-
1
-
-
0000714693
-
Some properties of a growth factor for Lactobacillus casei
-
Stokstad ELR. Some properties of a growth factor for Lactobacillus casei. J Biol Chem 1943;149:573-4.
-
(1943)
J Biol Chem
, vol.149
, pp. 573-574
-
-
Stokstad, E.L.R.1
-
2
-
-
33744813184
-
Pteroylaspartic acid, an antagonist for pteroylglutamic acid
-
Hutchings BL, Mowat JH, Oleson JJ, et al. Pteroylaspartic acid, an antagonist for pteroylglutamic acid. J Biol Chem 1947; 170:323-8.
-
(1947)
J Biol Chem
, vol.170
, pp. 323-328
-
-
Hutchings, B.L.1
Mowat, J.H.2
Oleson, J.J.3
-
4
-
-
0009397214
-
The action of pteroylglutamic conjugates on man
-
Farber S, Cutler EC, Hawkins JW, et al. The action of pteroylglutamic conjugates on man. Science 1947; 106:619-21.
-
(1947)
Science
, vol.106
, pp. 619-621
-
-
Farber, S.1
Cutler, E.C.2
Hawkins, J.W.3
-
5
-
-
78651010566
-
Temporary remission in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl glutamic acid (aminopterin)
-
Farber S, Diamond LK, Mercer RD, Sylvester RF, Wolff VA. Temporary remission in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl glutamic acid (aminopterin). N Engl J Med 1948;238: 787-93.
-
(1948)
N Engl J Med
, vol.238
, pp. 787-793
-
-
Farber, S.1
Diamond, L.K.2
Mercer, R.D.3
Sylvester, R.F.4
Wolff, V.A.5
-
6
-
-
0001347264
-
Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer
-
Farber S. Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer. Blood 1949;4: 160-7.
-
(1949)
Blood
, vol.4
, pp. 160-167
-
-
Farber, S.1
-
7
-
-
0001051251
-
Specific Binding of 4-amino folic acid analogues by folic acid reductase
-
Werkheiser WC. Specific Binding of 4-amino folic acid analogues by folic acid reductase. J Biol Chem 1961;236:888-93.
-
(1961)
J Biol Chem
, vol.236
, pp. 888-893
-
-
Werkheiser, W.C.1
-
8
-
-
30444437486
-
Treatment of acute lymphoblastic leukemia
-
Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006;354:166-78.
-
(2006)
N Engl J Med
, vol.354
, pp. 166-178
-
-
Pui, C.H.1
Evans, W.E.2
-
9
-
-
0031426332
-
The rational use of methotrexate in rheumatoid arthritis and other rheumatic diseases
-
Furst DE. The rational use of methotrexate in rheumatoid arthritis and other rheumatic diseases. Br J Rheumatol 1997;36:1196-204.
-
(1997)
Br J Rheumatol
, vol.36
, pp. 1196-1204
-
-
Furst, D.E.1
-
10
-
-
0031891059
-
Methotrexate in psoriasis: Consensus conference
-
Roenigk HH, Jr., Auerbach R, Maibach H, Weinstein G, Lebwohl M. Methotrexate in psoriasis: consensus conference. J Am Acad Dermatol 1998;38:478-85.
-
(1998)
J Am Acad Dermatol
, vol.38
, pp. 478-485
-
-
Roenigk Jr., H.H.1
Auerbach, R.2
Maibach, H.3
Weinstein, G.4
Lebwohl, M.5
-
12
-
-
0017344954
-
Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells
-
Whitehead VM. Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells. Cancer Res 1977;37:408-12.
-
(1977)
Cancer Res
, vol.37
, pp. 408-412
-
-
Whitehead, V.M.1
-
13
-
-
0017904277
-
Synthesis of methotrexate polyglutamates in cultured human cells
-
Rosenblatt DS, Whitehead VM, Dupont MM, Vuchich MJ, Vera N. Synthesis of methotrexate polyglutamates in cultured human cells. Mol Pharmacol 1978;14:210-4.
-
(1978)
Mol Pharmacol
, vol.14
, pp. 210-214
-
-
Rosenblatt, D.S.1
Whitehead, V.M.2
Dupont, M.M.3
Vuchich, M.J.4
Vera, N.5
-
14
-
-
0019951735
-
Synthesis, retention, and biological activity of methotrexate polyglutamates in cultured human breast cancer cells
-
Jolivet J, Schilsky RL, Bailey BD, Drake JC, Chabner BA. Synthesis, retention, and biological activity of methotrexate polyglutamates in cultured human breast cancer cells. J Clin Invest 1982;70:351-60.
-
(1982)
J Clin Invest
, vol.70
, pp. 351-360
-
-
Jolivet, J.1
Schilsky, R.L.2
Bailey, B.D.3
Drake, J.C.4
Chabner, B.A.5
-
16
-
-
0020081481
-
Rapid formation of poly-gammaglutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascited tumor cell in vitro
-
Fry DW, Yalowich JC, Goldman ID. Rapid formation of poly-gammaglutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascited tumor cell in vitro. J Biol Chem 1982;257:1890-6.
-
(1982)
J Biol Chem
, vol.257
, pp. 1890-1896
-
-
Fry, D.W.1
Yalowich, J.C.2
Goldman, I.D.3
-
17
-
-
0019800796
-
Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo
-
Poser RG, Sirotnak FM, Chello PL. Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo. Cancer Res 1981;41:4441-6.
-
(1981)
Cancer Res
, vol.41
, pp. 4441-4446
-
-
Poser, R.G.1
Sirotnak, F.M.2
Chello, P.L.3
-
18
-
-
0020686617
-
Analysis of the role of membrane transport and polyglutamylation of methotrexate in gut and Ehrlich tumor in vivo as factors in drug sensitivity and selectivity
-
Fry DW, Anderson LA, Borst M, Goldman ID. Analysis of the role of membrane transport and polyglutamylation of methotrexate in gut and Ehrlich tumor in vivo as factors in drug sensitivity and selectivity. Cancer Res 1983;43:1087-92.
-
(1983)
Cancer Res
, vol.43
, pp. 1087-1092
-
-
Fry, D.W.1
Anderson, L.A.2
Borst, M.3
Goldman, I.D.4
-
19
-
-
0021167732
-
Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro
-
Fabre I, Fabre G, Goldman ID. Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro. Cancer Res 1984;44:3190-5.
-
(1984)
Cancer Res
, vol.44
, pp. 3190-3195
-
-
Fabre, I.1
Fabre, G.2
Goldman, I.D.3
-
20
-
-
0021991778
-
Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow
-
Koizumi S, Curt GA, Fine RL, Griffin JD, Chabner BA. Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow. J Clin Invest 1985;75:1008-14.
