • 6
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics-drug disposition, drug targets, and side effects
    • Evans WE, McLeod HL. Pharmacogenomics-drug disposition, drug targets, and side effects. N Engl J Med 2003; 348: 538-549.
    • (2003) N Engl J Med , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 7
    • 84864408125 scopus 로고    scopus 로고
    • Pharmacogenetics of conventional chemotherapy in non-small-cell lung cancer: A changing landscape?
    • Giovannetti E, Toffalorio F, De Pas T, Peters GJ. Pharmacogenetics of conventional chemotherapy in non-small-cell lung cancer: a changing landscape? Pharmacogenomics 2012; 13: 1073-1086.
    • (2012) Pharmacogenomics , vol.13 , pp. 1073-1086
    • Giovannetti, E.1    Toffalorio, F.2    de Pas, T.3    Peters, G.J.4
  • 8
    • 79960543781 scopus 로고    scopus 로고
    • Role of DNA repair gene polymorphisms in the efficiency of platinum-based adjuvant chemotherapy for non-small cell lung cancer
    • Mathiaux J, Le Morvan V, Pulido M, et al. Role of DNA repair gene polymorphisms in the efficiency of platinum-based adjuvant chemotherapy for non-small cell lung cancer. Mol Diagn Ther 2011; 15(3): 159-166.
    • (2011) Mol Diagn Ther , vol.15 , Issue.3 , pp. 159-166
    • Mathiaux, J.1    Le Morvan, V.2    Pulido, M.3
  • 9
    • 33644801241 scopus 로고    scopus 로고
    • Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines
    • Peters GJ, Van Moorsel CJ, Lakerveld B, et al. Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines. Int J Oncol 2006; 28(1): 237-244.
    • (2006) Int J Oncol , vol.28 , Issue.1 , pp. 237-244
    • Peters, G.J.1    van Moorsel, C.J.2    Lakerveld, B.3
  • 10
    • 0029618266 scopus 로고
    • DNA repair in humans
    • Sancar A. DNA repair in humans. Annu Rev Genet 1995; 29: 69-105.
    • (1995) Annu Rev Genet , vol.29 , pp. 69-105
    • Sancar, A.1
  • 11
    • 0031224917 scopus 로고    scopus 로고
    • A nucleotide polymorphism in ERCC1 in human ovarian cancer cell lines and tumor tissues
    • Yu JJ, Mu C, Lee KB, et al. A nucleotide polymorphism in ERCC1 in human ovarian cancer cell lines and tumor tissues. Mutat Res 1997; 382:13-20.
    • (1997) Mutat Res , vol.382 , pp. 13-20
    • Yu, J.J.1    Mu, C.2    Lee, K.B.3
  • 12
    • 0033848268 scopus 로고    scopus 로고
    • Association of an ERCC1 polymorphism with adult-onset glioma. Cancer Epidemiol
    • Chen P, Wiencke J, Aldape K, et al. Association of an ERCC1 polymorphism with adult-onset glioma. Cancer Epidemiol. Bio-markers Prev 2000; 9: 843-847.
    • (2000) Bio-markers Prev , vol.9 , pp. 843-847
    • Chen, P.1    Wiencke, J.2    Aldape, K.3
  • 13
    • 84865362198 scopus 로고    scopus 로고
    • A meta-analytic review of ERCC1/MDR1 polymorphism and chemosensitivity to platinum in patients with advanced non-small cell lung cancer
    • Wei HB, Hu J, Shang LH, et al. A meta-analytic review of ERCC1/MDR1 polymorphism and chemosensitivity to platinum in patients with advanced non-small cell lung cancer. Chin Med J (Engl) 2012; 125(16): 2902-2907.
    • (2012) Chin Med J (Engl) , vol.125 , Issue.16 , pp. 2902-2907
    • Wei, H.B.1    Hu, J.2    Shang, L.H.3
  • 14
    • 84874043473 scopus 로고    scopus 로고
    • Predictive role of ERCC1 and XPD genetic polymorphisms in survival of Chinese non-small cell lung cancer patients receiving chemotherapy
    • Zhang ZY, Tian X, Wu R, et al. Predictive role of ERCC1 and XPD genetic polymorphisms in survival of Chinese non-small cell lung cancer patients receiving chemotherapy. Asian Pac J Cancer Prev 2012; 13(6): 2583-2586.
    • (2012) Asian Pac J Cancer Prev , vol.13 , Issue.6 , pp. 2583-2586
    • Zhang, Z.Y.1    Tian, X.2    Wu, R.3
  • 15
    • 2342616723 scopus 로고    scopus 로고
    • Association between polymorphisms of ERCC1 and XPD and survival in non-small-cell lung cancer patients treated with cisplatin combination chemotherapy
    • Ryu JS, Hong YC, Han HS, et al. Association between polymorphisms of ERCC1 and XPD and survival in non-small-cell lung cancer patients treated with cisplatin combination chemotherapy. Lung Cancer 2004; 44: 311-316.
    • (2004) Lung Cancer , vol.44 , pp. 311-316
    • Ryu, J.S.1    Hong, Y.C.2    Han, H.S.3
  • 16
    • 4444256594 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms and outcome in docetaxel-cisplatin-treated advanced non-small-cell lung cancer
    • Isla D, Sarries C, Rosell R, et al. Single nucleotide polymorphisms and outcome in docetaxel-cisplatin-treated advanced non-small-cell lung cancer. Ann Oncol 2004; 15: 1194-1203.
    • (2004) Ann Oncol , vol.15 , pp. 1194-1203
    • Isla, D.1    Sarries, C.2    Rosell, R.3
  • 17
    • 79952251471 scopus 로고    scopus 로고
    • Predictive value of ERCC1 and XPD polymorphism in patients with advanced non-small cell lung cancer receiving platinum-based chemotherapy: A systematic review and meta-analysis
    • Wei SZ, Zhan P, Shi MQ, et al. Predictive value of ERCC1 and XPD polymorphism in patients with advanced non-small cell lung cancer receiving platinum-based chemotherapy: a systematic review and meta-analysis. Med Oncol 2011; 28(1): 315-321.
    • (2011) Med Oncol , vol.28 , Issue.1 , pp. 315-321
    • Wei, S.Z.1    Zhan, P.2    Shi, M.Q.3
  • 18
    • 77957696698 scopus 로고    scopus 로고
    • Predictive effects of ERCC1 and XRCC3 SNP on efficacy of platinum-based chemotherapy in advanced NSCLC patients
    • Zhou C, Ren S, Zhou S, et al. Predictive effects of ERCC1 and XRCC3 SNP on efficacy of platinum-based chemotherapy in advanced NSCLC patients. Jpn J Clin Oncol 2010; 40: 954-9560.
    • (2010) Jpn J Clin Oncol , vol.40 , pp. 954-9560
    • Zhou, C.1    Ren, S.2    Zhou, S.3
  • 19
    • 79952455724 scopus 로고    scopus 로고
    • The ERCC1 N118N polymorphism does not change cellular ERCC1 protein expression or platinum sensitivity
    • Gao R, Reece K, Sissung T, et al. The ERCC1 N118N polymorphism does not change cellular ERCC1 protein expression or platinum sensitivity. Mut Res 2011; 708(1-2): 21-7.
    • (2011) Mut Res , vol.708 , Issue.1-2 , pp. 21-27
    • Gao, R.1    Reece, K.2    Sissung, T.3
  • 20
    • 71549134934 scopus 로고    scopus 로고
    • Effects of excision repair cross-complementation group 1 (ERCC1) single nucleotide polymorphisms on the prognosis of non-small cell lung cancer patients
    • Takenaka T, Yano T, Kiyohara C, et al. Effects of excision repair cross-complementation group 1 (ERCC1) single nucleotide polymorphisms on the prognosis of non-small cell lung cancer patients. Lung Cancer 2010; 67: 101-107.
    • (2010) Lung Cancer , vol.67 , pp. 101-107
    • Takenaka, T.1    Yano, T.2    Kiyohara, C.3
  • 21
    • 84877064645 scopus 로고    scopus 로고
    • ERCC1/BRCA1 expression and gene polymorphisms as prognostic and predictive factors in advanced NSCLC treated with or without cisplatin
    • doi: 10.1038/bjc.2013.127. [Epub ahead of print]
    • Tiseo M, Bordi P, Bortesi B, et al. ERCC1/BRCA1 expression and gene polymorphisms as prognostic and predictive factors in advanced NSCLC treated with or without cisplatin. Br J Cancer 2013. doi: 10.1038/bjc.2013.127. [Epub ahead of print]
    • (2013) Br J Cancer
    • Tiseo, M.1    Bordi, P.2    Bortesi, B.3
  • 22
    • 33748435058 scopus 로고    scopus 로고
    • DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
    • Olaussen KA, Dunant A, Fouret P, et al. DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med 2006; 355: 983-991.
    • (2006) N Engl J Med , vol.355 , pp. 983-991
    • Olaussen, K.A.1    Dunant, A.2    Fouret, P.3
  • 23
    • 79251503287 scopus 로고    scopus 로고
    • ERCC1 and RRM1 in the international adjuvant lung trial by automated quantitative in situ analysis
    • Bepler G, Olaussen KA, Vataire AL, et al. ERCC1 and RRM1 in the international adjuvant lung trial by automated quantitative in situ analysis. Am J Pathol 2011; 178(1): 69-78.
    • (2011) Am J Pathol , vol.178 , Issue.1 , pp. 69-78
    • Bepler, G.1    Olaussen, K.A.2    Vataire, A.L.3
  • 24
    • 33847107236 scopus 로고    scopus 로고
    • DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer
    • Zheng Z, Chen T, Li X, et al. DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. N Engl J Med 2007; 356(8): 800-808.
    • (2007) N Engl J Med , vol.356 , Issue.8 , pp. 800-808
    • Zheng, Z.1    Chen, T.2    Li, X.3
  • 25
    • 80155141268 scopus 로고    scopus 로고
    • Prognostic role of ERCC1 in advanced non-small-cell lung cancer: A systematic review and meta-analysis
    • Roth JA, Carlson JJ. Prognostic role of ERCC1 in advanced non-small-cell lung cancer: a systematic review and meta-analysis. Clin Lung Cancer 2011; 12(6): 393-401.
