Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation

Biochemistry

Volumn 47, Issue 18, 2008, Pages 5088-5100

  Liu, Dingjiang ^a   Ren, Da ^a   Huang, Holly ^a   Dankberg, Jane ^a   Rosenfeld, Robert ^a   Cocco, Melanie J ^b   Li, Luke ^a   Brems, David N ^a   Remmele Jr , Richard L ^a  

^a AMGEN INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; MELTING POINT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHASE STABILITY; THERMOOXIDATION;

METHIONINE MUTANTS; METHIONINE OXIDATION; RESIDUES;

AMINO ACIDS;

IMMUNOGLOBULIN G1; METHIONINE;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DEAMINATION; DIFFERENTIAL SCANNING CALORIMETRY; ESCHERICHIA COLI; GEL PERMEATION CHROMATOGRAPHY; INCUBATION TIME; MASS SPECTROMETRY; MELTING POINT; MUTANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THERMOSTABILITY;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; KINETICS; METHIONINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATION-REDUCTION; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE;

ESCHERICHIA COLI;

EID: 42949139842     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi702238b     Document Type: Article

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