-
(1985)
J Clin Invest
, vol.75
, pp. 1008-1014
-
-
Koizumi, S.1
Curt, G.A.2
Fine, R.L.3
Griffin, J.D.4
Chabner, B.A.5
-
21
-
-
0010105962
-
Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates
-
Allegra CJ, Drake JC, Jolivet J, Chabner BA. Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates. Proc Natl Acad Sci U S A 1985;82: 4881-5.
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, pp. 4881-4885
-
-
Allegra, C.J.1
Drake, J.C.2
Jolivet, J.3
Chabner, B.A.4
-
22
-
-
0022262215
-
Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates
-
Allegra CJ, Chabner BA, Drake JC, et al. Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. J Biol Chem 1985; 260:9720-6.
-
(1985)
J Biol Chem
, vol.260
, pp. 9720-9726
-
-
Allegra, C.J.1
Chabner, B.A.2
Drake, J.C.3
-
23
-
-
0022637441
-
Inhibition of 5-aminoimidazole4-carboxamide ribotide transformylase, adenosine deaminase and 5′-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide
-
Baggott JE, Vaughn WH, Hudson BB. Inhibition of 5-aminoimidazole4-carboxamide ribotide transformylase, adenosine deaminase and 5′-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide. Biochem J 1986;236:193-200.
-
(1986)
Biochem J
, vol.236
, pp. 193-200
-
-
Baggott, J.E.1
Vaughn, W.H.2
Hudson, B.B.3
-
24
-
-
0022410582
-
Polyglutamation of methotrexate. Is methotrexate a prodrug?
-
Chabner BA, Allegra CJ, Curt GA, et al. Polyglutamation of methotrexate. Is methotrexate a prodrug? J Clin Invest 1985;76:907-12.
-
(1985)
J Clin Invest
, vol.76
, pp. 907-912
-
-
Chabner, B.A.1
Allegra, C.J.2
Curt, G.A.3
-
25
-
-
0019368721
-
A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice
-
Jones TR, Calvert AH, Jackman AL, et al. A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice. Eur J Cancer 1981;17: 11-9.
-
(1981)
Eur J Cancer
, vol.17
, pp. 11-19
-
-
Jones, T.R.1
Calvert, A.H.2
Jackman, A.L.3
-
26
-
-
0025997350
-
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study
-
Jackman AL, Taylor GA, Gibson W, et al. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer Res 1991;51:5579-86.
-
(1991)
Cancer Res
, vol.51
, pp. 5579-5586
-
-
Jackman, A.L.1
Taylor, G.A.2
Gibson, W.3
-
27
-
-
0021813844
-
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin
-
Taylor EC, Harrington PJ, Fletcher SR, Beardsley GP, Moran RG. Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. J Med Chem 1985;28: 914-21.
-
(1985)
J Med Chem
, vol.28
, pp. 914-921
-
-
Taylor, E.C.1
Harrington, P.J.2
Fletcher, S.R.3
Beardsley, G.P.4
Moran, R.G.5
-
28
-
-
0024499104
-
A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis
-
Beardsley GP, Moroson BA, Taylor EC, Moran RG. A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis. J Biol Chem 1989;264:328-33.
-
(1989)
J Biol Chem
, vol.264
, pp. 328-333
-
-
Beardsley, G.P.1
Moroson, B.A.2
Taylor, E.C.3
Moran, R.G.4
-
29
-
-
0024802389
-
The 6S- abd 6R-diastereomers of 5,10-dideaza-5,6,7,8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis
-
Moran RG, Baldwin SW, Taylor EC, Shih C. The 6S- abd 6R-diastereomers of 5,10-dideaza-5,6,7,8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis. J Biol Chem 1989;264: 21047-51.
-
(1989)
J Biol Chem
, vol.264
, pp. 21047-21051
-
-
Moran, R.G.1
Baldwin, S.W.2
Taylor, E.C.3
Shih, C.4
-
30
-
-
0025752884
-
Structural features of 5,10-dideaza-5, 6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase
-
Baldwin SW, Tse A, Gossett LS, et al. Structural features of 5,10-dideaza-5, 6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase. Biochemistry 1991;30: 1997-2006.
-
(1991)
Biochemistry
, vol.30
, pp. 1997-2006
-
-
Baldwin, S.W.1
Tse, A.2
Gossett, L.S.3
-
31
-
-
0030803790
-
Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase
-
Sanghani SP, Moran RG. Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase. Biochemistry 1997;36:10506-16.
-
(1997)
Biochemistry
, vol.36
, pp. 10506-10516
-
-
Sanghani, S.P.1
Moran, R.G.2
-
32
-
-
0023717301
-
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase
-
Piper JR, McCaleb GS, Montgomery JA, et al. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase. J Med Chem 1988;31:2164-9.
-
(1988)
J Med Chem
, vol.31
, pp. 2164-2169
-
-
Piper, J.R.1
McCaleb, G.S.2
Montgomery, J.A.3
-
33
-
-
0024393007
-
Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogues
-
Taylor EC, Hamby JM, Shih C, et al. Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogues. J Med Chem 1989;32:1517-22.
-
(1989)
J Med Chem
, vol.32
, pp. 1517-1522
-
-
Taylor, E.C.1
Hamby, J.M.2
Shih, C.3
-
34
-
-
0028267011
-
A novel class of monoglutamated antifolates exhibits tight- Binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors
-
Habeck LL, Leitner TA, Schackelford KA, et al. A novel class of monoglutamated antifolates exhibits tight- binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors. Cancer Res 1994;54:1021-6.
-
(1994)
Cancer Res
, vol.54
, pp. 1021-1026
-
-
Habeck, L.L.1
Leitner, T.A.2
Schackelford, K.A.3
-
36
-
-
0041833660
-
Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway
-
Desharnais J, Hwang I, Zhang Y, et al. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. Bioorg Med Chem 2003;11:4511-21.
-
(2003)
Bioorg Med Chem
, vol.11
, pp. 4511-4521
-
-
Desharnais, J.1
Hwang, I.2
Zhang, Y.3
-
37
-
-
0026494947
-
A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2, 3- d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid, is an inhibitor of thymidylate synthase
-
Taylor EC, Kuhnt D, Shih C, et al. A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2, 3- d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid, is an inhibitor of thymidylate synthase. J Med Chem 1992;35:4450-4.
-
(1992)
J Med Chem
, vol.35
, pp. 4450-4454
-
-
Taylor, E.C.1
Kuhnt, D.2
Shih, C.3
-
38
-
-
0030891198
-
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
-
Shih C, Chen VJ, Gossett LS, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 1997;57:1116-23.