    • (2011) Clin Lung Cancer , vol.12 , Issue.6 , pp. 393-401
    • Roth, J.A.1    Carlson, J.J.2
  • 26
    • 77956188702 scopus 로고    scopus 로고
    • The platinum-based treatments for advanced non-small cell lung cancer, is low/negative ERCC1 expression better than high/positive ERCC1 expression? A meta-analysis
    • Chen S, Zhang J, Wang R, et al. The platinum-based treatments for advanced non-small cell lung cancer, is low/negative ERCC1 expression better than high/positive ERCC1 expression? A meta-analysis. Lung Cancer 2010; 70: 63-70.
    • (2010) Lung Cancer , vol.70 , pp. 63-70
    • Chen, S.1    Zhang, J.2    Wang, R.3
  • 27
    • 79955615272 scopus 로고    scopus 로고
    • Prognostic significance of ERCC1 expression in resected non small cell lung carcinoma
    • Seyhan EC, Altin S, Cetinkaya E, et al. Prognostic significance of ERCC1 expression in resected non small cell lung carcinoma. Ann Thorac Cardiovasc Surg 2011; 17(2): 110-117.
    • (2011) Ann Thorac Cardiovasc Surg , vol.17 , Issue.2 , pp. 110-117
    • Seyhan, E.C.1    Altin, S.2    Cetinkaya, E.3
  • 28
    • 61449247252 scopus 로고    scopus 로고
    • Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
    • Ota S, Ishii G, Goto K, et al. Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy. Lung Cancer 2009; 64(1): 98-104.
    • (2009) Lung Cancer , vol.64 , Issue.1 , pp. 98-104
    • Ota, S.1    Ishii, G.2    Goto, K.3
  • 29
    • 34848849833 scopus 로고    scopus 로고
    • ERCC1 mRNA expression is not associated with response and survival after platinum-based chemotherapy regimens in advanced non-small cell lung cancer
    • Booton R, Ward T, Ashcroft L, et al. ERCC1 mRNA expression is not associated with response and survival after platinum-based chemotherapy regimens in advanced non-small cell lung cancer. J Thorac Oncol 2007; 2(10): 902-906.
    • (2007) J Thorac Oncol , vol.2 , Issue.10 , pp. 902-906
    • Booton, R.1    Ward, T.2    Ashcroft, L.3
  • 30
    • 33847107236 scopus 로고    scopus 로고
    • The DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer
    • Zheng Z, Chen T, Li X, et al. The DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. N Engl J Med 2007; 356: 800-808.
    • (2007) N Engl J Med , vol.356 , pp. 800-808
    • Zheng, Z.1    Chen, T.2    Li, X.3
  • 31
    • 84875181563 scopus 로고    scopus 로고
    • ERCC1 isoform expression and DNA repair in non-small-cell lung cancer
    • Friboulet L, Olaussen KA, Pignon JP, et al. ERCC1 isoform expression and DNA repair in non-small-cell lung cancer. N Engl J Med 2013; 368(12): 1101-1110.
    • (2013) N Engl J Med , vol.368 , Issue.12 , pp. 1101-1110
    • Friboulet, L.1    Olaussen, K.A.2    Pignon, J.P.3
  • 32
    • 0011511768 scopus 로고    scopus 로고
    • Mechanisms of action of cancer chemotherapeutic agents: DNA-interactive alkylating agents and antitumour platinum-based drugs
    • Alison MR (Ed.). Nature Publishing Group, London, UK
    • Siddik ZH. Mechanisms of action of cancer chemotherapeutic agents: DNA-interactive alkylating agents and antitumour platinum-based drugs. In: The Cancer Handbook. Alison MR (Ed.). Nature Publishing Group, London, UK 2002; 1295-1313.
    • (2002) The Cancer Handbook , pp. 1295-1313
    • Siddik, Z.H.1
  • 33
    • 84874043473 scopus 로고    scopus 로고
    • Predictive role of ERCC1 and XPD genetic polymorphisms in survival of Chinese non-small cell lung cancer patients receiving chemotherapy
    • Zhang ZY, Tian X, Wu R, et al. Predictive role of ERCC1 and XPD genetic polymorphisms in survival of Chinese non-small cell lung cancer patients receiving chemotherapy. Asian Pac J Cancer Prev 2012; 13(6): 2583-2586.
    • (2012) Asian Pac J Cancer Prev , vol.13 , Issue.6 , pp. 2583-2586
    • Zhang, Z.Y.1    Tian, X.2    Wu, R.3
  • 34
    • 4344567395 scopus 로고    scopus 로고
    • XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy
    • Gurubhagavatula S, Liu G, Park S, et al. XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy. J Clin Oncol 2004; 22(13): 2594-2601.
    • (2004) J Clin Oncol , vol.22 , Issue.13 , pp. 2594-2601
    • Gurubhagavatula, S.1    Liu, G.2    Park, S.3
  • 35
    • 79955471779 scopus 로고    scopus 로고
    • No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non-small cell lung cancer: A meta-analysis
    • Yin M, Yan J, Voutsina A et al. No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non-small cell lung cancer: a meta-analysis. Lung Cancer 2010; 72 (3): 370377.
    • (2010) Lung Cancer , vol.72 , Issue.3 , pp. 370377
    • Yin, M.1    Yan, J.2    Voutsina, A.3
  • 37
    • 84878865076 scopus 로고    scopus 로고
    • Prognostic factors in gemcit-abine-cisplatin polychemotherapy regimens in pancreatic cancer: XPD-Lys751Gln polymorphism strikes back
    • doi: 10.1002/ijc.28078. [Epub ahead of print]
    • Avan A, Pacetti P, Reni M, et al. Prognostic factors in gemcit-abine-cisplatin polychemotherapy regimens in pancreatic cancer: XPD-Lys751Gln polymorphism strikes back. Int J Cancer 2013. doi: 10.1002/ijc.28078. [Epub ahead of print]
    • (2013) Int J Cancer
    • Avan, A.1    Pacetti, P.2    Reni, M.3
  • 38
    • 0036802287 scopus 로고    scopus 로고
    • Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans
    • Mohrenweiser HW, Xi T, Vazquez-Matias J, Jones IM. Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans. Cancer Epidemiol Biomarkers Prev 2002; 11(10 Pt 1): 1054-1064.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , Issue.10 PART 1 , pp. 1054-1064
    • Mohrenweiser, H.W.1    Xi, T.2    Vazquez-Matias, J.3    Jones, I.M.4
  • 39
    • 38049091607 scopus 로고    scopus 로고
    • XRCC1 and XPD genetic polymorphisms predict clinical responses to platinum-based chemotherapy in advanced non-small cell lung cancer
    • Yuan P, Miao XP, Zhang XM, et al. XRCC1 and XPD genetic polymorphisms predict clinical responses to platinum-based chemotherapy in advanced non-small cell lung cancer. Chin J Oncol 2006; 28(3): 196-199.
    • (2006) Chin J Oncol , vol.28 , Issue.3 , pp. 196-199
    • Yuan, P.1    Miao, X.P.2    Zhang, X.M.3
  • 40
    • 67449162069 scopus 로고    scopus 로고
    • Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients
    • Sun X, Li F, Sun N, et al. Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients. Lung Cancer 2009; 65(2): 230-236.
    • (2009) Lung Cancer , vol.65 , Issue.2 , pp. 230-236
    • Sun, X.1    Li, F.2    Sun, N.3
  • 41
    • 84860216677 scopus 로고    scopus 로고
    • Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: A prospective clinical study
    • Joerger M, Burgers SA, Baas P, et al. Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: a prospective clinical study. Cancer 2012; 118(9): 2466-2475.
    • (2012) Cancer , vol.118 , Issue.9 , pp. 2466-2475
    • Joerger, M.1    Burgers, S.A.2    Baas, P.3
  • 42
    • 84869202178 scopus 로고    scopus 로고
    • XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer: A meta-analysis in 17 studies
    • Chen J, Zhao QW, Shi GM, et al. XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer: a meta-analysis in 17 studies. J Zhejiang Univ Sci B 2012; 13(11): 875-883.
    • (2012) J Zhejiang Univ Sci B , vol.13 , Issue.11 , pp. 875-883
    • Chen, J.1    Zhao, Q.W.2    Shi, G.M.3
  • 43
    • 77952544071 scopus 로고    scopus 로고
    • The prognostic significance of ERCC1, BRCA1, XRCC1, and pIII-tubulin expression in patients with non-small cell lung cancer treated by platinu- and taxane-based neoadjuvant chemotherapy and surgical resection
    • Kang CH, Jang BG, Kim DW, et al. The prognostic significance of ERCC1, BRCA1, XRCC1, and pIII-tubulin expression in patients with non-small cell lung cancer treated by platinu- and taxane-based neoadjuvant chemotherapy and surgical resection. Lung Cancer 2010; 68(3): 478-483.
    • (2010) Lung Cancer , vol.68 , Issue.3 , pp. 478-483
    • Kang, C.H.1    Jang, B.G.2    Kim, D.W.3
  • 44
    • 84867183651 scopus 로고    scopus 로고
    • RAGE Genetic Polymorphisms Are Associated with Risk, Chemotherapy Response and Prognosis in Patients with Advanced NSCLC
    • Wang X, Cui E, Zeng H, et al. RAGE Genetic Polymorphisms Are Associated with Risk, Chemotherapy Response and Prognosis in Patients with Advanced NSCLC. PLoS One 2012; 7(10): e43734.
    • (2012) PLoS One , vol.7 , Issue.10
    • Wang, X.1    Cui, E.2    Zeng, H.3
  • 45
    • 78651359460 scopus 로고    scopus 로고
    • PI3K/PTEN/AKT/mTOR Pathway Genetic Variation Predicts Toxicity and Distant Progression in Lung Cancer Patients Receiving Platinum-based Chemotherapy
    • Pu X, Hildebrandt MAT, Lu C, et al. PI3K/PTEN/AKT/mTOR Pathway Genetic Variation Predicts Toxicity and Distant Progression in Lung Cancer Patients Receiving Platinum-based Chemotherapy. Lung Cancer 2011; 71(1): 82-88.
