A comprehensive picture of non-site specific oxidation of methionine residues by peroxides in protein pharmaceuticals

Journal of Pharmaceutical Sciences

Volumn 93, Issue 12, 2004, Pages 3096-3102

  Chu, Jhih Wei ^a   Yin, Jin ^a   Brooks, Bernard R ^b   Wang, Daniel I C ^a   Ricci, Margaret Speed ^c   Brems, David N ^c   Trout, Bernhardt L ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c AMGEN INC   (United States)

Author keywords

Ab initio calculations; GCSF; hPTH(1 34); Methionine; Molecular dynamics; Peroxides; Protein oxidation

Indexed keywords

DRUG RESIDUE; GRANULOCYTE COLONY STIMULATING FACTOR; METHIONINE; PARATHYROID HORMONE; PEROXIDE;

AB INITIO CALCULATION; AQUEOUS SOLUTION; ARTICLE; CALCULATION; DRUG FORMULATION; MOLECULAR DYNAMICS; OXIDATION; PROTEIN STRUCTURE; REACTION ANALYSIS;

EID: 10644230156     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20207     Document Type: Article

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