Active-state model of a dopamine D2 receptor - Gαi complex stabilized by aripiprazole-type partial agonists

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Kling, Ralf C ^a   Tschammer, Nuska ^a   Lanig, Harald ^a   Clark, Timothy ^a,b   Gmeiner, Peter ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; DOPAMINE; DOPAMINE 2 RECEPTOR; EPITOPE; FAUC 350; G ALPHA I PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PARTIAL AGONIST; UNCLASSIFIED DRUG; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; NEUROLEPTIC AGENT; PIPERAZINE DERIVATIVE; PROTEIN BINDING; QUINOLONE DERIVATIVE;

ARTICLE; BINDING SITE; COMPLEX FORMATION; MOLECULAR DYNAMICS; PARTIAL AGONISM; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM;

ANTIPSYCHOTIC AGENTS; ARIPIPRAZOLE; DOPAMINE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PIPERAZINES; PROTEIN BINDING; PROTEIN CONFORMATION; QUINOLONES; RECEPTORS, DOPAMINE D2;

EID: 84903206923     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100069     Document Type: Article

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