메뉴 건너뛰기




Volumn 26, Issue , 2014, Pages 24-32

Sirtuins, metabolism, and DNA repair

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; GLUCOSE; GLUTAMINE; HISTONE H3; NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN; SIRTUIN 1; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; SIRTUIN 6; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; WERNER SYNDROME PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SIRTUIN 2; SIRTUIN 7; TRANSCRIPTION FACTOR FKHRL1; TUMOR SUPPRESSOR PROTEIN; ISOENZYME;

EID: 84903847639     PISSN: 0959437X     EISSN: 18790380     Source Type: Journal    
DOI: 10.1016/j.gde.2014.05.005     Document Type: Review
Times cited : (116)

References (86)
  • 1
    • 0023340731 scopus 로고
    • Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
    • Rine J., Herskowitz I. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 1987, 116:9-22.
    • (1987) Genetics , vol.116 , pp. 9-22
    • Rine, J.1    Herskowitz, I.2
  • 2
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: biological insights and disease relevance
    • Haigis M.C., Sinclair D.A. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol Mech Dis 2010, 5:253-295.
    • (2010) Annu Rev Pathol Mech Dis , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 4
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel T., Deng C.-X., Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009, 460:587-591.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.-X.2    Mostoslavsky, R.3
  • 5
    • 26244436281 scopus 로고    scopus 로고
    • Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
    • Michshita E., Park J.Y., Burneskis J.M., Barrett J.C., Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell 2005, 16:4623-4635.
    • (2005) Mol Biol Cell , vol.16 , pp. 4623-4635
    • Michshita, E.1    Park, J.Y.2    Burneskis, J.M.3    Barrett, J.C.4    Horikawa, I.5
  • 7
    • 84882935541 scopus 로고    scopus 로고
    • Sirtuins' modulation of autophagy
    • Ng F., Tang B.L. Sirtuins' modulation of autophagy. J Cell Physiol 2013, 228:2262-2270.
    • (2013) J Cell Physiol , vol.228 , pp. 2262-2270
    • Ng, F.1    Tang, B.L.2
  • 8
    • 0027278557 scopus 로고
    • Instability and decay of the primary structure of DNA
    • Lindahl T. Instability and decay of the primary structure of DNA. Nature 1993, 362:709-715.
    • (1993) Nature , vol.362 , pp. 709-715
    • Lindahl, T.1
  • 10
    • 70349138701 scopus 로고    scopus 로고
    • The conserved role of sirtuins in chromatin regulation
    • Vaquero A. The conserved role of sirtuins in chromatin regulation. Int J Dev Biol 2009, 53:303-322.
    • (2009) Int J Dev Biol , vol.53 , pp. 303-322
    • Vaquero, A.1
  • 11
    • 78650747994 scopus 로고    scopus 로고
    • SIRT1 contributes to telomere maintenance and augments global homologous recombination
    • Palacios J.A., Herranz D., De Bonis M.L., Velasco S., Serrano M., Blasco M.A. SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol 2010, 191:1299-1313.
    • (2010) J Cell Biol , vol.191 , pp. 1299-1313
    • Palacios, J.A.1    Herranz, D.2    De Bonis, M.L.3    Velasco, S.4    Serrano, M.5    Blasco, M.A.6
  • 13
    • 79551580561 scopus 로고    scopus 로고
    • ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
    • Cosentino C., Grieco D., Costanzo V. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J 2010, 30:546-555.
    • (2010) EMBO J , vol.30 , pp. 546-555
    • Cosentino, C.1    Grieco, D.2    Costanzo, V.3
  • 14
    • 84876359638 scopus 로고    scopus 로고
    • SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism
    • Jeong S.M., Xiao C., Finley L.W.S., Lahusen T., Souza A.L., Pierce K., Li Y.-H., Wang X., Laurent G., German N.J., et al. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell 2013, 23:450-463.
    • (2013) Cancer Cell , vol.23 , pp. 450-463
    • Jeong, S.M.1    Xiao, C.2    Finley, L.W.S.3    Lahusen, T.4    Souza, A.L.5    Pierce, K.6    Li, Y.-H.7    Wang, X.8    Laurent, G.9    German, N.J.10
  • 15
    • 83455206803 scopus 로고    scopus 로고
    • Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
    • Cantó C., Auwerx J. Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?. Pharmacol Rev 2012, 64:166-187.
