Residual metals cause variability in methionine oxidation measurements in protein pharmaceuticals using LC-UV/MS peptide mapping

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 895-896, Issue , 2012, Pages 71-76

  Zang, Li ^a   Carlage, Tyler ^a   Murphy, David ^a   Frenkel, Ruth ^a   Bryngelson, Peter ^a   Madsen, Mark ^a   Lyubarskaya, Yelena ^a  

^a BIOGEN   (United States)

Author keywords

LC UV MS; Methionine oxidation; Protein digestion; Residual metal

Indexed keywords

ANALYTICAL METHOD; BIOPHARMACEUTICALS; CHROMATOGRAPHIC COLUMN; CHROMATOGRAPHIC PEAKS; CONTACT SURFACE; FORMULATION DEVELOPMENT; IMMUNOGENICITY; IN-VITRO; LC-UV/MS; LONG TERM STABILITY; LOW LEVEL; MAJOR FACTORS; MASS SPECTROMETRIC DETECTION; METHIONINE OXIDATION; PEPTIDE MAPPING; PROTEIN DIGESTION; PROTEIN PHARMACEUTICALS; PROTEIN STABILITY; RESIDUAL METALS; THERAPEUTIC PROTEIN; UV DETECTION;

AMINO ACIDS; CHROMATOGRAPHY; DRUG PRODUCTS; MAPPING; METAL IONS; PEPTIDES;

OXIDATION;

METAL ION; METHIONINE;

ARTICLE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PEPTIDE MAPPING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; ULTRAVIOLET SPECTROSCOPY;

BIOPHARMACEUTICS; CHROMATOGRAPHY, LIQUID; HUMANS; IMMUNOGLOBULIN G; MASS SPECTROMETRY; METHIONINE; OXIDATION-REDUCTION; PEPTIDE MAPPING; PHARMACEUTICAL PREPARATIONS; PROTEIN STABILITY;

EID: 84860150461     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.03.016     Document Type: Article

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