    • (2011) Lung Cancer , vol.71 , Issue.1 , pp. 82-88
    • Pu, X.1    Hildebrandt, M.A.T.2    Lu, C.3
  • 46
    • 84863046514 scopus 로고    scopus 로고
    • The role of expression and polymorphism of the BAG-1 gene in response to platinum-based chemotherapeutics in NSCLC
    • Wang YD, Ha MW, Cheng J, et al. The role of expression and polymorphism of the BAG-1 gene in response to platinum-based chemotherapeutics in NSCLC. Oncol Rep 2012; 27(4): 979-986.
    • (2012) Oncol Rep , vol.27 , Issue.4 , pp. 979-986
    • Wang, Y.D.1    Ha, M.W.2    Cheng, J.3
  • 47
    • 84862528550 scopus 로고    scopus 로고
    • Molecular Targets of Gem-citabine Action: Rationale for Development of Novel Drugs and Drug Combinations
    • Elnaggar M, Giovannetti E, Peters GJ. Molecular Targets of Gem-citabine Action: Rationale for Development of Novel Drugs and Drug Combinations. Curr Pharm Des 2012; 18(19): 2811-2829.
    • (2012) Curr Pharm Des , vol.18 , Issue.19 , pp. 2811-2829
    • Elnaggar, M.1    Giovannetti, E.2    Peters, G.J.3
  • 48
    • 5044225419 scopus 로고    scopus 로고
    • Determinants of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer
    • Achiwa H, Oguri T, Sato S, et al. Determinants of sensitivity and resistance to gemcitabine: the roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer. Cancer Sci 2004; 95: 753-757.
    • (2004) Cancer Sci , vol.95 , pp. 753-757
    • Achiwa, H.1    Oguri, T.2    Sato, S.3
  • 49
    • 33645731188 scopus 로고    scopus 로고
    • Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
    • Giovannetti E, Del Tacca M, Mey V, et al. Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 2006; 66: 3928-3925.
    • (2006) Cancer Res , vol.66 , pp. 3928-3935
    • Giovannetti, E.1    Del Tacca, M.2    Mey, V.3
  • 50
    • 59849115856 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer
    • Farrell JJ, Elsaleh H, Garcia M, et al. Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer. Gastroenterology 2009; 136(1): 187-195.
    • (2009) Gastroenterology , vol.136 , Issue.1 , pp. 187-195
    • Farrell, J.J.1    Elsaleh, H.2    Garcia, M.3
  • 51
    • 34548203759 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 expression predicts nonre-sponse to gemcitabine-containing chemotherapy in non-small cell lung cancer
    • Oguri T, Achiwa H, Muramatsu H, et al. The absence of human equilibrative nucleoside transporter 1 expression predicts nonre-sponse to gemcitabine-containing chemotherapy in non-small cell lung cancer. Cancer Lett 2007; 256(1): 112-119.
    • (2007) Cancer Lett , vol.256 , Issue.1 , pp. 112-119
    • Oguri, T.1    Achiwa, H.2    Muramatsu, H.3
  • 52
    • 84879663790 scopus 로고    scopus 로고
    • An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: Implications for adjuvant treatment
    • Avan A, Maftouh M, Giovannetti E. An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: Implications for adjuvant treatment. Cancer 2013; 119(14): 2662-2663.
    • (2013) Cancer , vol.119 , Issue.14 , pp. 2662-2663
    • Avan, A.1    Maftouh, M.2    Giovannetti, E.3
  • 53
    • 84855932882 scopus 로고    scopus 로고
    • Gemcitabine metabolic pathway genetic polymorphisms and response in patients with non-small cell lung cancer
    • Li L, Schaid DJ, Fridley BL, et al. Gemcitabine metabolic pathway genetic polymorphisms and response in patients with non-small cell lung cancer. Pharmacogenet Genomics 2012; 22(2): 105-116.
    • (2012) Pharmacogenet Genomics , vol.22 , Issue.2 , pp. 105-116
    • Li, L.1    Schaid, D.J.2    Fridley, B.L.3
  • 54
    • 62649161606 scopus 로고    scopus 로고
    • Pharmacogenomics of gemcitabine in non-small-cell lung cancer and other solid tumors
    • Danesi, G Altavilla, E Giovannetti, et al. Pharmacogenomics of gemcitabine in non-small-cell lung cancer and other solid tumors. Pharmacogenomics 2009; 10(1): 69-80.
    • (2009) Pharmacogenomics , vol.10 , Issue.1 , pp. 69-80
    • Danesi1    Altavilla, G.2    Giovannetti, E.3
  • 55
    • 0036716721 scopus 로고    scopus 로고
    • Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines
    • van Bree C, Castro Kreder N, Loves WJ, et al. Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines. Int J Radiat Oncol Biol Phys 2002; 54: 237-244.
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , pp. 237-244
    • van Bree, C.1    Castro Kreder, N.2    Loves, W.J.3
  • 56
    • 0002831066 scopus 로고    scopus 로고
    • Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity
    • Kroep JR, Loves WJ, van der Wilt CL, et al. Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 2002; 1: 371-376.
    • (2002) Mol Cancer Ther , vol.1 , pp. 371-376
    • Kroep, J.R.1    Loves, W.J.2    van der Wilt, C.L.3
  • 57
    • 23744495336 scopus 로고    scopus 로고
    • cN-II expression predicts survival in patients receiving gemcitabine for advanced non-small cell lung cancer
    • Sève P, Mackey JR, Isaac S, et al. cN-II expression predicts survival in patients receiving gemcitabine for advanced non-small cell lung cancer. Lung Cancer 2005; 49(3): 363-370.
    • (2005) Lung Cancer , vol.49 , Issue.3 , pp. 363-370
    • Sève, P.1    Mackey, J.R.2    Isaac, S.3
  • 58
    • 84865465698 scopus 로고    scopus 로고
    • Lack of association of genetic variations of deoxycytidine kinase with toxicity or survival of non-small-cell lung cancer patients treated with gemcitabine plus cis-platin
    • Nam HS, Cho JH, Lee JE
    • Ryu JS, Kim HJ, Shin ES, et al. Lack of association of genetic variations of deoxycytidine kinase with toxicity or survival of non-small-cell lung cancer patients treated with gemcitabine plus cis-platin. Nam HS, Cho JH, Lee JE. Oncol Res 2012; 20(1): 25-30.
    • (2012) Oncol Res , vol.20 , Issue.1 , pp. 25-30
    • Ryu, J.S.1    Kim, H.J.2    Shin, E.S.3
  • 59
    • 41549095093 scopus 로고    scopus 로고
    • Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients
    • Tibaldi C, Giovannetti E, Vasile E, et al. Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients. Clin Cancer Res 2008; 14: 1797-1803.
    • (2008) Clin Cancer Res , vol.14 , pp. 1797-1803
    • Tibaldi, C.1    Giovannetti, E.2    Vasile, E.3
  • 60
    • 84857584251 scopus 로고    scopus 로고
    • Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced non-small-cell lung cancer patients
    • Tibaldi C, Giovannetti E, Tiseo M, et al. Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced non-small-cell lung cancer patients. Ann Oncol 2012; 23(3): 670-677.
    • (2012) Ann Oncol , vol.23 , Issue.3 , pp. 670-677
    • Tibaldi, C.1    Giovannetti, E.2    Tiseo, M.3
  • 61
    • 57649112390 scopus 로고    scopus 로고
    • Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients
    • Soo RA, Wang LZ, Ng SS, et al. Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients. Lung Cancer 2009; 63(1): 121-127.
    • (2009) Lung Cancer , vol.63 , Issue.1 , pp. 121-127
    • Soo, R.A.1    Wang, L.Z.2    Ng, S.S.3
  • 62
    • 81755185463 scopus 로고    scopus 로고
    • Association of cytidine deaminase and xeroderma pigmentosum group D polymorphisms with response, toxicity, and survival inc isplatin/gemcitabine-treated advanced non-small cell lung cancer patients
    • Ludovini V, Floriani I, Pistola L, et al. Association of cytidine deaminase and xeroderma pigmentosum group D polymorphisms with response, toxicity, and survival inc isplatin/gemcitabine-treated advanced non-small cell lung cancer patients. J Thorac Oncol 2011; 6(12): 2018-2026.
    • (2011) J Thorac Oncol , vol.6 , Issue.12 , pp. 2018-2026
    • Ludovini, V.1    Floriani, I.2    Pistola, L.3
  • 63
    • 34447303456 scopus 로고    scopus 로고
    • Pharmacokinetics of gem-citabine in Japanese cancer patients: The impact of a cytidine deaminase polymorphism
    • Sugiyama E, Kaniwa N, Kim SR, et al. Pharmacokinetics of gem-citabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. J Clin Oncol 2007; 25(1): 32-42.
    • (2007) J Clin Oncol , vol.25 , Issue.1 , pp. 32-42
    • Sugiyama, E.1    Kaniwa, N.2    Kim, S.R.3
  • 64
    • 77954940510 scopus 로고    scopus 로고
    • Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: Impact of the 79A>C cytidine deaminase polymorphism
    • Maring JG, Wachters FM, Slijfer M, et al. Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism. Eur J Clin Pharmacol 2010; 66(6): 611-617.
    • (2010) Eur J Clin Pharmacol , vol.66 , Issue.6 , pp. 611-617
    • Maring, J.G.1    Wachters, F.M.2    Slijfer, M.3
  • 65
    • 84856732257 scopus 로고    scopus 로고
    • Gene polymorphisms, phar-macokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine
    • Joerger M, Burgers JA, Baas P, et al. Gene polymorphisms, phar-macokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine. Cancer Chemother Pharmacol 2012; 69(1): 25-33.
    • (2012) Cancer Chemother Pharmacol , vol.69 , Issue.1 , pp. 25-33
    • Joerger, M.1    Burgers, J.A.2    Baas, P.3
  • 66
    • 84860216677 scopus 로고    scopus 로고
    • Germline polymorphisms in patients with advanced non-small cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: A prospective clinical study
    • Joerger M, Burgers SA, Baas P, et al. Germline polymorphisms in patients with advanced non-small cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: A prospective clinical study. Cancer 2011; 118(9): 2466-2475.
    • (2011) Cancer , vol.118 , Issue.9 , pp. 2466-2475
    • Joerger, M.1    Burgers, S.A.2    Baas, P.3
  • 67
    • 79959984687 scopus 로고    scopus 로고
    • Integrating pharmacogenet-ics into gemcitabine dosing-time for a change?
