Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations

Journal of Clinical Oncology

Volumn 17, Issue 6, 1999, Pages 1786-1793

  Monzó, Mariano ^a   Rosell, Rafael ^a   Sánchez, José Javier ^a   Lee, Jin S ^a   O'Brate, Aurora ^a   González Larriba, José Luis ^a   Alberola, Vicente ^a   Lorenzo, Juan Carlos ^a   Núñez, Laura ^a   Ro, Jae Y ^a   Martín, Cristina ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; BETA TUBULIN; DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; OLIGONUCLEOTIDE; PACLITAXEL;

ARTICLE; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0033063875     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.1999.17.6.1786     Document Type: Article

References (36)

1. Non-Small Cell Lung Cancer Collaborative Group: Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 311:899-909, 1995
2. Rosell R, Gómez-Codina J, Camps C, et al: A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small cell lung cancer. N Engl J Med 330:153-158, 1994
3. Chang AY, Kim K, Glick J, et al: Phase II study of Taxol, merbarone, and piroxantrone in stage IV non-small-cell lung cancer: The Eastern Cooperative Oncology Group results. J Natl Cancer Inst 85:388-394, 1993
4. Murphy WK, Fossella FV, Winn RJ, et al: Phase II study of taxol in patients with untreated advanced non-small-cell lung cancer. J Natl Cancer Inst 85:384-388, 1993
5. Schiff PB, Fant J, Horwitz SB: Promotion of microtubule assembly in vitro by taxol. Nature 277:665-667, 1979
6. Horwitz SB, Cohen D, Rao S, et al: Taxol: Mechanisms of action and resistance. Monogr J Natl Cancer Inst 15:55-61, 1993
7. De Brabander M, Geuens G, Nuydens R, et al: Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochores. Proc Natl Acad Sci U S A 78:5608-5612, 1981
8. Schiff PB, Horwitz SB: Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci U S A 77:1561-1565, 1980
9. Milross CG, Mason KA, Hunter NR, et al: Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel. J Natl Cancer Inst 88:1308-1314, 1996
10. Long BH, Fairchild CR: Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telophase. Cancer Res 54:4355-4361, 1994
11. Cross SM, Sanchez CA, Morgan CA, et al: A p53-dependent mouse spindle checkpoint. Science 267:1353-1356, 1995
12. Maccioni BR, Cambiazo V: Role of microtubule-associated proteins in the control of microtubule assembly. Physiol Rev 75:835-864, 1995
13. Burns RG, Surridge CD: Tubulin: Conservation and structure, in Hyams JS, Lloyd CW (eds): Microtubules. New York, NY, Wiley-Liss, 1994, pp 3-31
14. Mandelkow E, Herrmann M, Ruhl U: Tubulin domains probed by limited proteolysis and subunit specific antibodies. J Mol Biol 185:311-327, 1985
15. Linse K, Mandelkow EM: The GTP-binding peptide of beta-tubulin. J Biol Chem 263:15205-15210, 1988
16. Shivanna BD, Mejillano MR, Todd DW, et al: Exchangeable GTP binding site of beta-tubulin. J Biol Chem 268:127-132, 1993
17. Díaz JF, Andreu JM: Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: Reversibility, ligand and stoichiometry, and competition. Biochemistry 32:2747-2755, 1993
18. Rao S, Krauss NE, Heerding JM, et al: 3′-(p-Azidobenzamido) taxol photolabels the N-terminal 31 amino acids of beta-tubulin. J Biol Chem 269:3132-3134, 1994
19. Kavallaris M, Kuo DYS, Burkhardt CA, et al: Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. J Clin Invest 100:1282-1293, 1997
20. Zaman GJR, Flens MJ, van Leusden HR, et al: The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci U S A 91:8822-8826, 1994
21. Cabrai F, Sobel ME, Gottesman MM: CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin. Cell 20:29-36, 1980
22. Cabral F, Wible L, Brenner S, et al: Taxol-requiring mutant of Chinese hamster ovary cells with impaired mitotic spindle assembly. J Cell Biol 97:30-39, 1983
23. Schibler MJ, Cabral F: Taxol-dependent mutants of Chinese hamster ovary cells with alterations in alpha-and beta-tubulin. J Cell Biol 102:1522-1531, 1986
24. Ohta SK, Nishio N, Kubota T, et al: Characterization of a taxol-resistant human small-cell lung cancer cell line. Jpn J Cancer Res 85:290-297, 1994
25. Giannakakou P, Sackett DL, Kang YK, et al: Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization. J Biol Chem 272:17118-17125, 1997
26. Murphy WK, Winn RJ, Huber M, et al: Phase II study of taxol in patients with non-small cell lung cancer who have failed platinum-containing chemotherapy. Proc Am Soc Clin Oncol 13:363, 1994 (abstr 1224)
27. 3H] (Azidophenyl)ureido taxoid photolabels peptide amino acids 281-304 of alpha-tubulin. Biochemistry 36:3820-3825, 1997
28. Ranganathan S, Dexter DW, Benetatos CA, et al: Increase of beta(III)-and beta(IVa)-tubulin isotypes in human prostate carcinoma cells as a result of estramustine resistance. Cancer Res 56:2584-2589, 1996
29. Zabala JC, Fontalba A, Avila J: Tubulin folding is altered by mutations in a putative GTP binding motif. J Cell Sci 109:1471-1478, 1996
30. Ibrado AM, Lin L, Bhalla K: Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells. Cancer Res 57:1109-1115, 1997
31. Kimura Y, Furuhata T, Shiratsuchi T, et al: GML sensitizes cancer cells to taxol by induction of apoptosis. Oncogene 15:1369-1374, 1997
32. Dumontet Ch, Duran GE, Steger KA, et al: Resistance mechanisms in human sarcoma mutants derived by single-step exposure to paclitaxel (Taxol). Cancer Res 56:1091-1097, 1996
33. Schinkel A, Mayer U, Wagenaar E, et al: Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug transporting) P-glycoproteins. Proc Natl Acad Sci U S A 94:4028-4033, 1997
34. Childs S, Lin Yeh R, Hui D, et al: Taxol resistance mediated by transfection of the liver-specific sister gene of P-glycoprotein. Cancer Res 58:4160-4167, 1998
35. Choi K, Chen C, Kriegler M, et al: An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell 53:519-529, 1988
36. Gros P, Dhir R, Croop J, et al: A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdrl and mdr3 drug efflux pumps. Proc Natl Acad Sci U S A 88:7289-7293, 1991