-
(1997)
Cancer Res
, vol.57
, pp. 1116-1123
-
-
Shih, C.1
Chen, V.J.2
Gossett, L.S.3
-
39
-
-
0029157160
-
Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs
-
Habeck LL, Mendelsohn LG, Shih C, et al. Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs. Mol Pharmacol 1995;48:326-33.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 326-333
-
-
Habeck, L.L.1
Mendelsohn, L.G.2
Shih, C.3
-
40
-
-
0017369470
-
Some observations on the reversibility of methotrexate toxicity in normal proliferating tissues
-
Straw JA, Talbot DC, Taylor GA, Harrap KR. Some observations on the reversibility of methotrexate toxicity in normal proliferating tissues. J Natl Cancer Inst 1977;58:91-7.
-
(1977)
J Natl Cancer Inst
, vol.58
, pp. 91-97
-
-
Straw, J.A.1
Talbot, D.C.2
Taylor, G.A.3
Harrap, K.R.4
-
41
-
-
0017102074
-
The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides
-
Pinedo HM, Zaharko DS, Bull JM, Chabner BA. The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides. Cancer Res 1976;36:4418-24.
-
(1976)
Cancer Res
, vol.36
, pp. 4418-4424
-
-
Pinedo, H.M.1
Zaharko, D.S.2
Bull, J.M.3
Chabner, B.A.4
-
42
-
-
0000622838
-
The ability of purine and thymine derivatives and of glycine to support the growth of mammalian cells in culture
-
Hakala MT, Taylor E. The ability of purine and thymine derivatives and of glycine to support the growth of mammalian cells in culture. J Biol Chem 1959;234:126-8.
-
(1959)
J Biol Chem
, vol.234
, pp. 126-128
-
-
Hakala, M.T.1
Taylor, E.2
-
43
-
-
12944312685
-
Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis
-
Zhao R, Zhang S, Hanscom M, Chattopadhyay S, Goldman ID. Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis. Clin Cancer Res 2005;11: 1294-301.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1294-1301
-
-
Zhao, R.1
Zhang, S.2
Hanscom, M.3
Chattopadhyay, S.4
Goldman, I.D.5
-
44
-
-
0035313188
-
Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells
-
Zhao R, Gao F, Goldman ID. Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells. Biochem Pharmacol 2001;61: 857-65.
-
(2001)
Biochem Pharmacol
, vol.61
, pp. 857-865
-
-
Zhao, R.1
Gao, F.2
Goldman, I.D.3
-
45
-
-
0037039451
-
Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors
-
Andreassi JL, Moran RG. Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors. Biochemistry 2002;41:226-35.
-
(2002)
Biochemistry
, vol.41
, pp. 226-235
-
-
Andreassi, J.L.1
Moran, R.G.2
-
46
-
-
0032898580
-
Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514
-
Schultz RM, Patel VF, Worzalla JF, Shih C. Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514. Anticancer Res 1999;19:437-43.
-
(1999)
Anticancer Res
, vol.19
, pp. 437-443
-
-
Schultz, R.M.1
Patel, V.F.2
Worzalla, J.F.3
Shih, C.4
-
47
-
-
0344393780
-
Resistance to antifolates
-
Zhao R, Goldman ID. Resistance to antifolates. Oncogene 2003;22: 7431-57.
-
(2003)
Oncogene
, vol.22
, pp. 7431-7457
-
-
Zhao, R.1
Goldman, I.D.2
-
48
-
-
0041305877
-
Membrane transport of folates
-
Matherly LH, Goldman DI. Membrane transport of folates. Vitam Horm 2003;66:403-56.
-
(2003)
Vitam Horm
, vol.66
, pp. 403-456
-
-
Matherly, L.H.1
Goldman, D.I.2
-
49
-
-
0014232666
-
On the nature of a transport alteration determining resistance to amethopterin in the L1210 leukemia
-
Sirotnak FM, Kurita S, Hutchison DJ. On the nature of a transport alteration determining resistance to amethopterin in the L1210 leukemia. Cancer Res 1968;28:75-80.
-
(1968)
Cancer Res
, vol.28
, pp. 75-80
-
-
Sirotnak, F.M.1
Kurita, S.2
Hutchison, D.J.3
-
50
-
-
0014410041
-
Carrier-mediated transport of the folic acid analogue methotrexate, in the L1210 leukemia cell
-
Goldman ID, Lichtenstein NS, Oliverio VT. Carrier-mediated transport of the folic acid analogue methotrexate, in the L1210 leukemia cell. J Biol Chem 1968;243:5007-17.
-
(1968)
J Biol Chem
, vol.243
, pp. 5007-5017
-
-
Goldman, I.D.1
Lichtenstein, N.S.2
Oliverio, V.T.3
-
51
-
-
0014690663
-
Transport energetics of the folic acid analogue, methotrexate, in L1210 cells: Enhanced accumulation by metabolic inhibitors
-
Goldman ID. Transport energetics of the folic acid analogue, methotrexate, in L1210 cells: enhanced accumulation by metabolic inhibitors. J Biol Chem 1969;244:3779-85.
-
(1969)
J Biol Chem
, vol.244
, pp. 3779-3785
-
-
Goldman, I.D.1
-
52
-
-
0015246387
-
The characteristics of the membrane transport of amethopterin and the naturally occurring folates
-
Goldman ID. The characteristics of the membrane transport of amethopterin and the naturally occurring folates. Ann N Y Acad Sci 1971;186:400-22.
-
(1971)
Ann N Y Acad Sci
, vol.186
, pp. 400-422
-
-
Goldman, I.D.1
-
53
-
-
0029118446
-
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: Correlates of molecular-structure and biological activity
-
Westerhof GR, Schornagel JH, Kathmann I, et al. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity. Mol Pharmacol 1995;48:459-71.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 459-471
-
-
Westerhof, G.R.1
Schornagel, J.H.2
Kathmann, I.3
-
54
-
-
4644224936
-
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier
-
Wang Y, Zhao R, Goldman ID. Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier. Clin Cancer Res 2004;10:6256-64.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6256-6264
-
-
Wang, Y.1
Zhao, R.2
Goldman, I.D.3
-
55
-
-
0034890087
-
Potocytosis. Robert Feulgen Lecture
-
Mineo C, Anderson RG. Potocytosis. Robert Feulgen Lecture. Histochem Cell Biol 2001;116:109-18.
-
(2001)
Histochem Cell Biol
, vol.116
, pp. 109-118
-
-
Mineo, C.1
Anderson, R.G.2
-
56
-
-
0028884105
-
Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells
-
Sierra EE, Brigle KE, Spinella MJ, Goldman ID. Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells. Biochem Pharmacol 1995;50:1287-94.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 1287-1294
-
-
Sierra, E.E.1
Brigle, K.E.2
Spinella, M.J.3
Goldman, I.D.4
-
57
-
-
0028986856
-
Distinguishing between folate receptor-α-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells
-
Spinella MJ, Brigle KE, Sierra EE, Goldman ID. Distinguishing between folate receptor-α-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells. J Biol Chem 1995;270: 7842-9.