    • Ciccolini J, Mercier C, Dahan L, et al. Integrating pharmacogenet-ics into gemcitabine dosing-time for a change? Nat Rev Clin Oncol 2011; 8(7): 439-444.
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.7 , pp. 439-444
    • Ciccolini, J.1    Mercier, C.2    Dahan, L.3
  • 68
    • 2542530631 scopus 로고    scopus 로고
    • An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines
    • Davidson JD, Ma L, Flagella M, et al. An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines. Cancer Res 2004; 64: 3761-3766.
    • (2004) Cancer Res , vol.64 , pp. 3761-3766
    • Davidson, J.D.1    Ma, L.2    Flagella, M.3
  • 69
    • 3042665933 scopus 로고    scopus 로고
    • Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery
    • Rosell R, Felip E, Taron M, et al. Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery. Clin Cancer Res 2004; 10: 4215s-4219s.
    • (2004) Clin Cancer Res , vol.10
    • Rosell, R.1    Felip, E.2    Taron, M.3
  • 70
    • 33750579074 scopus 로고    scopus 로고
    • RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer
    • Bepler G, Kusmartseva I, Sharma S, et al. RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer. J Clin Oncol 2006; 24: 4731-4737.
    • (2006) J Clin Oncol , vol.24 , pp. 4731-4737
    • Bepler, G.1    Kusmartseva, I.2    Sharma, S.3
  • 71
    • 33847107236 scopus 로고    scopus 로고
    • DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer
    • Zheng Z, Chen T, Xueli L, et al. DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. N Engl J Med 2007; 356: 800-808.
    • (2007) N Engl J Med , vol.356 , pp. 800-808
    • Zheng, Z.1    Chen, T.2    Xueli, L.3
  • 72
    • 84859796195 scopus 로고    scopus 로고
    • Preliminary indication of survival benefit from ERCC1 and RRM1-tailored chemotherapy in patients with advanced nonsmall cell lung cancer: Evidence from an individual patient analysis
    • Simon GR, Schell MJ, Begum M, et al. Preliminary indication of survival benefit from ERCC1 and RRM1-tailored chemotherapy in patients with advanced nonsmall cell lung cancer: Evidence from an individual patient analysis. Cancer 2011; 118(9): 2525-2531.
    • (2011) Cancer , vol.118 , Issue.9 , pp. 2525-2531
    • Simon, G.R.1    Schell, M.J.2    Begum, M.3
  • 73
    • 0034059127 scopus 로고    scopus 로고
    • Expression of ERCC1 antisense RNA abrogates gemicitabine-mediated cytotoxic synergism with cisplatin in human colon tumor cells defective in mismatch repair but proficient in nucleotide excision repair
    • Yang LY, Li L, Jiang H, et al. Expression of ERCC1 antisense RNA abrogates gemicitabine-mediated cytotoxic synergism with cisplatin in human colon tumor cells defective in mismatch repair but proficient in nucleotide excision repair. Clin Cancer Res 2000; 6: 773-781.
    • (2000) Clin Cancer Res , vol.6 , pp. 773-781
    • Yang, L.Y.1    Li, L.2    Jiang, H.3
  • 74
    • 0033801694 scopus 로고    scopus 로고
    • Basis for effective combination cancer chemotherapy with antimetabolites
    • Peters GJ, van der Wilt CL, van Moorsel CJ, et al. Basis for effective combination cancer chemotherapy with antimetabolites. Pharmacol Ther 2000; 87(2-3): 227-253.
    • (2000) Pharmacol Ther , vol.87 , Issue.2-3 , pp. 227-253
    • Peters, G.J.1    van der Wilt, C.L.2    van Moorsel, C.J.3
  • 75
    • 19944429421 scopus 로고    scopus 로고
    • Ribonucleotide reductase M1 gene promoter activity, polymorphisms, population frequencies, and clinical relevance
    • Bepler G, Zheng Z, Gautam A, et al. Ribonucleotide reductase M1 gene promoter activity, polymorphisms, population frequencies, and clinical relevance. Lung Cancer 2005; 47: 183-192.
    • (2005) Lung Cancer , vol.47 , pp. 183-192
    • Bepler, G.1    Zheng, Z.2    Gautam, A.3
  • 76
    • 77949465829 scopus 로고    scopus 로고
    • RRM1 single nucleotide polymorphism -37C-->A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy
    • Dong S, Guo AL, Chen ZH, et al. RRM1 single nucleotide polymorphism -37C-->A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy. J Hematol Oncol 2010; 3: 10.
    • (2010) J Hematol Oncol , vol.3 , pp. 10
    • Dong, S.1    Guo, A.L.2    Chen, Z.H.3
  • 77
    • 49649099763 scopus 로고    scopus 로고
    • Efficacy of gemcitabine in patients with non-small cell lung cancer according to promoter polymorphisms of the ribonucleotide reductase M1 gene
    • Kim SO, Jeong JY, Kim MR, et al. Efficacy of gemcitabine in patients with non-small cell lung cancer according to promoter polymorphisms of the ribonucleotide reductase M1 gene. Clin Cancer Res 2008; 14: 3083-3088.
    • (2008) Clin Cancer Res , vol.14 , pp. 3083-3088
    • Kim, S.O.1    Jeong, J.Y.2    Kim, M.R.3
  • 78
    • 33744486046 scopus 로고    scopus 로고
    • Ribonucleotide reductase M1 (RRM1) 2464G>A polymorphism shows an association with gem-citabine chemosensitivity in cancer cell lines
    • Kwon WS, Rha SY, Choi YH, et al. Ribonucleotide reductase M1 (RRM1) 2464G>A polymorphism shows an association with gem-citabine chemosensitivity in cancer cell lines. Pharmacogenet Ge-nomics 2006; 16: 429-438.
    • (2006) Pharmacogenet Ge-nomics , vol.16 , pp. 429-438
    • Kwon, W.S.1    Rha, S.Y.2    Choi, Y.H.3
  • 79
    • 80051798346 scopus 로고    scopus 로고
    • Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or tax-ane/cisplatinum
    • Ryu JS, Shin ES, Nam HS, et al. Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or tax-ane/cisplatinum. J Thorac Oncol 2011; 6(8): 1320-1329.
    • (2011) J Thorac Oncol , vol.6 , Issue.8 , pp. 1320-1329
    • Ryu, J.S.1    Shin, E.S.2    Nam, H.S.3
  • 80
    • 84869112263 scopus 로고    scopus 로고
    • High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer
    • Giovannetti E, van der Velde A, Funel N, et al. High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer. PLoS One 2012; 7(11): e49145.
    • (2012) PLoS One , vol.7 , Issue.11
    • Giovannetti, E.1    van der Velde, A.2    Funel, N.3
  • 81
    • 0033063875 scopus 로고    scopus 로고
    • Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations
    • Monzo M, Rosell R, Sanchez JJ, et al. Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations. J Clin Oncol 1999; 17: 1786-93.
    • (1999) J Clin Oncol , vol.17 , pp. 1786-1793
    • Monzo, M.1    Rosell, R.2    Sanchez, J.J.3
  • 82
    • 0034786834 scopus 로고    scopus 로고
    • Predicting response to paclitaxel/carboplatin-based therapy in non-small cell lung cancer
    • Rosell R, Felip E. Predicting response to paclitaxel/carboplatin-based therapy in non-small cell lung cancer. Semin Oncol 2001; 28: 37-44.
    • (2001) Semin Oncol , vol.28 , pp. 37-44
    • Rosell, R.1    Felip, E.2
  • 83
    • 0037094288 scopus 로고    scopus 로고
    • Re: Genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer
    • Monzo M, Taron M, Rosell R, Re: Genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer. J Natl Cancer Inst 2002; 94: 774-776.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 774-776
    • Monzo, M.1    Taron, M.2    Rosell, R.3
  • 84
    • 0038219598 scopus 로고    scopus 로고
    • Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry
    • Verdier-Pinard P, Wang F, Martello L, et al. Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry. Biochemistry 2003; 42: 5349-5357.
    • (2003) Biochemistry , vol.42 , pp. 5349-5357
    • Verdier-Pinard, P.1    Wang, F.2    Martello, L.3
  • 85
    • 0031985608 scopus 로고    scopus 로고
    • Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells
    • Ranganathan S, Benetatos CA, Colarusso PJ, et al. Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells. Br J Cancer 1998; 77: 562-566.
    • (1998) Br J Cancer , vol.77 , pp. 562-566
    • Ranganathan, S.1    Benetatos, C.A.2    Colarusso, P.J.3
  • 86
    • 19944428644 scopus 로고    scopus 로고
    • Transcripts in pre-treatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer
    • Rosell R, Scagliotti G, Danenberg KD, et al. Transcripts in pre-treatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer. Oncogene. 2003; 223: 548-553.
    • (2003) Oncogene , vol.223 , pp. 548-553
    • Rosell, R.1    Scagliotti, G.2    Danenberg, K.D.3
  • 87
    • 0035807219 scopus 로고    scopus 로고
    • Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway
    • Lafarge S, Sylvain V, Ferrara M, et al. Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. Oncogene 2001; 20: 6597-6606.
    • (2001) Oncogene , vol.20 , pp. 6597-6606
    • Lafarge, S.1    Sylvain, V.2    Ferrara, M.3
  • 88
    • 0034604716 scopus 로고    scopus 로고
    • The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
    • Bhattacharyya A, Ear US, Koller BH, et al. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin. J Biol Chem 2000; 275: 23899-23903.
    • (2000) J Biol Chem , vol.275 , pp. 23899-23903
    • Bhattacharyya, A.1    Ear, U.S.2    Koller, B.H.3
  • 89
    • 0035959804 scopus 로고    scopus 로고
    • BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents
    • Mullan PB, Quinn JE, Gilmore PM, et al. BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents. Oncogene 2001; 20: 6123-6131.
    • (2001) Oncogene , vol.20 , pp. 6123-6131
    • Mullan, P.B.1    Quinn, J.E.2    Gilmore, P.M.3
  • 90
    • 0141954010 scopus 로고    scopus 로고
    • BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis
    • Quinn JE, Kennedy RD, Mullan PB, et al. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Cancer Res 2003; 63: 6221-6228.
