-
1
-
-
0032522873
-
Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies
-
Lazarou, J.; Pomeranz, B. H.; Corey, P. N. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies JAMA, J. Am. Med. Assoc. 1998, 279, 1200-1205
-
(1998)
JAMA, J. Am. Med. Assoc.
, vol.279
, pp. 1200-1205
-
-
Lazarou, J.1
Pomeranz, B.H.2
Corey, P.N.3
-
2
-
-
84858329412
-
Data-driven prediction of drug effects and interactions
-
Tatonetti, N. P.; Ye, P. P.; Daneshjou, R.; Altman, R. B. Data-driven prediction of drug effects and interactions Sci. Transl. Med. 2012, 4, 125ra131
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Tatonetti, N.P.1
Ye, P.P.2
Daneshjou, R.3
Altman, R.B.4
-
3
-
-
76149120425
-
A side effect resource to capture phenotypic effects of drugs
-
Kuhn, M.; Campillos, M.; Letunic, I.; Jensen, L. J.; Bork, P. A side effect resource to capture phenotypic effects of drugs Mol. Syst. Biol. 2010, 6, 343
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 343
-
-
Kuhn, M.1
Campillos, M.2
Letunic, I.3
Jensen, L.J.4
Bork, P.5
-
4
-
-
78651317084
-
The Comparative Toxicogenomics Database: Update 2011
-
Davis, A. P.; King, B. L.; Mockus, S.; Murphy, C. G.; Saraceni-Richards, C.; Rosenstein, M.; Wiegers, T.; Mattingly, C. J. The Comparative Toxicogenomics Database: update 2011 Nucleic Acids Res. 2011, 39, D1067-1072
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 1067-1072
-
-
Davis, A.P.1
King, B.L.2
Mockus, S.3
Murphy, C.G.4
Saraceni-Richards, C.5
Rosenstein, M.6
Wiegers, T.7
Mattingly, C.J.8
-
5
-
-
31144432293
-
Literature mining for the biologist: From information retrieval to biological discovery
-
Jensen, L. J.; Saric, J.; Bork, P. Literature mining for the biologist: from information retrieval to biological discovery Nat. Rev. Genet. 2006, 7, 119-129
-
(2006)
Nat. Rev. Genet.
, vol.7
, pp. 119-129
-
-
Jensen, L.J.1
Saric, J.2
Bork, P.3
-
6
-
-
58149189856
-
McKusick's Online Mendelian Inheritance in Man (OMIM)
-
Amberger, J.; Bocchini, C. A.; Scott, A. F.; Hamosh, A. McKusick's Online Mendelian Inheritance in Man (OMIM) Nucleic Acids Res. 2009, 37, D793-796
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 793-796
-
-
Amberger, J.1
Bocchini, C.A.2
Scott, A.F.3
Hamosh, A.4
-
7
-
-
38949188630
-
Pharmacogenomic biomarkers for prediction of severe adverse drug reactions
-
Ingelman-Sundberg, M. Pharmacogenomic biomarkers for prediction of severe adverse drug reactions N. Engl. J. Med. 2008, 358, 637-639
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 637-639
-
-
Ingelman-Sundberg, M.1
-
8
-
-
84861346585
-
Novel Data-Mining Methodologies for Adverse Drug Event Discovery and Analysis
-
Harpaz, R.; Dumouchel, W.; Shah, N. H.; Madigan, D.; Ryan, P.; Friedman, C. Novel Data-Mining Methodologies for Adverse Drug Event Discovery and Analysis Clin. Pharmacol. Ther. 2012, 91, 1010-1021
-
(2012)
Clin. Pharmacol. Ther.
, vol.91
, pp. 1010-1021
-
-
Harpaz, R.1
Dumouchel, W.2
Shah, N.H.3
Madigan, D.4
Ryan, P.5
Friedman, C.6
-
9
-
-
79959380528
-
Predicting adverse drug reactions using publicly available PubChem BioAssay data
-
Pouliot, Y.; Chiang, A. P.; Butte, A. J. Predicting adverse drug reactions using publicly available PubChem BioAssay data Clin. Pharmacol. Ther. 2011, 90, 90-99
-
(2011)
Clin. Pharmacol. Ther.
