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Volumn 69, Issue 1, 2006, Pages 397-405

The carboxyl terminus of the Gα-subunit is the latch for triggered activation of heterotrimeric G proteins

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MAGNESIUM ION; RECEPTOR; TRYPTOPHAN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MAGNESIUM;

EID: 30044447642     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.016725     Document Type: Article
Times cited : (33)

References (40)
  • 1
    • 0031467960 scopus 로고    scopus 로고
    • Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interaction
    • Bae H, Anderson K, Flood LA, Skiba NP, Hamm HE, and Graber SG (1997) Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interaction. J Biol Chem 272:32071-32077.
    • (1997) J Biol Chem , vol.272 , pp. 32071-32077
    • Bae, H.1    Anderson, K.2    Flood, L.A.3    Skiba, N.P.4    Hamm, H.E.5    Graber, S.G.6
  • 3
    • 0034692687 scopus 로고    scopus 로고
    • Binding of calmodulin to the D2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch
    • Bofill-Cardona E, Kudlacek O, Yang Q, Ahorn H, Freissmuth M, and Nanoff CJ (2000) Binding of calmodulin to the D2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch. J Biol Chem 275:32672-32680.
    • (2000) J Biol Chem , vol.275 , pp. 32672-32680
    • Bofill-Cardona, E.1    Kudlacek, O.2    Yang, Q.3    Ahorn, H.4    Freissmuth, M.5    Nanoff, C.J.6
  • 5
    • 0037221946 scopus 로고    scopus 로고
    • Activation of G-protein Galpha subunits by receptors through Galpha-Gbeta and Galpha-Ggamma interactions
    • Cherfils J and Chabre M (2003) Activation of G-protein Galpha subunits by receptors through Galpha-Gbeta and Galpha-Ggamma interactions. Trends Biochem Sci 28:13-17.
    • (2003) Trends Biochem Sci , vol.28 , pp. 13-17
    • Cherfils, J.1    Chabre, M.2
  • 7
    • 0028988578 scopus 로고
    • Interactions between the amino- and carboxyl-terminal regions of G alpha subunits: Analysis of mutated G alpha o/G alpha i2 chimeras
    • Denker BM, Boutin PM, and Neer EJ (1995) Interactions between the amino- and carboxyl-terminal regions of G alpha subunits: analysis of mutated G alpha o/G alpha i2 chimeras. Biochemistry 34:5544-5553.
    • (1995) Biochemistry , vol.34 , pp. 5544-5553
    • Denker, B.M.1    Boutin, P.M.2    Neer, E.J.3
  • 9
    • 0025947347 scopus 로고
    • Interactions of the bovine brain A1-adenosine receptor with recombinant G protein α-subunits. Selectivity for rGi α-3
    • Freissmuth M, Schütz W, and Linder ME (1991) Interactions of the bovine brain A1-adenosine receptor with recombinant G protein α-subunits. Selectivity for rGi α-3. J Biol Chem 266:17778-17783.
    • (1991) J Biol Chem , vol.266 , pp. 17778-17783
    • Freissmuth, M.1    Schütz, W.2    Linder, M.E.3
  • 10
    • 0026493757 scopus 로고
    • A truncated recombinant α subunit of Gi3 with a reduced affinity for βγ dimers and altered guanosine 5′-3-O-(thio)triphosphate binding
    • Graf R, Mattera R, Codina J, Estes MK, and Birnbaumer LJ (1992) A truncated recombinant α subunit of Gi3 with a reduced affinity for βγ dimers and altered guanosine 5′-3-O-(thio)triphosphate binding. J Biol Chem 267:24307-24314.
    • (1992) J Biol Chem , vol.267 , pp. 24307-24314
    • Graf, R.1    Mattera, R.2    Codina, J.3    Estes, M.K.4    Birnbaumer, L.J.5
  • 11
    • 0034098381 scopus 로고    scopus 로고
    • A surface-exposed region of G(sα) in which substitutions decrease receptor-mediated activation and increase receptor affinity
    • Grishina G and Berlot CH (2000) A surface-exposed region of G(sα) in which substitutions decrease receptor-mediated activation and increase receptor affinity. Mol Pharmacol 57:1081-1092.
