Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays

Current Topics in Medicinal Chemistry

Volumn 14, Issue 11, 2014, Pages 1356-1364

  Low, Yen Sia ^a,b   Sedykh, Alexander Yeugenyevich ^a   Rusyn, Ivan ^b   Tropsha, Alexander ^a  

^a Laboratory for Molecular Modeling Division of Chemical Biology and Medicinal Chemistry   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Bioinformatics; Predictive toxicology; QSAR; Systems pharmacology

Indexed keywords

BIOASSAY; BIOINFORMATICS; CHEMICAL STRUCTURE; HIGH THROUGHPUT SCREENING; MEASUREMENT ACCURACY; MOLECULAR INTERACTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; RISK ASSESSMENT; TRANSCRIPTOMICS; BIOLOGY; CHEMICAL MODEL; CHEMISTRY; PROCEDURES; TOXICOLOGY;

DRUG;

COMPUTATIONAL BIOLOGY; HIGH-THROUGHPUT SCREENING ASSAYS; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TOXICOLOGY;

EID: 84903693496     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026614666140506121116     Document Type: Review

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