, vol.90
, pp. 90-99
-
-
Pouliot, Y.1
Chiang, A.P.2
Butte, A.J.3
-
10
-
-
79960601887
-
Can network analysis improve pattern recognition among adverse events following immunization reported to VAERS?
-
Ball, R.; Botsis, T. Can network analysis improve pattern recognition among adverse events following immunization reported to VAERS? Clin. Pharmacol. Ther. 2011, 90, 271-278
-
(2011)
Clin. Pharmacol. Ther.
, vol.90
, pp. 271-278
-
-
Ball, R.1
Botsis, T.2
-
11
-
-
84255163374
-
Predicting adverse side effects of drugs
-
Huang, L. C.; Wu, X.; Chen, J. Y. Predicting adverse side effects of drugs BMC Genom. 2011, 12 (Suppl 5) S11
-
(2011)
BMC Genom.
, vol.12
, Issue.SUPPL. 5
, pp. 11
-
-
Huang, L.C.1
Wu, X.2
Chen, J.Y.3
-
12
-
-
78951492723
-
Biclustering of adverse drug events in the FDA's spontaneous reporting system
-
Harpaz, R.; Perez, H.; Chase, H. S.; Rabadan, R.; Hripcsak, G.; Friedman, C. Biclustering of adverse drug events in the FDA's spontaneous reporting system Clin. Pharmacol. Ther. 2010, 89, 243-250
-
(2010)
Clin. Pharmacol. Ther.
, vol.89
, pp. 243-250
-
-
Harpaz, R.1
Perez, H.2
Chase, H.S.3
Rabadan, R.4
Hripcsak, G.5
Friedman, C.6
-
13
-
-
77449114835
-
Predicting drug side-effects by chemical systems biology
-
Tatonetti, N. P.; Liu, T.; Altman, R. B. Predicting drug side-effects by chemical systems biology Genome Biol. 2009, 10, 238
-
(2009)
Genome Biol.
, vol.10
, pp. 238
-
-
Tatonetti, N.P.1
Liu, T.2
Altman, R.B.3
-
14
-
-
78951492723
-
Biclustering of adverse drug events in the FDA's spontaneous reporting system
-
Harpaz, R.; Perez, H.; Chase, H. S.; Rabadan, R.; Hripcsak, G.; Friedman, C. Biclustering of adverse drug events in the FDA's spontaneous reporting system Clin. Pharmacol. Ther. 2011, 89, 243-250
-
(2011)
Clin. Pharmacol. Ther.
, vol.89
, pp. 243-250
-
-
Harpaz, R.1
Perez, H.2
Chase, H.S.3
Rabadan, R.4
Hripcsak, G.5
Friedman, C.6
-
15
-
-
79951813616
-
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs
-
Adkins, D. E.; Aberg, K.; McClay, J. L.; Bukszar, J.; Zhao, Z.; Jia, P.; Stroup, T. S.; Perkins, D.; McEvoy, J. P.; Lieberman, J. A.; Sullivan, P. F.; van den Oord, E. J. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs Mol. Psychiat. 2011, 16, 321-332
-
(2011)
Mol. Psychiat.
, vol.16
, pp. 321-332
-
-
Adkins, D.E.1
Aberg, K.2
McClay, J.L.3
Bukszar, J.4
Zhao, Z.5
Jia, P.6
Stroup, T.S.7
Perkins, D.8
McEvoy, J.P.9
Lieberman, J.A.10
Sullivan, P.F.11
Van Den Oord, E.J.12
-
16
-
-
60349110472
-
Data-driven methods to discover molecular determinants of serious adverse drug events
-
Chiang, A. P.; Butte, A. J. Data-driven methods to discover molecular determinants of serious adverse drug events Clin. Pharmacol. Ther. 2009, 85, 259-268
-
(2009)
Clin. Pharmacol. Ther.
