Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods

Current Pharmaceutical Biotechnology

Volumn 9, Issue 6, 2008, Pages 468-481

  Vlasak, Josef ^a   Ionescu, R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Charge heterogeneity; Chromatography; Deamidation; Degradation; Isomerization; Monoclonal antibody

Indexed keywords

ASPARAGINE; ASPARTIC ACID; CYSTEINE; FC RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2 ANTIBODY; IMMUNOGLOBULIN LIGHT CHAIN; LYSINE; MONOCLONAL ANTIBODY; TRASTUZUMAB; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIBODY DETECTION; ANTIBODY STRUCTURE; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHEMICAL REACTION KINETICS; CYCLIZATION; DEAMINATION; DRUG DETERMINATION; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; ELUTION; ENZYME MODIFICATION; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; HYDROPHOBICITY; ION EXCHANGE CHROMATOGRAPHY; ISOMERIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR MODEL; NONHUMAN; OXIDATION; PEPTIDE MAPPING; PHYSICAL CHEMISTRY; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN VARIANT; PROTON TRANSPORT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVIEW; SIALYLATION; UBIQUITINATION;

ANTIBODIES, MONOCLONAL; DRUG EVALUATION, PRECLINICAL; ELECTROCHEMISTRY; STATIC ELECTRICITY;

EID: 60849102492     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920108786786402     Document Type: Review

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