    • (2012) Pharmacol Rev , vol.64 , pp. 166-187
    • Cantó, C.1    Auwerx, J.2
  • 16
    • 84891860991 scopus 로고    scopus 로고
    • The many faces of sirtuins: coupling of NAD metabolism, sirtuins and lifespan
    • Verdin E. The many faces of sirtuins: coupling of NAD metabolism, sirtuins and lifespan. Nat Med 2014, 20:25-27.
    • (2014) Nat Med , vol.20 , pp. 25-27
    • Verdin, E.1
  • 18
    • 78651468722 scopus 로고    scopus 로고
    • Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    • Someya S., Yu W., Hallows W.C., Xu J., Vann J.M., Leeuwenburgh C., Tanokura M., Denu J.M., Prolla T.A. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010, 143:802-812.
    • (2010) Cell , vol.143 , pp. 802-812
    • Someya, S.1    Yu, W.2    Hallows, W.C.3    Xu, J.4    Vann, J.M.5    Leeuwenburgh, C.6    Tanokura, M.7    Denu, J.M.8    Prolla, T.A.9
  • 19
    • 77956173286 scopus 로고    scopus 로고
    • SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity
    • Bao J., Scott I., Lu Z., Pang L., Dimond C.C., Gius D., Sack M.N. SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity. Free Radical Biol Med 2010, 49:1230-1237.
    • (2010) Free Radical Biol Med , vol.49 , pp. 1230-1237
    • Bao, J.1    Scott, I.2    Lu, Z.3    Pang, L.4    Dimond, C.C.5    Gius, D.6    Sack, M.N.7
  • 20
    • 75349111140 scopus 로고    scopus 로고
    • Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria
    • Cimen H., Han M.-J., Yang Y., Tong Q., Koc H., Koc E.C. Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Biochemistry 2010, 49:304-311.
    • (2010) Biochemistry , vol.49 , pp. 304-311
    • Cimen, H.1    Han, M.-J.2    Yang, Y.3    Tong, Q.4    Koc, H.5    Koc, E.C.6
  • 22
    • 80052291180 scopus 로고    scopus 로고
    • Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
    • Jing E., Emanuelli B., Hirschey M.D., Boucher J., Lee K.Y., Lombard D., Verdin E.M., Kahn C.R. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A 2011, 108:14608-14613.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 14608-14613
    • Jing, E.1    Emanuelli, B.2    Hirschey, M.D.3    Boucher, J.4    Lee, K.Y.5    Lombard, D.6    Verdin, E.M.7    Kahn, C.R.8
  • 24
    • 84879059766 scopus 로고    scopus 로고
    • SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage
    • Tseng A.H.H., Shieh S.-S., Wang D.L. SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage. Free Radical Biol Med 2013, 63:222-234.
    • (2013) Free Radical Biol Med , vol.63 , pp. 222-234
    • Tseng, A.H.H.1    Shieh, S.-S.2    Wang, D.L.3
  • 25
    • 84861161546 scopus 로고    scopus 로고
    • SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis
    • Haigis M.C., Deng C.X., Finley L.W.S., Kim H.S., Gius D. SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res 2012, 72:2468-2472.
    • (2012) Cancer Res , vol.72 , pp. 2468-2472
    • Haigis, M.C.1    Deng, C.X.2    Finley, L.W.S.3    Kim, H.S.4    Gius, D.5
  • 27
    • 79959819034 scopus 로고    scopus 로고
    • SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
    • Bell E.L., Emerling B.M., Ricoult S.J.H., Guarente L. SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production. Oncogene 2011, 30:2986-2996.
    • (2011) Oncogene , vol.30 , pp. 2986-2996
    • Bell, E.L.1    Emerling, B.M.2    Ricoult, S.J.H.3    Guarente, L.4
  • 29
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008, 7:11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 33
    • 79952274786 scopus 로고    scopus 로고
    • SIRT6: a master epigenetic gatekeeper of glucose metabolism
    • Zhong L., Mostoslavsky R. SIRT6: a master epigenetic gatekeeper of glucose metabolism. Transcription 2010, 1:17-21.
