Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: A prospective clinical study

Cancer

Volumn 118, Issue 9, 2012, Pages 2466-2475

  Joerger, Markus ^a,b,c   Burgers, Sjaak A ^b   Baas, Paul ^b   Smit, Egbert F ^d   Haitjema, Tjeerd J ^e   Bard, Martin P L ^f   Doodeman, Valerie D ^a   Smits, Paul H M ^a   Vincent, Andrew ^b   Huitema, Alwin D R ^a   Beijnen, Jos H ^a,b,g   Schellens, Jan H M ^b,g  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e Northwest Clinics   (Netherlands)

^f N   (Netherlands)

^g UTRECHT UNIVERSITY   (Netherlands)

Author keywords

bronchial neoplasms; carboplatin; cisplatin; DNA repair; gemcitabine; pharmacogenetics

Indexed keywords

ADENINE; CARBOPLATIN; CISPLATIN; CYTIDINE DEAMINASE; CYTOSINE; DNA HELICASE Q1; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; GEMCITABINE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE PI 1; HELICASE; MUTANT PROTEIN; PLATINUM; THYMINE; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP A PROTEIN; XRCC1 PROTEIN;

ADULT; ADVANCED CANCER; ALLELE; ARTICLE; BONE MARROW SUPPRESSION; CANCER STAGING; CLINICAL STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA REPAIR; DRUG EFFICACY; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HEARING IMPAIRMENT; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; KIDNEY DISEASE; LEUKOPENIA; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; ONCOGENE; ONCOGENE CDA; ONCOGENE ERCC1; ONCOGENE RECQ1; ONCOGENE XPD10; ONCOGENE XRCC1; OVERALL SURVIVAL; PERIPHERAL NEUROPATHY; POLYNEUROPATHY; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; TREATMENT DURATION; TREATMENT RESPONSE;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CARCINOMA, NON-SMALL-CELL LUNG; CISPLATIN; DEOXYCYTIDINE; DISEASE-FREE SURVIVAL; FEMALE; GERM CELLS; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROGNOSIS; TREATMENT OUTCOME;

EID: 84860216677     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.26562     Document Type: Article

References (33)