    • (2000) Mol Pharmacol , vol.57 , pp. 1081-1092
    • Grishina, G.1    Berlot, C.H.2
  • 13
    • 0025193034 scopus 로고
    • Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity
    • Higashijima T, Burnier J, and Ross EM (1990) Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity. J Biol Chem 265:14176-14186.
    • (1990) J Biol Chem , vol.265 , pp. 14176-14186
    • Higashijima, T.1    Burnier, J.2    Ross, E.M.3
  • 14
    • 0023654308 scopus 로고
    • Regulation of hormone-sensitive GTP-dependent regulatory proteins by chloride
    • Higashijima T, Ferguson KM, and Sternweis PC (1987) Regulation of hormone-sensitive GTP-dependent regulatory proteins by chloride. J Biol Chem 262:3597-3602.
    • (1987) J Biol Chem , vol.262 , pp. 3597-3602
    • Higashijima, T.1    Ferguson, K.M.2    Sternweis, P.C.3
  • 16
    • 0032474767 scopus 로고    scopus 로고
    • G-protein diseases furnish a model for the turn-on switch
    • Iiri T, Farfel Z, and Bourne HR (1998) G-protein diseases furnish a model for the turn-on switch. Nature (Lond) 394:35-38.
    • (1998) Nature (Lond) , vol.394 , pp. 35-38
    • Iiri, T.1    Farfel, Z.2    Bourne, H.R.3
  • 19
    • 0033609101 scopus 로고    scopus 로고
    • Signal transfer from rhodopsin to the G-protein: Evidence for a two-site sequential fit mechanism
    • Kisselev OG, Meyer CK, Heck M, Ernst OP, and Hofmann KP (1999) Signal transfer from rhodopsin to the G-protein: evidence for a two-site sequential fit mechanism. Proc Natl Acad Sci USA 96:4898-4903.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4898-4903
    • Kisselev, O.G.1    Meyer, C.K.2    Heck, M.3    Ernst, O.P.4    Hofmann, K.P.5
  • 21
    • 0346755948 scopus 로고    scopus 로고
    • Rapid activation of transducin by mutations distant from the nucleotide-binding site: Evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins
    • Marin EP, Krishna AG, and Sakmar TP (2001) Rapid activation of transducin by mutations distant from the nucleotide-binding site: evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins. J Biol Chem 276:27400-27405.
    • (2001) J Biol Chem , vol.276 , pp. 27400-27405
    • Marin, E.P.1    Krishna, A.G.2    Sakmar, T.P.3
  • 22
    • 0037018839 scopus 로고    scopus 로고
    • Disruption of the alpha5 helix of transducin impairs rhodopsin-catalyzed nucleotide exchange
    • Marin EP, Krishna AG, and Sakmar TP (2002) Disruption of the alpha5 helix of transducin impairs rhodopsin-catalyzed nucleotide exchange. Biochemistry 41:6988-6994.
    • (2002) Biochemistry , vol.41 , pp. 6988-6994
    • Marin, E.P.1    Krishna, A.G.2    Sakmar, T.P.3
  • 23
    • 0028142193 scopus 로고
    • Myristoylation of G-protein alpha subunits
    • Mumby SM and Linder ME (1994) Myristoylation of G-protein alpha subunits. Methods Enzymol 237:254-267.
    • (1994) Methods Enzymol , vol.237 , pp. 254-267
    • Mumby, S.M.1    Linder, M.E.2
  • 24
    • 0034636206 scopus 로고    scopus 로고
    • Coupling between the N- and C-terminal domains influences transducin-alpha intrinsic GDP/GTP exchange
    • Muradov KG and Artemyev NO (2000) Coupling between the N- and C-terminal domains influences transducin-alpha intrinsic GDP/GTP exchange. Biochemistry 39:3937-3942.