    • (2010) Transcription , vol.1 , pp. 17-21
    • Zhong, L.1    Mostoslavsky, R.2
  • 36
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 38
  • 39
    • 84883223984 scopus 로고    scopus 로고
    • Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients
    • Marquardt J.U., Fischer K., Baus K., Kashyap A., Ma S., Krupp M., Linke M., Teufel A., Zechner U., Strand D., et al. Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. Hepatology 2013, 58:1054-1064.
    • (2013) Hepatology , vol.58 , pp. 1054-1064
    • Marquardt, J.U.1    Fischer, K.2    Baus, K.3    Kashyap, A.4    Ma, S.5    Krupp, M.6    Linke, M.7    Teufel, A.8    Zechner, U.9    Strand, D.10
  • 41
    • 77953291369 scopus 로고    scopus 로고
    • Sirtuins regulate key aspects of lipid metabolism
    • Lomb D.J., Laurent G., Haigis M.C. Sirtuins regulate key aspects of lipid metabolism. Biochim Biophys Acta 2010, 1804:1652-1657.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1652-1657
    • Lomb, D.J.1    Laurent, G.2    Haigis, M.C.3
  • 44
    • 34547906123 scopus 로고    scopus 로고
    • Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
    • Rodgers J.T., Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A 2007, 104:12861-12866.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12861-12866
    • Rodgers, J.T.1    Puigserver, P.2
  • 46
    • 63449112017 scopus 로고    scopus 로고
    • Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    • Purushotham A., Schug T.T., Xu Q., Surapureddi S., Guo X., Li X. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 2009, 9:327-338.
    • (2009) Cell Metab , vol.9 , pp. 327-338
    • Purushotham, A.1    Schug, T.T.2    Xu, Q.3    Surapureddi, S.4    Guo, X.5    Li, X.6
  • 48
    • 84874817589 scopus 로고    scopus 로고
    • Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1 complex
    • Lim J.H., Gerhart-Hines Z., Dominy J.E., Lee Y., Kim S., Tabata M., Xiang Y.K., Puigserver P. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1 complex. J Biol Chem 2013, 288:7117-7126.
    • (2013) J Biol Chem , vol.288 , pp. 7117-7126
    • Lim, J.H.1    Gerhart-Hines, Z.2    Dominy, J.E.3    Lee, Y.4    Kim, S.5    Tabata, M.6    Xiang, Y.K.7    Puigserver, P.8
  • 54
  • 55
    • 84885637201 scopus 로고    scopus 로고
    • FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression
    • Tao H., Xiong X., DePinho R.A., Deng C.X., Dong X.C. FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. J Biol Chem 2013, 288:29252-29259.
    • (2013) J Biol Chem , vol.288 , pp. 29252-29259
    • Tao, H.1    Xiong, X.2    DePinho, R.A.3    Deng, C.X.4    Dong, X.C.5
  • 56
    • 84884134120 scopus 로고    scopus 로고
    • Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6
    • Tao H., Xiong X., DePinho R.A., Deng C.X., Dong X.C. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res 2013, 54:2745-2753.
    • (2013) J Lipid Res , vol.54 , pp. 2745-2753
    • Tao, H.1    Xiong, X.2    DePinho, R.A.3    Deng, C.X.4    Dong, X.C.5
  • 60
    • 84886686038 scopus 로고    scopus 로고
    • Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins [internet]
    • Feldman J.L., Baeza J., Denu J.M. Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins [internet]. J Biol Chem 2013, 288:31350-31356.
    • (2013) J Biol Chem , vol.288 , pp. 31350-31356
    • Feldman, J.L.1    Baeza, J.2    Denu, J.M.3
  • 63
    • 80053920774 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
    • Yoshino J., Mills K.F., Yoon M.J., Imai S.-I. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab 2011, 14:528-536.
    • (2011) Cell Metab , vol.14 , pp. 528-536
    • Yoshino, J.1    Mills, K.F.2    Yoon, M.J.3    Imai, S.-I.4
  • 66
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers J.-H.J. Genome maintenance mechanisms for preventing cancer. Nature 2001, 411:366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.-H.J.1
  • 68
    • 34250897968 scopus 로고    scopus 로고
    • SIRT1 regulates the function of the Nijmegen breakage syndrome protein
    • Yuan Z., Zhang X., Sengupta N., Lane W.S., Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell 2007, 27:149-162.