-
(1995)
J Biol Chem
, vol.270
, pp. 7842-7849
-
-
Spinella, M.J.1
Brigle, K.E.2
Sierra, E.E.3
Goldman, I.D.4
-
58
-
-
0027058186
-
Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75- 1 human breast cancer cells
-
Dixon KH, Mulligan T, Chung K-N, Elwood PC, Cowan KH. Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75- 1 human breast cancer cells. J Biol Chem 1992;267:24140-7.
-
(1992)
J Biol Chem
, vol.267
, pp. 24140-24147
-
-
Dixon, K.H.1
Mulligan, T.2
Chung, K.-N.3
Elwood, P.C.4
Cowan, K.H.5
-
59
-
-
0023923392
-
Mediated uptake of folate by a high-affinity binding protein in sublines of L1210 cells adapted to nanomolar concentrations of folate
-
Henderson GB, Tsuji JM, Kumar HP. Mediated uptake of folate by a high-affinity binding protein in sublines of L1210 cells adapted to nanomolar concentrations of folate. J Membr Biol 1988;101:247-58.
-
(1988)
J Membr Biol
, vol.101
, pp. 247-258
-
-
Henderson, G.B.1
Tsuji, J.M.2
Kumar, H.P.3
-
60
-
-
0037742256
-
Selective delivery of CB300638, a cyclopenta[g]quinazoline-based thymidylate synthase inhibitor into human tumor cell lines overexpressing the alpha-isoform of the folate receptor
-
Theti DS, Bavetsias V, Skelton LA, et al. Selective delivery of CB300638, a cyclopenta[g]quinazoline-based thymidylate synthase inhibitor into human tumor cell lines overexpressing the alpha-isoform of the folate receptor. Cancer Res 2003;63:3612-8.
-
(2003)
Cancer Res
, vol.63
, pp. 3612-3618
-
-
Theti, D.S.1
Bavetsias, V.2
Skelton, L.A.3
-
61
-
-
0032883172
-
Expression of folate receptor type alpha in relation to cell type, malignancy, and differentiation in ovary, uterus, and cervix
-
Wu M, Gunning W, Ratnam M. Expression of folate receptor type alpha in relation to cell type, malignancy, and differentiation in ovary, uterus, and cervix. Cancer Epidemiol Biomarkers Prev 1999;8:775-82.
-
(1999)
Cancer Epidemiol Biomarkers Prev
, vol.8
, pp. 775-782
-
-
Wu, M.1
Gunning, W.2
Ratnam, M.3
-
62
-
-
0028302477
-
Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19
-
[A]
-
Mantovani LT, Miotti S, Ménard S, et al. Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19. Eur J Cancer [A] 1994;30A:363-9.
-
(1994)
Eur J Cancer
, vol.30 A
, pp. 363-369
-
-
Mantovani, L.T.1
Miotti, S.2
Ménard, S.3
-
63
-
-
0030910859
-
Overexpression of folate binding protein in ovarian cancers
-
Toffoli G, Cernigoi C, Russo A, et al. Overexpression of folate binding protein in ovarian cancers. Int J Cancer 1997;74:193-8.
-
(1997)
Int J Cancer
, vol.74
, pp. 193-198
-
-
Toffoli, G.1
Cernigoi, C.2
Russo, A.3
-
64
-
-
0018744075
-
Enzymatic reduction and methylation of folate following pH-dependent, carrier-mediated transport in rat jejunum
-
Strum WB. Enzymatic reduction and methylation of folate following pH-dependent, carrier-mediated transport in rat jejunum. Biochim Biophys Acta 1979;554:249-57.
-
(1979)
Biochim Biophys Acta
, vol.554
, pp. 249-257
-
-
Strum, W.B.1
-
65
-
-
0020525020
-
A pH-dependent, carrier-mediated system for transport of 5-methyltetrahydrofolate in rat jejunum
-
Said HM, Strum WB. A pH-dependent, carrier-mediated system for transport of 5-methyltetrahydrofolate in rat jejunum. J Pharmacol Exp Ther 1983;226:95-9.
-
(1983)
J Pharmacol Exp Ther
, vol.226
, pp. 95-99
-
-
Said, H.M.1
Strum, W.B.2
-
66
-
-
0019498699
-
Folate transport in isolated brush border membrane vesicles from rat intestine
-
Selhub J, Rosenberg IH. Folate transport in isolated brush border membrane vesicles from rat intestine. J Biol Chem 1981;256:4489-93.
-
(1981)
J Biol Chem
, vol.256
, pp. 4489-4493
-
-
Selhub, J.1
Rosenberg, I.H.2
-
67
-
-
0022380156
-
The transmembrane pH gradient drives uphill folate transport in rabbit jejunum. Direct evidence for folate/hydroxyl exchange in brush border membrane vesicles
-
Schron CM, Washington C, Jr., Blitzer BL. The transmembrane pH gradient drives uphill folate transport in rabbit jejunum. Direct evidence for folate/hydroxyl exchange in brush border membrane vesicles. J Clin Invest 1985;76:2030-3.
-
(1985)
J Clin Invest
, vol.76
, pp. 2030-2033
-
-
Schron, C.M.1
Washington Jr., C.2
Blitzer, B.L.3
-
68
-
-
0030934828
-
Intracellular regulation of intestinal folate uptake: Studies with cultured IEC-6 epithelial cells
-
Said HM, Ma TY, Ortiz A, Tapia A, Valerio CK. Intracellular regulation of intestinal folate uptake: studies with cultured IEC-6 epithelial cells. Am J Physiol Cell Physiol 1997;272:C729-36.
-
(1997)
Am J Physiol Cell Physiol
, vol.272
-
-
Said, H.M.1
Ma, T.Y.2
Ortiz, A.3
Tapia, A.4
Valerio, C.K.5
-
69
-
-
0035204297
-
Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities
-
Rajgopal A, Sierra EE, Zhao R, Goldman ID. Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities. Am J Physiol Cell Physiol 2001;281:C1579-86.
-
(2001)
Am J Physiol Cell Physiol
, vol.281
-
-
Rajgopal, A.1
Sierra, E.E.2
Zhao, R.3
Goldman, I.D.4
-
70
-
-
0022373193
-
Folic acid uptake characteristics of a human colon carcinoma cell line, Caco-2. A newly-described cellular model for small intestinal epithelium
-
Vincent ML, Russell RM, Sasak V. Folic acid uptake characteristics of a human colon carcinoma cell line, Caco-2. A newly-described cellular model for small intestinal epithelium. Hum Nutr Clin Nutr 1985; 39:355-60.
