메뉴 건너뛰기




Volumn 20, Issue 10, 2011, Pages 1343-1356

Thymidylate synthase inhibitors for non-small cell lung cancer

Author keywords

NSCLC; Pemetrexed; Pharmacogenetics; Thymidylate synthase

Indexed keywords

AFATINIB; BEVACIZUMAB; BORTEZOMIB; CARBOPLATIN; CETUXIMAB; CISPLATIN; DASATINIB; DOCETAXEL; ENZASTAURIN; ERLOTINIB; EVEROLIMUS; GEFITINIB; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; IFOSFAMIDE; IRINOTECAN; LAPATINIB; METHOTREXATE; MITOMYCIN C; NAVELBINE; PACLITAXEL; PEMETREXED; SORAFENIB; SUNITINIB; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UFT; UNINDEXED DRUG; VINBLASTINE; VINDESINE;

EID: 80052755036     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2011.617742     Document Type: Review
Times cited : (36)

References (107)
  • 1
    • 13744251436 scopus 로고    scopus 로고
    • Systemic therapy for colorectal cancer
    • Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med 2005;20:476-87
    • (2005) N Engl J Med , vol.20 , pp. 476-487
    • Meyerhardt, J.A.1    Mayer, R.J.2
  • 2
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti GV, Parikh P, von PJ, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26:3543-51.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Von, P.J.3
  • 3
    • 79951911908 scopus 로고    scopus 로고
    • Phase III trial comparing oral S-1 plus carboplatin with paclitaxel plus carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer: Results of a west Japan oncology group study
    • Okamoto I, Yoshioka H,Morita S, et al. Phase III trial comparing oral S-1 plus carboplatin with paclitaxel plus carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer: results of a west Japan oncology group study. J Clin Oncol 2010;28:5240-6
    • (2010) J Clin Oncol , vol.28 , pp. 5240-5246
    • Okamoto, I.1    Yoshioka Hmorita, S.2
  • 4
    • 0036906795 scopus 로고    scopus 로고
    • Future potential of thymidylate syntase inhibitors in cancer therapy
    • DOI 10.1517/13543784.11.12.1775
    • Lehman NL. Future potential of thymidylate synthase inhibitors in cancer therapy. Expert Opin Investig Drugs 2002;11:1775-87 (Pubitemid 35469921)
    • (2002) Expert Opinion on Investigational Drugs , vol.11 , Issue.12 , pp. 1775-1787
    • Lehman, N.L.1
  • 6
    • 0038121547 scopus 로고    scopus 로고
    • The role of radiotherapy in treatment of stage I non-small cell lung cancer
    • DOI 10.1016/S0169-5002(03)00152-1
    • Qiao X, Tullgren O, Lax I, et al. The role of radiotherapy in treatment of stage I non-small cell lung cancer. Lung Cancer 2003;41:1-11 (Pubitemid 36765477)
    • (2003) Lung Cancer , vol.41 , Issue.1 , pp. 1-11
    • Qiao, X.1    Tullgren, O.2    Lax, I.3    Sirzen, F.4    Lewensohn, R.5
  • 7
    • 0034718966 scopus 로고    scopus 로고
    • A randomized trial of postoperative adjuvant therapy in patients with completely resected stage II or IIIA non-small-cell lung cancer. Eastern Cooperative Oncology Group
    • Keller SM, Adak S, Wagner H, et al. A randomized trial of postoperative adjuvant therapy in patients with completely resected stage II or IIIA non-small-cell lung cancer. Eastern Cooperative Oncology Group. N Engl J Med 2000;343:1217-22
    • (2000) N Engl J Med , vol.343 , pp. 1217-1222
    • Keller, S.M.1    Adak, S.2    Wagner, H.3
  • 8
    • 77954332103 scopus 로고    scopus 로고
    • Early stage and locally advanced (non-metastatic) non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Crino L, Weder W, van MJ, et al. Early stage and locally advanced (non-metastatic) non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010;21(Suppl 5):v103-15
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 5
    • Crino, L.1    Weder, W.2    Van, M.J.3
  • 9
    • 0029130583 scopus 로고
    • Single-agent chemotherapy versus combination chemotherapy in advanced non-small cell lung cancer: A quality and meta-analysis study
    • Marino P, Preatoni A, Cantoni A, et al. Single-agent chemotherapy versus combination chemotherapy in advanced non-small cell lung cancer: a quality and meta-analysis study. Lung Cancer 1995;13:1-12
    • (1995) Lung Cancer , vol.13 , pp. 1-12
    • Marino, P.1    Preatoni, A.2    Cantoni, A.3
  • 11
    • 34347379142 scopus 로고    scopus 로고
    • Cisplatin-versus carboplatin-based chemotherapy in first-line treatment of advanced non-small-cell lung cancer: An individual patient data meta-analysis