    • (2003) Cancer Res , vol.63 , pp. 6221-6228
    • Quinn, J.E.1    Kennedy, R.D.2    Mullan, P.B.3
  • 91
    • 37549025804 scopus 로고    scopus 로고
    • BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy
    • Quinn JE, James CR, Stewart GE, et al. BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy. Clin Cancer Res 2007; 13: 7413-7420.
    • (2007) Clin Cancer Res , vol.13 , pp. 7413-7420
    • Quinn, J.E.1    James, C.R.2    Stewart, G.E.3
  • 92
    • 44349090911 scopus 로고    scopus 로고
    • ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel
    • Wang L, Wei J, Qian X, et al. ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel. BMC Cancer 2008; 8: 97.
    • (2008) BMC Cancer , vol.8 , pp. 97
    • Wang, L.1    Wei, J.2    Qian, X.3
  • 93
    • 19544379515 scopus 로고    scopus 로고
    • BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer
    • Taron M, Rosell R, Felip E, et al. BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer. Hum Mol Genet 2004; 13: 2443-2449.
    • (2004) Hum Mol Genet , vol.13 , pp. 2443-2449
    • Taron, M.1    Rosell, R.2    Felip, E.3
  • 94
    • 67649431893 scopus 로고    scopus 로고
    • Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression
    • Rosell R, Perez-Roca L, Sanchez JJ, et al. Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. PLoS One 2009; 4(5): e5133.
    • (2009) PLoS One , vol.4 , Issue.5
    • Rosell, R.1    Perez-Roca, L.2    Sanchez, J.J.3
  • 95
    • 34249946686 scopus 로고    scopus 로고
    • Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    • Wang B, Matsuoka S, Ballif BA, et al. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 2007; 316: 1194-1198.
    • (2007) Science , vol.316 , pp. 1194-1198
    • Wang, B.1    Matsuoka, S.2    Ballif, B.A.3
  • 96
    • 33847364471 scopus 로고    scopus 로고
    • Pemetrexed: Biochemical and cellular pharmacology, mechanisms, and clinical applications
    • Chattopadhyay S, Moran RG, Goldman ID. Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications. Mol.Cancer Ther 2007; 6: 404-417.
    • (2007) Mol.Cancer Ther , vol.6 , pp. 404-417
    • Chattopadhyay, S.1    Moran, R.G.2    Goldman, I.D.3
  • 97
    • 41149096042 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitar-geted antifolate pemetrexed in non-small-cell lung cancer cells
    • Giovannetti E, Lemos C, Tekle C, et al. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitar-geted antifolate pemetrexed in non-small-cell lung cancer cells. Mol.Pharmacol 2008; 73: 1290-1300.
    • (2008) Mol.Pharmacol , vol.73 , pp. 1290-1300
    • Giovannetti, E.1    Lemos, C.2    Tekle, C.3
  • 98
    • 79955813242 scopus 로고    scopus 로고
    • Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer
    • Takezawa K, Okamoto I, Okamoto W, et al. Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer. Br J Cancer 2011; 104: 1594-1601.
    • (2011) Br J Cancer , vol.104 , pp. 1594-1601
    • Takezawa, K.1    Okamoto, I.2    Okamoto, W.3
  • 99
    • 34547669346 scopus 로고    scopus 로고
    • In vitro che-mosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression
    • Hanauske AR, Eismann U, Oberschmidt O, et al. In vitro che-mosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression. Invest New Drugs 2007; 25: 417-423.
    • (2007) Invest New Drugs , vol.25 , pp. 417-423
    • Hanauske, A.R.1    Eismann, U.2    Oberschmidt, O.3
  • 100
    • 80052554890 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed
    • Chen CY, Chang YL, Shih JY, et al. Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed. Lung Cancer 2011; 74(1): 132-138.
    • (2011) Lung Cancer , vol.74 , Issue.1 , pp. 132-138
    • Chen, C.Y.1    Chang, Y.L.2    Shih, J.Y.3
  • 101
    • 80051785282 scopus 로고    scopus 로고
    • Significance of Thymidylate Syn-thase and Thyroid Transcription Factor 1 Expression in Patients with Nonsquamous Non-small Cell Lung Cancer Treated with Pe-metrexed-Based Chemotherapy
    • Sun JM, Han J, Ahn JS, et al. Significance of Thymidylate Syn-thase and Thyroid Transcription Factor 1 Expression in Patients with Nonsquamous Non-small Cell Lung Cancer Treated with Pe-metrexed-Based Chemotherapy. J Thorac Oncol 2011; 6(8): 1392-1399.
    • (2011) J Thorac Oncol , vol.6 , Issue.8 , pp. 1392-1399
    • Sun, J.M.1    Han, J.2    Ahn, J.S.3
  • 102
    • 33749587054 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
    • Ceppi P, Volante M, Saviozzi S, et al. Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase. Cancer 2006; 107: 1589-1596.
    • (2006) Cancer , vol.107 , pp. 1589-1596
    • Ceppi, P.1    Volante, M.2    Saviozzi, S.3
  • 103
    • 80052755036 scopus 로고    scopus 로고
    • Thymidylate synthase inhibitors for non-small cell lung cancer
    • Galvani E, Peters GJ, Giovannetti E. Thymidylate synthase inhibitors for non-small cell lung cancer. Expert Opin Investig Drugs 2011; 20(10): 1343-1356.
    • (2011) Expert Opin Investig Drugs , vol.20 , Issue.10 , pp. 1343-1356
    • Galvani, E.1    Peters, G.J.2    Giovannetti, E.3
  • 104
    • 80052724195 scopus 로고    scopus 로고
    • International tailored chemotherapy adjuvant trial: ITACA trial
    • suppl; abstr e17514
    • Novello S, Scagliotti G, Torri V, et al. International tailored chemotherapy adjuvant trial: ITACA trial. J Clin Oncol 2011; 29 (suppl; abstr e17514).
    • (2011) J Clin Oncol , vol.29
    • Novello, S.1    Scagliotti, G.2    Torri, V.3
  • 105
    • 0029122937 scopus 로고
    • Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate syn-thase
    • Horie N, Aiba H, Oguro K, et al. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate syn-thase. Cell Struct Funct 1995; 20: 191-197.
    • (1995) Cell Struct Funct , vol.20 , pp. 191-197
    • Horie, N.1    Aiba, H.2    Oguro, K.3
  • 106
    • 0035430487 scopus 로고    scopus 로고
    • Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer
    • Marsh S, McKay JA, Cassidy J, et al. Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. Int J Oncol 2001; 19: 383-386.
    • (2001) Int J Oncol , vol.19 , pp. 383-386
    • Marsh, S.1    McKay, J.A.2    Cassidy, J.3
  • 107
    • 0035868667 scopus 로고    scopus 로고
    • Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer
    • Villafranca E, Okruzhnov Y, Dominguez MA, et al. Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol 2001; 19: 1779-1786.
    • (2001) J Clin Oncol , vol.19 , pp. 1779-1786
    • Villafranca, E.1    Okruzhnov, Y.2    Dominguez, M.A.3
  • 108
    • 14944380124 scopus 로고    scopus 로고
    • Thymidylate syn-thase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity
    • Jakobsen A, Nielsen JN, Gyldenkerne N, et al. Thymidylate syn-thase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol 2005; 23: 1365-1369.
    • (2005) J Clin Oncol , vol.23 , pp. 1365-1369
    • Jakobsen, A.1    Nielsen, J.N.2    Gyldenkerne, N.3
  • 109
    • 43749114271 scopus 로고    scopus 로고
    • Role of genetic and nonge-netic factors for fluorouracil treatment-related severe toxicity: A prospective clinical trial by the German 5-FU Toxicity Study Group
    • Schwab M, Zanger UM, Marx C, et al. Role of genetic and nonge-netic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J Clin Oncol 2008; 26: 2131-2138.
    • (2008) J Clin Oncol , vol.26 , pp. 2131-2138
    • Schwab, M.1    Zanger, U.M.2    Marx, C.3
  • 110
    • 84872806269 scopus 로고    scopus 로고
    • Association of thymidylate syn-thase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC
    • Wang X, Wang Y, Wang Y, et al. Association of thymidylate syn-thase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC. J Biomed Sci 2013; 20: 5.
    • (2013) J Biomed Sci , vol.20 , pp. 5
    • Wang, X.1    Wang, Y.2    Wang, Y.3
  • 111
    • 84874413584 scopus 로고    scopus 로고
    • Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy
    • Li WJ, Jiang H, Fang XJ, et al. Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy. Oncol Lett 2013; 5(4): 1165-1170.
    • (2013) Oncol Lett , vol.5 , Issue.4 , pp. 1165-1170
    • Li, W.J.1    Jiang, H.2    Fang, X.J.3
  • 112
    • 69549138586 scopus 로고    scopus 로고
    • Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer
    • Mauritz R, Giovannetti E, Beumer IJ, et al. Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer. Clin Colorectal Cancer 2009; 8: 146-154.
    • (2009) Clin Colorectal Cancer , vol.8 , pp. 146-154
    • Mauritz, R.1    Giovannetti, E.2    Beumer, I.J.3
  • 113
    • 84867272757 scopus 로고    scopus 로고
    • Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer
    • Hu Q, Li X, Su C, et al. Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer. Exp Ther Med 2012; 4(6): 1010-1016.
    • (2012) Exp Ther Med , vol.4 , Issue.6 , pp. 1010-1016
    • Hu, Q.1    Li, X.2    Su, C.3
  • 114
    • 65349091355 scopus 로고    scopus 로고
    • Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer
    • Smit EF, Burgers SA, Biesma B, et al. Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer. J Clin Oncol 2009; 27: 2038-2045.
    • (2009) J Clin Oncol , vol.27 , pp. 2038-2045
    • Smit, E.F.1    Burgers, S.A.2    Biesma, B.3
  • 115
    • 84866173015 scopus 로고    scopus 로고
    • Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin
    • Tiseo M, Giovannetti E, Tibaldi C, et al. Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin. Lung Cancer 2012; 78(1): 92-99.
    • (2012) Lung Cancer , vol.78 , Issue.1 , pp. 92-99
    • Tiseo, M.1    Giovannetti, E.2    Tibaldi, C.3
  • 116
    • 84874413584 scopus 로고    scopus 로고
    • Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy
    • Li WJ, Jiang H, Fang XJ, et al. Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy. Oncol Lett 2013; 5(4): 1165-1170.
