Use of cell viability assay date improves the prediction accuracy of conventional quantitative structure-activity relationships models of animal carcinogenicity

Environmental Health Perspectives

Volumn 116, Issue 4, 2008, Pages 506-513

  Zhu, Hao ^a   Rusyn, Ivan ^a,b   Richard, Ann ^c   Tropsha, Alexander ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Carcinogenesis; Computational toxicology; High throughput screening; QSAR

Indexed keywords

1 METHYLNAPHTHALENE; 1 NITRONAPHTHALENE; 1,1,2 TRICHLOROETHANE; 1,2 DIBROMOETHANE; 2 PROPANOL; 2,4 DICHLOROPHENOL; 4,4' ISOPROPYLIDENEDIPHENOL; ACETONITRILE; ACETYLSALICYLIC ACID; AZINPHOS METHYL; BENZIDINE; BROMODICHLOROMETHANE; CHLORENDIC ACID; COUMARIN; DACARBAZINE; DACTINOMYCIN; DICHLORVOS; DIMETHOXANE; DIMPYLATE; FLUTONIDINE; FURFURAL; HEXACHLOROBUTADIENE; HEXACHLOROETHANE; HYDROCHLOROTHIAZIDE; MALATHION; METHOXSALEN; MONURON; PARATHION METHYL; PROPIOLACTONE;

ACCURACY; ANIMAL CELL; ARTICLE; CARCINOGENICITY; CELL ASSAY; CELL VIABILITY; CONTROLLED STUDY; DATA ANALYSIS; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; HUMAN CELL; K NEAREST NEIGHBOR; MALE; MATHEMATICAL MODEL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RODENT; SENSITIVITY AND SPECIFICITY; TOXICITY TESTING; VALIDATION STUDY;

ANIMALS; CARCINOGENS, ENVIRONMENTAL; CELL LINE; CELL SURVIVAL; HUMANS; NEOPLASMS, EXPERIMENTAL; PREDICTIVE VALUE OF TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS;

ANIMALIA; RODENTIA;

EID: 45749129400     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.10573     Document Type: Article

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