    • Ardizzoni A, Boni L, Tiseo M, et al. Cisplatin-versus carboplatin-based chemotherapy in first-line treatment of advanced non-small-cell lung cancer: an individual patient data meta-analysis. J Natl Cancer Inst 2007;99:847-57
    • (2007) J Natl Cancer Inst , vol.99 , pp. 847-857
    • Ardizzoni, A.1    Boni, L.2    Tiseo, M.3
  • 13
    • 19444365516 scopus 로고    scopus 로고
    • Platinum-based versus non-platinum-based chemotherapy in advanced non-small-cell lung cancer: A meta-analysis of the published literature
    • DOI 10.1200/JCO.2005.03.045
    • D'Addario G, Pintilie M, Leighl NB, et al. Platinum-based versus non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a meta-analysis of the published literature. J Clin Oncol 2005;23:2926-36 (Pubitemid 46224111)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.13 , pp. 2926-2936
    • D'Addario, G.1    Pintilie, M.2    Leighl, N.B.3    Feld, R.4    Cerny, T.5    Shepherd, F.A.6
  • 14
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M, von PJ, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009;27:1227-34
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    Von Pj Zatloukal, P.2
  • 15
    • 67651216410 scopus 로고    scopus 로고
    • Next generation oncology drug development: Opportunities and challenges
    • Gutierrez ME, Kummar S, Giaccone G. Next generation oncology drug development: opportunities and challenges. Nat Rev Clin Oncol 2009;6:259-65
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 259-265
    • Gutierrez, M.E.1    Kummar, S.2    Giaccone, G.3
  • 16
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
    • Pirker R, Pereira JR, Szczesna A, et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 2009;373:1525-31
    • (2009) Lancet , vol.373 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3
  • 17
    • 68249134187 scopus 로고    scopus 로고
    • How much is life worth: Cetuximab, non-small cell lung cancer, and the $440 billion question
    • Fojo T, Grady C. How much is life worth: cetuximab, non-small cell lung cancer, and the $440 billion question. J Natl Cancer Inst 2009;101:1044-8
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1044-1048
    • Fojo, T.1    Grady, C.2
  • 18
    • 80052746384 scopus 로고    scopus 로고
    • Gefitinib vs. chemotherapy as first-line therapy in advanced non-small cell lung cancer: Meta-analysis of phase III trials
    • May 10. [Epub ahead of print]
    • Ku GY, Haaland BA, de Lima LG. Gefitinib vs. chemotherapy as first-line therapy in advanced non-small cell lung cancer: meta-analysis of phase III trials. Lung Cancer 2011 May 10. [Epub ahead of print]
    • (2011) Lung Cancer
    • Ku, G.Y.1    Haaland, B.A.2    De Lima, L.G.3
  • 19
    • 74949133978 scopus 로고    scopus 로고
    • American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer
    • Azzoli CG, Baker S Jr, Temin S, et al. American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol 2009;27:6251-66
    • (2009) J Clin Oncol , vol.27 , pp. 6251-6266
    • Azzoli, C.G.1    Baker Jr., S.2    Temin, S.3
  • 21
    • 0028944053 scopus 로고
    • Phase II study of docetaxel for advanced or metastatic platinum-refractory non-small-cell lung cancer
    • Fossella FV, Lee JS, Shin DM, et al. Phase II study of docetaxel for advanced or metastatic platinum-refractory non-small-cell lung cancer. J Clin Oncol 1995;13:645-51
    • (1995) J Clin Oncol , vol.13 , pp. 645-651
    • Fossella, F.V.1    Lee, J.S.2    Shin, D.M.3
  • 23
    • 78650438578 scopus 로고    scopus 로고
    • Reviewing the safety of erlotinib in non-small cell lung cancer
    • Reck M, Mok T, Wolf J, et al. Reviewing the safety of erlotinib in non-small cell lung cancer. Expert Opin Drug Saf 2011;10:147-57
    • (2011) Expert Opin Drug Saf , vol.10 , pp. 147-157
    • Reck, M.1    Mok, T.2    Wolf, J.3
  • 24
    • 61449282562 scopus 로고    scopus 로고
    • New avenues for second-line treatment of metastatic non-small-cell lung cancer
    • Gridelli C, Maione P, Rossi A, et al. New avenues for second-line treatment of metastatic non-small-cell lung cancer. Expert Rev Anticancer Ther 2009;9:115-24
    • (2009) Expert Rev Anticancer Ther , vol.9 , pp. 115-124
    • Gridelli, C.1    Maione, P.2    Rossi, A.3