, vol.85
, pp. 259-268
-
-
Chiang, A.P.1
Butte, A.J.2
-
17
-
-
84863548955
-
Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs
-
Liu, M.; Wu, Y.; Chen, Y.; Sun, J.; Zhao, Z.; Chen, X. W.; Matheny, M. E.; Xu, H. Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs J. Am. Med. Inf. Assoc. 2012, 19, e28-e35
-
(2012)
J. Am. Med. Inf. Assoc.
, vol.19
-
-
Liu, M.1
Wu, Y.2
Chen, Y.3
Sun, J.4
Zhao, Z.5
Chen, X.W.6
Matheny, M.E.7
Xu, H.8
-
18
-
-
79956321442
-
Pharmacological mechanism-based drug safety assessment and prediction
-
Abernethy, D. R.; Woodcock, J.; Lesko, L. J. Pharmacological mechanism-based drug safety assessment and prediction Clin. Pharmacol. Ther. 2011, 89, 793-797
-
(2011)
Clin. Pharmacol. Ther.
, vol.89
, pp. 793-797
-
-
Abernethy, D.R.1
Woodcock, J.2
Lesko, L.J.3
-
19
-
-
79953669856
-
Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome -Clozapine-induced agranulocytosis as a case study
-
Yang, L.; Wang, K.; Chen, J.; Jegga, A. G.; Luo, H.; Shi, L.; Wan, C.; Guo, X.; Qin, S.; He, G.; Feng, G.; He, L. Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome -clozapine-induced agranulocytosis as a case study PLoS Comput. Biol. 2011, 7, e1002016
-
(2011)
PLoS Comput. Biol.
, vol.7
, pp. 1002016
-
-
Yang, L.1
Wang, K.2
Chen, J.3
Jegga, A.G.4
Luo, H.5
Shi, L.6
Wan, C.7
Guo, X.8
Qin, S.9
He, G.10
Feng, G.11
He, L.12
-
20
-
-
36949009488
-
In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators
-
10.1371/journal.pcbi.0030217
-
Xie, L.; Wang, J.; Bourne, P. E. In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators PLoS Comput. Biol. 2007, 3, e217 10.1371/journal.pcbi.0030217
-
(2007)
PLoS Comput. Biol.
, vol.3
, pp. 217
-
-
Xie, L.1
Wang, J.2
Bourne, P.E.3
-
21
-
-
67049100457
-
Drug discovery using chemical systems biology: Identification of the protein-ligand binding network to explain the side effects of CETP inhibitors
-
Xie, L.; Li, J.; Bourne, P. E. Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors PLoS Comput. Biol. 2009, 5, e1000387
-
(2009)
PLoS Comput. Biol.
, vol.5
, pp. 1000387
-
-
Xie, L.1
Li, J.2
Bourne, P.E.3
-
22
-
-
84255172340
-
Predicting adverse drug events using pharmacological network models
-
Cami, A.; Arnold, A.; Manzi, S.; Reis, B. Predicting adverse drug events using pharmacological network models Sci. Transl. Med. 2011, 3, 114ra127
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Cami, A.1
Arnold, A.2
Manzi, S.3
Reis, B.4
-
23
-
-
84871595040
-
Extracting Sets of Chemical Substructures and Protein Domains Governing Drug-Target Interactions
-
Yamanishi, Y.; Pauwels, E.; Saigo, H.; Stoven, V. Extracting Sets of Chemical Substructures and Protein Domains Governing Drug-Target Interactions J. Chem. Inf. Model. 2012, 52, 3284-3292
-
(2012)
J. Chem. Inf. Model.
, vol.52
, pp. 3284-3292
-
-
Yamanishi, Y.1
Pauwels, E.2
Saigo, H.3
Stoven, V.4
-
24
-
-
84856805878
-
A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports
-
Tatonetti, N. P.; Fernald, G. H.; Altman, R. B. A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports J. Am. Med. Inf. Assoc. 2012, 19, 79-85
-
(2012)
J. Am. Med. Inf. Assoc.
, vol.19
, pp. 79-85
-
-
Tatonetti, N.P.1
Fernald, G.H.2
Altman, R.B.3
-
25
-
-
68149124572
-
Quantitative signal detection using spontaneous ADR reporting
-
Bate, A.; Evans, S. J. Quantitative signal detection using spontaneous ADR reporting Pharmacoepidem. Dr. S. 2009, 18, 427-436
-
(2009)
Pharmacoepidem. Dr. S.
