Ranking the susceptibility of disulfide bonds in human IgG1 antibodies by reduction, differential alkylation, and LC-MS analysis

Analytical Chemistry

Volumn 82, Issue 12, 2010, Pages 5219-5226

  Liu, Hongcheng ^a   Chumsae, Chris ^a   Gaza Bulseco, Georgeen ^a   Hurkmans, Karen ^a   Radziejewski, Czeslaw H ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; DISULFIDE BONDS; HEAVY CHAIN; LIGHT CHAIN; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; RECOMBINANT MONOCLONAL ANTIBODY; STRUCTURAL FEATURE;

ALKYLATION; HYDROCARBONS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES;

LIQUID CHROMATOGRAPHY;

DISULFIDE; IMMUNOGLOBULIN G;

ALKYLATION; ARTICLE; CHEMISTRY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; OXIDATION REDUCTION REACTION; PROCEDURES;

ALKYLATION; CHROMATOGRAPHY, LIQUID; DISULFIDES; HUMANS; IMMUNOGLOBULIN G; MASS SPECTROMETRY; OXIDATION-REDUCTION;

EID: 77953603827     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac100575n     Document Type: Article

References (34)

1. Chumsae, C., Gaza-Bulseco, G., and Liu, H. Anal. Chem. 2009, 81, 6449-6457
2. Xiang, T., Chumsae, C., and Liu, H. Anal. Chem. 2009, 81, 8101-8108
3. Schuurman, J., Perdok, G. J., Gorter, A. D., and Aalberse, R. C. Mol. Immunol. 2001, 38, 1-8
4. Bloom, J. W., Madanat, M. S., Marriott, D., Wong, T., and Chan, S. Y. Protein Sci. 1997, 6, 407-415
5. Labrijn, A. F., Buijsse, A. O., van den Bremer, E. T., Verwilligen, A. Y., Bleeker, W. K., Thorpe, S. J., Killestein, J., Polman, C. H., Aalberse, R. C., Schuurman, J., van de Winkel, J. G., and Parren, P. W. Nat. Biotechnol. 2009, 27, 767-771
6. Wypych, J., Li, M., Guo, A., Zhang, Z., Martinez, T., Allen, M. J., Fodor, S., Kelner, D. N., Flynn, G. C., Liu, Y. D., Bondarenko, P. V., Ricci, M. S., Dillon, T. M., and Balland, A. J. Biol. Chem. 2008, 283, 16194-16205
7. Martinez, T., Guo, A., Allen, M. J., Han, M., Pace, D., Jones, J., Gillespie, R., Ketchem, R. R., Zhang, Y., and Balland, A. Biochemistry 2008, 47, 7496-7508
8. Zhang, B., Harder, A. G., Connelly, H. M., Maheu, L. L., and Cockrill, S. L. Anal. Chem. 2010, 82, 1090-1099
9. Pristatsky, P., Cohen, S. L., Krantz, D., Acevedo, J., Ionescu, R., and Vlasak, J. Anal. Chem. 2009, 81, 6148-6155
10. Gu, S., Wen, D., Weinreb, P. H., Sun, Y., Zhang, L., Foley, S. F., Kshirsagar, R., Evans, D., Mi, S., Meier, W., and Pepinsky, R. B. Anal. Biochem. 2010, 400, 89-98
11. Van Buren, N., Rehder, D., Gadgil, H., Matsumura, M., and Jacob, J. J. Pharm. Sci. 2009, 98, 3013-3030
12. Brych, S. R., Gokarn, Y. R., Hultgen, H., Stevenson, R. J., Rajan, R., and Matsumura, M. J. Pharm. Sci. 2010, 99, 764-781
13. Lacy, E. R., Baker, M., and Brigham-Burke, M. Anal. Biochem. 2008, 382, 66-68
14. Thies, M. J., Talamo, F., Mayer, M., Bell, S., Ruoppolo, M., Marino, G., and Buchner, J. J. Mol. Biol. 2002, 319, 1267-1277
15. McAuley, A., Jacob, J., Kolvenbach, C. G., Westland, K., Lee, H. J., Brych, S. R., Rehder, D., Kleemann, G. R., Brems, D. N., and Matsumura, M. Protein Sci. 2008, 17, 95-106
16. Harris, R. J. Dev. Biol. (Basel) 2005, 122, 117-127
17. Gillies, S. D. and Wesolowski, J. S. Hum. Antibodies Hybridomas 1990, 1, 47-54
18. Dorai, H., Wesolowski, J. S., and Gillies, S. D. Mol. Immunol. 1992, 29, 1487-1491
19. Press, E. M. Biochem. J. 1975, 149, 285-288
20. Wright, J. K. Biochem. Biophys. Res. Commun. 1978, 83, 1284-1290
21. Johnson, B. A. and Hoffmann, L. G. Mol. Immunol. 1981, 18, 181-188
22. Isenman, D. E., Dorrington, K. J., and Painter, R. H. J. Immunol. 1975, 114, 1726-1729
23. Johnson, B. A. and Hoffmann, L. G. Mol. Immunol. 1984, 21, 77-87
24. Cecil, R. and Stevenson, G. T. Biochem. J. 1965, 97, 569-572
25. Sears, D. W., Mohrer, J., and Beychok, S. Biochemistry 1977, 16, 2031-2035
26. Schauenstein, E., Dachs, F., Reiter, M., Gombotz, H., and List, W. Int. Arch. Allergy Immunol. 1986, 80, 174-179
27. Schauenstein, E., Schauenstein, K., Dachs, F., Reiter, M., Leitsberger, A., Weblacher, M., Maninger, K., Horejsi, H., Steinschifter, W., Hirschmann, C., and Felsner, P. Biochem. Mol. Biol. Int. 1996, 40, 433-446
28. Mohammad, S. F., Sharma, N., and Woodward, S. C. Biochim. Biophys. Acta 1983, 749, 47-51
29. Virella, G. and Parkhouse, R. M. Immunochemistry 1973, 10, 213-217
30. Hong, J., Lee, A., Han, H., and Kim, J. Anal. Biochem. 2009, 384, 368-370
31. Montano, R. F. and Morrison, S. L. J. Immunol. 2002, 168, 224-231
32. Liu, H., Chumsae, C., Gaza-Bulseco, G., and Goedken, E. R. Anal. Biochem. 2010, 400, 244-250
33. Padlan, E. A. Mol. Immunol. 1994, 31, 169-217
34. Bolen, D. W. and Santoro, M. M. Biochemistry 1988, 27, 8069-8074