  • 25
    • 0029036377 scopus 로고
    • The catalytic mechanism and structure of thymidylate synthase
    • Carreras CW, Santi DV. The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem 1995;64:721-62
    • (1995) Annu Rev Biochem , vol.64 , pp. 721-762
    • Carreras, C.W.1    Santi, D.V.2
  • 28
    • 66849099602 scopus 로고    scopus 로고
    • XIII International Charles Heidelberger Symposium and 50 Years of Fluoropyrimidines in Cancer Therapy Held on september 6 to 8 2007 at New York University Cancer Institute, Smilow Conference Center
    • Muggia FM, Peters GJ, Landolph JR. XIII International Charles Heidelberger Symposium and 50 Years of Fluoropyrimidines in Cancer Therapy Held on september 6 to 8, 2007 at New York University Cancer Institute, Smilow Conference Center. Mol Cancer Ther 2009;8:992-9
    • (2009) Mol Cancer Ther , vol.8 , pp. 992-999
    • Muggia, F.M.1    Peters, G.J.2    Landolph, J.R.3
  • 29
    • 0038387494 scopus 로고    scopus 로고
    • 5-Fluorouracil: Mechanisms of action and clinical strategies
    • DOI 10.1038/nrc1074
    • Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003;3:330-8 (Pubitemid 37328853)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.5 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 32
    • 46749123442 scopus 로고    scopus 로고
    • Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering ts levels in colorectal cancer cells
    • DOI 10.1080/15257770802145512, PII 794710631
    • Giovannetti E, Backus HH, Wouters D, et al. Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells. Nucleosides Nucleotides Nucleic Acids 2008;27:740-5 (Pubitemid 351948577)
    • (2008) Nucleosides, Nucleotides and Nucleic Acids , vol.27 , Issue.6-7 , pp. 740-745
    • Giovannetti, E.1    Backus, H.H.J.2    Wouters, D.3    Peters, G.J.4
  • 33
    • 0029049577 scopus 로고
    • Cellular targets for activation by the E2F1 transcription factor include DNA synthesis-and G1/S-regulatory genes
    • DeGregori J, Kowalik T, Nevins JR. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis-and G1/S-regulatory genes. Mol Cell Biol 1995;15:4215-24
    • (1995) Mol Cell Biol , vol.15 , pp. 4215-4224
    • Degregori, J.1    Kowalik, T.2    Nevins, J.R.3
  • 36
    • 77956291666 scopus 로고    scopus 로고
    • Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos
    • Zhang Y, Yang S, Liu M, et al. Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos. PLoS One 2010;5:e10618
    • (2010) PLoS One , vol.5
    • Zhang, Y.1    Yang, S.2    Liu, M.3
  • 37
    • 0033617219 scopus 로고    scopus 로고
    • Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation
    • Kitchens ME, Forsthoefel AM, Rafique Z, et al. Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation. J Biol Chem 1999;274:12544-7
    • (1999) J Biol Chem , vol.274 , pp. 12544-7
    • Kitchens, M.E.1    Forsthoefel, A.M.2    Rafique, Z.3
  • 38
    • 33847364471 scopus 로고    scopus 로고
    • Pemetrexed: Biochemical and cellular pharmacology, mechanisms, and clinical applications
    • DOI 10.1158/1535-7163.MCT-06-0343
    • Chattopadhyay S, Moran RG, Goldman ID. Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications. Mol Cancer Ther 2007;6:404-17. (Pubitemid 46332443)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.2 , pp. 404-417
    • Chattopadhyay, S.1    Moran, R.G.2    Goldman, I.D.3
  • 40
    • 67650281462 scopus 로고    scopus 로고
    • Phase III study by the Norwegian lung cancer study group: Pemetrexed plus carboplatin compared with gemcitabine plus carboplatin as first-line chemotherapy in advanced non-small-cell lung cancer
    • Gronberg BH, Bremnes RM, Flotten O, et al. Phase III study by the Norwegian lung cancer study group: pemetrexed plus carboplatin compared with gemcitabine plus carboplatin as first-line chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2009;27:3217-24
    • (2009) J Clin Oncol , vol.27 , pp. 3217-3224
    • Gronberg, B.H.1    Bremnes, R.M.2    Flotten, O.3
  • 41
    • 64049115311 scopus 로고    scopus 로고
    • The differential efficacy of pemetrexed according to NSCLC histology: A review of two Phase III studies
    • Scagliotti G, Hanna N, Fossella F, et al. The differential efficacy of pemetrexed according to NSCLC histology: a review of two Phase III studies. Oncologist 2009;14:253-63.