    • (2000) Biochemistry , vol.39 , pp. 3937-3942
    • Muradov, K.G.1    Artemyev, N.O.2
  • 25
    • 0028972629 scopus 로고
    • Species differences in A1 adenosine receptor/G protein coupling: Identification of a membrane protein that stabilizes the association of the receptor/G protein complex
    • Nanoff C, Mitterauer T, Roka F, Hohenegger M, and Freissmuth M (1995) Species differences in A1 adenosine receptor/G protein coupling: identification of a membrane protein that stabilizes the association of the receptor/G protein complex. Mol Pharmacol 48:806-817.
    • (1995) Mol Pharmacol , vol.48 , pp. 806-817
    • Nanoff, C.1    Mitterauer, T.2    Roka, F.3    Hohenegger, M.4    Freissmuth, M.5
  • 26
    • 0030669722 scopus 로고    scopus 로고
    • G protein coupling of the rat A1-adenosine receptor-partial purification of a protein which stabilizes the receptor-G protein association
    • Nanoff C, Waldhoer M, Roka F, and Freissmuth M (1997) G protein coupling of the rat A1-adenosine receptor-partial purification of a protein which stabilizes the receptor-G protein association. Neuropharmacology 36:1211-1219.
    • (1997) Neuropharmacology , vol.36 , pp. 1211-1219
    • Nanoff, C.1    Waldhoer, M.2    Roka, F.3    Freissmuth, M.4
  • 27
    • 0025744421 scopus 로고
    • Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide
    • Okamoto T and Nishimoto I (1991) Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide. Proc Natl Acad Sci USA 88:8020-8023.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8020-8023
    • Okamoto, T.1    Nishimoto, I.2
  • 28
    • 0026630552 scopus 로고
    • Detection of G protein-activator regions in M4 subtype muscarinic, cholinergic, and α2-adrenergic receptors based upon characteristics in primary structure
    • Okamoto T and Nishimoto I (1992) Detection of G protein-activator regions in M4 subtype muscarinic, cholinergic, and α2-adrenergic receptors based upon characteristics in primary structure. J Biol Chem 267:8342-8346.
    • (1992) J Biol Chem , vol.267 , pp. 8342-8346
    • Okamoto, T.1    Nishimoto, I.2
  • 30
    • 0032555296 scopus 로고    scopus 로고
    • The A326S mutant of Giα1 as an approximation of the receptor-bound state
    • Posner BA, Mixon MB, Wall MA, Sprang SR, and Gilman AG (1998) The A326S mutant of Giα1 as an approximation of the receptor-bound state. J Biol Chem 273:21752-21758.
    • (1998) J Biol Chem , vol.273 , pp. 21752-21758
    • Posner, B.A.1    Mixon, M.B.2    Wall, M.A.3    Sprang, S.R.4    Gilman, A.G.5
  • 31
  • 32
    • 0028037835 scopus 로고
    • Regulation of G-protein activation by mastoparans and other cationic peptides
    • Ross EM and Higashijima T (1994) Regulation of G-protein activation by mastoparans and other cationic peptides. Methods Enzymol 237:26-37.
    • (1994) Methods Enzymol , vol.237 , pp. 26-37
    • Ross, E.M.1    Higashijima, T.2
  • 33
    • 0032478328 scopus 로고    scopus 로고
    • Transition-state structure for the ADP-ribosylation of recombinant Gialpha1 subunits by pertussis toxin
    • Scheuring J, Berti PJ, and Schramm VL (1998) Transition-state structure for the ADP-ribosylation of recombinant Gialpha1 subunits by pertussis toxin. Biochemistry 37:2748-2758.