    • (2013) Oncol Lett , vol.5 , Issue.4 , pp. 1165-1170
    • Li, W.J.1    Jiang, H.2    Fang, X.J.3
  • 117
    • 33947375647 scopus 로고    scopus 로고
    • Molecular basis of antifolate resistance
    • Assaraf YG. Molecular basis of antifolate resistance. Cancer Metastasis Rev 2007; 26: 153-181.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 153-181
    • Assaraf, Y.G.1
  • 118
    • 66049102881 scopus 로고    scopus 로고
    • Aberrant splicing of folylpoly-glutamate synthetase as a novel mechanism of antifolate resistance in leukemia
    • Stark M, Wichman C, Avivi I, et al. Aberrant splicing of folylpoly-glutamate synthetase as a novel mechanism of antifolate resistance in leukemia. Blood 2009; 113(18): 4362-4369.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4362-4369
    • Stark, M.1    Wichman, C.2    Avivi, I.3
  • 119
    • 78049426102 scopus 로고    scopus 로고
    • ABCC11/MRP8 confers pe-metrexed resistance in lung cancer
    • Uemura T, Oguri T, Ozasa H, et al. ABCC11/MRP8 confers pe-metrexed resistance in lung cancer. Cancer Sci 2010; 101: 2404-2410.
    • (2010) Cancer Sci , vol.101 , pp. 2404-2410
    • Uemura, T.1    Oguri, T.2    Ozasa, H.3
  • 120
    • 77449098773 scopus 로고    scopus 로고
    • Phase II trial of pe-metrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426
    • Adjei AA, Mandrekar SJ, Dy GK, et al. Phase II trial of pe-metrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. J Clin Oncol 2010; 28: 614-619.
    • (2010) J Clin Oncol , vol.28 , pp. 614-619
    • Adjei, A.A.1    Mandrekar, S.J.2    Dy, G.K.3
  • 121
    • 77956268512 scopus 로고    scopus 로고
    • Correlation between polymorphisms of the reduced folate carrier gene (SLC19A1) and survival after pemetrexed-based therapy in non-small cell lung cancer: A North Central Cancer Treatment Group-based exploratory study
    • Adjei AA, Salavaggione OE, Mandrekar SJ, et al. Correlation between polymorphisms of the reduced folate carrier gene (SLC19A1) and survival after pemetrexed-based therapy in non-small cell lung cancer: a North Central Cancer Treatment Group-based exploratory study. J Thorac Oncol 2010; 5: 1346-1353.
    • (2010) J Thorac Oncol , vol.5 , pp. 1346-1353
    • Adjei, A.A.1    Salavaggione, O.E.2    Mandrekar, S.J.3
  • 122
    • 0035939330 scopus 로고    scopus 로고
    • Studies leading to the identification of ZD1839 (IRESSA): An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer
    • Barker AJ, Gibson KH, Grundy W, et al. Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. Bioorg Med Chem Lett 2001; 11(14): 1911-1914.
    • (2001) Bioorg Med Chem Lett , vol.11 , Issue.14 , pp. 1911-1914
    • Barker, A.J.1    Gibson, K.H.2    Grundy, W.3
  • 123
    • 0037211253 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs): Simple drugs with a complex mechanism of action?
    • Normanno N, Maiello MR, De Luca A. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs): simple drugs with a complex mechanism of action? J Cell Physiol 2003; 194(1): 13-19.
    • (2003) J Cell Physiol , vol.194 , Issue.1 , pp. 13-19
    • Normanno, N.1    Maiello, M.R.2    de Luca, A.3
  • 124
    • 3042665929 scopus 로고    scopus 로고
    • The biology of epidermal growth factor receptor in lung cancer
    • Scagliotti GV, Selvaggi G, Novello S, Hirsch FR. The biology of epidermal growth factor receptor in lung cancer. Clin Cancer Res 2004; 10(12 Pt 2): 4227s-4232s.
    • (2004) Clin Cancer Res , vol.10 , Issue.12 PART 2
    • Scagliotti, G.V.1    Selvaggi, G.2    Novello, S.3    Hirsch, F.R.4
  • 125
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
    • Kim ES, Hirsh V, Mok T, et al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet 2008; 372(9652): 1809-1818.
    • (2008) Lancet , vol.372 , Issue.9652 , pp. 1809-1818
    • Kim, E.S.1    Hirsh, V.2    Mok, T.3
  • 126
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. New Engl J Med 2005; 353(2): 123-132.
    • (2005) New Engl J Med , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 127
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, Yang CH, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009; 361(10): 947-957.
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3    Yang, C.H.4
  • 128
    • 70350772288 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors - a review on pharmacology, metabolism and side effects
    • Hartmann JT, Haap M, Kopp HG, Lipp H-P. Tyrosine kinase inhibitors - a review on pharmacology, metabolism and side effects. Curr Drug Metab 2009; 10(5): 470-481
    • (2009) Curr Drug Metab , vol.10 , Issue.5 , pp. 470-481
    • Hartmann, J.T.1    Haap, M.2    Kopp, H.G.3    Lipp, H.-P.4
  • 129
    • 84903972782 scopus 로고    scopus 로고
    • http://www.cancer.gov/cancertopics/druginfo/fda-erlotinib-hydrochloride
  • 130
    • 84881253216 scopus 로고    scopus 로고
    • Primary resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with non-small-cell lung cancer harboring TKI-sensitive EGFR mutations: An exploratory study
    • [Epub ahead of print]
    • Lee JK, Shin JY, Kim S, et al. Primary resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with non-small-cell lung cancer harboring TKI-sensitive EGFR mutations: an exploratory study. Ann Oncol 2013. [Epub ahead of print]
    • (2013) Ann Oncol
    • Lee, J.K.1    Shin, J.Y.2    Kim, S.3
  • 131
    • 84873053331 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors: Current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer
    • Galvani E, Alfieri R, Giovannetti E, et al. Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer. Curr Pharm Des 2013; 19(5): 818-832.
    • (2013) Curr Pharm Des , vol.19 , Issue.5 , pp. 818-832
    • Galvani, E.1    Alfieri, R.2    Giovannetti, E.3
  • 132
    • 33845803204 scopus 로고    scopus 로고
    • Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels
    • Helfrich BA, Raben D, Varella-Garcia M, et al. Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels. Clin Cancer Res 2006; 12(23): 7117-7125.
    • (2006) Clin Cancer Res , vol.12 , Issue.23 , pp. 7117-7125
    • Helfrich, B.A.1    Raben, D.2    Varella-Garcia, M.3
  • 133
    • 84874781893 scopus 로고    scopus 로고
    • Alterations in EGFR and Related Genes following Neo-Adjuvant Chemotherapy in Chinese Patients with Non-Small Cell Lung Cancer
    • Wang S, An T, Duan J, et al. Alterations in EGFR and Related Genes following Neo-Adjuvant Chemotherapy in Chinese Patients with Non-Small Cell Lung Cancer. PLoS One 2013; 8(3): e51021.
    • (2013) PLoS One , vol.8 , Issue.3
    • Wang, S.1    An, T.2    Duan, J.3
  • 134
    • 34247477205 scopus 로고    scopus 로고
    • Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers
    • Nomura M, Shigematsu H, Li L, et al. Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers. PLoS Med 2007; 4(4): e125.
    • (2007) PLoS Med , vol.4 , Issue.4
    • Nomura, M.1    Shigematsu, H.2    Li, L.3
  • 135
    • 0028043510 scopus 로고
    • A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling
    • Moriai T, Kobrin MS, Hope C, Speck L, Korc M. A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling. P Natl Acad Sci USA 1994; 91(21): 10217-10221.
    • (1994) P Natl Acad Sci USA , vol.91 , Issue.21 , pp. 10217-10221
    • Moriai, T.1    Kobrin, M.S.2    Hope, C.3    Speck, L.4    Korc, M.5
  • 136
    • 11244319884 scopus 로고    scopus 로고
    • A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter
    • Liu W, Innocenti F, Wu MH, et al. A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter. Cancer Res 2005; 65(1): 46-53.
    • (2005) Cancer Res , vol.65 , Issue.1 , pp. 46-53
    • Liu, W.1    Innocenti, F.2    Wu, M.H.3
  • 137
    • 40949096067 scopus 로고    scopus 로고
    • Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib
    • Liu G, Gurubhagavatula S, Zhou W, et al. Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib. Pharmacogenomics J 2008; 8(2): 129-138.
    • (2008) Pharmacogenomics J , vol.8 , Issue.2 , pp. 129-138
    • Liu, G.1    Gurubhagavatula, S.2    Zhou, W.3
  • 138
    • 84868117908 scopus 로고    scopus 로고
    • EGFR polymorphism as a predictor of clinical outcome in advanced lung cancer patients treated with EGFR-TKI
    • Jung M, Cho BC, Lee CH, et al. EGFR polymorphism as a predictor of clinical outcome in advanced lung cancer patients treated with EGFR-TKI. Yonsei Med J 2012; 53(6): 1128-1135.
    • (2012) Yonsei Med J , vol.53 , Issue.6 , pp. 1128-1135
    • Jung, M.1    Cho, B.C.2    Lee, C.H.3
  • 139
    • 33846994719 scopus 로고    scopus 로고
    • The impact of epidermal growth factor receptor gene status on gefitinib-treated Japanese patients with non-small-cell lung cancer
    • Ichihara S, Toyooka S, Fujiwara Y, et al. The impact of epidermal growth factor receptor gene status on gefitinib-treated Japanese patients with non-small-cell lung cancer. Int J Cancer. 2007; 120(6): 1239-1247.
    • (2007) Int J Cancer , vol.120 , Issue.6 , pp. 1239-1247
    • Ichihara, S.1    Toyooka, S.2    Fujiwara, Y.3
  • 140
    • 84866382941 scopus 로고    scopus 로고
    • Polymorphisms in intron 1 of the EGFR gene in non-small cell lung cancer patients
    • Shitara M, Sasaki H, Yokota K, et al. Polymorphisms in intron 1 of the EGFR gene in non-small cell lung cancer patients. Exp Ther Med 2012; 4(5): 785-789.