    • (2007) Mol Cell , vol.27 , pp. 149-162
    • Yuan, Z.1    Zhang, X.2    Sengupta, N.3    Lane, W.S.4    Seto, E.5
  • 70
    • 43149118368 scopus 로고    scopus 로고
    • Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
    • Li K., Casta A., Wang R., Lozada E., Fan W., Kane S., Ge Q., Gu W., Orren D., Luo J. Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem 2008, 283:7590-7598.
    • (2008) J Biol Chem , vol.283 , pp. 7590-7598
    • Li, K.1    Casta, A.2    Wang, R.3    Lozada, E.4    Fan, W.5    Kane, S.6    Ge, Q.7    Gu, W.8    Orren, D.9    Luo, J.10
  • 72
    • 77955501963 scopus 로고    scopus 로고
    • SIRT1 regulates UV-induced DNA repair through deacetylating XPA
    • Fan W., Luo J. SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol Cell 2010, 39:247-258.
    • (2010) Mol Cell , vol.39 , pp. 247-258
    • Fan, W.1    Luo, J.2
  • 73
    • 78651105018 scopus 로고    scopus 로고
    • Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
    • Ming M., Shea C.R., Guo X., Li X., Soltani K., Han W., He Y.-Y. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci U S A 2010, 107:22623-22628.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 22623-22628
    • Ming, M.1    Shea, C.R.2    Guo, X.3    Li, X.4    Soltani, K.5    Han, W.6    He, Y.-Y.7
  • 74
    • 0037405043 scopus 로고    scopus 로고
    • Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
    • Dryden S.C., Nahhas F.A., Nowak J.E., Goustin A.S., Tainsky M.A. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol 2003, 23:3173-3185.
    • (2003) Mol Cell Biol , vol.23 , pp. 3173-3185
    • Dryden, S.C.1    Nahhas, F.A.2    Nowak, J.E.3    Goustin, A.S.4    Tainsky, M.A.5
  • 78
    • 78649521247 scopus 로고    scopus 로고
    • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    • Qiu X., Brown K., Hirschey M.D., Verdin E., Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010, 12:662-667.
    • (2010) Cell Metab , vol.12 , pp. 662-667
    • Qiu, X.1    Brown, K.2    Hirschey, M.D.3    Verdin, E.4    Chen, D.5
  • 79
    • 79957979314 scopus 로고    scopus 로고
    • Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS
    • Chen Y., Zhang J., Lin Y., Lei Q., Guan K.-L., Zhao S., Xiong Y. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep 2011, 12:534-541.
    • (2011) EMBO Rep , vol.12 , pp. 534-541
    • Chen, Y.1    Zhang, J.2    Lin, Y.3    Lei, Q.4    Guan, K.-L.5    Zhao, S.6    Xiong, Y.7
  • 82
    • 77956550868 scopus 로고    scopus 로고
    • Human SIRT6 promotes DNA end resection through CtIP deacetylation
    • Kaidi A., Weinert B.T., Choudhary C., Jackson S.P. Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 2010, 329:1348-1353.
    • (2010) Science , vol.329 , pp. 1348-1353
    • Kaidi, A.1    Weinert, B.T.2    Choudhary, C.3    Jackson, S.P.4
  • 85
    • 84877616759 scopus 로고    scopus 로고
    • A tale of metabolites: the cross-talk between chromatin and energy metabolism
    • Martinez-Pastor B., Cosentino C., Mostoslavsky R. A tale of metabolites: the cross-talk between chromatin and energy metabolism. Cancer Discov 2013, 3:497-501.
    • (2013) Cancer Discov , vol.3 , pp. 497-501
    • Martinez-Pastor, B.1    Cosentino, C.2    Mostoslavsky, R.3
  • 86
    • 84886056389 scopus 로고    scopus 로고
    • Metabolic modulation of chromatin: implications for DNA repair and genomic integrity
    • Liu J., Kim J., Oberdoerffer P. Metabolic modulation of chromatin: implications for DNA repair and genomic integrity. Front Genet 2013, 4:1-11.
    • (2013) Front Genet , vol.4 , pp. 1-11
    • Liu, J.1    Kim, J.2    Oberdoerffer, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.