    • (2009) Oncologist , vol.14 , pp. 253-263
    • Scagliotti, G.1    Hanna, N.2    Fossella, F.3
  • 42
    • 70350225538 scopus 로고    scopus 로고
    • Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomised, double-blind, phase 3 study
    • Ciuleanu T, Brodowicz T, Zielinski C, et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study. Lancet 2009;374:1432-40
    • (2009) Lancet , vol.374 , pp. 1432-1440
    • Ciuleanu, T.1    Brodowicz, T.2    Zielinski, C.3
  • 43
    • 80052748728 scopus 로고    scopus 로고
    • PARAMOUNT: Phase III study of maintenance pemetrexed (pem) plus best supportive care (BSC) versus placebo plus BSC immediately following induction treatment with pem plus cisplatin for advanced nonsquamous non-small cell lung cancer (NSCLC)
    • abstract CRA7510
    • Paz-Ares LG, De Marinis F, Dediu M, et al. PARAMOUNT: Phase III study of maintenance pemetrexed (pem) plus best supportive care (BSC) versus placebo plus BSC immediately following induction treatment with pem plus cisplatin for advanced nonsquamous non-small cell lung cancer (NSCLC). J Clin Oncol 2011;29(Suppl):abstract CRA7510
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Paz-Ares, L.G.1    De Marinis, F.2    Dediu, M.3
  • 46
    • 0031858217 scopus 로고    scopus 로고
    • Preclinical cellular pharmacology of LY231514 (MTA): A comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells
    • Chen VJ, Bewley JR, Andis SL, et al. Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Br J Cancer 1998;78(Suppl 3):27-34
    • (1998) Br J Cancer , vol.78 , Issue.SUPPL. 3 , pp. 27-34
    • Chen, V.J.1    Bewley, J.R.2    Andis, S.L.3
  • 47
    • 0001845556 scopus 로고    scopus 로고
    • New antifolates: Pharmacology and clinical applications
    • Takimoto CH. New antifolates: pharmacology and clinical applications. Oncologist 1996;1:68-81 (Pubitemid 126669374)
    • (1996) Oncologist , vol.1 , Issue.1-2 , pp. 68-81
    • Takimoto, C.H.1
  • 48
    • 22344449812 scopus 로고    scopus 로고
    • Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells
    • DOI 10.1124/mol.104.009373
    • Giovannetti E, Mey V, Nannizzi S, et al. Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. Mol Pharmacol 2005;68:110-18 (Pubitemid 41002949)
    • (2005) Molecular Pharmacology , vol.68 , Issue.1 , pp. 110-118
    • Giovannetti, E.1    Mey, V.2    Nannizzi, S.3    Pasqualetti, G.4    Marini, L.5    Del Tacca, M.6    Danesi, R.7
  • 49
    • 41149096042 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells
    • DOI 10.1124/mol.107.042382
    • Giovannetti E, Lemos C, Tekle C, et al. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells. Mol Pharmacol 2008;73:1290-300. (Pubitemid 351439211)
    • (2008) Molecular Pharmacology , vol.73 , Issue.4 , pp. 1290-1300
    • Giovannetti, E.1    Lemos, C.2    Tekle, C.3    Smid, K.4    Nannizzi, S.5    Rodriguez, J.A.6    Ricciardi, S.7    Danesi, R.8    Giaccone, G.9    Peters, G.J.10
  • 50
    • 79955813242 scopus 로고    scopus 로고
    • Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer
    • Takezawa K, Okamoto I, Okamoto W, et al. Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer. Br J Cancer 2011;104:1594-601
    • (2011) Br J Cancer , vol.104 , pp. 1594-601
    • Takezawa, K.1    Okamoto, I.2    Okamoto, W.3
  • 53
    • 77951894575 scopus 로고    scopus 로고
    • Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy
    • Righi L, Papotti MG, Ceppi P, et al. Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy. J Clin Oncol 2010;28:1534-9.
    • (2010) J Clin Oncol , vol.28 , pp. 1534-1539
    • Righi, L.1    Papotti, M.G.2    Ceppi, P.3
  • 54
    • 79954607787 scopus 로고    scopus 로고
    • Thymidylate synthase and excision repair cross-complementing group-1 as predictors of responsiveness in mesothelioma patients treated with pemetrexed/carboplatin
    • Zucali PA, Giovannetti E, Destro A, et al. Thymidylate synthase and excision repair cross-complementing group-1 as predictors of responsiveness in mesothelioma patients treated with pemetrexed/carboplatin. Clin Cancer Res 2011;17:2581-90
    • (2011) Clin Cancer Res , vol.17 , pp. 2581-2590
    • Zucali, P.A.1    Giovannetti, E.2    Destro, A.3
  • 55
    • 80052554890 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed
    • [Epub ahead of print]
    • Chen CY, Chang YL, Shih JY, et al. Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: the association with treatment efficacy of pemetrexed. Lung Cancer 2011; [Epub ahead of print]
    • (2011) Lung Cancer
    • Chen, C.Y.1    Chang, Y.L.2    Shih, J.Y.3
  • 56
    • 80051785282 scopus 로고    scopus 로고
    • Significance of thymidylate synthase and thyroid transcription factor 1 expression in patients with nonsquamous non-small cell lung cancer treated with pemetrexed-based chemotherapy
    • [Epub ahead of print]