-
(1985)
Hum Nutr Clin Nutr
, vol.39
, pp. 355-360
-
-
Vincent, M.L.1
Russell, R.M.2
Sasak, V.3
-
71
-
-
0842304934
-
A prominent low-pH methotrexate transport activity in human solid tumor cells: Contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier
-
Zhao R, Gao F, Hanscom M, Goldman ID. A prominent low-pH methotrexate transport activity in human solid tumor cells: contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier. Clin Cancer Res 2004; 10:718-27.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 718-727
-
-
Zhao, R.1
Gao, F.2
Hanscom, M.3
Goldman, I.D.4
-
72
-
-
23844507754
-
The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells
-
Zhao R, Hanscom M, Goldman ID. The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells. Biochim Biophys Acta 2005;1715: 57-64.
-
(2005)
Biochim Biophys Acta
, vol.1715
, pp. 57-64
-
-
Zhao, R.1
Hanscom, M.2
Goldman, I.D.3
-
73
-
-
33644975527
-
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line
-
Chattopadhyay S, Zhao R, Krupenko SA, Krupenko N, Goldman ID. The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Mol Cancer Ther 2006;5:438-49.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 438-449
-
-
Chattopadhyay, S.1
Zhao, R.2
Krupenko, S.A.3
Krupenko, N.4
Goldman, I.D.5
-
74
-
-
10644265252
-
Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function
-
Wang Y, Rajgopal A, Goldman ID, Zhao R. Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function. Am J Physiol Cell Physiol 2005;288:C65-71.
-
(2005)
Am J Physiol Cell Physiol
, vol.288
-
-
Wang, Y.1
Rajgopal, A.2
Goldman, I.D.3
Zhao, R.4
-
75
-
-
33751244559
-
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption
-
Qiu A, Jansen M, Sakaris A, et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 2006;127:917-28.
-
(2006)
Cell
, vol.127
, pp. 917-928
-
-
Qiu, A.1
Jansen, M.2
Sakaris, A.3
-
76
-
-
2342461116
-
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier; association with the presence of a secondary transport pathway
-
Zhao R, Hanscom M, Chattopadhyay S, Goldman ID. Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier; association with the presence of a secondary transport pathway. Cancer Res 2004;64:3313-9.
-
(2004)
Cancer Res
, vol.64
, pp. 3313-3319
-
-
Zhao, R.1
Hanscom, M.2
Chattopadhyay, S.3
Goldman, I.D.4
-
77
-
-
11144237445
-
Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier
-
Zhao R, Chattopadhyay S, Hanscom M, Goldman ID. Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier. Clin Cancer Res 2005;10: 8735-42.
-
(2005)
Clin Cancer Res
, vol.10
, pp. 8735-8742
-
-
Zhao, R.1
Chattopadhyay, S.2
Hanscom, M.3
Goldman, I.D.4
-
78
-
-
0037427972
-
The superfamily of organic anion transporting polypeptides
-
Hagenbuch B, Meier PJ. The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 2003;1609:1-18.
-
(2003)
Biochim Biophys Acta
, vol.1609
, pp. 1-18
-
-
Hagenbuch, B.1
Meier, P.J.2
-
79
-
-
0345724724
-
The MRP family of drug efflux pumps
-
Kruh GD, Belinsky MG. The MRP family of drug efflux pumps. Oncogene 2003;22:7537-52.
-
(2003)
Oncogene
, vol.22
, pp. 7537-7552
-
-
Kruh, G.D.1
Belinsky, M.G.2
-
80
-
-
0141815941
-
Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter
-
Volk EL, Schneider E. Wild-type breast cancer resistance protein (BCRP/ ABCG2) is a methotrexate polyglutamate transporter. Cancer Res 2003;63:5538-43.
-
(2003)
Cancer Res
, vol.63
, pp. 5538-5543
-
-
Volk, E.L.1
Schneider, E.2
-
81
-
-
0033817515
-
The mechanism of transport of the multitargeted antifolate, MTA-LY231514, and its cross resistance pattern in cell with impaired transport of methotrexate
-
Zhao R, Babani S, Gao F, Liu L, Goldman ID. The mechanism of transport of the multitargeted antifolate, MTA-LY231514, and its cross resistance pattern in cell with impaired transport of methotrexate. Clin Cancer Res 2000;6:3687-95.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3687-3695
-
-
Zhao, R.1
Babani, S.2
Gao, F.3
Liu, L.4
Goldman, I.D.5
-
82
-
-
0032493644
-
Folylpoly-gammaglutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II
-
Halsted CH, Ling EH, Luthi-Carter R, et al. Folylpoly-gammaglutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II. J Biol Chem 1998;273: 20417-24.
-
(1998)
J Biol Chem
, vol.273
, pp. 20417-20424
-
-
Halsted, C.H.1
Ling, E.H.2
Luthi-Carter, R.3
-
83
-
-
0035360869
-
Effects of overexpression of gamma-Glutamyl hydrolase on methotrexate metabolism and resistance
-
Cole PD, Kamen BA, Gorlick R, et al. Effects of overexpression of gamma-Glutamyl hydrolase on methotrexate metabolism and resistance. Cancer Res 2001;61:4599-604.
-
(2001)
Cancer Res
, vol.61
, pp. 4599-4604
-
-
Cole, P.D.1
Kamen, B.A.2
Gorlick, R.3
-
84
-
-
0023217483
-
Inhibition of gammaglutamyl hydrolases in human cells by 2-mercaptomethylglutaric acid
-
Whitehead VM, Kalman TI, Vuchich MJ. Inhibition of gammaglutamyl hydrolases in human cells by 2-mercaptomethylglutaric acid. Biochem Biophys Res Commun 1987;144:292-7.
-
(1987)
Biochem Biophys Res Commun
, vol.144
, pp. 292-297
-
-
Whitehead, V.M.1
Kalman, T.I.2
Vuchich, M.J.3
-
85
-
-
0027222801
-
Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity
-
Rhee MS, Wang Y, Nair MG, Galivan J. Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity. Cancer Res 1993;53:2227-30.
-
(1993)
Cancer Res
, vol.53
, pp. 2227-2230
-
-
Rhee, M.S.1
Wang, Y.2
Nair, M.G.3
Galivan, J.4
-
86
-
-
33750082401
-
Gamma-glutamyl hydrolase and drug resistance
-
Epub
-
Schneider E, Ryan TJ. Gamma-glutamyl hydrolase and drug resistance. Clin Chim Acta. Epub 2006.
