Application of toxicogenomics in hepatic systems toxicology for risk assessment: Acetaminophen as a case study

Toxicology and Applied Pharmacology

Volumn 250, Issue 2, 2011, Pages 96-107

  Kienhuis, Anne S ^a,b,c   Bessems, Jos G M ^a   Pennings, Jeroen L A ^a,c   Driessen, Marja ^a,c,d   Luijten, Mirjam ^a,c   van Delft, Joost H M ^c   Peijnenburg, Ad A C M ^b,c   der Ven, Leo T M van ^a,c  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Acetaminophen; Hepatic systems toxicology; Quantitative dose response modeling; Risk assessment; Toxicity pathways; Toxicogenomics

Indexed keywords

PARACETAMOL;

BIOINFORMATICS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; METABOLOMICS; PROTEOMICS; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; TECHNOLOGY; TOXICOGENETICS; TRANSCRIPTOMICS;

ACETAMINOPHEN; ANIMALS; COMPUTATIONAL BIOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; HUMANS; RISK ASSESSMENT; TOXICITY TESTS; TOXICOGENETICS;

ANIMALIA;

EID: 78650561076     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.10.013     Document Type: Review

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