EGF receptor-targeted therapy in non-small-cell lung cancer: Role of germline polymorphisms in outcome and toxicity

Future Oncology

Volumn 8, Issue 8, 2012, Pages 1015-1029

  Galvani, Elena ^a   Peters, Godefridus J ^a   Giovannetti, Elisa ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

EGFR tyrosine kinase inhibitor; erlotinib; gefitinib; non small cell lung cancer; outcome; polymorphism; toxicity

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; GEFITINIB; GEMCITABINE; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN KINASE B; TRANSCRIPTION FACTOR SP1;

ALLELE; BINDING SITE; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CANCER RESISTANCE; CANCER SURVIVAL; CAUCASIAN; DIARRHEA; DNA FLANKING REGION; DRUG APPROVAL; DRUG ERUPTION; DRUG INDICATION; DRUG RESPONSE; EXCISION REPAIR; EXON; GENE EXPRESSION; GENE MUTATION; GENETIC CORRELATION; GENETIC POLYMORPHISM; HUMAN; INTRON; JAPANESE; LUNG NON SMALL CELL CANCER; OVERALL SURVIVAL; PERSONALIZED MEDICINE; PHARMACOGENETICS; POST TREATMENT SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROMOTER REGION; QUALITY OF LIFE; REVIEW; TREATMENT OUTCOME;

ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; GERM-LINE MUTATION; HUMANS; POLYMORPHISM, GENETIC; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TREATMENT OUTCOME;

EID: 84865243290     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.12.89     Document Type: Review

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