    • Sun JM, Han J, Ahn JS, et al. Significance of thymidylate synthase and thyroid transcription factor 1 expression in patients with nonsquamous non-small cell lung cancer treated with pemetrexed-based chemotherapy. J Thorac Oncol 2011; [Epub ahead of print]
    • (2011) J Thorac Oncol
    • Sun, J.M.1    Han, J.2    Ahn, J.S.3
  • 57
    • 0034758473 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydropyrimidine dehydrogenase activities in non-small cell lung cancer tissues: Relationship with in vitro sensitivity to 5-fluorouracil
    • PII S0169500201002483
    • Higashiyama M, Kodama K, Yokouchi H, et al. Thymidylate synthase and dihydropyrimidine dehydrogenase activities in non-small cell lung cancer tissues: relationship with in vitro sensitivity to 5-fluorouracil. Lung Cancer 2001;34:407-16 (Pubitemid 33041477)
    • (2001) Lung Cancer , vol.34 , Issue.3 , pp. 407-416
    • Higashiyama, M.1    Kodama, K.2    Yokouchi, H.3    Takami, K.4    Fukushima, M.5    Minamigawa, K.6    Takano, T.7    Kobayashi, H.8
  • 59
    • 46049107879 scopus 로고    scopus 로고
    • Thymidylate synthase in situ protein expression and survival in stage I nonsmall-cell lung cancer
    • DOI 10.1002/cncr.23491
    • Zheng Z, Li X, Schell MJ, et al. Thymidylate synthase in situ protein expression and survival in stage I nonsmall-cell lung cancer. Cancer 2008;112:2765-73 (Pubitemid 351969222)
    • (2008) Cancer , vol.112 , Issue.12 , pp. 2765-2773
    • Zheng, Z.1    Li, X.2    Schell, M.J.3    Chen, T.4    Boulware, D.5    Robinson, L.6    Sommers, E.7    Bepler, G.8
  • 61
    • 80052724195 scopus 로고    scopus 로고
    • International tailored chemotherapy adjuvant trial: ITACA trial
    • abstract e17514
    • Novello S, Scagliotti G, Torri V, et al. International tailored chemotherapy adjuvant trial: ITACA trial. J Clin Oncol 2011;29(Suppl):abstract e17514
    • (2011) J Clin Oncol , Issue.SUPPL. , pp. 29
    • Novello, S.1    Scagliotti, G.2    Torri, V.3
  • 62
    • 33947375647 scopus 로고    scopus 로고
    • Molecular basis of antifolate resistance
    • DOI 10.1007/s10555-007-9049-z, Special Issue on Transporters in Cancer
    • Assaraf YG. Molecular basis of antifolate resistance. Cancer Metastasis Rev 2007;26:153-81 (Pubitemid 46452189)
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.1 , pp. 153-181
    • Assaraf, Y.G.1
  • 63
    • 78049426102 scopus 로고    scopus 로고
    • ABCC11/MRP8 confers pemetrexed resistance in lung cancer
    • Uemura T, Oguri T, Ozasa H, et al. ABCC11/MRP8 confers pemetrexed resistance in lung cancer. Cancer Sci 2010;101:2404-10
    • (2010) Cancer Sci , vol.101 , pp. 2404-2410
    • Uemura, T.1    Oguri, T.2    Ozasa, H.3
  • 64
    • 33750975065 scopus 로고    scopus 로고
    • The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis
    • DOI 10.1016/j.drup.2006.09.001, PII S1368764606000628
    • Assaraf YG. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist Updat 2006;9:227-46 (Pubitemid 44750843)
    • (2006) Drug Resistance Updates , vol.9 , Issue.4-5 , pp. 227-246
    • Assaraf, Y.G.1
  • 65
    • 0037455808 scopus 로고    scopus 로고
    • Loss of folylpoly-γ-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines
    • DOI 10.1002/ijc.10829
    • Liani E, Rothem L, Bunni MA, et al. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer 2003;103:587-99 (Pubitemid 36091461)
    • (2003) International Journal of Cancer , vol.103 , Issue.5 , pp. 587-599
    • Liani, E.1    Rothem, L.2    Bunni, M.A.3    Smith, C.A.4    Jansen, G.5    Assaraf, Y.G.6
  • 66
    • 0034714363 scopus 로고    scopus 로고
    • Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase
    • Zhao R, Titus S, Gao F, et al. Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase. J Biol Chem 2000;275:26599-606
    • (2000) J Biol Chem , vol.275 , pp. 26599-606
    • Zhao, R.1    Titus, S.2    Gao, F.3
  • 67
    • 0028909247 scopus 로고
    • Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM
    • Pizzorno G, Moroson BA, Cashmore AR, et al. Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM. Cancer Res 1995;55:566-73
    • (1995) Cancer Res , vol.55 , pp. 566-573
    • Pizzorno, G.1    Moroson, B.A.2    Cashmore, A.R.3
  • 68
    • 66049102881 scopus 로고    scopus 로고
    • Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia
    • Stark M, Wichman C, Avivi I, et al. Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia. Blood 2009;113:4362-9
    • (2009) Blood , vol.113 , pp. 4362-4369
    • Stark, M.1    Wichman, C.2    Avivi, I.3
  • 69
    • 0035313188 scopus 로고    scopus 로고
    • Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells
    • DOI 10.1016/S0006-2952(01)00532-9, PII S0006295201005329
    • Zhao R, Gao F, Goldman ID. Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells. Biochem Pharmacol 2001;61:857-65 (Pubitemid 32245569)
    • (2001) Biochemical Pharmacology , vol.61 , Issue.7 , pp. 857-865
    • Zhao, R.1    Gao, F.2    Goldman I.David3
