A new tool for monoclonal antibody analysis Application of IdeS proteolysis in IgG domain-specific characterization

mAbs

Volumn 6, Issue 4, 2014, Pages 879-893

  An, Yan ^a   Zhang, Ying ^a   Mueller, Hans Martin ^a   Shameem, Mohammed ^a   Chen, Xiaoyu ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Batch release; Charge variant; Domain specific modification; Fc fusion protein; Formal identity; Glycosylation; IdeS; IgG; Methionine oxidation; Monoclonal antibody; Stability testing

Indexed keywords

CYSTEINE; FC RECEPTOR; GLYCAN; HYBRID PROTEIN; IMMUNOGLOBULIN DEGRADING ENZYME OF STREPTOCOCCUS PYOGENES; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G4; METHIONINE; METHIONINE SULFOXIDE; MONOCLONAL ANTIBODY; PROTEIN A; PROTEINASE; SERINE; TRASTUZUMAB; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CYSTEINE PROTEINASE; IMMUNOGLOBULIN CONSTANT REGION; IMMUNOGLOBULIN F(AB) FRAGMENT; MAC-1-LIKE PROTEIN, STREPTOCOCCUS;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BIOLOGICAL ACTIVITY; CAPILLARY ISOELECTRIC FOCUSING; CHEMICAL STRESS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DEAMINATION; DISULFIDE BOND; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HINGE REGION; HUMAN; HYDROPHOBICITY; MASS SPECTROMETRY; OXIDATION; PEPTIDE MAPPING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; QUALITY CONTROL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEQUENCE ALIGNMENT; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; HAMSTER; IMMUNOGLOBULIN CONSTANT REGION; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ANTIBODIES, MONOCLONAL; BACTERIAL PROTEINS; CHO CELLS; CRICETINAE; CRICETULUS; CYSTEINE ENDOPEPTIDASES; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RECOMBINANT FUSION PROTEINS;

EID: 84903756237     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.28762     Document Type: Article

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