Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes

European Journal of Endocrinology

Volumn 165, Issue 4, 2011, Pages 589-595

  Olsson, Anders H ^a   Yang, Beatrice T ^a   Hall, Elin ^a   Taneera, Jalal ^a   Salehi, Albert ^a   Nitert, Marloes Dekker ^a   Ling, Charlotte ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; GLUCOSE; HEMOGLOBIN A1C; INSULIN; MESSENGER RNA; RNA;

ADULT; AGED; ARTICLE; ATP6V1H GENE; CLINICAL ARTICLE; CONTROLLED STUDY; COX11 GENE; CPG ISLAND; DIABETOGENESIS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA METHYLATION; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN RELEASE; MALE; MICROARRAY ANALYSIS; NDUFA10 GENE; NDUFA5 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE PHOSPHORYLATION; PANCREAS ISLET; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION SITE;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; DNA METHYLATION; DOWN-REGULATION; ELECTRON TRANSPORT COMPLEX IV; FEMALE; GENE EXPRESSION; HUMANS; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; NADH DEHYDROGENASE; OXIDATIVE PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 80052618443     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-11-0282     Document Type: Article

References (27)

1. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR &Mandarino LJ. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. PNAS 2003 100 8466-8471. (doi:10.1073/pnas.1032913100)
2. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D & Groop LC. PGC-1 alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics 2003 34 267-273. (doi:10.1038/ng1180)
3. Dahlman I, Forsgren M, Sjogren A, Nordstrom EA, Kaaman M, Naslund E, Attersand A & Arner P. Downregulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis factor-alpha. Diabetes 2006 55 1792-1799. (doi:10.2337/db05-1421)
4. Lu H, Yang Y, Allister EM, Wijesekara N & Wheeler MB. The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach. Molecular and Cellular Proteomics 2008 7 1434-1451. (doi:10.1074/mcp.M700478-MCP200)
5. Ling C, Poulsen P, Simonsson S, Ronn T, Holmkvist J, Almgren P, Hagert P, Nilsson E, Mabey AG, Nilsson P, Vaag A & Groop L. Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. Journal of Clinical Investigation 2007 117 3427-3435. (doi:10.1172/JCI30938)
6. Ronn T, Poulsen P, Hansson O, Holmkvist J, Almgren P, Nilsson P, Tuomi T, Isomaa B, Groop L, Vaag A & Ling C. Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle. Diabetologia 2008 51 1159-1168. (doi:10.1007/s00125-008-1018-8)
7. Ronn T, Poulsen P, Tuomi T, Isomaa B, Groop L, Vaag A & Ling C. Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins. PLoS ONE 2009 4 e4793. (doi:10.1371/journal.pone.0004793)
8. Brons C, Jacobsen S, Nilsson E, Ronn T, Jensen CB, Storgaard H, Poulsen P, Groop L, Ling C, Astrup A & Vaag A. Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner. Journal of Clinical Endocrinology and Metabolism 2010 95 3048-3056. (doi:10.1210/jc.2009-2413)
9. Ling C, Del Guerra S, Lupi R, Ronn T, Granhall C, Luthman H, Masiello P, Marchetti P, Groop L & Del Prato S. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 2008 51 615-622. (doi:10.1007/s00125-007-0916-5)
10. Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, Nagaraj V, Reinbothe TM, Tuncel J, Eliasson L, Groop L, Rorsman P, Salehi A, Lyssenko V, Luthman H & Renstrom E. Overexpression of alpha 2A-adrenergic receptors contributes to type 2 diabetes. Science 2010 327 217-220. (doi:10.1126/science. 1176827)
11. Yang BT, Dayeh TA, Kirkpatrick CL, Taneera J, Kumar R, Groop L, Wollheim CB, Nitert MD & Ling C. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA (1c) levels in human pancreatic islets. Diabetologia 2011 54 360-367. (doi:10.1007/s00125-010- 1967-6)
12. Huang da W, Sherman BT & Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Research 2009 37 1-13. (doi:10.1093/nar/gkn923)
13. Huang da W, Sherman BT & Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature Protocols 2009 4 44-57. (doi:10.1038/nprot.2008.211)
14. Mulder H & Ling C. Mitochondrial dysfunction in pancreatic beta-cells in type 2 diabetes. Molecular and Cellular Endocrinology 2009 297 34-40. (doi:10.1016/j.mce.2008.05.015)
15. Kelley DE, He J, Menshikova EV & Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002 51 2944-2950. (doi:10.2337/diabetes.51.10.2944)
16. Anello M, Lupi R, Spampinato D, Piro S, Masini M, Boggi U, Del Prato S, Rabuazzo AM, Purrello F & Marchetti P. Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 2005 48 282-289. (doi:10.1007/s00125-004-1627-9)
17. Petersen KF, Dufour S, Befroy D, Garcia R & Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. New England Journal of Medicine 2004 350 664-671. (doi:10.1056/NEJMoa031314)
18. Ling C, Poulsen P, Carlsson E, Ridderstrale M, Almgren P, Wojtaszewski J, Beck-Nielsen H, Groop L & Vaag A. Multiple environmental and genetic factors influence skeletal muscle PGC-1 alpha and PGC-1 beta gene expression in twins. Journal of Clinical Investigation 2004 114 1518-1526. (Pubitemid 40385582)
19. Koeck T, Olsson AH, Nitert MD, Sharoyko VV, Ladenvall C, Kotova O, Reiling E, Ronn T, Parikh H, Taneera J, Eriksson JG, Metodiev MD, Larsson NG, Balhuizen A, Luthman H, Stancakova A, Kuusisto J, Laakso M, Poulsen P, Vaag A, Groop L, Lyssenko V, Mulder H & Ling C. A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes. Cell Metabolism 2011 13 80-91. (doi:10.1016/j.cmet.2010.12.007)
20. Olsson AH, Ronn T, Ladenvall C, Parikh H, Isomaa B, Groop L &Ling C. Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo. European Journal of Endocrinology 2011 164 765-771. (doi:10.1530/EJE-10-0995)
21. Wiederkehr A & Wollheim CB. Minireview: implication of mitochondria in insulin secretion and action. Endocrinology 2006 147 2643-2649. (doi:10.1210/en.2006-0057)
22. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA & Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003 52 102-110. (doi:10.2337/diabetes.52.1.102)
23. Clark A, Jones LC, De Koning E, Hansen BC & Matthews DR. Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function? Diabetes 2001 50 (Supplement 1) S169-S171. (doi:10.2337/diabetes.50.2007.S169)
24. Perales-Clemente E, Fernandez-Vizarra E, Acin-Perez R, Movilla N, Bayona-Bafaluy MP, Moreno-Loshuertos R, Perez-Martos A, Fernandez-Silva P & Enriquez JA. Five entry points of the mitochondrially encoded subunits in mammalian complex I assembly. Molecular and Cellular Biology 2010 30 3038-3047. (doi:10.1128/MCB.00025-10)
25. Chomyn A. Mitochondrial genetic control of assembly and function of complex I in mammalian cells. Journal of Bioenergetics and Biomembranes 2001 33 251-257. (doi:10.1023/A:1010791204961)
26. Dreja T, Jovanovic Z, Rasche A, Kluge R, Herwig R, Tung YC, Joost HG, Yeo GS & Al-Hasani H. Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome. Diabetologia 2010 53 309-320. (doi:10.1007/s00125-009-1576-4)
27. Fex M, Nitert MD, Wierup N, Sundler F, Ling C & Mulder H. Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet. Diabetologia 2007 50 74-83. (doi:10.1007/s00125-006-0464-4)