  • 70
    • 12944312685 scopus 로고    scopus 로고
    • Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis
    • Zhao R, Zhang S, Hanscom M, et al. Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis. Clin Cancer Res 2005;11:1294-301 (Pubitemid 40175783)
    • (2005) Clinical Cancer Research , vol.11 , Issue.3 , pp. 1294-1301
    • Zhao, R.1    Zhang, S.2    Hanscom, M.3    Chattopadhyay, S.4    Goldman, I.D.5
  • 71
    • 33644975527 scopus 로고    scopus 로고
    • The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line
    • Chattopadhyay S, Zhao R, Krupenko SA, et al. The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Mol Cancer Ther 2006;5:438-49
    • (2006) Mol Cancer Ther , vol.5 , pp. 438-449
    • Chattopadhyay, S.1    Zhao, R.2    Krupenko, S.A.3
  • 72
    • 0041305877 scopus 로고    scopus 로고
    • Membrane transport of folates
    • DOI 10.1016/S0083-6729(03)01012-4, PII S0083672903010124
    • Matherly LH, Goldman DI. Membrane transport of folates. Vitam Horm 2003;66:403-56 (Pubitemid 137640823)
    • (2003) Vitamins and Hormones , vol.66 , pp. 403-456
    • Matherly, L.H.1    Goldman, I.D.2
  • 73
    • 0030948473 scopus 로고    scopus 로고
    • Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression
    • Gorlick R, Goker E, Trippett T, et al. Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. Blood 1997;89:1013-18 (Pubitemid 27121295)
    • (1997) Blood , vol.89 , Issue.3 , pp. 1013-1018
    • Gorlick, R.1    Goker, E.2    Trippett, T.3    Steinherz, P.4    Elisseyeff, Y.5    Mazumdar, M.6    Flintoff, W.F.7    Bertino, J.R.8
  • 74
    • 0842304934 scopus 로고    scopus 로고
    • A prominent low-pH methotrexate transport activity in human solid tumors: Contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier
    • DOI 10.1158/1078-0432.CCR-1066-03
    • Zhao R, Gao F, Hanscom M, et al. A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier. Clin Cancer Res 2004;10:718-27 (Pubitemid 38180440)
    • (2004) Clinical Cancer Research , vol.10 , Issue.2 , pp. 718-727
    • Zhao, R.1    Gao, F.2    Hanscom, M.3    Goldman, I.D.4
  • 75
    • 50549085728 scopus 로고    scopus 로고
    • The proton-coupled folate transporter: Impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier
    • Zhao R, Qiu A, Tsai E, et al. The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol 2008;74:854-62
    • (2008) Mol Pharmacol , vol.74 , pp. 854-862
    • Zhao, R.1    Qiu, A.2    Tsai, E.3
  • 76
    • 53449097226 scopus 로고    scopus 로고
    • PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells
    • Gonen N, Bram EE, Assaraf YG. PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells. Biochem Biophys Res Commun 2008;376:787-92
    • (2008) Biochem Biophys Res Commun , vol.376 , pp. 787-792
    • Gonen, N.1    Bram, E.E.2    Assaraf, Y.G.3
  • 77
    • 68849117681 scopus 로고    scopus 로고
    • Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line
    • Diop-Bove NK, Wu J, Zhao R, et al. Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line. Mol Cancer Ther 2009;8:2424-31
    • (2009) Mol Cancer Ther , vol.8 , pp. 2424-2431
    • Diop-Bove, N.K.1    Wu, J.2    Zhao, R.3
  • 79
    • 0022727721 scopus 로고
    • Phase II study of UFT in patients with advanced non-small cell lung cancer
    • Keicho N, Saijo N, Shinkai T, et al. Phase II study of UFT in patients with advanced non-small cell lung cancer. Jpn J Clin Oncol 1986;16:143-6
    • (1986) Jpn J Clin Oncol , vol.16 , pp. 143-146
    • Keicho, N.1    Saijo, N.2    Shinkai, T.3
  • 80
    • 0029835349 scopus 로고    scopus 로고
    • Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators
    • Shirasaka T, Shimamato Y, Ohshimo H, et al. Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs 1996;7:548-57 (Pubitemid 26276346)
    • (1996) Anti-Cancer Drugs , vol.7 , Issue.5 , pp. 548-557
    • Shirasaka, T.1    Shimamato, Y.2    Ohshimo, H.3    Yamaguchi, M.4    Kato, T.5    Yonekura, K.6    Fukushima, M.7
  • 82
    • 70449102943 scopus 로고    scopus 로고
    • Oral UFT, etoposide and leucovorin in recurrent non-small cell lung cancer: A non-randomized phase II study
    • Surmont V, Aerts JG, Pouw E, et al. Oral UFT, etoposide and leucovorin in recurrent non-small cell lung cancer: a non-randomized phase II study. Lung Cancer 2009;66:333-7
    • (2009) Lung Cancer , vol.66 , pp. 333-337
    • Surmont, V.1    Aerts, J.G.2    Pouw, E.3
  • 83
    • 80051781864 scopus 로고    scopus 로고
    • An open-label, multicenter, three-stage, phase ii study of S-1 in combination with cisplatin as first-line therapy for patients with advanced non-small cell lung cancer
    • Epub ahead of print
    • Sandler A, Graham C, Baggstrom M, et al. An open-label, multicenter, three-stage, phase ii study of S-1 in combination with cisplatin as first-line therapy for patients with advanced non-small cell lung cancer. J Thorac Oncol 2011; Epub ahead of print.