    • (2012) Exp Ther Med , vol.4 , Issue.5 , pp. 785-789
    • Shitara, M.1    Sasaki, H.2    Yokota, K.3
  • 141
    • 39449096577 scopus 로고    scopus 로고
    • Germline polymorphisms in EGFR and survival in patients with lung cancer receiving gefitinib
    • Gregorc V, Hidalgo M, Spreafico A, et al. Germline polymorphisms in EGFR and survival in patients with lung cancer receiving gefitinib. Clin Pharmacol Ther 2008; 83(3): 477-484.
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.3 , pp. 477-484
    • Gregorc, V.1    Hidalgo, M.2    Spreafico, A.3
  • 142
    • 0033914059 scopus 로고    scopus 로고
    • Modulation of EGFR gene transcription by secondary structures, a polymorphic repetitive sequence and mutations--a link between genetics and epigenetics
    • Gebhardt F, Bürger H, Brandt B. Modulation of EGFR gene transcription by secondary structures, a polymorphic repetitive sequence and mutations--a link between genetics and epigenetics. Histol Histopathol 2000; 15(3): 929-936.
    • (2000) Histol Histopathol , vol.15 , Issue.3 , pp. 929-936
    • Gebhardt, F.1    Bürger, H.2    Brandt, B.3
  • 143
    • 10844264628 scopus 로고    scopus 로고
    • An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors
    • Amador ML, Oppenheimer D, Perea S, et al. An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors. Cancer Res 2004; 64(24): 9139-9143.
    • (2004) Cancer Res , vol.64 , Issue.24 , pp. 9139-9143
    • Amador, M.L.1    Oppenheimer, D.2    Perea, S.3
  • 144
    • 0040886242 scopus 로고    scopus 로고
    • Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1
    • Gebhardt F, Zänker KS, Brandt B. Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1. J Biol Chem 1999; 274(19): 13176-13180.
    • (1999) J Biol Chem , vol.274 , Issue.19 , pp. 13176-13180
    • Gebhardt, F.1    Zänker, K.S.2    Brandt, B.3
  • 145
    • 0034652578 scopus 로고    scopus 로고
    • Length and loss of het-erozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression
    • Buerger H, Gebhardt F, Schmidt H, et al. Length and loss of het-erozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression. Cancer Res 2000; 60(4): 854-857.
    • (2000) Cancer Res , vol.60 , Issue.4 , pp. 854-857
    • Buerger, H.1    Gebhardt, F.2    Schmidt, H.3
  • 146
    • 34247281406 scopus 로고    scopus 로고
    • Intron 1 CA dinucleotide repeat polymorphism and mutations of epidermal growth factor receptor and gefitinib responsiveness in non-small-cell lung cancer
    • Han S-W, Jeon YK, Lee KH, et al. Intron 1 CA dinucleotide repeat polymorphism and mutations of epidermal growth factor receptor and gefitinib responsiveness in non-small-cell lung cancer. Phar-macogenet Genom 2007; 17(5): 313-319.
    • (2007) Phar-macogenet Genom , vol.17 , Issue.5 , pp. 313-319
    • Han, S.-W.1    Jeon, Y.K.2    Lee, K.H.3
  • 147
    • 68949208058 scopus 로고    scopus 로고
    • Polymorphisms of EGFR predict clinical outcome in advanced non-small-cell lung cancer patients treated with Gefitinib
    • Ma F, Sun T, Shi Y, et al. Polymorphisms of EGFR predict clinical outcome in advanced non-small-cell lung cancer patients treated with Gefitinib. Lung Cancer 2009; 66(1): 114-119.
    • (2009) Lung Cancer , vol.66 , Issue.1 , pp. 114-119
    • Ma, F.1    Sun, T.2    Shi, Y.3
  • 148
    • 33846979362 scopus 로고    scopus 로고
    • EGFR dinucleotide repeat polymorphism as a prognostic indicator in non-small cell lung cancer
    • Dubey S, Stephenson P, Levy DE, et al. EGFR dinucleotide repeat polymorphism as a prognostic indicator in non-small cell lung cancer. J Thorac Oncol 2006; 1(5): 406-412.
    • (2006) J Thorac Oncol , vol.1 , Issue.5 , pp. 406-412
    • Dubey, S.1    Stephenson, P.2    Levy, D.E.3
  • 149
    • 34547841540 scopus 로고    scopus 로고
    • The epidermal growth factor receptor intron1 (CA) n microsatellite polymorphism is a potential predictor of treatment outcome in patients with advanced lung cancer treated with Gefitinib
    • Nie Q, Wang Z, Zhang GC, et al. The epidermal growth factor receptor intron1 (CA) n microsatellite polymorphism is a potential predictor of treatment outcome in patients with advanced lung cancer treated with Gefitinib. Eur J Pharmacol 2007; 570(1-3): 175-181.
    • (2007) Eur J Pharmacol , vol.570 , Issue.1-3 , pp. 175-181
    • Nie, Q.1    Wang, Z.2    Zhang, G.C.3
  • 150
    • 58949098405 scopus 로고    scopus 로고
    • Epidermal growth factor receptor intron-1 polymorphism predicts gefitinib outcome in advanced non-small cell lung cancer
    • Tiseo M, Capelletti M, De Palma G, et al. Epidermal growth factor receptor intron-1 polymorphism predicts gefitinib outcome in advanced non-small cell lung cancer. J Thorac Oncol 2008; 3(10): 1104-1111.
    • (2008) J Thorac Oncol , vol.3 , Issue.10 , pp. 1104-1111
    • Tiseo, M.1    Capelletti, M.2    de Palma, G.3
  • 151
    • 75749153247 scopus 로고    scopus 로고
    • Predictors of gefitinib outcomes in advanced non-small cell lung cancer (NSCLC): Study of a comprehensive panel of molecular markers
    • Tiseo M, Rossi G, Capelletti M, et al. Predictors of gefitinib outcomes in advanced non-small cell lung cancer (NSCLC): study of a comprehensive panel of molecular markers. Lung Cancer 2010; 67(3): 355-360.
    • (2010) Lung Cancer , vol.67 , Issue.3 , pp. 355-360
    • Tiseo, M.1    Rossi, G.2    Capelletti, M.3
  • 152
    • 77949686314 scopus 로고    scopus 로고
    • Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib
    • Giovannetti E, Zucali PA, Peters GJ, et al. Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib. Mol Cancer Ther 2010; 9(3): 581-593.
    • (2010) Mol Cancer Ther , vol.9 , Issue.3 , pp. 581-593
    • Giovannetti, E.1    Zucali, P.A.2    Peters, G.J.3
  • 153
    • 80755181069 scopus 로고    scopus 로고
    • Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer
    • Brugger W, Triller N, Blasinska-Morawiec M, et al. Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer. J Clin Oncol 2011; 29(31): 4113-4120.
    • (2011) J Clin Oncol , vol.29 , Issue.31 , pp. 4113-4120
    • Brugger, W.1    Triller, N.2    Blasinska-Morawiec, M.3
  • 154
    • 84875551505 scopus 로고    scopus 로고
    • Association among Polymorphisms in EGFR Gene Exons, Lifestyle and Risk of Gastric Cancer with Gender Differences in Chinese Han Subjects
    • Zhang J, Zhan Z, Wu J, et al. Association among Polymorphisms in EGFR Gene Exons, Lifestyle and Risk of Gastric Cancer with Gender Differences in Chinese Han Subjects. PLoS One 2013; 8(3): e59254.
    • (2013) PLoS One , vol.8 , Issue.3
    • Zhang, J.1    Zhan, Z.2    Wu, J.3
  • 155
    • 84866382941 scopus 로고    scopus 로고
    • Polymorphisms in intron 1 of the EGFR gene in non-small cell lung cancer patients
    • Shitara M, Sasaki H, Yokota K, et al. Polymorphisms in intron 1 of the EGFR gene in non-small cell lung cancer patients. Exp Ther Med 2012; 4(5): 785-789.
    • (2012) Exp Ther Med , vol.4 , Issue.5 , pp. 785-789
    • Shitara, M.1    Sasaki, H.2    Yokota, K.3
  • 156
    • 4444332925 scopus 로고    scopus 로고
    • Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
    • Cappuzzo F, Magrini E, Ceresoli GL, et al. Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J Natl Cancer I 2004; 96(15): 1133-1141.
    • (2004) J Natl Cancer I , vol.96 , Issue.15 , pp. 1133-1141
    • Cappuzzo, F.1    Magrini, E.2    Ceresoli, G.L.3
  • 157
    • 34250161814 scopus 로고    scopus 로고
    • Prospective study of gefit-inib in epidermal growth factor receptor fluorescence in situ hy-bridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: The ONCOBELL trial
    • Cappuzzo F, Ligorio C, Jänne PA, et al. Prospective study of gefit-inib in epidermal growth factor receptor fluorescence in situ hy-bridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial. J Clin Oncol. 2007; 25(16): 2248-2255.
    • (2007) J Clin Oncol , vol.25 , Issue.16 , pp. 2248-2255
    • Cappuzzo, F.1    Ligorio, C.2    Jänne, P.A.3
  • 158
    • 43249115083 scopus 로고    scopus 로고
    • Mutational analysis of onco-genic AKT E17K mutation in common solid cancers and acute leukaemias
    • Kim MS, Jeong EG, Yoo NJ, Lee SH. Mutational analysis of onco-genic AKT E17K mutation in common solid cancers and acute leukaemias. Brit J Cancer 2008; 98(9): 1533-1535.
    • (2008) Brit J Cancer , vol.98 , Issue.9 , pp. 1533-1535
    • Kim, M.S.1    Jeong, E.G.2    Yoo, N.J.3    Lee, S.H.4
  • 159
    • 28044453746 scopus 로고    scopus 로고
    • Detection of functional single-nucleotide polymorphisms that affect apoptosis
    • Harris SL, Gil G, Robins H, et al. Detection of functional single-nucleotide polymorphisms that affect apoptosis. P Natl Acad Sci USA 2005; 102(45): 16297-1302.
    • (2005) P Natl Acad Sci USA , vol.102 , Issue.45 , pp. 16297-16302
    • Harris, S.L.1    Gil, G.2    Robins, H.3
  • 160
    • 0842310838 scopus 로고    scopus 로고
    • Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia
    • Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 2004; 36(2): 131-137.
    • (2004) Nat Genet , vol.36 , Issue.2 , pp. 131-137
    • Emamian, E.S.1    Hall, D.2    Birnbaum, M.J.3    Karayiorgou, M.4    Gogos, J.A.5
  • 161
    • 60849109531 scopus 로고    scopus 로고
    • Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradio-therapy
    • Hildebrandt MAT, Yang H, Hung M-C, et al. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradio-therapy. J Clin Oncol 2009; 27(6): 857-871.