1. Le Chevalier T, Scagliotti G, Natale R, et al. Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes. Lung Cancer. 2005; 47: 69-80.
2. Smit EF, van Meerbeeck JP, Lianes P, et al. Three-arm randomized study of 2 cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975. J Clin Oncol. 2003; 21: 3909-3917.
3. Sancar A,. DNA repair in humans. Annu Rev Genet. 1995; 29: 69-105.
4. Isla D, Sarries C, Rosell R, et al. Single nucleotide polymorphisms and outcome in docetaxel-cisplatin-treated advanced non-small-cell lung cancer. Ann Oncol. 2004; 15: 1194-1203.
5. Kalikaki A, Kanaki M, Vassalou H, et al. DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer. Clin Lung Cancer. 2009; 10: 118-123.
6. Ryu JS, Hong YC, Han HS, et al. Association between polymorphisms of ERCC1 and XPD and survival in non-small-cell lung cancer patients treated with cisplatin combination chemotherapy. Lung Cancer. 2004; 44: 311-316.
7. de las Penas R, Sanchez-Ronco M, Alberola V, et al. Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients. Ann Oncol. 2006; 17: 668-675.
8. Takenaka T, Yano T, Kiyohara C, et al. Effects of excision repair cross-complementation group 1 (ERCC1) single nucleotide polymorphisms on the prognosis of non-small cell lung cancer patients. Lung Cancer. 2010; 67: 101-107.
9. Tibaldi C, Giovannetti E, Vasile E, et al. Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients. Clin Cancer Res. 2008; 14: 1797-1803.
10. Zhou W, Gurubhagavatula S, Liu G, et al. Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Clin Cancer Res. 2004; 10: 4939-4943.
11. Gurubhagavatula S, Liu G, Park S, et al. XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy. J Clin Oncol. 2004; 22: 2594-2601.
12. Giachino DF, Ghio P, Regazzoni S, et al. Prospective assessment of XPD Lys751Gln and XRCC1 Arg399Gln single nucleotide polymorphisms in lung cancer. Clin Cancer Res. 2007; 13: 2876-2881.
13. Yao CY, Huang XE, Li C, et al. Lack of influence of XRCC1 and XPD gene polymorphisms on outcome of platinum-based chemotherapy for advanced non small cell lung cancers. Asian Pac J Cancer Prev. 2009; 10: 859-864.
14. Yuan P, Liu L, Wu C, et al. No association between XRCC1 polymorphisms and survival in non-small-cell lung cancer patients treated with platinum-based chemotherapy. Cancer Biol Ther. 2010; 10: 854-859.
15. Fukunaga AK, Marsh S, Murry DJ, Hurley TD, McLeod HL,. Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway. Pharmacogenomics J. 2004; 4: 307-314.
16. Ueno H, Kaniwa N, Okusaka T, et al. Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients. Br J Cancer. 2009; 100: 870-873.
17. Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000; 92: 205-216.
18. Greatens TM, Niehans GA, Rubins JB, et al. Do molecular markers predict survival in non-small-cell lung cancer? Am J Respir Crit Care Med. 1998; 157: 1093-1097.
19. Salgia R, Skarin AT,. Molecular abnormalities in lung cancer. J Clin Oncol. 1998; 16: 1207-1217.
20. Ceppi P, Volante M, Novello S, et al. ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine. Ann Oncol. 2006; 17: 1818-1825.
21. Holm B, Mellemgaard A, Skov T, Skov BG,. Different impact of excision repair cross-complementation group 1 on survival in male and female patients with inoperable non-small-cell lung cancer treated with carboplatin and gemcitabine. J Clin Oncol. 2009; 27: 4254-4259.
22. Vilmar AC, Santoni-Rugiu E, Sorensen JB,. ERCC1 and histopathology in advanced NSCLC patients randomized in a large multicenter phase III trial. Ann Oncol. 2010; 21: 1817-1824.
23. Bepler G, Sommers KE, Cantor A, et al. Clinical efficacy and predictive molecular markers of neoadjuvant gemcitabine and pemetrexed in resectable non-small cell lung cancer. J Thorac Oncol. 2008; 3: 1112-1118.
24. Reynolds C, Obasaju C, Schell MJ, et al. Randomized phase III trial of gemcitabine-based chemotherapy with in situ RRM1 and ERCC1 protein levels for response prediction in non-small-cell lung cancer. J Clin Oncol. 2009; 27: 5808-5815.
25. Souglakos J, Boukovinas I, Taron M, et al. Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine. Br J Cancer. 2008; 98: 1710-1715.
26. Joerger M, Burgers SA, Baas P, et al. Gene polymorphisms, pharmacokinetics and hematological toxicity in advanced non small-cell lung cancer patients receiving cisplatin/gemcitabine [published online ahead of print May 18, 2011]. Cancer Chemother Pharmacol. 2011.
27. McLeod HL, Sargent DJ, Marsh S, et al. Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741. J Clin Oncol. 2010; 28: 3227-3233.
28. Gamelin L, Capitain O, Morel A, et al. Predictive factors of oxaliplatin neurotoxicity: the involvement of the oxalate outcome pathway. Clin Cancer Res. 2007; 13: 6359-6368.
29. Lecomte T, Landi B, Beaune P, Laurent-Puig P, Loriot MA,. Glutathione S-transferase P1 polymorphism (Ile105Val) predicts cumulative neuropathy in patients receiving oxaliplatin-based chemotherapy. Clin Cancer Res. 2006; 12: 3050-3056.
30. Dong S, Guo AL, Chen ZH, et al. RRM1 single nucleotide polymorphism -37C→A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy [serial online]. J Hematol Oncol. 2010; 3: 10.
31. Kim SO, Jeong JY, Kim MR, et al. Efficacy of gemcitabine in patients with non-small cell lung cancer according to promoter polymorphisms of the ribonucleotide reductase M1 gene. Clin Cancer Res. 2008; 14: 3083-3088.
32. Li F, Sun X, Sun N, et al. Association between polymorphisms of ERCC1 and XPD and clinical response to platinum-based chemotherapy in advanced non-small cell lung cancer. Am J Clin Oncol. 2010; 33: 489-494.
33. Horgan AM, Yang B, Azad AK, et al. Pharmacogenetic and germline prognostic markers of lung cancer. J Thorac Oncol. 2011; 6: 296-304.