-
(2006)
Clin Chim Acta
-
-
Schneider, E.1
Ryan, T.J.2
-
87
-
-
9744265751
-
Lack of impact of the loss of constitutive folate receptor alpha expression, achieved by RNA Interference, on the activity of the new generation antifolate pemetrexed in HeLa cells
-
Chattopadhyay S, Wang Y, Zhao R, Goldman ID. Lack of impact of the loss of constitutive folate receptor alpha expression, achieved by RNA Interference, on the activity of the new generation antifolate pemetrexed in HeLa cells. Clin Cancer Res 2004;10:7986-93.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7986-7993
-
-
Chattopadhyay, S.1
Wang, Y.2
Zhao, R.3
Goldman, I.D.4
-
88
-
-
14644392093
-
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
-
Parker N, Turk MJ, Westrick E, et al. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 2005;338:284-93.
-
(2005)
Anal Biochem
, vol.338
, pp. 284-293
-
-
Parker, N.1
Turk, M.J.2
Westrick, E.3
-
89
-
-
0023130109
-
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue
-
Matherly LH, Barlowe CK, Phillips VM, Goldman ID. The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue. J Biol Chem 1987;262:710-7.
-
(1987)
J Biol Chem
, vol.262
, pp. 710-717
-
-
Matherly, L.H.1
Barlowe, C.K.2
Phillips, V.M.3
Goldman, I.D.4
-
90
-
-
0031858217
-
Preclinical cellular pharmacology of LY231514 (MTA): A comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells
-
Chen VJ, Bewley JR, Andis SL, et al. Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate. LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Br J Cancer 1998;78 Suppl 3:27-34.
-
(1998)
Br J Cancer
, vol.78
, Issue.SUPPL. 3
, pp. 27-34
-
-
Chen, V.J.1
Bewley, J.R.2
Andis, S.L.3
-
91
-
-
0018682878
-
Role of thymidylate synthetase activity in development of methotrexate cytotoxicity
-
Moran RG, Mulkins M, Heidelberger C. Role of thymidylate synthetase activity in development of methotrexate cytotoxicity. Proc Natl Acad Sci U S A 1979;76:5924-8.
-
(1979)
Proc Natl Acad Sci U S A
, vol.76
, pp. 5924-5928
-
-
Moran, R.G.1
Mulkins, M.2
Heidelberger, C.3
-
92
-
-
0034714363
-
Molecular analysis of murine leukemia cell lines resistant to 5,10- Ideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase
-
Zhao R, Titus S, Gao F, Moran RG, Goldman ID. Molecular analysis of murine leukemia cell lines resistant to 5,10- ideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase. J Biol Chem 2000;275:26599-606.
-
(2000)
J Biol Chem
, vol.275
, pp. 26599-26606
-
-
Zhao, R.1
Titus, S.2
Gao, F.3
Moran, R.G.4
Goldman, I.D.5
-
93
-
-
0037455808
-
Loss of folylpoly-gammaglutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines
-
Liani E, Rothem L, Bunni MA, et al. Loss of folylpoly-gammaglutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer 2003;103:587-99.
-
(2003)
Int J Cancer
, vol.103
, pp. 587-599
-
-
Liani, E.1
Rothem, L.2
Bunni, M.A.3
-
94
-
-
0032914341
-
Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs
-
Schultz RM, Chen VJ, Bewley JR, et al. Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs. Semin Oncol 1999; 26 Suppl 6:68-73.
-
(1999)
Semin Oncol
, vol.26
, Issue.SUPPL. 6
, pp. 68-73
-
-
Schultz, R.M.1
Chen, V.J.2
Bewley, J.R.3
-
95
-
-
0029031286
-
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines
-
Jackman AL, Kelland LR, Kimbell R, et al. Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines. Br J Cancer 1995;71: 914-24.
-
(1995)
Br J Cancer
, vol.71
, pp. 914-924
-
-
Jackman, A.L.1
Kelland, L.R.2
Kimbell, R.3
-
96
-
-
0033845077
-
Folate depletion increases sensitivity of solid tumor cell lines to 5- fluorouracil and antifolates
-
Backus HH, Pinedo HM, Wouters D, et al. Folate depletion increases sensitivity of solid tumor cell lines to 5- fluorouracil and antifolates. Int J Cancer 2000;87:771-8.
-
(2000)
Int J Cancer
, vol.87
, pp. 771-778
-
-
Backus, H.H.1
Pinedo, H.M.2
Wouters, D.3
-
97
-
-
9244240774
-
Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors
-
Clarke SJ, Hanwell J, de Boer M, et al. Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors. J Clin Oncol 1996;14:1495-503.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1495-1503
-
-
Clarke, S.J.1
Hanwell, J.2
de Boer, M.3
-
98
-
-
0038387494
-
5-fluorouracil: Mechanisms of action and clinical strategies
-
Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003;3:330-8.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 330-338
-
-
Longley, D.B.1
Harkin, D.P.2
Johnston, P.G.3
-
99
-
-
0021015054
-
Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino) benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid cells
-
Jackson RC, Jackman AL, Calvert AH. Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino) benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid cells. Biochem Pharmacol 1983;32: 3783-90.
-
(1983)
Biochem Pharmacol
, vol.32
, pp. 3783-3790
-
-
Jackson, R.C.1
Jackman, A.L.2
Calvert, A.H.3
-
100
-
-
0024542257
-
The quantitation by radioimmunoassay of 2′-deoxyuridine 5′-triphosphate in extracts of thymidylate synthase-inhibited cells
-
Piall EM, Curtin NJ, Aherne GW, Harris AL, Marks V. The quantitation by radioimmunoassay of 2'-deoxyuridine 5'-triphosphate in extracts of thymidylate synthase-inhibited cells. Anal Biochem 1989;l77: 347-52.
-
(1989)
Anal Biochem
, vol.177
, pp. 347-352
-
-
Piall, E.M.1
Curtin, N.J.2
Aherne, G.W.3
Harris, A.L.4
Marks, V.5
-
102
-
-
0016695115
-
Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion
-
Myers CE, Young RC, Chabner BA. Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion. J Clin Invest 1975;56:1231-8.
-
(1975)
J Clin Invest
, vol.56
, pp. 1231-1238
-
-
Myers, C.E.1
Young, R.C.2
Chabner, B.A.3
-
103
-
-
0016298569
-
Assay of 5-fluorodeoxyuridine 5′-monophosphate deoxyuridine 5′-monophosphate pools following 5-fluorouracil
-
Myers CE, Young RC, Johns DG, Chabner BA. Assay of 5-fluorodeoxyuridine 5'-monophosphate deoxyuridine 5'-monophosphate pools following 5-fluorouracil. Cancer Res 1974;34:2682-8.
-
(1974)
Cancer Res
, vol.34
, pp. 2682-2688
-
-
Myers, C.E.1
Young, R.C.2
Johns, D.G.3
Chabner, B.A.4
-
104
-
-
0642319762
-
Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase
-
Moran RG, Spears CP, Heidelberger C. Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase. Proc Natl Acad Sci U S A 1979;76:1456-60.
