Predictive models of prenatal developmental toxicity from toxcast high-throughput screening data

Toxicological Sciences

Volumn 124, Issue 1, 2011, Pages 109-127

  Sipes, Nisha S ^a   Martin, Matthew T ^a   Reif, David M ^a   Kleinstreuer, Nicole C ^a   Judson, Richard S ^a   Singh, Amar V ^b   Chandler, Kelly J ^c   Dix, David J ^a   Kavlock, Robert J ^a   Knudsen, Thomas B ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b LOCKHEED MARTIN   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Computational models predictive toxicology; Developmental toxicity; High throughput screening; Predictive models; ToxCast; ToxRefDB

Indexed keywords

G PROTEIN COUPLED RECEPTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; RETINOIC ACID RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLEFT PALATE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DISCRIMINANT ANALYSIS; EMBRYOTOXICITY; FETUS MALFORMATION; GOVERNMENT; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; NONHUMAN; OUTCOME ASSESSMENT; PRENATAL DEVELOPMENT; PRENATAL EXPOSURE; RAT; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; UNIVARIATE ANALYSIS; UROGENITAL TRACT MALFORMATION;

ANIMALS; CONGENITAL ABNORMALITIES; DATABASES, FACTUAL; EMBRYONIC DEVELOPMENT; ENDPOINT DETERMINATION; ENVIRONMENTAL POLLUTANTS; FETAL DEVELOPMENT; HIGH-THROUGHPUT SCREENING ASSAYS; MODELS, BIOLOGICAL; RABBITS; RATS; SPECIES SPECIFICITY; TERATOGENS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 80053516123     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr220     Document Type: Article

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