    • (1998) Biochemistry , vol.37 , pp. 2748-2758
    • Scheuring, J.1    Berti, P.J.2    Schramm, V.L.3
  • 34
    • 0025237409 scopus 로고
    • Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system
    • Senogles SE, Spiegel AM, Padrell E, Iyengar R, and Caron MG (1990) Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system. J Biol Chem 265:4507-4514.
    • (1990) J Biol Chem , vol.265 , pp. 4507-4514
    • Senogles, S.E.1    Spiegel, A.M.2    Padrell, E.3    Iyengar, R.4    Caron, M.G.5
  • 35
    • 0030920782 scopus 로고    scopus 로고
    • G protein mechanisms: Insights from structural analysis
    • Sprang SR (1997) G protein mechanisms: insights from structural analysis. Annu Rev Biochem 66:639-678.
    • (1997) Annu Rev Biochem , vol.66 , pp. 639-678
    • Sprang, S.R.1
  • 36
    • 0028172426 scopus 로고
    • Binding of an α2 adrenergic receptor third intracellular loop peptide to Gβ and the amino terminus of Gα
    • Taylor JM, Jacob-Mosier GG, Lawton RG, Remmers AE, and Neubig RR (1994) Binding of an α2 adrenergic receptor third intracellular loop peptide to Gβ and the amino terminus of Gα. J Biol Chem 269:27618-27124.
    • (1994) J Biol Chem , vol.269 , pp. 27618-127124
    • Taylor, J.M.1    Jacob-Mosier, G.G.2    Lawton, R.G.3    Remmers, A.E.4    Neubig, R.R.5
  • 37
    • 0027491658 scopus 로고
    • G-protein alpha o subunit: Mutation of conserved cysteines identifies a subunit contact surface and alters GDP affinity
    • Thomas TC, Schmidt CJ, and Neer EJ (1993) G-protein alpha o subunit: mutation of conserved cysteines identifies a subunit contact surface and alters GDP affinity. Proc Natl Acad Sci USA 90:10295-10298.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10295-10298
    • Thomas, T.C.1    Schmidt, C.J.2    Neer, E.J.3
  • 38
    • 0027456328 scopus 로고
    • Amphipathic α-helical structure does not predict the ability of receptor-derived synthetic peptides to interact with guanine nucleotide-binding regulatory proteins
    • Voss T, Wallner E, Cernilovsky AP, and Freissmuth M (1993) Amphipathic α-helical structure does not predict the ability of receptor-derived synthetic peptides to interact with guanine nucleotide-binding regulatory proteins. J Biol Chem 268:4637-4642.
    • (1993) J Biol Chem , vol.268 , pp. 4637-4642
    • Voss, T.1    Wallner, E.2    Cernilovsky, A.P.3    Freissmuth, M.4
  • 39
    • 0029841941 scopus 로고    scopus 로고
    • Structural requirements for G(o) activation by receptor-derived peptides: Activation and modulation domains of the α2-adrenergic receptor i3c region
    • Wade SM, Scribner MK, Dalman HM, Taylor JM, and Neubig RR (1996) Structural requirements for G(o) activation by receptor-derived peptides: activation and modulation domains of the α2-adrenergic receptor i3c region. Mol Pharmacol 50:351-358.
    • (1996) Mol Pharmacol , vol.50 , pp. 351-358
    • Wade, S.M.1    Scribner, M.K.2    Dalman, H.M.3    Taylor, J.M.4    Neubig, R.R.5
  • 40
    • 0025353245 scopus 로고
    • Mastoparan interacts with the carboxyl terminus of the αsubunit of Gi
    • Weingarten R, Ransnäs L, Mueller H, Sklar LA, and Bokoch GM (1990) Mastoparan interacts with the carboxyl terminus of the αsubunit of Gi. J Biol Chem 265:11044-11049.
    • (1990) J Biol Chem , vol.265 , pp. 11044-11049
    • Weingarten, R.1    Ransnäs, L.2    Mueller, H.3    Sklar, L.A.4    Bokoch, G.M.5


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