-
(1979)
Proc Natl Acad Sci U S A
, vol.76
, pp. 1456-1460
-
-
Moran, R.G.1
Spears, C.P.2
Heidelberger, C.3
-
105
-
-
0017169509
-
Demonstration of separate binding sites for the folate coenzymes and deoxynucleotides with inactivated Lactobacillus casei thymidylate synthetase
-
Galivan JH, Maley F, Baugh CM. Demonstration of separate binding sites for the folate coenzymes and deoxynucleotides with inactivated Lactobacillus casei thymidylate synthetase. Biochem Biophys Res Commun 1976;71:527-34.
-
(1976)
Biochem Biophys Res Commun
, vol.71
, pp. 527-534
-
-
Galivan, J.H.1
Maley, F.2
Baugh, C.M.3
-
106
-
-
0029036377
-
The catalytic mechanism and structure of thymidylate synthase
-
Carreras CW, Santi DV. The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem 1995;64:721-62.
-
(1995)
Annu Rev Biochem
, vol.64
, pp. 721-762
-
-
Carreras, C.W.1
Santi, D.V.2
-
107
-
-
0023705723
-
Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells
-
Keyomarsi K, Moran RG. Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J Biol Chem 1988;263:14402-9.
-
(1988)
J Biol Chem
, vol.263
, pp. 14402-14409
-
-
Keyomarsi, K.1
Moran, R.G.2
-
108
-
-
0028849683
-
Initial phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified continual reassessment method for dose escalation
-
Rinaldi DA, Burris HA, Dorr FA, et al. Initial phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified continual reassessment method for dose escalation. J Clin Oncol 1995; 13:2842-50.
-
(1995)
J Clin Oncol
, vol.13
, pp. 2842-2850
-
-
Rinaldi, D.A.1
Burris, H.A.2
Dorr, F.A.3
-
109
-
-
15644372742
-
A phase I and pharmacokinetic study of LY231514, the multitargeted antifolate
-
McDonald AC, Vasey PA, Adams L, et al. A phase I and pharmacokinetic study of LY231514, the multitargeted antifolate. Clin Cancer Res 1998;4:605-10.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 605-610
-
-
McDonald, A.C.1
Vasey, P.A.2
Adams, L.3
-
110
-
-
0032859301
-
A phase I evaluation of multitargeted antifolate (MTA, LY231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation
-
Rinaldi DA, Kuhn JG, Burris HA, et al. A phase I evaluation of multitargeted antifolate (MTA, LY231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation. Cancer Chemother Pharmacol 1999;44:372-80.
-
(1999)
Cancer Chemother Pharmacol
, vol.44
, pp. 372-380
-
-
Rinaldi, D.A.1
Kuhn, J.G.2
Burris, H.A.3
-
111
-
-
0032964124
-
Overview of phase I trials of multitargeted antifolate (MTA, LY231514)
-
Rinaldi DA. Overview of phase I trials of multitargeted antifolate (MTA, LY231514). Semin Oncol 1999;26 suppl 6:82-8.
-
(1999)
Semin Oncol
, vol.26
, Issue.SUPPL. 6
, pp. 82-88
-
-
Rinaldi, D.A.1
-
112
-
-
33644839682
-
Phase I and pharmacokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function
-
Mita AC, Sweeney CJ, Baker SD, et al. Phase I and pharmacokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function. J Clin Oncol 2006;24: 552-62.
-
(2006)
J Clin Oncol
, vol.24
, pp. 552-562
-
-
Mita, A.C.1
Sweeney, C.J.2
Baker, S.D.3
-
113
-
-
0026570125
-
Methotrexate and nonsteroidal antiinflammatory drug interactions
-
Frenia ML, Long KS. Methotrexate and nonsteroidal antiinflammatory drug interactions. Ann Pharmacother 1992;26:234-7.
-
(1992)
Ann Pharmacother
, vol.26
, pp. 234-237
-
-
Frenia, M.L.1
Long, K.S.2
-
114
-
-
31544476910
-
Two drug interaction studies evaluating the pharmacokinetics and toxicity of pemetrexed when coadministered with aspirin or ibuprofen in patients with advanced cancer
-
Sweeney CJ, Takimoto CH, Latz JE, et al. Two drug interaction studies evaluating the pharmacokinetics and toxicity of pemetrexed when coadministered with aspirin or ibuprofen in patients with advanced cancer. Clin Cancer Res 2006;12:536-42.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 536-542
-
-
Sweeney, C.J.1
Takimoto, C.H.2
Latz, J.E.3
-
115
-
-
0344980120
-
Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin
-
Thodtmann R, Depenbrock H, Dumez H, at al. Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin. J Clin Oncol 1999;17:3009-16.
-
(1999)
J Clin Oncol
, vol.17
, pp. 3009-3016
-
-
Thodtmann, R.1
Depenbrock, H.2
Dumez, H.3
-
116
-
-
20244374653
-
Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma
-
Hughes A, Calvert P, Azzabi A, et al. Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma. J Clin Oncol 2002;20:3533-44.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3533-3544
-
-
Hughes, A.1
Calvert, P.2
Azzabi, A.3
-
117
-
-
0036179706
-
The emerging role of antifolates in the treatment of malignant pleural mesothelioma
-
Fizazi K, John WJ, Vogelzang NJ. The emerging role of antifolates in the treatment of malignant pleural mesothelioma. Semin Oncol 2002;29: 77-81.