    • (2011) J Thorac Oncol
    • Sandler, A.1    Graham, C.2    Baggstrom, M.3
  • 85
    • 61349153697 scopus 로고    scopus 로고
    • Addition of S-1 to the epidermal growth factor receptor inhibitor gefitinib overcomes gefitinib resistance in non-small cell lung cancer cell lines withMET amplification
    • Okabe T, Okamoto I, Tsukioka S, et al. Addition of S-1 to the epidermal growth factor receptor inhibitor gefitinib overcomes gefitinib resistance in non-small cell lung cancer cell lines withMET amplification. Clin Cancer Res 2009;15:907-13
    • (2009) Clin Cancer Res , vol.15 , pp. 907-913
    • Okabe, T.1    Okamoto, I.2    Tsukioka, S.3
  • 86
    • 79957713253 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydropyrimidine dehydrogenase expression levels are associated with response to S-1 plus carboplatin in advanced non-small cell lung cancer
    • Takeda M, Okamoto I, Hirabayashi N, et al. Thymidylate synthase and dihydropyrimidine dehydrogenase expression levels are associated with response to S-1 plus carboplatin in advanced non-small cell lung cancer. Lung Cancer 2011;73:103-9
    • (2011) Lung Cancer , vol.73 , pp. 103-109
    • Takeda, M.1    Okamoto, I.2    Hirabayashi, N.3
  • 87
    • 77955833044 scopus 로고    scopus 로고
    • Pooled analysis of S-1 trials in non-small cell lung cancer according to histological type
    • Yamamoto N, Yamanaka T, Ichinose Y, et al. Pooled analysis of S-1 trials in non-small cell lung cancer according to histological type. Anticancer Res 2010;30:2985-90
    • (2010) Anticancer Res , vol.30 , pp. 2985-2990
    • Yamamoto, N.1    Yamanaka, T.2    Ichinose, Y.3
  • 88
    • 0036214481 scopus 로고    scopus 로고
    • Phase I dose-escalating study of raltitrexed ('Tomudex') and cisplatin in metastatic non-small cell lung cancer
    • DOI 10.1016/S0169-5002(01)00491-3, PII S0169500201004913
    • Manegold C, Buchholz E, Kloeppel R, et al. Phase I dose-escalating study of raltitrexed ('Tomudex') and cisplatin in metastatic non-small cell lung cancer. Lung Cancer 2002;36:183-9 (Pubitemid 34296560)
    • (2002) Lung Cancer , vol.36 , Issue.2 , pp. 183-189
    • Manegold, C.1    Buchholz, E.2    Kloeppel, R.3    Kreisel, C.4    Smith, M.5
  • 89
    • 74049092356 scopus 로고    scopus 로고
    • Is capecitabine a new choice of treatment for lung adenocarcinoma? A case report involving partial response in second line of treatment and hypothesis of the biological basis
    • Mendiola C, Vaz MA. Is capecitabine a new choice of treatment for lung adenocarcinoma? A case report involving partial response in second line of treatment and hypothesis of the biological basis. Clin Transl Oncol 2009;11:554-7
    • (2009) Clin Transl Oncol , vol.11 , pp. 554-557
    • Mendiola, C.1    Vaz, M.A.2
  • 90
    • 20444467767 scopus 로고    scopus 로고
    • Thymidine phosphorylase expression in tumour cells and tumour response to capecitabine plus docetaxel chemotherapy in non-small cell lung cancer
    • DOI 10.1136/jcp.2004.022764
    • Han JY, Hong EK, Lee SY, et al. Thymidine phosphorylase expression in tumour cells and tumour response to capecitabine plus docetaxel chemotherapy in non-small cell lung cancer. J Clin Pathol 2005;58:650-4 (Pubitemid 40814029)
    • (2005) Journal of Clinical Pathology , vol.58 , Issue.6 , pp. 650-654
    • Han, J.-Y.1    Hong, E.K.2    Lee, S.Y.3    Yoon, S.M.4    Lee, D.H.5    Lee, J.S.6
  • 91
    • 79551495377 scopus 로고    scopus 로고
    • Modulation of Rad51 ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine
    • Ko JC, Tsai MS, Kuo YH, et al. Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine. Biochem Pharmacol 2011;81:680-90
    • (2011) Biochem Pharmacol , vol.81 , pp. 680-690
    • Ko, J.C.1    Tsai, M.S.2    Kuo, Y.H.3
  • 93
    • 77949686314 scopus 로고    scopus 로고
    • Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib
    • Giovannetti E, Zucali PA, Peters GJ, et al. Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib. Mol Cancer Ther 2010;9:581-93
    • (2010) Mol Cancer Ther , vol.9 , pp. 581-593
    • Giovannetti, E.1    Zucali, P.A.2    Peters, G.J.3
  • 94
    • 0037567591 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity
    • Mandola MV, Stoehlmacher J, Muller-Weeks S, et al. A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res 2003;63:2898-904 (Pubitemid 36667162)
    • (2003) Cancer Research , vol.63 , Issue.11 , pp. 2898-2904
    • Mandola, M.V.1    Stoehlmacher, J.2    Muller-Weeks, S.3    Cesarone, G.4    Yu, M.C.5    Lenz, H.-J.6    Ladner, R.D.7
  • 95
    • 0029122937 scopus 로고
    • Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase
    • Horie N, Aiba H, Oguro K, et al. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct 1995;20:191-7
    • (1995) Cell Struct Funct , vol.20 , pp. 191-197
    • Horie, N.1    Aiba, H.2    Oguro, K.3
  • 96
    • 65349091355 scopus 로고    scopus 로고
    • Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer
    • Smit EF, Burgers SA, Biesma B, et al. Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer. J Clin Oncol 2009;27:2038-45
    • (2009) J Clin Oncol , vol.27 , pp. 2038-2045
    • Smit, E.F.1    Burgers, S.A.2    Biesma, B.3
  • 97
    • 77449098773 scopus 로고    scopus 로고
    • Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426
    • Adjei AA, Mandrekar SJ, Dy GK, et al. Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. J Clin Oncol 2010;28:614-19.