, vol.18
, pp. 427-436
-
-
Bate, A.1
Evans, S.J.2
-
26
-
-
0036300732
-
Use of screening algorithms and computer systems to efficiently signal higher-than-expected combinations of drugs and events in the US FDA's spontaneous reports database
-
Szarfman, A.; Machado, S. G.; O'Neill, R. T. Use of screening algorithms and computer systems to efficiently signal higher-than-expected combinations of drugs and events in the US FDA's spontaneous reports database Drug Safety 2002, 25, 381-392
-
(2002)
Drug Safety
, vol.25
, pp. 381-392
-
-
Szarfman, A.1
MacHado, S.G.2
O'Neill, R.T.3
-
27
-
-
78651287426
-
DrugBank 3.0: A comprehensive resource for 'omics' research on drugs
-
Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs Nucleic Acids Res. 2011, 39, D1035-1041
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 1035-1041
-
-
Knox, C.1
Law, V.2
Jewison, T.3
Liu, P.4
Ly, S.5
Frolkis, A.6
Pon, A.7
Banco, K.8
Mak, C.9
Neveu, V.10
Djoumbou, Y.11
Eisner, R.12
Guo, A.C.13
Wishart, D.S.14
-
28
-
-
84859267371
-
Therapeutic target database update 2012: A resource for facilitating target-oriented drug discovery
-
Zhu, F.; Shi, Z.; Qin, C.; Tao, L.; Liu, X.; Xu, F.; Zhang, L.; Song, Y.; Zhang, J.; Han, B.; Zhang, P.; Chen, Y. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery Nucleic Acids Res. 2012, 40, D1128-1136
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 1128-1136
-
-
Zhu, F.1
Shi, Z.2
Qin, C.3
Tao, L.4
Liu, X.5
Xu, F.6
Zhang, L.7
Song, Y.8
Zhang, J.9
Han, B.10
Zhang, P.11
Chen, Y.12
-
29
-
-
38549137931
-
The pharmacogenetics and pharmacogenomics knowledge base: Accentuating the knowledge
-
Hernandez-Boussard, T.; Whirl-Carrillo, M.; Hebert, J. M.; Gong, L.; Owen, R.; Gong, M.; Gor, W.; Liu, F.; Truong, C.; Whaley, R.; Woon, M.; Zhou, T.; Altman, R. B.; Klein, T. E. The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge Nucleic Acids Res. 2008, 36, D913-918
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 913-918
-
-
Hernandez-Boussard, T.1
Whirl-Carrillo, M.2
Hebert, J.M.3
Gong, L.4
Owen, R.5
Gong, M.6
Gor, W.7
Liu, F.8
Truong, C.9
Whaley, R.10
Woon, M.11
Zhou, T.12
Altman, R.B.13
Klein, T.E.14
-
30
-
-
80053512597
-
Open Babel: An open chemical toolbox
-
[Online], Article 33; (accessed Nov 19, 2011)
-
Boyle, N. M; Banck, M.; James, C. A.; Morley, C.; Vandermeersch, T.; Hutchison, G. R. Open Babel: an open chemical toolbox. J. Cheminf. [Online] 2011, 3, Article 33; http://www.jcheminf.com/content/3/1/33 (accessed Nov 19, 2011).
-
(2011)
J. Cheminf.
, vol.3
-
-
Boyle, N.M.1
Banck, M.2
James, C.A.3
Morley, C.4
Vandermeersch, T.5
Hutchison, G.R.6
-
31
-
-
84870017710
-
AdmetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties
-
Cheng, F.; Li, W.; Zhou, Y.; Shen, J.; Wu, Z.; Liu, G.; Lee, P. W.; Tang, Y. admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties J. Chem. Inf. Model. 2012, 52, 3099-3105
-
(2012)