-
(2002)
Semin Oncol
, vol.29
, pp. 77-81
-
-
Fizazi, K.1
John, W.J.2
Vogelzang, N.J.3
-
118
-
-
0041629528
-
Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
-
Vogelzang NJ, Rusthoven JJ, Symanowski J, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003;21: 2636-44.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2636-2644
-
-
Vogelzang, N.J.1
Rusthoven, J.J.2
Symanowski, J.3
-
119
-
-
0036562507
-
Homocysteine and methylmalonic acid: Markers to predict and avoid toxicity from pemetrexed therapy
-
Niyikiza C, Baker SD, Seitz DE, et al. Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol Cancer Ther 2002;1:545-52.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 545-552
-
-
Niyikiza, C.1
Baker, S.D.2
Seitz, D.E.3
-
120
-
-
0003340561
-
Vitamin B12 and folate reduce toxicity of ALIMTA (pemetrexed disodium, LY231514, MTA), a novel antifolate/antimetabolite
-
[abstr 300]
-
Bunn P, Paoletti P, Niyikiza C, et al. Vitamin B12 and folate reduce toxicity of ALIMTA (pemetrexed disodium, LY231514, MTA), a novel antifolate/antimetabolite [abstr 300]. Proc Am Soc Clin Oncol 2001; 20:76a.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Bunn, P.1
Paoletti, P.2
Niyikiza, C.3
-
121
-
-
0242288252
-
Improving quality of life in patients with malignant pleural mesothelioma: Results of the randomized pemetrexed + cisplatin vs. cisplatin trial using the LCSS-meso instrument
-
[abstract 2946]
-
Gralla RJ, Hollen PJ, Liepa AM, et al. Improving quality of life in patients with malignant pleural mesothelioma: results of the randomized pemetrexed + cisplatin vs. cisplatin trial using the LCSS-meso instrument [abstract 2946]. Proc Am Soc Clin Oncol 2003;22:621.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 621
-
-
Gralla, R.J.1
Hollen, P.J.2
Liepa, A.M.3
-
122
-
-
0242351377
-
Correlation of pulmonary function tests with best tumor response status: Results from the phase III study of pemetrexed + cisplatin vs. cisplatin in malignant pleural mesothelioma
-
[abstract 2651]
-
Paoletti P, Pistolesi M, Rusthoven JJ, et al. Correlation of pulmonary function tests with best tumor response status: results from the phase III study of pemetrexed + cisplatin vs. cisplatin in malignant pleural mesothelioma [abstract 2651]. Proc Am Soc Clin Oncol 2003;22:659.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 659
-
-
Paoletti, P.1
Pistolesi, M.2
Rusthoven, J.J.3
-
124
-
-
2442661845
-
Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
-
Hanna N, Shepherd FA, Fossella FV, et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004;22:1589-97.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1589-1597
-
-
Hanna, N.1
Shepherd, F.A.2
Fossella, F.V.3
-
125
-
-
27144445928
-
Pemetrexed vs docetaxel for non-small cell lung cancer (NSCLC): Could vitamin supplementation affect docetaxel survival? An exploratory analysis
-
[abstract 7131]. (July 15)
-
Fossella F, Obasaju C, Paul S. Pemetrexed vs docetaxel for non-small cell lung cancer (NSCLC): could vitamin supplementation affect docetaxel survival? [abstract 7131]. An exploratory analysis. J Clin Oncol 2004;22 (July 15 Suppl):649S.
-
(2004)
J Clin Oncol
, vol.22
, Issue.SUPPL.
-
-
Fossella, F.1
Obasaju, C.2
Paul, S.3
-
126
-
-
22244446806
-
FDA drug approval summary: Pemetrexed for injection (Alimta) for the treatment of non-small cell lung cancer
-
Cohen MH, Johnson JR, Wang YC, Sridhara R, Pazdur R. FDA drug approval summary: pemetrexed for injection (Alimta) for the treatment of non-small cell lung cancer. Oncologist 2005;10:363-8.
-
(2005)
Oncologist
, vol.10
, pp. 363-368
-
-
Cohen, M.H.1
Johnson, J.R.2
Wang, Y.C.3
Sridhara, R.4
Pazdur, R.5
-
127
-
-
3042575322
-
Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent
-
Adjei AA. Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent. Clin Cancer Res 2004;10:4276-80S.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Adjei, A.A.1
-
128
-
-
0033179374
-
Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma
-
Tonkinson JL, Worzalla JF, Tang CH, Mendelsohn LG. Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma. Cancer Res 1999;59:3671-6.
-
(1999)
Cancer Res
, vol.59
, pp. 3671-3676
-
-
Tonkinson, J.L.1
Worzalla, J.F.2
Tang, C.H.3
Mendelsohn, L.G.4
-
129
-
-
2442451440
-
Synergistic cytotoxicity and pharmacogenetics of gemcitabine and pemetrexed combination in pancreatic cancer cell lines
-
Giovannetti E, Mey V, Danesi R, Mosca I, Del Tacca M. Synergistic cytotoxicity and pharmacogenetics of gemcitabine and pemetrexed combination in pancreatic cancer cell lines. Clin Cancer Res 2004;10: 2936-43.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2936-2943
-
-
Giovannetti, E.1
Mey, V.2
Danesi, R.3
Mosca, I.4
Del Tacca, M.5
-
130
-
-
22344449812
-
Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells
-
Giovannetti E, May V, Nannizzi S, et al. Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. Mol Pharmacol 2005;68: 110-8.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 108-110
-
-
Giovannetti, E.1
Mey, V.2
Nannizzi, S.3
-
131
-
-
27144530079
-
A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer
-
Oettle H, Richards D, Ramanathan RK, et al. A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer. Ann Oncol 2005;16: 1639-45.
-
(2005)
Ann Oncol
, vol.16
, pp. 1639-1645
-
-
Oettle, H.1
Richards, D.2
Ramanathan, R.K.3
-
132
-
-
24944485165
-
Randomized phase II trial of three schedules of pemetrexed and gemcitabine as front-line therapy for advanced non-small-cell lung cancer
-
Me CX, Nair S, Thomas S, et al. Randomized phase II trial of three schedules of pemetrexed and gemcitabine as front-line therapy for advanced non-small-cell lung cancer. J Clin Oncol 2005;23:5929-37.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5929-5937
-
-
Me, C.X.1
Nair, S.2
Thomas, S.3
-
133
-
-
0037842139
-
Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma
-
Scagliotti GV, Shin DM, Kindler HL, et al. Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma. J Clin Oncol 2003;21: 1556-61
-
(2003)
J Clin Oncol
, vol.21
, pp. 1556-1561
-
-
Scagliotti, G.V.1
Shin, D.M.2
Kindler, H.L.3
-
134
-
-
27744603884
-
Dose-dependent effects of folic acid on blood concentrations of homocysteine: A meta-analysis of the randomized trials
-
Homocysteine Lowering Trialists' Collaboration
-
Homocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 2005;82:806-12.
-
(2005)
Am J Clin Nutr
, vol.82
, pp. 806-812
-
-
-
136
-
-
34548217699
-
-
Eli Lilly and Company. 59th ed. Montvale (NJ): Thomson PDR
-
Eli Lilly and Company. Alimta product information. Physicians' desk reference. 59th ad. Montvale (NJ): Thomson PDR; 2005. p. 1824-8.
-
(2005)
Alimta Product Information. Physicians' Desk Reference
, pp. 1824-1828
-
-
-
137
-
-
0034141427
-
Purification and characteristics of recombinant human folylpoly-gamma-glutamate synthetase expressed at high levels in insect cells
-
Sanghani PC, Moran RG. Purification and characteristics of recombinant human folylpoly-gamma-glutamate synthetase expressed at high levels in insect cells. Protein Expr Purif 2000;18:36-45.
-
(2000)
Protein Expr Purif
, vol.18
, pp. 36-45
-
-
Sanghani, P.C.1
Moran, R.G.2
|