Nondenaturing size-exclusion chromatography-mass spectrometry to measure stress-induced aggregation in a complex mixture of monoclonal antibodies

Analytical Chemistry

Volumn 85, Issue 13, 2013, Pages 6429-6436

  Woodard, Jonathan ^a   Lau, Hollis ^a   Latypov, Ramil F ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION PROPENSITY; BIOCHEMICAL STABILITY; CANDIDATE SELECTION; CHROMATOGRAPHY-MASS SPECTROMETRY; HIGH-THROUGHPUT METHOD; INDIVIDUAL COMPONENTS; INSOLUBLE AGGREGATES; MONOCLONAL ANTIBODIES (MABS);

AGGREGATES; CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULES; MONOCLONAL ANTIBODIES; SURFACE PLASMON RESONANCE;

MIXTURES;

MONOCLONAL ANTIBODY;

ARTICLE; CHEMISTRY; GEL CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; METHODOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, GEL; HUMANS; MASS SPECTROMETRY; STRESS, PHYSIOLOGICAL;

EID: 84879997610     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac401455f     Document Type: Article

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