Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets

BMC Medicine

Volumn 12, Issue 1, 2014, Pages

  Hall, Elin ^a   Volkov, Petr ^a   Dayeh, Tasnim ^a   Bacos, Karl ^a   Rönn, Tina ^a   Nitert, Marloes D ^b   Ling, Charlotte ^a  

^a LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

DNA methylation; Epigenetics; Human pancreatic islets; Insulin secretion; Lipotoxicity; mRNA expression; Palmitate; Type 2 diabetes

Indexed keywords

CARBON; FOLIC ACID; GLUCOSE; GLUTATHIONE; HEMOGLOBIN A1C; INSULIN; MESSENGER RNA; PALMITIC ACID; PYRUVIC ACID; CASPASE 3; CASPASE 7; DNA; HEPATOCYTE NUCLEAR FACTOR 1BETA; TRANSCRIPTION FACTOR 7 LIKE 2; PALMITIC ACID DERIVATIVE; TRANSCRIPTOME;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADULT; APOPTOSIS; ARTICLE; BODY MASS; BODY REGIONS; CLINICAL ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; CPG ISLAND; DNA ISOLATION; DNA METHYLATION; ENZYME ASSAY; EPIGENETICS; FATTY ACID METABOLISM; FEMALE; GENE; GENE EXPRESSION; GLIS3 GENE; GLUCONEOGENESIS; GLUTATHIONE METABOLISM; GLYCOLYSIS; HNF1B GENE; HUMAN; HUMAN TISSUE; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; RNA ISOLATION; SLC30A8 GENE; TCF7L2 GENE; DNA MICROARRAY; GENETIC ASSOCIATION; HUMAN CELL; LIPOTOXICITY; OXIDATIVE PHOSPHORYLATION; SINGLE NUCLEOTIDE POLYMORPHISM; CYTOLOGY; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; LIPID METABOLISM; METABOLISM; OBESITY; PROMOTER REGION; SECRETION (PROCESS);

APOPTOSIS; CASPASE 3; CASPASE 7; CPG ISLANDS; DIABETES MELLITUS, TYPE 2; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; LIPID METABOLISM; OBESITY; PALMITATES; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; TRANSCRIPTOME;

EID: 84902987423     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-12-103     Document Type: Article

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