J. Chem. Inf. Model.
, vol.52
, pp. 3099-3105
-
-
Cheng, F.1
Li, W.2
Zhou, Y.3
Shen, J.4
Wu, Z.5
Liu, G.6
Lee, P.W.7
Tang, Y.8
-
32
-
-
79952689290
-
SnapShot: Protein-protein interaction networks
-
Seebacher, J.; Gavin, A. C. SnapShot: Protein-protein interaction networks Cell 2011, 144, 1000-1000.e1
-
(2011)
Cell
, vol.144
-
-
Seebacher, J.1
Gavin, A.C.2
-
33
-
-
38349107283
-
Basic notions for the analysis of large two-mode networks
-
Matthieu, L.; Mahnien, C.; Vecchio, N. D. Basic notions for the analysis of large two-mode networks Social Networks 2008, 30, 31-48
-
(2008)
Social Networks
, vol.30
, pp. 31-48
-
-
Matthieu, L.1
Mahnien, C.2
Vecchio, N.D.3
-
34
-
-
84863695210
-
Prediction of drug-target interactions and drug repositioning via network-based inference
-
Cheng, F.; Liu, C.; Jiang, J.; Lu, W.; Li, W.; Liu, G.; Zhou, W.; Huang, J.; Tang, Y. Prediction of drug-target interactions and drug repositioning via network-based inference PLoS Comput. Biol. 2012, 8, e1002503
-
(2012)
PLoS Comput. Biol.
, vol.8
, pp. 1002503
-
-
Cheng, F.1
Liu, C.2
Jiang, J.3
Lu, W.4
Li, W.5
Liu, G.6
Zhou, W.7
Huang, J.8
Tang, Y.9
-
35
-
-
84864003584
-
Prediction of chemical-protein interactions network with weighted network-based inference method
-
Cheng, F.; Zhou, Y.; Li, W.; Liu, G.; Tang, Y. Prediction of chemical-protein interactions network with weighted network-based inference method PLoS One 2012, 7, e41064
-
(2012)
PLoS One
, vol.7
, pp. 41064
-
-
Cheng, F.1
Zhou, Y.2
Li, W.3
Liu, G.4
Tang, Y.5
-
36
-
-
84866446560
-
Drug target prediction using adverse event report systems: A pharmacogenomic approach
-
Takarabe, M.; Kotera, M.; Nishimura, Y.; Goto, S.; Yamanishi, Y. Drug target prediction using adverse event report systems: a pharmacogenomic approach Bioinformatics 2012, 28, i611-i618
-
(2012)
Bioinformatics
, vol.28
-
-
Takarabe, M.1
Kotera, M.2
Nishimura, Y.3
Goto, S.4
Yamanishi, Y.5
-
37
-
-
0345863927
-
The Unified Medical Language System (UMLS): Integrating biomedical terminology
-
Bodenreider, O. The Unified Medical Language System (UMLS): integrating biomedical terminology Nucleic Acids Res. 2004, 32, D267-270
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 267-270
-
-
Bodenreider, O.1
-
38
-
-
33749249600
-
The Relationship between Precision-Recall and ROC Curves
-
Pittsburgh, PA, June 25-29, 2006; Cohen, W. W. A. M. ACM Press: PA
-
Davis, J.; Goadrich, M. The Relationship Between Precision-Recall and ROC Curves. In Proceedings of the Twenty Third International Conference on Machine Learning; Pittsburgh, PA, June 25-29, 2006; Cohen, W. W. A. M., Ed.; ACM Press: PA, 2006; pp 233-240.
-
(2006)
Proceedings of the Twenty Third International Conference on Machine Learning
, pp. 233-240
-
-
Davis, J.1
Goadrich, M.2
-
39
-
-
0027440420
-
The placebo effect in healthy volunteers: Influence of experimental conditions on the adverse events profile during phase i studies
-
Rosenzweig, P.; Brohier, S.; Zipfel, A. The placebo effect in healthy volunteers: influence of experimental conditions on the adverse events profile during phase I studies Clin. Pharmacol. Ther. 1993, 54, 578-583
-
(1993)
Clin. Pharmacol. Ther.
, vol.54
, pp. 578-583
-
-
Rosenzweig, P.1
Brohier, S.2
Zipfel, A.3
-
40
-
-
84870853693
-
GlaxoSmithKline opens the door on clinical data sharing
-
Harrison, C. GlaxoSmithKline opens the door on clinical data sharing Nat. Rev. Drug Discovery 2012, 11, 891-892
-
(2012)
Nat. Rev. Drug Discovery
, vol.11
, pp. 891-892
-
-
Harrison, C.1
|