High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing

Cancer Discovery

Volumn 2, Issue 1, 2012, Pages 82-93

  Wagle, Nikhil ^a,b   Berger, Michael F ^b   Davis, Matthew J ^a   Blumenstiel, Brendan ^b   De Felice, Matthew ^b   Pochanard, Panisa ^a   Ducar, Matthew ^a   Van Hummelen, Paul ^a   MacConaill, Laura E ^a   Hahn, William C ^a,b   Meyerson, Matthew ^a,b   Gabriel, Stacey B ^b   Garraway, Levi A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; B RAF KINASE; BRCA1 PROTEIN; CADHERIN; CYCLIN DEPENDENT KINASE 8; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FORMALDEHYDE; GENOMIC DNA; K RAS PROTEIN; MYC PROTEIN; PARAFFIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4, 5 BISPHOSPHATE 3 KINASE; PROTEIN MSH2; PROTEIN P53; SMAD2 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOTINYLATION; BREAST CANCER; CLINICAL ARTICLE; COLON CANCER; CONTROLLED STUDY; COPY NUMBER VARIATION; DIAGNOSTIC TEST ACCURACY STUDY; DNA HYBRIDIZATION; DNA LIBRARY; DNA SEQUENCE; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENE INSERTION; GENOTYPING TECHNIQUE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; MASS SPECTROMETRY; MICROARRAY ANALYSIS; NEOPLASM; POINT MUTATION; POLYMERASE CHAIN REACTION; REPRODUCIBILITY; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

CELL LINE, TUMOR; DNA MUTATIONAL ANALYSIS; GENE DOSAGE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; NEOPLASMS;

EID: 84865833740     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-11-0184     Document Type: Article

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