    • (2009) J Clin Oncol , vol.27 , Issue.6 , pp. 857-871
    • Hildebrandt, M.A.T.1    Yang, H.2    Hung, M.-C.3
  • 162
    • 84855347923 scopus 로고    scopus 로고
    • AKT1 polymorphisms and survival of early stage non-small cell lung cancer
    • Kim MJ, Kang H-G, Lee SY, et al. AKT1 polymorphisms and survival of early stage non-small cell lung cancer. J Surg Oncol 2012; 105(2): 167-174
    • (2012) J Surg Oncol , vol.105 , Issue.2 , pp. 167-174
    • Kim, M.J.1    Kang, H.-G.2    Lee, S.Y.3
  • 163
    • 40349098162 scopus 로고    scopus 로고
    • Drug transporters: Recent advances concerning BCRP and tyrosine kinase inhibitors
    • Lemos C, Jansen G, Peters GJ. Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors. Brit J Cancer 2008; 98(5): 857-862.
    • (2008) Brit J Cancer , vol.98 , Issue.5 , pp. 857-862
    • Lemos, C.1    Jansen, G.2    Peters, G.J.3
  • 164
    • 34548240764 scopus 로고    scopus 로고
    • Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyro-sine kinase inhibitors in cancer patients
    • Li J, Cusatis G, Brahmer J, et al. Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyro-sine kinase inhibitors in cancer patients. Cancer Biol Ther 2007; 6(3): 432-438.
    • (2007) Cancer Biol Ther , vol.6 , Issue.3 , pp. 432-438
    • Li, J.1    Cusatis, G.2    Brahmer, J.3
  • 165
    • 79951937698 scopus 로고    scopus 로고
    • Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients
    • Lemos C, Giovannetti E, Zucali PA, et al. Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients. Pharmacogenomics 2011; 12(2): 159-170.
    • (2011) Pharmacogenomics , vol.12 , Issue.2 , pp. 159-170
    • Lemos, C.1    Giovannetti, E.2    Zucali, P.A.3
  • 166
    • 24644513947 scopus 로고    scopus 로고
    • Cutaneous adverse effects with HER1/EGFR-targeted agents: Is there a silver lining?
    • Peréz-Soler R, Saltz L. Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining? J Clin Oncol 2005; 23(22): 5235-5246.
    • (2005) J Clin Oncol , vol.23 , Issue.22 , pp. 5235-5246
    • Peréz-Soler, R.1    Saltz, L.2
  • 167
    • 84865243290 scopus 로고    scopus 로고
    • EGF receptor-targeted therapy in non-small-cell lung cancer: Role of germline polymorphisms in outcome and toxicity
    • Galvani E, Peters GJ, Giovannetti E. EGF receptor-targeted therapy in non-small-cell lung cancer: role of germline polymorphisms in outcome and toxicity. Future Oncol 2012; 8(8): 1015-1029.
    • (2012) Future Oncol , vol.8 , Issue.8 , pp. 1015-1029
    • Galvani, E.1    Peters, G.J.2    Giovannetti, E.3
  • 168
    • 67349206986 scopus 로고    scopus 로고
    • EGFR intron 1 dinucleo-tide repeat polymorphism is associated with the occurrence of skin rash with gefitinib treatment
    • Huang C-L, Yang C-H, Yeh K-H, et al. EGFR intron 1 dinucleo-tide repeat polymorphism is associated with the occurrence of skin rash with gefitinib treatment. Lung Cancer 2009; 64(3): 346-351.
    • (2009) Lung Cancer , vol.64 , Issue.3 , pp. 346-351
    • Huang, C.-L.1    Yang, C.-H.2    Yeh, K.-H.3
  • 169
    • 41949140593 scopus 로고    scopus 로고
    • Pharmacogenomic and pharma-cokinetic determinants of erlotinib toxicity
    • Rudin CM, Liu W, Desai A, et al. Pharmacogenomic and pharma-cokinetic determinants of erlotinib toxicity. J Clin Oncol 2008; 26(7): 1119-1127
    • (2008) J Clin Oncol , vol.26 , Issue.7 , pp. 1119-1127
    • Rudin, C.M.1    Liu, W.2    Desai, A.3
  • 170
    • 33845657889 scopus 로고    scopus 로고
    • Pharmacogenetics of ABCG2 and adverse reactions to gefitinib
    • Cusatis G, Gregorc V, Li J, et al. Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer I 2006; 98(23): 1739-1742.
    • (2006) J Natl Cancer I , vol.98 , Issue.23 , pp. 1739-1742
    • Cusatis, G.1    Gregorc, V.2    Li, J.3
  • 171
    • 84859248858 scopus 로고    scopus 로고
    • Association of ABCB1 polymorphisms with erlotinib pharmacokinetics and toxicity in Japanese patients with non-small-cell lung cancer
    • Hamada A, Sasaki J, Saeki S, et al. Association of ABCB1 polymorphisms with erlotinib pharmacokinetics and toxicity in Japanese patients with non-small-cell lung cancer. Pharmacogenomics 2012; 13(5): 615-624.
    • (2012) Pharmacogenomics , vol.13 , Issue.5 , pp. 615-624
    • Hamada, A.1    Sasaki, J.2    Saeki, S.3
  • 172
    • 34250694236 scopus 로고    scopus 로고
    • Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes
    • Li J, Zhao M, He P, Hidalgo M, Baker SD. Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res 2007; 13(12): 3731-3737.
    • (2007) Clin Cancer Res , vol.13 , Issue.12 , pp. 3731-3737
    • Li, J.1    Zhao, M.2    He, P.3    Hidalgo, M.4    Baker, S.D.5
  • 173
    • 79951906119 scopus 로고    scopus 로고
    • Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers
    • Von Hoff DD, Stephenson JJ Jr., Rosen P, et al. Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers. J Clin Oncol 2010; 28: 4877-4883.
    • (2010) J Clin Oncol , vol.28 , pp. 4877-4883
    • von Hoff, D.D.1    Stephenson Jr., J.J.2    Rosen, P.3
  • 174
    • 84855558810 scopus 로고    scopus 로고
    • Personalized medicine in a phase I clinical trials program: The M. D. Anderson Cancer Center Initiative
    • Abstr CRA2500
    • Tsimberidou AM, Iskander NG, Hong DS, et al. Personalized medicine in a phase I clinical trials program: The M. D. Anderson Cancer Center Initiative. J Clin Oncol 2011; 29(suppl). (Abstr CRA2500).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Tsimberidou, A.M.1    Iskander, N.G.2    Hong, D.S.3
  • 175
    • 79957857433 scopus 로고    scopus 로고
    • The BATTLE trial: Personalizing therapy for lung cancer
    • Kim ES, Herbst RS, Wistuba II, et al. The BATTLE trial: personalizing therapy for lung cancer. Cancer Discov 2011; 1: 44-53.
    • (2011) Cancer Discov , vol.1 , pp. 44-53
    • Kim, E.S.1    Herbst, R.S.2    Wistuba, I.I.3
  • 176
    • 52649154223 scopus 로고    scopus 로고
    • Bayesian adaptive design for targeted therapy development in lung cancer--a step toward personalized medicine
    • Zhou X, Liu S, Kim ES, et al. Bayesian adaptive design for targeted therapy development in lung cancer--a step toward personalized medicine. Clin Trials 2008; 5: 181-193.
    • (2008) Clin Trials , vol.5 , pp. 181-193
    • Zhou, X.1    Liu, S.2    Kim, E.S.3
  • 177
    • 33847293670 scopus 로고    scopus 로고
    • High-throughput onco-gene mutation profiling in human cancer
    • Thomas RK, Baker AC, Debiasi RM, et al. High-throughput onco-gene mutation profiling in human cancer. Nat Genet 2007; 39: 347-351.
    • (2007) Nat Genet , vol.39 , pp. 347-351
    • Thomas, R.K.1    Baker, A.C.2    Debiasi, R.M.3
  • 178
    • 77954566882 scopus 로고    scopus 로고
    • Rapid targeted mutational analysis of human tumours: A clinical platform to guide personalized cancer medicine
    • Dias-Santagata D, Akhavanfard S, David SS, et al. Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine. Embo Mol Med 2010; 2: 146-158.
    • (2010) Embo Mol Med , vol.2 , pp. 146-158
    • Dias-Santagata, D.1    Akhavanfard, S.2    David, S.S.3
  • 179
    • 78651079558 scopus 로고    scopus 로고
    • A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer
    • Su Z, Dias-Santagata D, Duke M, et al. A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer. J Mol Diagn 2011; 13: 74-84.
    • (2011) J Mol Diagn , vol.13 , pp. 74-84
    • Su, Z.1    Dias-Santagata, D.2    Duke, M.3
  • 180
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies-the next generation
    • Metzker ML. Sequencing technologies - the next generation. Nat Rev Genet 2010; 11: 31-46.
    • (2010) Nat Rev Genet , vol.11 , pp. 31-46
    • Metzker, M.L.1
  • 181
    • 77956838065 scopus 로고    scopus 로고
    • Advances in understanding cancer genomes through second-generation sequencing
    • Meyerson M, Gabriel S, Getz G. Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet 2010; 11: 685-696.
    • (2010) Nat Rev Genet , vol.11 , pp. 685-696
    • Meyerson, M.1    Gabriel, S.2    Getz, G.3
  • 182
    • 84865833740 scopus 로고    scopus 로고
    • High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
    • Wagle N, Berger MF, Davis MJ, et al. High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discov 2012; 2: 82.
    • (2012) Cancer Discov , vol.2 , pp. 82
    • Wagle, N.1    Berger, M.F.2    Davis, M.J.3
  • 183
    • 84874575119 scopus 로고    scopus 로고
    • The efficacy of targeted next-generation sequencing for detection of clinically actionable mutations in cancer
    • Abstr 10598
    • Wen Y-Y, Fang E, Li Y, et al. The efficacy of targeted next-generation sequencing for detection of clinically actionable mutations in cancer. J Clin Oncol 2012; 30(suppl). (Abstr 10598).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Wen, Y.-Y.1    Fang, E.2    Li, Y.3


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