Ribonucleotide reductase M1 gene promoter activity, polymorphisms, population frequencies, and clinical relevance

Lung Cancer

Volumn 47, Issue 2, 2005, Pages 183-192

  Bepler, Gerold ^a   Zheng, Zhong ^a   Gautam, Ashish ^a   Sharma, Swati ^a   Cantor, Alan ^a   Sharma, Anupama ^a   Cress, W Douglas ^a   Kim, Young Chul ^b   Rosell, Rafael ^c   McBride, Colleen ^d   Robinson, Lary ^a   Sommers, Eric ^a   Haura, Eric ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b Chonnam National University   (South Korea)

^c HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Lung cancer; Polymorphisms; Promoter; Ribonucleotide reductase; RRM1

Indexed keywords

AFRICAN AMERICAN; ALLELE; ARTICLE; ASIA; BIOASSAY; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; EUROPEAN AMERICAN; GENE; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FREQUENCY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; NUCLEOTIDE SEQUENCE; POPULATION GENETICS; PRIORITY JOURNAL; PROMOTER REGION; RIBONUCLEOTIDE REDUCTASE M1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL ASSAY; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENETIC MARKERS; HUMANS; LUNG NEOPLASMS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; PROMOTER REGIONS (GENETICS); SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 19944429421     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2004.07.043     Document Type: Article

References (15)

1. S.J. Elledge, Z. Zhou, and J.B. Allen Ribonucleotide reductase: regulation, regulation, regulation Trends Biochem. Sci. 17 1992 119 123
2. D. Filatov, R. Ingemarson, E. Johansson, U. Rova, and L. Thelander Mouse ribonucleotide reducatse: from genes to proteins Biochem. Soc. Trans. 23 1995 903 905
3. J. Stubbe Ribonucleotide reductases in the twenty-first century Proc. Natl. Acad. Sci. U.S.A. 95 1998 2723 2724
4. Y. Engstroem, S. Eriksson, I. Jildevik, S. Skog, L. Thelander, and B. Tribukait Cell cycle-dependent expression of mammalian ribonucleotide reductase J. Biol. Chem. 260 1985 9114 9116
5. G.J. Mann, E.A. Musgrove, R.M. Fox, and L. Thelander Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation Cancer Res. 48 1988 5151 5156
6. J.E. Brissenden, I. Caras, L. Thelander, and U. Francke The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band 15, in human and to chromosome 7 in mouse Exp. Cell Res. 174 1988 302 308
7. G. Bepler, and M.A. Garcia-Blanco Three tumor-suppressor regions on chromosome 11p identified by high-resolution deletion mapping in human non-small-cell lung cancer Proc. Natl. Acad. Sci. U.S.A. 91 1994 5513 5517
8. G. Bepler, A. Gautam, and L.M. McIntyre Prognostic significance of molecular genetic aberrations on chromosome segment 11p15.5 in non-small-cell lung cancer J. Clin. Oncol. 20 2002 1353 1360
9. K. O'Briant, E. Jolicoeur, J. Garst, M. Campa, G. Schreiber, and G. Bepler Growth inhibition of a human lung adenocarcinoma cell line by genetic complementation with chromosome 11 Anticancer Res. 17 1997 3243 3252
10. H. Fan, A. Huang, C. Villegas, and J.A. Wright The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments Proc. Natl. Acad. Sci. U.S.A. 94 1997 13181 13186
11. A. Gautam, Z.R. Li, and G. Bepler RRM1-induced metastasis suppression through PTEN-regulated pathways Oncogene 22 2003 2135 2142
12. G. Bepler, S. Sharma, and A. Cantor RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer J. Clin. Oncol. 22 2004 1878 1885
13. R. Rosell, G. Scagliotti, and K.D. Danenberg Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer Oncogene 22 2003 3548 3553
14. R. Rosell, K. Danenberg, and V. Alberola Ribonucleotide reductase mRNA expression and survival in gemcitabine/cisplatin-treated advanced non-small-cell lung cancer patients Clin. Cancer Res. 10 2004 1318 1325
15. W. Plunkett, P. Huang, and Y.Z. Xu Gemcitabine: metabolism, mechanism of action, and self potentiation Semin. Oncol. 22 Suppl 11 1995 3 10