Systems toxicology approaches for understanding the joint effects of environmental chemical mixtures

Science of the Total Environment

Volumn 408, Issue 18, 2010, Pages 3725-3734

  Spurgeon, David J ^a   Jones, Oliver A H ^b,c   Dorne, Jean Lou C M ^d,e   Svendsen, Claus ^a   Swain, Suresh ^f   Stürzenbaum, Stephen R ^f  

^a CENTRE FOR ECOLOGY AND HYDROLOGY   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c DURHAM UNIVERSITY   (United Kingdom)

^d EUROPEAN FOOD SAFETY AUTHORITY   (Italy)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^f KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

'omics; External exposure; Interaction; Mixture toxicity; Toxicodynamics; Toxicokinetics

Indexed keywords

COMBINED EFFECT; CONCENTRATION ADDITION; CONCEPTUAL FRAMEWORKS; ECO-TOXICOLOGY; ECOLOGICAL RISK ASSESSMENT; ENVIRONMENTAL CHEMICALS; ENVIRONMENTAL CHEMISTRY; EXPERIMENTAL STUDIES; EXTERNAL EXPOSURE; INDEPENDENT ACTION; JOINT EFFECT; MIXTURE TOXICITY; MULTI-DISCIPLINARY; RESEARCH NEEDS; STATE OF THE ART; SYSTEMS BIOLOGY; TARGET SITES; THREE STAGES; TOOLS AND TECHNIQUES; TOXICODYNAMICS; TOXICOKINETICS;

ADSORPTION; ASSOCIATION REACTIONS; BIOCHEMISTRY; CHEMICAL SPECIATION; FORECASTING; INDICATORS (CHEMICAL); MIXTURES; PHYSIOLOGY; RISK ASSESSMENT; RISK MANAGEMENT;

TOXICITY;

ANTIDEPRESSANT AGENT; ANTIINFLAMMATORY AGENT; CADMIUM; CAFFEINE; METAL; NANOMATERIAL; ORGANIC COMPOUND; ORGANOPHOSPHATE; PESTICIDE; PROCHLORAZ; THEOPHYLLINE; XENOBIOTIC AGENT;

BIOAVAILABILITY; CHEMICAL POLLUTANT; CONCEPTUAL FRAMEWORK; ECOTOXICOLOGY; ENVIRONMENTAL ISSUE; POLLUTION EXPOSURE; RISK ASSESSMENT; TOXICITY;

ADSORPTION; ARTICLE; BIOAVAILABILITY; CHEMICAL INTERACTION; CONCEPTUAL FRAMEWORK; ECOTOXICOLOGY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL IMPACT; EXPOSURE; HUMAN; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; RISK ASSESSMENT; SYSTEMS BIOLOGY; TOXICOGENETICS; TOXICOKINETICS; WASTE WATER MANAGEMENT;

BIOTRANSFORMATION; COMPLEX MIXTURES; DRUG INTERACTIONS; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; KINETICS; MODELS, CHEMICAL; SYSTEMS ANALYSIS;

EID: 77955049841     PISSN: 00489697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2010.02.038     Document Type: Article

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