    • (2010) J Clin Oncol , vol.28 , pp. 614-619
    • Adjei, A.A.1    Mandrekar, S.J.2    Dy, G.K.3
  • 98
    • 80052749223 scopus 로고    scopus 로고
    • Thymidylate synthase (TS) gene copy number in NSCLC
    • abstract e21063
    • Wynes MW, Dziadziuszko R, Singh S, et al. Thymidylate synthase (TS) gene copy number in NSCLC. J Clin Oncol 2010;28(Suppl):abstract e21063
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Wynes, M.W.1    Dziadziuszko, R.2    Singh, S.3
  • 99
    • 77955478900 scopus 로고    scopus 로고
    • MiR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation
    • Boni V, Bitarte N, Cristobal I, et al. miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation. Mol Cancer Ther 2010;9:2265-75
    • (2010) Mol Cancer Ther , vol.9 , pp. 2265-2275
    • Boni, V.1    Bitarte, N.2    Cristobal, I.3
  • 100
    • 80052718930 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice
    • [Epub ahead of print]
    • Giovannetti E, Erozenci A, Smit J, et al. Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice. Crit Rev Oncol Hematol 2011; [Epub ahead of print]
    • (2011) Crit Rev Oncol Hematol
    • Giovannetti, E.1    Erozenci, A.2    Smit, J.3
  • 101
    • 34250637524 scopus 로고    scopus 로고
    • Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells
    • DOI 10.1158/1078-0432.CCR-06-2923
    • Li T, Ling YH, Goldman ID, et al. Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells. Clin Cancer Res 2007;13:3413-22 (Pubitemid 46944930)
    • (2007) Clinical Cancer Research , vol.13 , Issue.11 , pp. 3413-3422
    • Li, T.1    Ling, Y.-H.2    Goldman, I.D.3    Perez-Soler, R.4
  • 102
    • 77953394930 scopus 로고    scopus 로고
    • Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor
    • Takezawa K, Okamoto I, Tanizaki J, et al. Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor. Mol Cancer Ther 2010;9:1647-56
    • (2010) Mol Cancer Ther , vol.9 , pp. 1647-1656
    • Takezawa, K.1    Okamoto, I.2    Tanizaki, J.3
  • 103
    • 50249122093 scopus 로고    scopus 로고
    • Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells
    • Tekle C, Giovannetti E, Sigmond J, et al. Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells. Br J Cancer 2008;99:750-9
    • (2008) Br J Cancer , vol.99 , pp. 750-759
    • Tekle, C.1    Giovannetti, E.2    Sigmond, J.3
  • 104
    • 80052744396 scopus 로고    scopus 로고
    • Expression and pharmacological inhibition of thymidilate synthase and Src kinase in non-small cell lung cancer
    • [Epub ahead of print]
    • Ceppi P, Rapa I, Lo IM, et al. Expression and pharmacological inhibition of thymidilate synthase and Src kinase in non-small cell lung cancer. Int J Cancer 2011; [Epub ahead of print]
    • (2011) Int J Cancer
    • Ceppi, P.1    Rapa, I.2    Lo, I.M.3
  • 105
    • 69849093398 scopus 로고    scopus 로고
    • Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer
    • Hanauske AR, Lahn M, Musib LC, et al. Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer. Ann Oncol 2009;20:1565-75
    • (2009) Ann Oncol , vol.20 , pp. 1565-1575
    • Hanauske, A.R.1    Lahn, M.2    Musib, L.C.3
  • 106
    • 77949429934 scopus 로고    scopus 로고
    • Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC)
    • Giovannetti E, Honeywell R, Hanauske AR, et al. Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC). Curr Drug Targets 2010;11:12-28
    • (2010) Curr Drug Targets , vol.11 , pp. 12-28
    • Giovannetti, E.1    Honeywell, R.2    Hanauske, A.R.3
  • 107
    • 0023726563 scopus 로고
    • Report on nationwide pooled data and cohort investigation in UFT phase II study
    • Ota K, Taguchi T, Kimura K. Report on nationwide pooled data and cohort investigation in UFT phase II study. Cancer Chemother Pharmacol 1988;22(4):333-8
    • (1988) Cancer Chemother Pharmacol , vol.22 , Issue.4 , pp. 333-338
    • Ota, K.1    Taguchi, T.2    Kimura, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.